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The map label for this gene is degA [H]

Identifier: 73540893

GI number: 73540893

Start: 1280817

End: 1281830

Strand: Direct

Name: degA [H]

Synonym: Reut_A1198

Alternate gene names: 73540893

Gene position: 1280817-1281830 (Clockwise)

Preceding gene: 73540885

Following gene: 73540896

Centisome position: 33.65

GC content: 59.57

Gene sequence:

>1014_bases
ATGACGCAACGCGTATCAGTGAGGGATGTGGCAGAGGCTGCAGGCGTTTCGATCGGCAGCGTGTCACGCGTGTTGAATGA
AACGGGTTATGCCAGCGCTGCGCTGCGCGCACGGGTCCTGGCGGCTGTGGAAAAGCTGGGATATGCGCCGAGCTTTGCCG
CGAAGCACCTGCGCACAGGACGCAGCCACACGGTGGGATACCTGGTCTCGAACATTCGCAATCCGCTGCTGGCTGCACAT
TTCAGCGAAGTGGAGCGTCACCTGCAGGCGGCAGGCTATTCGGTCATTGTGGGAAATACGCTTGACCAGCCTCACCGCGA
TCGAGAGCTAGTTTCACTCTTTGAGACACGGCGGTTGGAGGGCATCATTGCCGCGCCCAGCGTGGAAAGCGAGTCGGCGA
CGGACTTCTTGTTTGGTGCATGCGGCCTGCCCGTCGTCATTCTTGATCGGGAGACGCCAAAGCCAATGGATGCGGTCATG
CTCGACCATCGGGCCGGCGTTCGGCAGTCCGTGGACTACCTGGTTTCCCTTGGCCATCGTCGCATTGCTTTGTTCGGCCC
CGGCGAGCACATTCGGCCGGGGCGCGAGAAGTTGTTGGGCTACCAGGACGGTCTTCAGGCAGCGGGGATTCCCTTTGATC
CGATGCTGGTATTCATGTCGCGGTCTGCTGTGGATTCATCGCGAACGCAGATGAGCGCGATGCTTGCCCTCGAAAAGCCA
CCCACTGCAATGATCGGGCTTGGGACCCGTTTGCTCTCAGGTGCCATCTATGCGGCAAGGAAAGCCGGCTTGGATATTCC
GCGAGATCTTTCGGTGATAGGCATTGGTACCCCGGAAACCCTGGAACTGATGTACCCGCCGTTAACCACGCTGCGCTTCA
ATATCGAAGCCGCGGCGCAAGCTGCTGCACAGTTGATGCTGGATAGATTGGAAGGCGTAGTCGATGAGCCCGCACGCCAG
GTAAATGTGCCGTTGGATCTCGTGCTGGGCGAGTCCTGCGCGATACGAATGTGA

Upstream 100 bases:

>100_bases
ACGTTTTCAGATCGAAAATGCACTGAAAAACGGCTTGGTGGTAAATTAGCAGTCGGAAAAATTGGCGTCCAACTGTGGAA
CGTTTTCATTAGGGAAGACC

Downstream 100 bases:

>100_bases
CGGCTTTTGGCGGCAGCCAACAGAATGCGAGCATGTTGAGGGTCAGCCGGAATTCGTGAAATTTTCGCCGATAATTGATC
TGGATGGGAGTCGCAATGAG

Product: LacI family transcription regulator

Products: NA

Alternate protein names: Degradation activator [H]

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MTQRVSVRDVAEAAGVSIGSVSRVLNETGYASAALRARVLAAVEKLGYAPSFAAKHLRTGRSHTVGYLVSNIRNPLLAAH
FSEVERHLQAAGYSVIVGNTLDQPHRDRELVSLFETRRLEGIIAAPSVESESATDFLFGACGLPVVILDRETPKPMDAVM
LDHRAGVRQSVDYLVSLGHRRIALFGPGEHIRPGREKLLGYQDGLQAAGIPFDPMLVFMSRSAVDSSRTQMSAMLALEKP
PTAMIGLGTRLLSGAIYAARKAGLDIPRDLSVIGIGTPETLELMYPPLTTLRFNIEAAAQAAAQLMLDRLEGVVDEPARQ
VNVPLDLVLGESCAIRM

Sequences:

