Click here to switch to the map view.

The map label for this gene is ggt [H]

Identifier: 73540708

GI number: 73540708

Start: 1092491

End: 1094368

Strand: Direct

Name: ggt [H]

Synonym: Reut_A1005

Alternate gene names: 73540708

Gene position: 1092491-1094368 (Clockwise)

Preceding gene: 73540707

Following gene: 73540714

Centisome position: 28.7

GC content: 66.45

Gene sequence:

>1878_bases
ATGGCTCACCTGCTTGCATCCCGATTGGCGTGGCGCGGTTCGATCATTGTGACGTTCACGGCGCTGATGGCCGCGTGCGG
CACGCAAAGCGGGGCACCTGCGGCGCCTGCCGCGCCCGCGGCACCTCAGCCTCCCGCCACGGCAACGCTGCCACCTGCAC
CTGAAATAGCGTCGGGTTACCGCACCGACATGTCGACGGTGTACGCCGAGAAATACATGGCAGCGGCAGCCAATCCTCTG
GCCACCGAAGCCGGGCGCGACGTACTGCGCCAGGGCGGCTCGGCAATCGATGCCGCCATCGCCATGCAGGCGGTATTGAC
ACTGGTGGAACCACAGGCCTCGGGTGTCGGTGGCGGCGCCTTCATCATGTACTGGGACGGCAAGCGCGTGCAGGCCTTCG
ACGGCCGCGAGACCGCACCGGCCGGCGCCACGGAAAACCTGTTCCTCCGCCCCGACGGCAAGCCGATGGAATTCAGCGAG
GCGCAGATCGGCGGGCGCTCGGTGGGCACGCCCGGGGTGCTGCGCGCGCTTGAAATGGCGCACCGCGAGCATGGCAAGCT
CAAGTGGTCGCAACTGTTCCAGCGCGCGATCTCGCTTGCGGAGAAGGGATTCCCGATCTCTCCACGGCTTTACGCGCAGG
TGGCGAGCGACAAGTTCATGTCGAACTCTCCTGAGATGTCCGCGTATTTCCTCGACGCCCAGGGCAAGCCCAAGCCGGCC
GGTACCATCCTGAAGAACCCGCAACTCGCGCAGACGCTGCGCGCGATTGCCGCTAATGGTCCCAACGCGCTGTACACCGG
ACCGATCGCGCGCGACATCGTCACCAAGGTCAACGGAAGCCTCAATCCGGGCAGCCTGTCCACGCGCGACCTCGTGAACT
ACCGGGCCAAATTGCGTGTTCCGGTCTGTACCGACTACAAGCGCTGGAAGATCTGCGGCATGCCACCGCCGTCGTCGGGC
GGGATCGCGCTGGCGCAGATTCTTGGCACGCTGCAGGCGCTGGAAACGCGTAACCCGAAGTACGCGCTCGCCGCACTCAA
GCCATCCGCGGTCAGCACGCCCGCTGTCTTGGAAGCCAATCCCGATGCCGTCCACGCCATCGCCGAAGCCGATCGCCTGG
CCTACGCCGACCGTGGCCTCTACGTGGCGGATTCGGACTTCGTGCAAGTCGATATCGCGGGCATGGTCAATCCGGCCTAC
CTGGAGCAGCGCGCGTCGCTGATCAGTGACAAGAGCATGGGGAAGGCCCAGCCCGGCGTGCCGCCAGGCACCTCGGTGGC
CTTCGCGCCGGACCGCTCGCCGCCGCGCATCTCAACGTCGCAGATCGTCGCGGTGGACAGCCGCGGCGGTGCCATTTCCA
TGACGACGACGGTCGAGTCCTACTTCGGCTCGCACATCATGGTGCGCGGCTTCATGCTCAACAACCAGCTCACGGACTTC
TCCTTCCTGCCGAGCGAAAACGGCAAGCCCGTGGCCAACCGCGTCGAGCCGGGCAAGCGCCCGCGTTCGTCGATGGCGCC
GACGCTCGTGTTCGACCGGGAGAGCGGCAAATTCCTGGGCACGGTGGGATCGCCGGGCGGCTCGCAGATCATCGAGTACG
TTTCCAAGACGCTGGTTGGACTGCTCGACTGGAATATGGACGTGCAGGCGGCCATCGGCATGGCCAACTTTGGTAGCCGC
AACGGGCCGACCGAGCTGGAGAAGGGTTTGGTTACGCCGGCTTTGGCCGAGGCGCTGAAGCAGCGCGGCCATCAGGTGGC
GGAGATCGAGATGACGAGCGGCACGCAGGCCATCATGCGGCGTCAGCGGGCCGATGGGCGGCTGGTATGGGCGGGTGGGG
CCGATCCGCGGCGGGAAGGCGTGGCGATGGGGGACTGA

Upstream 100 bases:

>100_bases
GCGTATCGTGCACACCGGGTGAGCTTGTCGGGCTTTGTCTGACACCGCCGTGCGTCTGCGGCCACTACAATCGGCAGATC
GTTCGTGGCGGAGATATCGC

Downstream 100 bases:

>100_bases
GCGCCGGAAACCAGAAGAGGGCGGGATTCGAAGTCCCGCCCTTTTGTTTTCTATCGGACTTTCTTCAACAATTACCGCCG
TCAGGCGTCCAGCTTCACCC

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 625; Mature: 624

Protein sequence:

>625_residues
MAHLLASRLAWRGSIIVTFTALMAACGTQSGAPAAPAAPAAPQPPATATLPPAPEIASGYRTDMSTVYAEKYMAAAANPL
ATEAGRDVLRQGGSAIDAAIAMQAVLTLVEPQASGVGGGAFIMYWDGKRVQAFDGRETAPAGATENLFLRPDGKPMEFSE
AQIGGRSVGTPGVLRALEMAHREHGKLKWSQLFQRAISLAEKGFPISPRLYAQVASDKFMSNSPEMSAYFLDAQGKPKPA
GTILKNPQLAQTLRAIAANGPNALYTGPIARDIVTKVNGSLNPGSLSTRDLVNYRAKLRVPVCTDYKRWKICGMPPPSSG
GIALAQILGTLQALETRNPKYALAALKPSAVSTPAVLEANPDAVHAIAEADRLAYADRGLYVADSDFVQVDIAGMVNPAY
LEQRASLISDKSMGKAQPGVPPGTSVAFAPDRSPPRISTSQIVAVDSRGGAISMTTTVESYFGSHIMVRGFMLNNQLTDF
SFLPSENGKPVANRVEPGKRPRSSMAPTLVFDRESGKFLGTVGSPGGSQIIEYVSKTLVGLLDWNMDVQAAIGMANFGSR
NGPTELEKGLVTPALAEALKQRGHQVAEIEMTSGTQAIMRRQRADGRLVWAGGADPRREGVAMGD

Sequences:

>Translated_625_residues
MAHLLASRLAWRGSIIVTFTALMAACGTQSGAPAAPAAPAAPQPPATATLPPAPEIASGYRTDMSTVYAEKYMAAAANPL
ATEAGRDVLRQGGSAIDAAIAMQAVLTLVEPQASGVGGGAFIMYWDGKRVQAFDGRETAPAGATENLFLRPDGKPMEFSE
AQIGGRSVGTPGVLRALEMAHREHGKLKWSQLFQRAISLAEKGFPISPRLYAQVASDKFMSNSPEMSAYFLDAQGKPKPA
GTILKNPQLAQTLRAIAANGPNALYTGPIARDIVTKVNGSLNPGSLSTRDLVNYRAKLRVPVCTDYKRWKICGMPPPSSG
GIALAQILGTLQALETRNPKYALAALKPSAVSTPAVLEANPDAVHAIAEADRLAYADRGLYVADSDFVQVDIAGMVNPAY
LEQRASLISDKSMGKAQPGVPPGTSVAFAPDRSPPRISTSQIVAVDSRGGAISMTTTVESYFGSHIMVRGFMLNNQLTDF
SFLPSENGKPVANRVEPGKRPRSSMAPTLVFDRESGKFLGTVGSPGGSQIIEYVSKTLVGLLDWNMDVQAAIGMANFGSR
NGPTELEKGLVTPALAEALKQRGHQVAEIEMTSGTQAIMRRQRADGRLVWAGGADPRREGVAMGD
>Mature_624_residues
AHLLASRLAWRGSIIVTFTALMAACGTQSGAPAAPAAPAAPQPPATATLPPAPEIASGYRTDMSTVYAEKYMAAAANPLA
TEAGRDVLRQGGSAIDAAIAMQAVLTLVEPQASGVGGGAFIMYWDGKRVQAFDGRETAPAGATENLFLRPDGKPMEFSEA
QIGGRSVGTPGVLRALEMAHREHGKLKWSQLFQRAISLAEKGFPISPRLYAQVASDKFMSNSPEMSAYFLDAQGKPKPAG
TILKNPQLAQTLRAIAANGPNALYTGPIARDIVTKVNGSLNPGSLSTRDLVNYRAKLRVPVCTDYKRWKICGMPPPSSGG
IALAQILGTLQALETRNPKYALAALKPSAVSTPAVLEANPDAVHAIAEADRLAYADRGLYVADSDFVQVDIAGMVNPAYL
EQRASLISDKSMGKAQPGVPPGTSVAFAPDRSPPRISTSQIVAVDSRGGAISMTTTVESYFGSHIMVRGFMLNNQLTDFS
FLPSENGKPVANRVEPGKRPRSSMAPTLVFDRESGKFLGTVGSPGGSQIIEYVSKTLVGLLDWNMDVQAAIGMANFGSRN
GPTELEKGLVTPALAEALKQRGHQVAEIEMTSGTQAIMRRQRADGRLVWAGGADPRREGVAMGD

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=569, Percent_Identity=31.4586994727592, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI73915090, Length=569, Percent_Identity=31.4586994727592, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI73915096, Length=569, Percent_Identity=31.4586994727592, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI73915094, Length=569, Percent_Identity=31.4586994727592, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI113429324, Length=569, Percent_Identity=31.4586994727592, Blast_Score=195, Evalue=1e-49,
Organism=Homo sapiens, GI113429326, Length=574, Percent_Identity=31.184668989547, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI109148539, Length=544, Percent_Identity=27.5735294117647, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI153266885, Length=516, Percent_Identity=27.1317829457364, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI153266901, Length=517, Percent_Identity=26.4990328820116, Blast_Score=133, Evalue=6e-31,
Organism=Homo sapiens, GI153266907, Length=514, Percent_Identity=25.875486381323, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI30581157, Length=194, Percent_Identity=33.5051546391753, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI30581155, Length=194, Percent_Identity=33.5051546391753, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1789856, Length=568, Percent_Identity=34.6830985915493, Blast_Score=271, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI17542894, Length=567, Percent_Identity=31.2169312169312, Blast_Score=208, Evalue=9e-54,
Organism=Caenorhabditis elegans, GI72000294, Length=504, Percent_Identity=30.952380952381, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI212646519, Length=504, Percent_Identity=30.952380952381, Blast_Score=207, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI193208245, Length=535, Percent_Identity=30.2803738317757, Blast_Score=199, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI193208247, Length=535, Percent_Identity=30.2803738317757, Blast_Score=198, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI17506189, Length=567, Percent_Identity=27.1604938271605, Blast_Score=166, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI72001497, Length=280, Percent_Identity=25.7142857142857, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI72001495, Length=280, Percent_Identity=25.7142857142857, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17564448, Length=442, Percent_Identity=25.5656108597285, Blast_Score=76, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6323330, Length=194, Percent_Identity=32.9896907216495, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI45551474, Length=567, Percent_Identity=28.9241622574956, Blast_Score=182, Evalue=8e-46,
Organism=Drosophila melanogaster, GI161077878, Length=567, Percent_Identity=28.9241622574956, Blast_Score=182, Evalue=9e-46,
Organism=Drosophila melanogaster, GI24642670, Length=567, Percent_Identity=28.9241622574956, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24642666, Length=567, Percent_Identity=28.9241622574956, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI161077880, Length=564, Percent_Identity=29.0780141843972, Blast_Score=181, Evalue=1e-45,
Organism=Drosophila melanogaster, GI18859893, Length=540, Percent_Identity=29.8148148148148, Blast_Score=174, Evalue=2e-43,
Organism=Drosophila melanogaster, GI161077496, Length=536, Percent_Identity=26.6791044776119, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI18859741, Length=537, Percent_Identity=25.512104283054, Blast_Score=133, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 65985; Mature: 65854

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHLLASRLAWRGSIIVTFTALMAACGTQSGAPAAPAAPAAPQPPATATLPPAPEIASGY
CHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCC
RTDMSTVYAEKYMAAAANPLATEAGRDVLRQGGSAIDAAIAMQAVLTLVEPQASGVGGGA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCE
FIMYWDGKRVQAFDGRETAPAGATENLFLRPDGKPMEFSEAQIGGRSVGTPGVLRALEMA
EEEEECCCEEEECCCCCCCCCCCCCCEEECCCCCCCCCCHHHCCCCCCCCHHHHHHHHHH
HREHGKLKWSQLFQRAISLAEKGFPISPRLYAQVASDKFMSNSPEMSAYFLDAQGKPKPA
HHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCC
GTILKNPQLAQTLRAIAANGPNALYTGPIARDIVTKVNGSLNPGSLSTRDLVNYRAKLRV
CCCCCCCHHHHHHHHHHCCCCCCEEECCHHHHHHHHHCCCCCCCCCCHHHHHCCHHEEEC
PVCTDYKRWKICGMPPPSSGGIALAQILGTLQALETRNPKYALAALKPSAVSTPAVLEAN
EEECCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEECC
PDAVHAIAEADRLAYADRGLYVADSDFVQVDIAGMVNPAYLEQRASLISDKSMGKAQPGV
CHHHHHHHHHHHHHHHCCCEEEECCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCC
PPGTSVAFAPDRSPPRISTSQIVAVDSRGGAISMTTTVESYFGSHIMVRGFMLNNQLTDF
CCCCEEEECCCCCCCCCCCCEEEEEECCCCEEEEEEEHHHHHCCEEEEEEEEECCCCCCC
SFLPSENGKPVANRVEPGKRPRSSMAPTLVFDRESGKFLGTVGSPGGSQIIEYVSKTLVG
EECCCCCCCCCHHCCCCCCCCCCCCCCEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHH
LLDWNMDVQAAIGMANFGSRNGPTELEKGLVTPALAEALKQRGHQVAEIEMTSGTQAIMR
HHCCCCCHHHHHCHHCCCCCCCCHHHHHCCCCHHHHHHHHHCCCEEEEEEECCCHHHHHH
RQRADGRLVWAGGADPRREGVAMGD
HHCCCCEEEEECCCCHHHCCCCCCC
>Mature Secondary Structure 
AHLLASRLAWRGSIIVTFTALMAACGTQSGAPAAPAAPAAPQPPATATLPPAPEIASGY
HHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCC
RTDMSTVYAEKYMAAAANPLATEAGRDVLRQGGSAIDAAIAMQAVLTLVEPQASGVGGGA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCE
FIMYWDGKRVQAFDGRETAPAGATENLFLRPDGKPMEFSEAQIGGRSVGTPGVLRALEMA
EEEEECCCEEEECCCCCCCCCCCCCCEEECCCCCCCCCCHHHCCCCCCCCHHHHHHHHHH
HREHGKLKWSQLFQRAISLAEKGFPISPRLYAQVASDKFMSNSPEMSAYFLDAQGKPKPA
HHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCC
GTILKNPQLAQTLRAIAANGPNALYTGPIARDIVTKVNGSLNPGSLSTRDLVNYRAKLRV
CCCCCCCHHHHHHHHHHCCCCCCEEECCHHHHHHHHHCCCCCCCCCCHHHHHCCHHEEEC
PVCTDYKRWKICGMPPPSSGGIALAQILGTLQALETRNPKYALAALKPSAVSTPAVLEAN
EEECCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEECC
PDAVHAIAEADRLAYADRGLYVADSDFVQVDIAGMVNPAYLEQRASLISDKSMGKAQPGV
CHHHHHHHHHHHHHHHCCCEEEECCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCC
PPGTSVAFAPDRSPPRISTSQIVAVDSRGGAISMTTTVESYFGSHIMVRGFMLNNQLTDF
CCCCEEEECCCCCCCCCCCCEEEEEECCCCEEEEEEEHHHHHCCEEEEEEEEECCCCCCC
SFLPSENGKPVANRVEPGKRPRSSMAPTLVFDRESGKFLGTVGSPGGSQIIEYVSKTLVG
EECCCCCCCCCHHCCCCCCCCCCCCCCEEEEECCCCCEEEECCCCCHHHHHHHHHHHHHH
LLDWNMDVQAAIGMANFGSRNGPTELEKGLVTPALAEALKQRGHQVAEIEMTSGTQAIMR
HHCCCCCHHHHHCHHCCCCCCCCHHHHHCCCCHHHHHHHHHCCCEEEEEEECCCHHHHHH
RQRADGRLVWAGGADPRREGVAMGD
HHCCCCEEEEECCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA