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The map label for this gene is hutC [H]

Identifier: 73540598

GI number: 73540598

Start: 976430

End: 977185

Strand: Direct

Name: hutC [H]

Synonym: Reut_A0895

Alternate gene names: 73540598

Gene position: 976430-977185 (Clockwise)

Preceding gene: 73540597

Following gene: 73540599

Centisome position: 25.65

GC content: 66.53

Gene sequence:

>756_bases
TTGTCTCAAGCCACCGCACAGCCGGGCCAGCCCACCGCCGGGCTGTCCGACACGTTGCCAGCACCGCTCTATGCGCGCGT
CAAGCAGTTCATCAGCAGCAAGATTGCCGATGGCAGCTGGCCGCCGCATCACCGCGTGCCGTCCGAAACCGAGCTTGTCG
AAGAACTCGGCGTGAGCCGCATGACGGTCAACCGCGCGCTGCGCGAGCTGACTGCCGACGGCATGCTGGTGCGCATGCAA
GGCGTGGGCACTTTCGTCGCGGAGCCCAAGCGCAACTCCGCGCTGTATGCGGTCAATAACATCGCCGAGGAAATCGCGGC
GCGCGGCCGCCGCCACCATGCCAGGGTGGTCAAGAGCAGCGAGGAGGTCGCGGGCGCCGCGCGTGCGGCCGCGCTAGACG
TGGGCGAGAGCCAGCGCGTGTTCCACACGGTGATCGTGCACTACGAGGACGATGTGCCGATCCAGCTAGAGGACCGTTAC
GTCAACCCGACTGTCGCGGCCGATTACCTCGAGCAGGACTTCACGCGCCAGACGCCTTACGAATACCTGTCACGCGTGGC
ACCGCTGACGGAGGGCGAGCACGTGGTCGAAGCCGTTCTGGCCACGCCCGACGAATGCGCGCTGCTGCAGATCGATCGCG
GTGAGCCATGCCTGCTGATCCGCCGGCGCACATGGTCGGGCAACCGCGTCGTGACGTCAGTGCGCCTGCTGCATCCAGGG
TCGATGCATCGGCTGGAAGGGCGCTTCACTTCCTGA

Upstream 100 bases:

>100_bases
CGCGTGGTACATTCGCCGATGATGTAAACACCGCCCTATACAAGTCCAGCGGGCGCCGCGGCAGGATTGCCGGCGGCGCC
AGCCTCAACGGGAAACAGTT

Downstream 100 bases:

>100_bases
CCCCGCGTTACTAGTCGACAGTCGCGCCCGGCCAAGTCCGGGCGCAGTCACTTCCAGGCATAGATCTCTGCTAGTCCTCG
GGAATACCCCAATACATCTA

Product: GntR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 251; Mature: 250

Protein sequence:

>251_residues
MSQATAQPGQPTAGLSDTLPAPLYARVKQFISSKIADGSWPPHHRVPSETELVEELGVSRMTVNRALRELTADGMLVRMQ
GVGTFVAEPKRNSALYAVNNIAEEIAARGRRHHARVVKSSEEVAGAARAAALDVGESQRVFHTVIVHYEDDVPIQLEDRY
VNPTVAADYLEQDFTRQTPYEYLSRVAPLTEGEHVVEAVLATPDECALLQIDRGEPCLLIRRRTWSGNRVVTSVRLLHPG
SMHRLEGRFTS

Sequences:

>Translated_251_residues
MSQATAQPGQPTAGLSDTLPAPLYARVKQFISSKIADGSWPPHHRVPSETELVEELGVSRMTVNRALRELTADGMLVRMQ
GVGTFVAEPKRNSALYAVNNIAEEIAARGRRHHARVVKSSEEVAGAARAAALDVGESQRVFHTVIVHYEDDVPIQLEDRY
VNPTVAADYLEQDFTRQTPYEYLSRVAPLTEGEHVVEAVLATPDECALLQIDRGEPCLLIRRRTWSGNRVVTSVRLLHPG
SMHRLEGRFTS
>Mature_250_residues
SQATAQPGQPTAGLSDTLPAPLYARVKQFISSKIADGSWPPHHRVPSETELVEELGVSRMTVNRALRELTADGMLVRMQG
VGTFVAEPKRNSALYAVNNIAEEIAARGRRHHARVVKSSEEVAGAARAAALDVGESQRVFHTVIVHYEDDVPIQLEDRYV
NPTVAADYLEQDFTRQTPYEYLSRVAPLTEGEHVVEAVLATPDECALLQIDRGEPCLLIRRRTWSGNRVVTSVRLLHPGS
MHRLEGRFTS

Specific function: Repressor which binds to the hutP region in the histidine utilization (hut) operon. It blocks the expression of all the hut genes in the absence of inducer [H]

COG id: COG2188

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082252, Length=211, Percent_Identity=29.3838862559242, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1786950, Length=199, Percent_Identity=27.6381909547739, Blast_Score=80, Evalue=1e-16,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010248
- InterPro:   IPR000524
- InterPro:   IPR011663
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00392 GntR; PF07702 UTRA [H]

EC number: NA

Molecular weight: Translated: 27785; Mature: 27654

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQATAQPGQPTAGLSDTLPAPLYARVKQFISSKIADGSWPPHHRVPSETELVEELGVSR
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCHH
MTVNRALRELTADGMLVRMQGVGTFVAEPKRNSALYAVNNIAEEIAARGRRHHARVVKSS
HHHHHHHHHHCCCCEEEEEECCCCEEECCCCCCEEEHHHHHHHHHHHCCHHHHHHHHHCC
EEVAGAARAAALDVGESQRVFHTVIVHYEDDVPIQLEDRYVNPTVAADYLEQDFTRQTPY
HHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHCCCCHH
EYLSRVAPLTEGEHVVEAVLATPDECALLQIDRGEPCLLIRRRTWSGNRVVTSVRLLHPG
HHHHHHCCCCCCHHHHHHHHCCCCCEEEEEECCCCCEEEEEECCCCCCEEEEEEEEECCC
SMHRLEGRFTS
CCHHCCCCCCC
>Mature Secondary Structure 
SQATAQPGQPTAGLSDTLPAPLYARVKQFISSKIADGSWPPHHRVPSETELVEELGVSR
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCHH
MTVNRALRELTADGMLVRMQGVGTFVAEPKRNSALYAVNNIAEEIAARGRRHHARVVKSS
HHHHHHHHHHCCCCEEEEEECCCCEEECCCCCCEEEHHHHHHHHHHHCCHHHHHHHHHCC
EEVAGAARAAALDVGESQRVFHTVIVHYEDDVPIQLEDRYVNPTVAADYLEQDFTRQTPY
HHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCEEECCCCCCCHHHHHHHHHHHCCCCHH
EYLSRVAPLTEGEHVVEAVLATPDECALLQIDRGEPCLLIRRRTWSGNRVVTSVRLLHPG
HHHHHHCCCCCCHHHHHHHHCCCCCEEEEEECCCCCEEEEEECCCCCCEEEEEEEEECCC
SMHRLEGRFTS
CCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]