>Translated_337_residues
MTQRVSVRDVAEAAGVSIGSVSRVLNETGYASAALRARVLAAVEKLGYAPSFAAKHLRTGRSHTVGYLVSNIRNPLLAAH
FSEVERHLQAAGYSVIVGNTLDQPHRDRELVSLFETRRLEGIIAAPSVESESATDFLFGACGLPVVILDRETPKPMDAVM
LDHRAGVRQSVDYLVSLGHRRIALFGPGEHIRPGREKLLGYQDGLQAAGIPFDPMLVFMSRSAVDSSRTQMSAMLALEKP
PTAMIGLGTRLLSGAIYAARKAGLDIPRDLSVIGIGTPETLELMYPPLTTLRFNIEAAAQAAAQLMLDRLEGVVDEPARQ
VNVPLDLVLGESCAIRM
>Mature_336_residues
TQRVSVRDVAEAAGVSIGSVSRVLNETGYASAALRARVLAAVEKLGYAPSFAAKHLRTGRSHTVGYLVSNIRNPLLAAHF
SEVERHLQAAGYSVIVGNTLDQPHRDRELVSLFETRRLEGIIAAPSVESESATDFLFGACGLPVVILDRETPKPMDAVML
DHRAGVRQSVDYLVSLGHRRIALFGPGEHIRPGREKLLGYQDGLQAAGIPFDPMLVFMSRSAVDSSRTQMSAMLALEKPP
TAMIGLGTRLLSGAIYAARKAGLDIPRDLSVIGIGTPETLELMYPPLTTLRFNIEAAAQAAAQLMLDRLEGVVDEPARQV
NVPLDLVLGESCAIRM

Specific function: Involved in the control of degradation of B.subtilis amidophosphoribosyltransferase (purF). Probably activates the gene for a degradative protease [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787948, Length=315, Percent_Identity=27.9365079365079, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1790369, Length=316, Percent_Identity=28.1645569620253, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1790194, Length=309, Percent_Identity=28.4789644012945, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1788474, Length=334, Percent_Identity=27.2455089820359, Blast_Score=114, Evalue=7e-27,
Organism=Escherichia coli, GI1789202, Length=292, Percent_Identity=27.3972602739726, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI1786540, Length=311, Percent_Identity=27.9742765273312, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1789068, Length=309, Percent_Identity=25.5663430420712, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI48994940, Length=312, Percent_Identity=26.2820512820513, Blast_Score=94, Evalue=9e-21,
Organism=Escherichia coli, GI1787906, Length=262, Percent_Identity=26.7175572519084, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1790715, Length=323, Percent_Identity=23.5294117647059, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787580, Length=298, Percent_Identity=25.503355704698, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 36314; Mature: 36183

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQRVSVRDVAEAAGVSIGSVSRVLNETGYASAALRARVLAAVEKLGYAPSFAAKHLRTG
CCCCCCHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCC
RSHTVGYLVSNIRNPLLAAHFSEVERHLQAAGYSVIVGNTLDQPHRDRELVSLFETRRLE
CCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHC
GIIAAPSVESESATDFLFGACGLPVVILDRETPKPMDAVMLDHRAGVRQSVDYLVSLGHR
CEEECCCCCCCCCHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHCCCC
RIALFGPGEHIRPGREKLLGYQDGLQAAGIPFDPMLVFMSRSAVDSSRTQMSAMLALEKP
EEEEECCCCCCCCCHHHHCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
PTAMIGLGTRLLSGAIYAARKAGLDIPRDLSVIGIGTPETLELMYPPLTTLRFNIEAAAQ
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCEEEEECCCHHEEEECHHHHHH
AAAQLMLDRLEGVVDEPARQVNVPLDLVLGESCAIRM
HHHHHHHHHHHHHHCCCHHHCCCCEEEEECCCCCCCC
>Mature Secondary Structure 
TQRVSVRDVAEAAGVSIGSVSRVLNETGYASAALRARVLAAVEKLGYAPSFAAKHLRTG
CCCCCHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHCC
RSHTVGYLVSNIRNPLLAAHFSEVERHLQAAGYSVIVGNTLDQPHRDRELVSLFETRRLE
CCHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHC
GIIAAPSVESESATDFLFGACGLPVVILDRETPKPMDAVMLDHRAGVRQSVDYLVSLGHR
CEEECCCCCCCCCHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHCCCC
RIALFGPGEHIRPGREKLLGYQDGLQAAGIPFDPMLVFMSRSAVDSSRTQMSAMLALEKP
EEEEECCCCCCCCCHHHHCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
PTAMIGLGTRLLSGAIYAARKAGLDIPRDLSVIGIGTPETLELMYPPLTTLRFNIEAAAQ
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCEEEEECCCHHEEEECHHHHHH
AAAQLMLDRLEGVVDEPARQVNVPLDLVLGESCAIRM
HHHHHHHHHHHHHHCCCHHHCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8407808; 9353932; 9384377 [H]