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The map label for this gene is nuoN [H]

Identifier: 73540677

GI number: 73540677

Start: 1062874

End: 1064349

Strand: Direct

Name: nuoN [H]

Synonym: Reut_A0974

Alternate gene names: 73540677

Gene position: 1062874-1064349 (Clockwise)

Preceding gene: 73540676

Following gene: 73540678

Centisome position: 27.92

GC content: 63.14

Gene sequence:

>1476_bases
ATGCAACCGTCCTCGAGTCTAGCCCCTGTGGCGCCGATTATTTTCCTTGCGATCGCGATTGCCGCGGTCAACTGGATCGA
CCTTGCCCGCGGCAAGGGCAAGCAAAGCGTCGCGTACCCGCTGTCGCTGCTGTTCACGGCGGTGCTGACCGTCTGGTTCG
GCATCAACGCCTCGACCGGCGAGACGCACTACGCGTTCGCCAACCTCGTCGTGATCGATCCGTTGGCCAATGTGCTGTCG
GCGTTCTGCTCGGCCGGTCTGTTCATGACGCTGGTCTACACGCGGCGCTACCTGGCCGACCGCGACATGTATGCCGGCGA
GTTCTACCAACTCGCGCTGTTCACGCTCGGTGGCCAGATCGTGATGATCACCGGCAACAACTTCCTGACCCTGTACCTGG
GTCTGGAACTGCTGTCGCTGTCGTCGTACGCACTGGTGGCGCTGCGCCGCGAGTCGCGCGTGACGTCGGAATCGGCGATG
AAGTACTTCGTGCTGGGCGCGCTGGCTTCGGGCTTCCTGTTGTACGGCATCTCGATGATGTACGGCGCGACGGGTTCGCT
GAACCTCGGCGAAGTATTCCGAGTGGTCGAGTCCGGCCGTGTCAACACGACCATGCTGGCCTTTGGCGTGGTGTTCATCG
TCGCCGGCCTGTCGTTCAAGCTGGGCGCCGCACCGTTCCACATGTGGATTCCGGACATCTACCAAGGCTCGCCGACCGCG
GTGACGCTGCTGATCGCAGGTGGCCCGAAGGTCGCGGCGTTCGCGCTGATCGTGCGCGTGCTGGTGGAAGGCCTGCTGCC
GCTGGCCGCCGACTGGCAGAGCATGCTGGTGGTGCTGGCCATCGTGTCGCTGGCAATCGGTAACCTGACCGCCATCGTCC
AGACCAACCTGAAGCGGATGCTGGCTTACTCGACCATTTCGCACATGGGCTTCATCCTGCTGGGCATGCTGTCCGGCGTG
GTGGCCAACAAGGCGGATGGCGCGGCGAATGCCTACAGTGCGTCGATGTTCTACTCGATCACGTATCTGCTGACGACGCT
GGGCACTTTCGGCCTGATCCTGCTGCGTACGACCAAGGGCTTCGAAGCCGAGACGCTGGAAGACCTGAAGGGCATGTCGC
GTCGCAACCCGTGGTTCGCGTTCCTGATGCTGGTGATGATGTTCTCGCTGGCCGGCATTCCGCCGACCGTGGGCTTCTAC
GCCAAGCTGGCGGTGCTCGAAGCCGTGGTGAGGTCCGGCATGACGTGGCTGGCGGTGGTGGCGGTGCTGTTCTCGCTGAT
CGGCGCGTTCTACTACCTGCGTGTCGTCAAGCTGATGTACTTCGATGCGCCGGTGGGCGAAGAGCCGCTCGAAGCGACGG
CTGGCCTTCGTTCGATGCTGAGCCTGAATGGTGCGGCAGTGATCGTGCTGGGCATCTTCCCGGCTGCGCTGATGAACCTG
TGCTATCAGGCCATCCGCGCAACGCTGGCCTCGTAA

Upstream 100 bases:

>100_bases
CCTGCACCCGAAGCCCTTCACCGACGTGATGCACGCTTCGGTGGTCAACCTGCTGTCCCACGTGGCGCAGTCGAAGCTGT
AAGCGGGGAGAGATAACACT

Downstream 100 bases:

>100_bases
GCGTCCGAGGCGACAAGGCATGAGTTCCCCGGCGGGCGGCTGGTTTGTCATCTTGTTGGCACTGGTGTGTGCCAACCTGC
CGTTCGTCAACCAGCGCCTG

Product: NADH dehydrogenase subunit N

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N [H]

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MQPSSSLAPVAPIIFLAIAIAAVNWIDLARGKGKQSVAYPLSLLFTAVLTVWFGINASTGETHYAFANLVVIDPLANVLS
AFCSAGLFMTLVYTRRYLADRDMYAGEFYQLALFTLGGQIVMITGNNFLTLYLGLELLSLSSYALVALRRESRVTSESAM
KYFVLGALASGFLLYGISMMYGATGSLNLGEVFRVVESGRVNTTMLAFGVVFIVAGLSFKLGAAPFHMWIPDIYQGSPTA
VTLLIAGGPKVAAFALIVRVLVEGLLPLAADWQSMLVVLAIVSLAIGNLTAIVQTNLKRMLAYSTISHMGFILLGMLSGV
VANKADGAANAYSASMFYSITYLLTTLGTFGLILLRTTKGFEAETLEDLKGMSRRNPWFAFLMLVMMFSLAGIPPTVGFY
AKLAVLEAVVRSGMTWLAVVAVLFSLIGAFYYLRVVKLMYFDAPVGEEPLEATAGLRSMLSLNGAAVIVLGIFPAALMNL
CYQAIRATLAS

Sequences:

>Translated_491_residues
MQPSSSLAPVAPIIFLAIAIAAVNWIDLARGKGKQSVAYPLSLLFTAVLTVWFGINASTGETHYAFANLVVIDPLANVLS
AFCSAGLFMTLVYTRRYLADRDMYAGEFYQLALFTLGGQIVMITGNNFLTLYLGLELLSLSSYALVALRRESRVTSESAM
KYFVLGALASGFLLYGISMMYGATGSLNLGEVFRVVESGRVNTTMLAFGVVFIVAGLSFKLGAAPFHMWIPDIYQGSPTA
VTLLIAGGPKVAAFALIVRVLVEGLLPLAADWQSMLVVLAIVSLAIGNLTAIVQTNLKRMLAYSTISHMGFILLGMLSGV
VANKADGAANAYSASMFYSITYLLTTLGTFGLILLRTTKGFEAETLEDLKGMSRRNPWFAFLMLVMMFSLAGIPPTVGFY
AKLAVLEAVVRSGMTWLAVVAVLFSLIGAFYYLRVVKLMYFDAPVGEEPLEATAGLRSMLSLNGAAVIVLGIFPAALMNL
CYQAIRATLAS
>Mature_491_residues
MQPSSSLAPVAPIIFLAIAIAAVNWIDLARGKGKQSVAYPLSLLFTAVLTVWFGINASTGETHYAFANLVVIDPLANVLS
AFCSAGLFMTLVYTRRYLADRDMYAGEFYQLALFTLGGQIVMITGNNFLTLYLGLELLSLSSYALVALRRESRVTSESAM
KYFVLGALASGFLLYGISMMYGATGSLNLGEVFRVVESGRVNTTMLAFGVVFIVAGLSFKLGAAPFHMWIPDIYQGSPTA
VTLLIAGGPKVAAFALIVRVLVEGLLPLAADWQSMLVVLAIVSLAIGNLTAIVQTNLKRMLAYSTISHMGFILLGMLSGV
VANKADGAANAYSASMFYSITYLLTTLGTFGLILLRTTKGFEAETLEDLKGMSRRNPWFAFLMLVMMFSLAGIPPTVGFY
AKLAVLEAVVRSGMTWLAVVAVLFSLIGAFYYLRVVKLMYFDAPVGEEPLEATAGLRSMLSLNGAAVIVLGIFPAALMNL
CYQAIRATLAS

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1007

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 2 (chain N)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831108, Length=327, Percent_Identity=26.605504587156, Blast_Score=73, Evalue=6e-13,
Organism=Escherichia coli, GI145693160, Length=408, Percent_Identity=34.8039215686275, Blast_Score=219, Evalue=3e-58,
Organism=Escherichia coli, GI1788614, Length=453, Percent_Identity=24.9448123620309, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI1788831, Length=383, Percent_Identity=24.2819843342037, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788827, Length=335, Percent_Identity=24.7761194029851, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788613, Length=354, Percent_Identity=25.9887005649718, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI2367154, Length=285, Percent_Identity=23.5087719298246, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788829, Length=340, Percent_Identity=22.9411764705882, Blast_Score=63, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010096
- InterPro:   IPR001750 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 52704; Mature: 52704

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPSSSLAPVAPIIFLAIAIAAVNWIDLARGKGKQSVAYPLSLLFTAVLTVWFGINASTG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
ETHYAFANLVVIDPLANVLSAFCSAGLFMTLVYTRRYLADRDMYAGEFYQLALFTLGGQI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEE
VMITGNNFLTLYLGLELLSLSSYALVALRRESRVTSESAMKYFVLGALASGFLLYGISMM
EEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
YGATGSLNLGEVFRVVESGRVNTTMLAFGVVFIVAGLSFKLGAAPFHMWIPDIYQGSPTA
HCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHCCCHHHCCCCCE
VTLLIAGGPKVAAFALIVRVLVEGLLPLAADWQSMLVVLAIVSLAIGNLTAIVQTNLKRM
EEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAYSTISHMGFILLGMLSGVVANKADGAANAYSASMFYSITYLLTTLGTFGLILLRTTKG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEHEEECCC
FEAETLEDLKGMSRRNPWFAFLMLVMMFSLAGIPPTVGFYAKLAVLEAVVRSGMTWLAVV
CCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHH
AVLFSLIGAFYYLRVVKLMYFDAPVGEEPLEATAGLRSMLSLNGAAVIVLGIFPAALMNL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
CYQAIRATLAS
HHHHHHHHHCC
>Mature Secondary Structure
MQPSSSLAPVAPIIFLAIAIAAVNWIDLARGKGKQSVAYPLSLLFTAVLTVWFGINASTG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
ETHYAFANLVVIDPLANVLSAFCSAGLFMTLVYTRRYLADRDMYAGEFYQLALFTLGGQI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEE
VMITGNNFLTLYLGLELLSLSSYALVALRRESRVTSESAMKYFVLGALASGFLLYGISMM
EEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
YGATGSLNLGEVFRVVESGRVNTTMLAFGVVFIVAGLSFKLGAAPFHMWIPDIYQGSPTA
HCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHCCCHHHCCCCCE
VTLLIAGGPKVAAFALIVRVLVEGLLPLAADWQSMLVVLAIVSLAIGNLTAIVQTNLKRM
EEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAYSTISHMGFILLGMLSGVVANKADGAANAYSASMFYSITYLLTTLGTFGLILLRTTKG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEHEEECCC
FEAETLEDLKGMSRRNPWFAFLMLVMMFSLAGIPPTVGFYAKLAVLEAVVRSGMTWLAVV
CCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCHHHHHH
AVLFSLIGAFYYLRVVKLMYFDAPVGEEPLEATAGLRSMLSLNGAAVIVLGIFPAALMNL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
CYQAIRATLAS
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA