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The map label for this gene is edd [H]

Identifier: 73540783

GI number: 73540783

Start: 1173667

End: 1175538

Strand: Direct

Name: edd [H]

Synonym: Reut_A1081

Alternate gene names: 73540783

Gene position: 1173667-1175538 (Clockwise)

Preceding gene: 73540781

Following gene: 73540784

Centisome position: 30.83

GC content: 70.19

Gene sequence:

>1872_bases
ATGCCCCACGCCGTCCATGCCGAAATCCTTGCCGTAACCCGGCGCATCACCGAGCGCAGCCGCGCCAGCCGCGCGGCCTA
CCTGGCGCGCTGCGAACGCGCCCAGGCAGAGCTTGGCCCGCTGCGCGGCCTCTCGTGCGCTAACCTGGCCCACGGCTTTG
CCGCGCTGCCGGCGCATGACAAGCTGAAGCTTCGCGTCGAACACGCACCGAACCTCGGCATCGTGACGGCCTACAACGAC
ATGCTGTCGGCGCACCAGCCGTACGAGCGCTATCCCGACGTGATTCGTGAGGCCGCACGTGCCGTGGGCGCCGTGGCGCA
GGTTGCCGGCGGCGTGCCGGCGATGTGCGACGGCATTACGCAGGGCAACCCGGGCATGGAGCTGTCGCTGTTCTCGCGCG
ATGCAATTGCCATGAGCACGGCGGTCTCGCTCTCGCACAACACCTTTGACGCCGCGGTGATGCTTGGCGTGTGCGACAAG
ATCGTGCCGGGGCTGGTCATGGGCGCGCTGCAGTTCGGCCACCTGCCGGTCGTGTTCGTGCCGGCCGGGCCGATGGCGAG
CGGCCTCCCGAACAAGGAAAAGGCGCGCGTGCGCCAGCTTTATGCGACCGGCCAGGTTGGCCGCGAAGCCTTGCTTGAAG
CCGAGTGCGAGGCCTACCACAGCGCAGGTACGTGCACGTTCTACGGCACCGCCAACAGTAACCAGTTCCTGATGGAAATC
ATGGGCCTGCACCTGCCCGGTGCAGCCTTCGTCCACCCGGACAGCGGCTTGCGCGATGCCCTGACCGCAGCGGCGGCGCA
GCGCGCGCTGGCGCTGTCGGCGCGAGGCACTGAATACATGCCGATGGCGCGCATCGTCGACGAGCGTGCCGTCGTCAATG
CGATGGTCGGCCTGCTGGCCACCGGCGGTTCCACCAACCACACCATCCACCTGGTCGCCATGGCGCGTGCCGCGGGCGTG
CTGATCGACTGGGACGATTTCGACCGGCTGTCCGGCATCACGCCGCTGCTGGCGCGCGTGTATCCGAACGGCTCGGCGGA
CGTGAACCATTTCCACGCCGCGGGCGGCACGGGCTTTGTGATCGGCCAGCTTCTGGAGGCCGGGCTCCTGCACGAGGACG
TGCAGACCGTCGCCGGCCCGGGTCTCGCGCGCTACACGCAGGAGCCGGTGCTGGCCGATGGCGTGCTGCGCTGGCGCGAT
GGCGCGAGCACCAGCGGCGACGCGCAGGTGCTGGCCACGGCGGCGGAGCCGTTCTCCGCCGAAGGCGGCCTGCGCCTGAT
GCAGGGCAACCTGGGGCGCGGCGTGATCAAGGTGTCCGCCGTGGCGCCGGAGCACCGCGTGGTCGAGGCGCCGGCGCGCG
TGTTCGATTCGCAGGAAGCGCTGCAGGCAGCCTTCAATGCAGGCGAGCTCAACGGCGACGTGGTAGCCGTGGTGCGCTTC
CAGGGACCCAATGCCAATGGCATGCCCGAATTGCATCGCCTCACGCCCGTGCTTGGTGCGCTGCAGGACGCCGGCCACAG
CGTCGCGCTGGTGACGGACGGGCGTATGTCCGGTGCATCGGGCAAGGTGCCGGCGGTGATCCACGTCGGCCCCGAGGCGC
TGGCTGGCGGCCCGCTGGCCCGGGTGCGTGACGGCGACCGCGTGCGTGTGGACGCCGTTGCCGGCACGCTTGCCTGGCTT
GGCGATCCGGCGGAATTCGCCGCGCGTTCGGTCGCGCCCGCGCCGGACGATGGCTTCGCCCAGTTCAGCGTCGGCCGGGG
GCTGTTCGGCCTGTTCCGGCGCCACGCGCGCAAGGCGGAAGAGGGTGGCAGTGCACTCGACCTGTCCGAAGCCGACGCCG
TTCCCGCGGCGACGCATTCCGTCGCACAATAG

Upstream 100 bases:

>100_bases
GTACGCAAGGCTGCGAGTGAGGTTTTTCTGTCGTTATAATGTAGAAAATCTACATGCCAGAGGCGGTCAGTCGCCCGGGT
TTCTAAAGGAACGTTCATCC

Downstream 100 bases:

>100_bases
TCGGGCCTGGGGCCTGTATCACCGCAATTTTTTTGAATCCCCGGGCGGCGCAGCCGCCGTCCGGCACCTGCGCGCCGTTT
GCCAGCGCGCGGGCTACCGA

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 623; Mature: 622

Protein sequence:

>623_residues
MPHAVHAEILAVTRRITERSRASRAAYLARCERAQAELGPLRGLSCANLAHGFAALPAHDKLKLRVEHAPNLGIVTAYND
MLSAHQPYERYPDVIREAARAVGAVAQVAGGVPAMCDGITQGNPGMELSLFSRDAIAMSTAVSLSHNTFDAAVMLGVCDK
IVPGLVMGALQFGHLPVVFVPAGPMASGLPNKEKARVRQLYATGQVGREALLEAECEAYHSAGTCTFYGTANSNQFLMEI
MGLHLPGAAFVHPDSGLRDALTAAAAQRALALSARGTEYMPMARIVDERAVVNAMVGLLATGGSTNHTIHLVAMARAAGV
LIDWDDFDRLSGITPLLARVYPNGSADVNHFHAAGGTGFVIGQLLEAGLLHEDVQTVAGPGLARYTQEPVLADGVLRWRD
GASTSGDAQVLATAAEPFSAEGGLRLMQGNLGRGVIKVSAVAPEHRVVEAPARVFDSQEALQAAFNAGELNGDVVAVVRF
QGPNANGMPELHRLTPVLGALQDAGHSVALVTDGRMSGASGKVPAVIHVGPEALAGGPLARVRDGDRVRVDAVAGTLAWL
GDPAEFAARSVAPAPDDGFAQFSVGRGLFGLFRRHARKAEEGGSALDLSEADAVPAATHSVAQ

Sequences:

>Translated_623_residues
MPHAVHAEILAVTRRITERSRASRAAYLARCERAQAELGPLRGLSCANLAHGFAALPAHDKLKLRVEHAPNLGIVTAYND
MLSAHQPYERYPDVIREAARAVGAVAQVAGGVPAMCDGITQGNPGMELSLFSRDAIAMSTAVSLSHNTFDAAVMLGVCDK
IVPGLVMGALQFGHLPVVFVPAGPMASGLPNKEKARVRQLYATGQVGREALLEAECEAYHSAGTCTFYGTANSNQFLMEI
MGLHLPGAAFVHPDSGLRDALTAAAAQRALALSARGTEYMPMARIVDERAVVNAMVGLLATGGSTNHTIHLVAMARAAGV
LIDWDDFDRLSGITPLLARVYPNGSADVNHFHAAGGTGFVIGQLLEAGLLHEDVQTVAGPGLARYTQEPVLADGVLRWRD
GASTSGDAQVLATAAEPFSAEGGLRLMQGNLGRGVIKVSAVAPEHRVVEAPARVFDSQEALQAAFNAGELNGDVVAVVRF
QGPNANGMPELHRLTPVLGALQDAGHSVALVTDGRMSGASGKVPAVIHVGPEALAGGPLARVRDGDRVRVDAVAGTLAWL
GDPAEFAARSVAPAPDDGFAQFSVGRGLFGLFRRHARKAEEGGSALDLSEADAVPAATHSVAQ
>Mature_622_residues
PHAVHAEILAVTRRITERSRASRAAYLARCERAQAELGPLRGLSCANLAHGFAALPAHDKLKLRVEHAPNLGIVTAYNDM
LSAHQPYERYPDVIREAARAVGAVAQVAGGVPAMCDGITQGNPGMELSLFSRDAIAMSTAVSLSHNTFDAAVMLGVCDKI
VPGLVMGALQFGHLPVVFVPAGPMASGLPNKEKARVRQLYATGQVGREALLEAECEAYHSAGTCTFYGTANSNQFLMEIM
GLHLPGAAFVHPDSGLRDALTAAAAQRALALSARGTEYMPMARIVDERAVVNAMVGLLATGGSTNHTIHLVAMARAAGVL
IDWDDFDRLSGITPLLARVYPNGSADVNHFHAAGGTGFVIGQLLEAGLLHEDVQTVAGPGLARYTQEPVLADGVLRWRDG
ASTSGDAQVLATAAEPFSAEGGLRLMQGNLGRGVIKVSAVAPEHRVVEAPARVFDSQEALQAAFNAGELNGDVVAVVRFQ
GPNANGMPELHRLTPVLGALQDAGHSVALVTDGRMSGASGKVPAVIHVGPEALAGGPLARVRDGDRVRVDAVAGTLAWLG
DPAEFAARSVAPAPDDGFAQFSVGRGLFGLFRRHARKAEEGGSALDLSEADAVPAATHSVAQ

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=602, Percent_Identity=60.2990033222591, Blast_Score=736, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=543, Percent_Identity=30.939226519337, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI2367371, Length=468, Percent_Identity=31.4102564102564, Blast_Score=162, Evalue=5e-41,
Organism=Escherichia coli, GI1786464, Length=466, Percent_Identity=31.1158798283262, Blast_Score=147, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6322476, Length=486, Percent_Identity=31.4814814814815, Blast_Score=186, Evalue=7e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 64941; Mature: 64809

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHAVHAEILAVTRRITERSRASRAAYLARCERAQAELGPLRGLSCANLAHGFAALPAHD
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCHHCCCCCC
KLKLRVEHAPNLGIVTAYNDMLSAHQPYERYPDVIREAARAVGAVAQVAGGVPAMCDGIT
CEEEEEECCCCCCEEEECHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCC
QGNPGMELSLFSRDAIAMSTAVSLSHNTFDAAVMLGVCDKIVPGLVMGALQFGHLPVVFV
CCCCCCEEEEECCCHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
PAGPMASGLPNKEKARVRQLYATGQVGREALLEAECEAYHSAGTCTFYGTANSNQFLMEI
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHH
MGLHLPGAAFVHPDSGLRDALTAAAAQRALALSARGTEYMPMARIVDERAVVNAMVGLLA
HHCCCCCCEEECCCCCHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHH
TGGSTNHTIHLVAMARAAGVLIDWDDFDRLSGITPLLARVYPNGSADVNHFHAAGGTGFV
CCCCCCCEEEEEEEHHHCCEEEECCCHHHHCCHHHHHHHHCCCCCCCCCEEECCCCCHHH
IGQLLEAGLLHEDVQTVAGPGLARYTQEPVLADGVLRWRDGASTSGDAQVLATAAEPFSA
HHHHHHHHHHHHHHHHHCCCCHHHHCCCCCHHCCEEEECCCCCCCCCCEEEEECCCCCCC
EGGLRLMQGNLGRGVIKVSAVAPEHRVVEAPARVFDSQEALQAAFNAGELNGDVVAVVRF
CCCCEEEECCCCCCEEEEEEECCCCHHHHHHHHHHCHHHHHHHHHCCCCCCCCEEEEEEE
QGPNANGMPELHRLTPVLGALQDAGHSVALVTDGRMSGASGKVPAVIHVGPEALAGGPLA
ECCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEEEECHHHHCCCCCC
RVRDGDRVRVDAVAGTLAWLGDPAEFAARSVAPAPDDGFAQFSVGRGLFGLFRRHARKAE
CCCCCCEEEEEHHHHHHHHCCCCHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHH
EGGSALDLSEADAVPAATHSVAQ
CCCCEECCCCCCCCCCCHHHCCC
>Mature Secondary Structure 
PHAVHAEILAVTRRITERSRASRAAYLARCERAQAELGPLRGLSCANLAHGFAALPAHD
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCHHCCCCCC
KLKLRVEHAPNLGIVTAYNDMLSAHQPYERYPDVIREAARAVGAVAQVAGGVPAMCDGIT
CEEEEEECCCCCCEEEECHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCC
QGNPGMELSLFSRDAIAMSTAVSLSHNTFDAAVMLGVCDKIVPGLVMGALQFGHLPVVFV
CCCCCCEEEEECCCHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
PAGPMASGLPNKEKARVRQLYATGQVGREALLEAECEAYHSAGTCTFYGTANSNQFLMEI
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHH
MGLHLPGAAFVHPDSGLRDALTAAAAQRALALSARGTEYMPMARIVDERAVVNAMVGLLA
HHCCCCCCEEECCCCCHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHH
TGGSTNHTIHLVAMARAAGVLIDWDDFDRLSGITPLLARVYPNGSADVNHFHAAGGTGFV
CCCCCCCEEEEEEEHHHCCEEEECCCHHHHCCHHHHHHHHCCCCCCCCCEEECCCCCHHH
IGQLLEAGLLHEDVQTVAGPGLARYTQEPVLADGVLRWRDGASTSGDAQVLATAAEPFSA
HHHHHHHHHHHHHHHHHCCCCHHHHCCCCCHHCCEEEECCCCCCCCCCEEEEECCCCCCC
EGGLRLMQGNLGRGVIKVSAVAPEHRVVEAPARVFDSQEALQAAFNAGELNGDVVAVVRF
CCCCEEEECCCCCCEEEEEEECCCCHHHHHHHHHHCHHHHHHHHHCCCCCCCCEEEEEEE
QGPNANGMPELHRLTPVLGALQDAGHSVALVTDGRMSGASGKVPAVIHVGPEALAGGPLA
ECCCCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCEEEEECHHHHCCCCCC
RVRDGDRVRVDAVAGTLAWLGDPAEFAARSVAPAPDDGFAQFSVGRGLFGLFRRHARKAE
CCCCCCEEEEEHHHHHHHHCCCCHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHH
EGGSALDLSEADAVPAATHSVAQ
CCCCEECCCCCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8045900; 10984043 [H]