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The map label for this gene is nuoL [H]

Identifier: 73540675

GI number: 73540675

Start: 1059274

End: 1061361

Strand: Direct

Name: nuoL [H]

Synonym: Reut_A0972

Alternate gene names: 73540675

Gene position: 1059274-1061361 (Clockwise)

Preceding gene: 73540674

Following gene: 73540676

Centisome position: 27.83

GC content: 61.64

Gene sequence:

>2088_bases
ATGGCAACCACGCTCAACCCCAACCTGCTGCTCGCGATTGCGCTGGCGCCGCTAGTCGGCTCAGCCATCGCCGGCCTGTT
CGGCACCAAGTTCTTTGGCCTGTTTTCCTCGGAGTCGCGCGGCGGCCGGATTGTGGCTCACTCCGCGACGATTCTCGGCG
TGGCCATTTCCTTCGTGCTGTCGGTGATGGTGCTGCTCGACGTGATGAACGGCGCGAGCTACAACGGCACCGTCTACGAG
TGGATGGCCATCGGCGACCTGAAGATGGAAGTCGGCTTCCTGGTCGATTCGCTGACCGCGATGATGATGGTCGTGGTGAC
CTTCGTGTCCCTGATGGTGCATATCTACACCGTCGGCTACATGGACGGGGACCCCGGCTACAACCGCTTCTTCTCGTACA
TCTCGCTCTTCACCTTCTCGATGCTGATGCTGGTGATGAGCAACAACTTCCTGCAGCTGTTCTTCGGCTGGGAAGCGGTG
GGCCTGGTGTCCTACCTGCTGATCGGCTTCTGGTACACCCGCCCGACCGCGATCTTCGCGAACCTGAAGGCGTTCCTGGT
GAACCGCGTCGGTGACTTCGGCTTCATCCTCGGCATCGGCCTGCTGCTGGCCTACAGCGGCAGCATGAACTACTCGGACG
TGTTCGCAGCCCGCGAGAAGCTGGCAACGGTGATCTTCCCGGGCACTGACTGGATGATGCTGACGGTGGCCTGCATCTGC
CTGTTCATCGGCGCCATGGGCAAGTCGGCCCAATTCCCGCTGCACGTCTGGCTGCCTGACTCGATGGAAGGCCCGACCCC
GATTTCCGCGCTGATCCACGCCGCTACCATGGTGACGGCCGGCATTTTCATGGTCAGCCGCATGTCGCCGCTGTTCGAGC
TGTCGGACACCGCACTGTCCTTCGTGCTGGTGATCGGCGCCATTACTGCGCTGTTCATGGGCTTCCTGGGCATCATCCAG
AACGACATCAAGCGCGTGGTCGCGTACTCGACGCTGTCGCAGCTCGGCTACATGACCGTGGCGCTGGGCGCGTCGGCCTA
CTCGGTCGCCGTGTTCCACCTGATGACCCACGCGTTCTTCAAGGCACTGCTGTTCCTTGGCGCGGGTTCGGTCATCATCG
GCATGCACCACGACCAGGACATCCGCAACATGGGCGGCCTGCGCAAGTACATGCCGATCACCTGGATCACCTCGCTGGTG
GGCTCGCTGGCACTGATCGGCACGCCGTTCTTCTCGGGCTTCTACTCGAAGGATTCGATCATCGAAGCCGTGGCCGAGTC
GCATCTGGCCGGTTCGGGCTTTGCGTACTTCGCCGTGCTGGCCGGCGTGTTCGTGACCGCGTTCTACTCGTTCCGCATGT
ACTTCCTGGTTTTCCACGGCAAGGAGCGCTGGGGCCAGAACCATGCTCACCATGGTCACGAAGGCGACCACGAGGATGAG
GAAGTTTCGCATGACCACCATCATGGCCTGTCTGCGGGCGAGAAGCCGCACGAGTCGCCGTGGGTGGTGACGCTGCCGCT
GGTGCTGCTGGCCATCCCGTCGGTGATCATCGGTGCGATCGCCATCGAGCCGATGCTGTTCGGTGAATTCTTCAAGCACG
GTGTGGCATTCAAGGACGTGATCTTCGTTGGCGAAAACCACCACGCCATGAAGGAACTGGAAGAAGCCTTCCACGGCTGG
GTGCCGATGGCGATTCATTCGCTGACCACCCCGGTCCTGTGGCTGGCCATCGCCGGTGTCGTGCTGTCGTGGTTCTTCTA
CATGAAGCGCCCGGACATCCCCGAAGCGATCAAGAACCGCTTCTCGGGCCTGTACAAGCTGCTCGACAACAAGTACTACA
TGGACGCCATCAACCAGGCCGTGTTCGCACGTGGTGCCCGCCTGCTGGGTACGGGCCTGTGGAAGGGTGGCGACCAGAGC
TTTATCGACGGCCTGTTCGTCAATGGTTCGGCGCGCGTGGTGGCTTCTTTCGCCGCAGCCAGCCGCTACCTGCAATCGGG
TTACATCTACCACTACGCATTCGCGATGATCGTCGGCATGCTGGTGCTGCTGACGCTCACCGTCACGGGCGTGATTGGCA
CCAAGTGA

Upstream 100 bases:

>100_bases
ACGATCAACGTGGATGACATGGATACCCTGAAGTACTGATCCATGACGCACCACGCAATGAACCCAGACTGCTCACCGCT
CGCACACCAATAAGCGTCCT

Downstream 100 bases:

>100_bases
TAGGCACCGAGTAAGGAAAACAAAGAAATGGTTCTGTCTTTCGCAATCTGGCTGCCTATCTTCTTCGGCTTGCTGGTACT
GGCCTCCGGCTCGGACCGCA

Product: NADH dehydrogenase subunit L

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 695; Mature: 694

Protein sequence:

>695_residues
MATTLNPNLLLAIALAPLVGSAIAGLFGTKFFGLFSSESRGGRIVAHSATILGVAISFVLSVMVLLDVMNGASYNGTVYE
WMAIGDLKMEVGFLVDSLTAMMMVVVTFVSLMVHIYTVGYMDGDPGYNRFFSYISLFTFSMLMLVMSNNFLQLFFGWEAV
GLVSYLLIGFWYTRPTAIFANLKAFLVNRVGDFGFILGIGLLLAYSGSMNYSDVFAAREKLATVIFPGTDWMMLTVACIC
LFIGAMGKSAQFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVSRMSPLFELSDTALSFVLVIGAITALFMGFLGIIQ
NDIKRVVAYSTLSQLGYMTVALGASAYSVAVFHLMTHAFFKALLFLGAGSVIIGMHHDQDIRNMGGLRKYMPITWITSLV
GSLALIGTPFFSGFYSKDSIIEAVAESHLAGSGFAYFAVLAGVFVTAFYSFRMYFLVFHGKERWGQNHAHHGHEGDHEDE
EVSHDHHHGLSAGEKPHESPWVVTLPLVLLAIPSVIIGAIAIEPMLFGEFFKHGVAFKDVIFVGENHHAMKELEEAFHGW
VPMAIHSLTTPVLWLAIAGVVLSWFFYMKRPDIPEAIKNRFSGLYKLLDNKYYMDAINQAVFARGARLLGTGLWKGGDQS
FIDGLFVNGSARVVASFAAASRYLQSGYIYHYAFAMIVGMLVLLTLTVTGVIGTK

Sequences:

>Translated_695_residues
MATTLNPNLLLAIALAPLVGSAIAGLFGTKFFGLFSSESRGGRIVAHSATILGVAISFVLSVMVLLDVMNGASYNGTVYE
WMAIGDLKMEVGFLVDSLTAMMMVVVTFVSLMVHIYTVGYMDGDPGYNRFFSYISLFTFSMLMLVMSNNFLQLFFGWEAV
GLVSYLLIGFWYTRPTAIFANLKAFLVNRVGDFGFILGIGLLLAYSGSMNYSDVFAAREKLATVIFPGTDWMMLTVACIC
LFIGAMGKSAQFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVSRMSPLFELSDTALSFVLVIGAITALFMGFLGIIQ
NDIKRVVAYSTLSQLGYMTVALGASAYSVAVFHLMTHAFFKALLFLGAGSVIIGMHHDQDIRNMGGLRKYMPITWITSLV
GSLALIGTPFFSGFYSKDSIIEAVAESHLAGSGFAYFAVLAGVFVTAFYSFRMYFLVFHGKERWGQNHAHHGHEGDHEDE
EVSHDHHHGLSAGEKPHESPWVVTLPLVLLAIPSVIIGAIAIEPMLFGEFFKHGVAFKDVIFVGENHHAMKELEEAFHGW
VPMAIHSLTTPVLWLAIAGVVLSWFFYMKRPDIPEAIKNRFSGLYKLLDNKYYMDAINQAVFARGARLLGTGLWKGGDQS
FIDGLFVNGSARVVASFAAASRYLQSGYIYHYAFAMIVGMLVLLTLTVTGVIGTK
>Mature_694_residues
ATTLNPNLLLAIALAPLVGSAIAGLFGTKFFGLFSSESRGGRIVAHSATILGVAISFVLSVMVLLDVMNGASYNGTVYEW
MAIGDLKMEVGFLVDSLTAMMMVVVTFVSLMVHIYTVGYMDGDPGYNRFFSYISLFTFSMLMLVMSNNFLQLFFGWEAVG
LVSYLLIGFWYTRPTAIFANLKAFLVNRVGDFGFILGIGLLLAYSGSMNYSDVFAAREKLATVIFPGTDWMMLTVACICL
FIGAMGKSAQFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVSRMSPLFELSDTALSFVLVIGAITALFMGFLGIIQN
DIKRVVAYSTLSQLGYMTVALGASAYSVAVFHLMTHAFFKALLFLGAGSVIIGMHHDQDIRNMGGLRKYMPITWITSLVG
SLALIGTPFFSGFYSKDSIIEAVAESHLAGSGFAYFAVLAGVFVTAFYSFRMYFLVFHGKERWGQNHAHHGHEGDHEDEE
VSHDHHHGLSAGEKPHESPWVVTLPLVLLAIPSVIIGAIAIEPMLFGEFFKHGVAFKDVIFVGENHHAMKELEEAFHGWV
PMAIHSLTTPVLWLAIAGVVLSWFFYMKRPDIPEAIKNRFSGLYKLLDNKYYMDAINQAVFARGARLLGTGLWKGGDQSF
IDGLFVNGSARVVASFAAASRYLQSGYIYHYAFAMIVGMLVLLTLTVTGVIGTK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=387, Percent_Identity=42.3772609819121, Blast_Score=301, Evalue=1e-81,
Organism=Escherichia coli, GI1788614, Length=558, Percent_Identity=39.9641577060932, Blast_Score=364, Evalue=1e-102,
Organism=Escherichia coli, GI1788829, Length=432, Percent_Identity=28.7037037037037, Blast_Score=148, Evalue=1e-36,
Organism=Escherichia coli, GI1788831, Length=360, Percent_Identity=28.3333333333333, Blast_Score=127, Evalue=3e-30,
Organism=Escherichia coli, GI1788827, Length=414, Percent_Identity=29.4685990338164, Blast_Score=125, Evalue=1e-29,
Organism=Escherichia coli, GI2367154, Length=136, Percent_Identity=35.2941176470588, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI145693160, Length=392, Percent_Identity=25.2551020408163, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI1788613, Length=398, Percent_Identity=23.1155778894472, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR002128
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF01010 Oxidored_q1_C; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 76050; Mature: 75919

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATTLNPNLLLAIALAPLVGSAIAGLFGTKFFGLFSSESRGGRIVAHSATILGVAISFVL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHH
SVMVLLDVMNGASYNGTVYEWMAIGDLKMEVGFLVDSLTAMMMVVVTFVSLMVHIYTVGY
HHHHHHHHHCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
MDGDPGYNRFFSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFWYTRPTAIFA
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEHCCHHHHHHHHHHHHHHHHHCHHHHHH
NLKAFLVNRVGDFGFILGIGLLLAYSGSMNYSDVFAAREKLATVIFPGTDWMMLTVACIC
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHEEEEECCCCHHHHHHHHHH
LFIGAMGKSAQFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVSRMSPLFELSDTALS
HHHHCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
FVLVIGAITALFMGFLGIIQNDIKRVVAYSTLSQLGYMTVALGASAYSVAVFHLMTHAFF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
KALLFLGAGSVIIGMHHDQDIRNMGGLRKYMPITWITSLVGSLALIGTPFFSGFYSKDSI
HHHHHHCCCCEEEEECCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCHHHH
IEAVAESHLAGSGFAYFAVLAGVFVTAFYSFRMYFLVFHGKERWGQNHAHHGHEGDHEDE
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHCCCCCCCCCCCCCCCH
EVSHDHHHGLSAGEKPHESPWVVTLPLVLLAIPSVIIGAIAIEPMLFGEFFKHGVAFKDV
HCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHE
IFVGENHHAMKELEEAFHGWVPMAIHSLTTPVLWLAIAGVVLSWFFYMKRPDIPEAIKNR
EEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
FSGLYKLLDNKYYMDAINQAVFARGARLLGTGLWKGGDQSFIDGLFVNGSARVVASFAAA
HHHHHHHHCCHHHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHCCEEECCCHHHHHHHHHH
SRYLQSGYIYHYAFAMIVGMLVLLTLTVTGVIGTK
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ATTLNPNLLLAIALAPLVGSAIAGLFGTKFFGLFSSESRGGRIVAHSATILGVAISFVL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHH
SVMVLLDVMNGASYNGTVYEWMAIGDLKMEVGFLVDSLTAMMMVVVTFVSLMVHIYTVGY
HHHHHHHHHCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
MDGDPGYNRFFSYISLFTFSMLMLVMSNNFLQLFFGWEAVGLVSYLLIGFWYTRPTAIFA
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEHCCHHHHHHHHHHHHHHHHHCHHHHHH
NLKAFLVNRVGDFGFILGIGLLLAYSGSMNYSDVFAAREKLATVIFPGTDWMMLTVACIC
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHEEEEECCCCHHHHHHHHHH
LFIGAMGKSAQFPLHVWLPDSMEGPTPISALIHAATMVTAGIFMVSRMSPLFELSDTALS
HHHHCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
FVLVIGAITALFMGFLGIIQNDIKRVVAYSTLSQLGYMTVALGASAYSVAVFHLMTHAFF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
KALLFLGAGSVIIGMHHDQDIRNMGGLRKYMPITWITSLVGSLALIGTPFFSGFYSKDSI
HHHHHHCCCCEEEEECCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCHHHH
IEAVAESHLAGSGFAYFAVLAGVFVTAFYSFRMYFLVFHGKERWGQNHAHHGHEGDHEDE
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHCCCCCCCCCCCCCCCH
EVSHDHHHGLSAGEKPHESPWVVTLPLVLLAIPSVIIGAIAIEPMLFGEFFKHGVAFKDV
HCCCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEHE
IFVGENHHAMKELEEAFHGWVPMAIHSLTTPVLWLAIAGVVLSWFFYMKRPDIPEAIKNR
EEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHH
FSGLYKLLDNKYYMDAINQAVFARGARLLGTGLWKGGDQSFIDGLFVNGSARVVASFAAA
HHHHHHHHCCHHHHHHHHHHHHHCCHHHHHCCCCCCCCHHHHCCEEECCCHHHHHHHHHH
SRYLQSGYIYHYAFAMIVGMLVLLTLTVTGVIGTK
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]