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The map label for this gene is nuoI [H]

Identifier: 73540672

GI number: 73540672

Start: 1057610

End: 1058101

Strand: Direct

Name: nuoI [H]

Synonym: Reut_A0969

Alternate gene names: 73540672

Gene position: 1057610-1058101 (Clockwise)

Preceding gene: 73540671

Following gene: 73540673

Centisome position: 27.78

GC content: 64.02

Gene sequence:

>492_bases
ATGCTGCTCGCCATCAAGGACTTCTTCAACAGCCTGCTCCTGAAGGAACTCTTCAAGGGTATGGCTCTGACCGGCCGCTA
TCTCTTCGCGCGCAAGGTCACGGTCCAGTTCCCGGAAGAGAAAACGCCGATCTCGCCGCGTTTCCGCGGCCTGCACGCGC
TGCGCCGCTACCCGAACGGGGAAGAGCGCTGCATCGCCTGCAAGCTGTGCGAAGCCGTGTGCCCGGCGCTGGCCATCACT
ATCGAGTCTGACGTGCGTGCCGACGGCACCCGCCGCACCACGCGCTACGACATCGACCTGACCAAGTGCATTTTCTGCGG
CTTCTGCGAAGAGGCCTGCCCGGTCGACGCCGTCGTCGAAACGCCGATCCTGGAATACCACGGCGAGAAGCGGGGCGACC
TGTACTTCACGAAGGACATGCTGCTGGCAGTGGGCGACCGCTACGAGCCGCAGATTGCCGCTGCGAAGGCTGCGGACGCC
AAGTACCGCTGA

Upstream 100 bases:

>100_bases
TCAAGTCGCCTTGGAACATCTGGCACTGAACGGCCAGGCGAGGGCGCGCACGCCGCAACGATACGGTGCGCCCCTCCGGA
AATACTAGGAAGCAATCGTC

Downstream 100 bases:

>100_bases
TATCTGTTGGCGCCGGCCCGGCCGGCGCTGCCAAGCGAATTTGAATCGGGTCCCGCAAGGGGCCAATGGAAGGATGCCGC
AGGCGCGGGCCACCCGGTAG

Product: NADH dehydrogenase subunit I

Products: NA

Alternate protein names: NADH dehydrogenase I subunit I; NDH-1 subunit I [H]

Number of amino acids: Translated: 163; Mature: 163

Protein sequence:

>163_residues
MLLAIKDFFNSLLLKELFKGMALTGRYLFARKVTVQFPEEKTPISPRFRGLHALRRYPNGEERCIACKLCEAVCPALAIT
IESDVRADGTRRTTRYDIDLTKCIFCGFCEEACPVDAVVETPILEYHGEKRGDLYFTKDMLLAVGDRYEPQIAAAKAADA
KYR

Sequences:

>Translated_163_residues
MLLAIKDFFNSLLLKELFKGMALTGRYLFARKVTVQFPEEKTPISPRFRGLHALRRYPNGEERCIACKLCEAVCPALAIT
IESDVRADGTRRTTRYDIDLTKCIFCGFCEEACPVDAVVETPILEYHGEKRGDLYFTKDMLLAVGDRYEPQIAAAKAADA
KYR
>Mature_163_residues
MLLAIKDFFNSLLLKELFKGMALTGRYLFARKVTVQFPEEKTPISPRFRGLHALRRYPNGEERCIACKLCEAVCPALAIT
IESDVRADGTRRTTRYDIDLTKCIFCGFCEEACPVDAVVETPILEYHGEKRGDLYFTKDMLLAVGDRYEPQIAAAKAADA
KYR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1143

COG function: function code C; Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I)

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI4505371, Length=153, Percent_Identity=62.7450980392157, Blast_Score=207, Evalue=3e-54,
Organism=Escherichia coli, GI1788617, Length=161, Percent_Identity=38.5093167701863, Blast_Score=109, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI17555194, Length=155, Percent_Identity=56.7741935483871, Blast_Score=196, Evalue=4e-51,
Organism=Drosophila melanogaster, GI17864306, Length=154, Percent_Identity=59.0909090909091, Blast_Score=201, Evalue=2e-52,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012285
- InterPro:   IPR010226 [H]

Pfam domain/function: PF00037 Fer4 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 18466; Mature: 18466

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
4.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLAIKDFFNSLLLKELFKGMALTGRYLFARKVTVQFPEEKTPISPRFRGLHALRRYPNG
CEEEHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHCCCCC
EERCIACKLCEAVCPALAITIESDVRADGTRRTTRYDIDLTKCIFCGFCEEACPVDAVVE
CHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCEEECCHHHHHHHHHHCCCCCCCCHHHH
TPILEYHGEKRGDLYFTKDMLLAVGDRYEPQIAAAKAADAKYR
CCHHHHCCCCCCCEEEHHHHHHHHCCCCCCCHHHHHCCCCCCC
>Mature Secondary Structure
MLLAIKDFFNSLLLKELFKGMALTGRYLFARKVTVQFPEEKTPISPRFRGLHALRRYPNG
CEEEHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHCCCCC
EERCIACKLCEAVCPALAITIESDVRADGTRRTTRYDIDLTKCIFCGFCEEACPVDAVVE
CHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCEEECCHHHHHHHHHHCCCCCCCCHHHH
TPILEYHGEKRGDLYFTKDMLLAVGDRYEPQIAAAKAADAKYR
CCHHHHCCCCCCCEEEHHHHHHHHCCCCCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA