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The map label for this gene is dapA [H]

Identifier: 73540806

GI number: 73540806

Start: 1196699

End: 1197658

Strand: Direct

Name: dapA [H]

Synonym: Reut_A1104

Alternate gene names: 73540806

Gene position: 1196699-1197658 (Clockwise)

Preceding gene: 73540805

Following gene: 73540807

Centisome position: 31.44

GC content: 64.06

Gene sequence:

>960_bases
TTGTCGGAACATCGGTCGAGGCGGCCGGCTGTTCCGGTACAATCTCGTTATTCGCATCCCGAATTCCCTAACGTTATGAC
ACAGATTACCGGCAGCATTGTTGCCATCGTCACCCCGATGCATGAGGACGGCAGCCTGGATTACCCGGCGCTGCGCGCGC
TCGTCGACTGGCACGTGGCCGAGGGCACCGATGCCATCGTGATCGTTGGCACCACCGGCGAATCGCCCACCGTCTCGGTG
GACGAGCACTGCGAACTGATTCGCATGGCGGTGGAGCAGGCTGGCAAGCGGATTCCCATCATCGCCGGTACCGGCGGCAA
CTCGACCAAGGAAGCCATCGAGCTGACGGCCTTCGCCAAGAAGGTTGGCGCCGACGCCTCGCTCCAGGTCGTGCCGTACT
ACAACAAGCCGACCCAGGAAGGCATGTACCGGCATTTCCGCACCATCGCCGAGGCGGTGGAACTGCCGGTGCTGCTGTAC
AACGTGCCGGGCCGCACCGTTGCGGACATGACCAACGACACCATCCTGCGCCTCGCGCAGGTGCCAGGCATCGTCGGGGT
GAAGGAAGCGACCGGCAACATCGACCGCGCCGCGCAACTGATCAAGGATGCGCCGGAAGGCTTTGCGATCTACAGCGGTG
ACGATCCGACCGCCGTGGCGCTGATCCTGCTGGGCGGCAAAGGCAATATCTCGGTGACCGCCAACGTGGCGCCGCGCAAG
ATGCACGAAATGTGCGTGGCCGCGCTCAAGGGCGACGTGGTGACCGCGCGCCGCCTGCACATGGAACTGATCGAGTTGAA
CAAGGCGATGTTCGTCGAAGCCAACCCGATTCCGGTCAAGTGGGCTCTGCAGCAGATGGGCAAGATGGAAGGCGGCATCC
GCCTGCCGCTCACGCCGCTGCTGGAGTCCAATCACGAGACCGTGCGCAAGGCACTGGCCGCCGCTGGCCTGCTGCGCTGA

Upstream 100 bases:

>100_bases
GCGGCAACGTGCCGCCACGCTACCCGCTCCCGACCTGAAGCGGCGTCTCCGTTATCCGCGAGAATGCCGCTTCACACGTT
GAACCGTTTGGTGTAACCCC

Downstream 100 bases:

>100_bases
TTTTCCGGCGCACCCGTGCCGTCCCCTCAACTAGGATTGCGTGTCAATGAAACTCAAGCTTAACCGCCGTGGCGCGACGC
AAGTCCGCCGCGCCGCACTG

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 319; Mature: 318

Protein sequence:

>319_residues
MSEHRSRRPAVPVQSRYSHPEFPNVMTQITGSIVAIVTPMHEDGSLDYPALRALVDWHVAEGTDAIVIVGTTGESPTVSV
DEHCELIRMAVEQAGKRIPIIAGTGGNSTKEAIELTAFAKKVGADASLQVVPYYNKPTQEGMYRHFRTIAEAVELPVLLY
NVPGRTVADMTNDTILRLAQVPGIVGVKEATGNIDRAAQLIKDAPEGFAIYSGDDPTAVALILLGGKGNISVTANVAPRK
MHEMCVAALKGDVVTARRLHMELIELNKAMFVEANPIPVKWALQQMGKMEGGIRLPLTPLLESNHETVRKALAAAGLLR

Sequences:

>Translated_319_residues
MSEHRSRRPAVPVQSRYSHPEFPNVMTQITGSIVAIVTPMHEDGSLDYPALRALVDWHVAEGTDAIVIVGTTGESPTVSV
DEHCELIRMAVEQAGKRIPIIAGTGGNSTKEAIELTAFAKKVGADASLQVVPYYNKPTQEGMYRHFRTIAEAVELPVLLY
NVPGRTVADMTNDTILRLAQVPGIVGVKEATGNIDRAAQLIKDAPEGFAIYSGDDPTAVALILLGGKGNISVTANVAPRK
MHEMCVAALKGDVVTARRLHMELIELNKAMFVEANPIPVKWALQQMGKMEGGIRLPLTPLLESNHETVRKALAAAGLLR
>Mature_318_residues
SEHRSRRPAVPVQSRYSHPEFPNVMTQITGSIVAIVTPMHEDGSLDYPALRALVDWHVAEGTDAIVIVGTTGESPTVSVD
EHCELIRMAVEQAGKRIPIIAGTGGNSTKEAIELTAFAKKVGADASLQVVPYYNKPTQEGMYRHFRTIAEAVELPVLLYN
VPGRTVADMTNDTILRLAQVPGIVGVKEATGNIDRAAQLIKDAPEGFAIYSGDDPTAVALILLGGKGNISVTANVAPRKM
HEMCVAALKGDVVTARRLHMELIELNKAMFVEANPIPVKWALQQMGKMEGGIRLPLTPLLESNHETVRKALAAAGLLR

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=293, Percent_Identity=26.962457337884, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI13540533, Length=242, Percent_Identity=26.8595041322314, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1788823, Length=291, Percent_Identity=51.5463917525773, Blast_Score=297, Evalue=6e-82,
Organism=Escherichia coli, GI87082415, Length=302, Percent_Identity=32.4503311258278, Blast_Score=148, Evalue=4e-37,
Organism=Escherichia coli, GI1786463, Length=245, Percent_Identity=33.8775510204082, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1789620, Length=237, Percent_Identity=30.8016877637131, Blast_Score=131, Evalue=6e-32,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 34393; Mature: 34262

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00665 DHDPS_1 ; PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHRSRRPAVPVQSRYSHPEFPNVMTQITGSIVAIVTPMHEDGSLDYPALRALVDWHVA
CCCCCCCCCCCCCHHCCCCCCCCHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHCC
EGTDAIVIVGTTGESPTVSVDEHCELIRMAVEQAGKRIPIIAGTGGNSTKEAIELTAFAK
CCCCEEEEEECCCCCCEEEHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHH
KVGADASLQVVPYYNKPTQEGMYRHFRTIAEAVELPVLLYNVPGRTVADMTNDTILRLAQ
HHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCEEHHCCCHHHHHHHH
VPGIVGVKEATGNIDRAAQLIKDAPEGFAIYSGDDPTAVALILLGGKGNISVTANVAPRK
CCCCEEEHHCCCCHHHHHHHHHCCCCCCEEECCCCCCEEEEEEECCCCCEEEEECCCHHH
MHEMCVAALKGDVVTARRLHMELIELNKAMFVEANPIPVKWALQQMGKMEGGIRLPLTPL
HHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCCCEECCCHHH
LESNHETVRKALAAAGLLR
HCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SEHRSRRPAVPVQSRYSHPEFPNVMTQITGSIVAIVTPMHEDGSLDYPALRALVDWHVA
CCCCCCCCCCCCHHCCCCCCCCHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHCC
EGTDAIVIVGTTGESPTVSVDEHCELIRMAVEQAGKRIPIIAGTGGNSTKEAIELTAFAK
CCCCEEEEEECCCCCCEEEHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHH
KVGADASLQVVPYYNKPTQEGMYRHFRTIAEAVELPVLLYNVPGRTVADMTNDTILRLAQ
HHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCEEHHCCCHHHHHHHH
VPGIVGVKEATGNIDRAAQLIKDAPEGFAIYSGDDPTAVALILLGGKGNISVTANVAPRK
CCCCEEEHHCCCCHHHHHHHHHCCCCCCEEECCCCCCEEEEEEECCCCCEEEEECCCHHH
MHEMCVAALKGDVVTARRLHMELIELNKAMFVEANPIPVKWALQQMGKMEGGIRLPLTPL
HHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHCCCEECCCHHH
LESNHETVRKALAAAGLLR
HCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]