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The map label for this gene is cvrA [H]

Identifier: 73540549

GI number: 73540549

Start: 915927

End: 917693

Strand: Direct

Name: cvrA [H]

Synonym: Reut_A0846

Alternate gene names: 73540549

Gene position: 915927-917693 (Clockwise)

Preceding gene: 73540546

Following gene: 73540553

Centisome position: 24.06

GC content: 69.1

Gene sequence:

>1767_bases
TTGGAGAGCGTCGACCATGTCATCCTGATCGGCGCCGTCGTGATGTCGCTCGGCATCGTGGTCGGCGCCTTTTCCGCACG
CGCGGGCGTGCCGTTCCTGCTAGTGTTCCTCGCGGTCGGCATGCTGGCCGGCGTGGACGGCCCGGGCGGCATCCGCTTCT
CGAACACCTGGCTCAGTTTCCTGGTGGGCAACCTTGCGCTCGCCGTGATCTTGCTCGATGGCGGCCTGCGCACCAGTTAT
GCGACGTTCCGCGTGGCATTGCGGCCTTCGCTCGCACTGGCCACCGTGGGTGTGCTGGTGACGGCCGGACTGGTGGGCCT
GTTCTCGGCCTCGGTGCTCGGCATCGACTGGAAGCTCGGCCTGCTGCTGGGCGCCATCGTGGGCTCCACGGATGCGGCGG
CCGTCTTTTCGCTGCTGCACAGCAGCGGCATCCGCCTGAAAGACCGCGTGGCGAGCGTGCTCGAAATCGAATCCGGCATC
AACGACCCGATGGCCATCTTCCTGACGCTGACCCTGATGGAGTGGATTGCCGCGCCGGACGGCCTGACGCCGCTAGCGCT
CGCCATGCGGCTGGGCGTCCAGTTCGGTGTGGGCGCGGTGCTGGGGGTCGGGCTCGGCTTGTGCCTGGCCAGCGTTCTCG
AGCGCATCGAGGTCGCGGAAGGCCTGCATGCGATCCTGATCTGCTCGGGCGGCGCGCTGATCTTTGCCATCACGCAGACT
CTGGGTGGCAGCGGCTTCCTCGCGGTGTACCTCGCCGGCATGCTGGTGGGGAACCGGGACAGGGCCGTGACATCGGACAC
CATGCGCGCCATGGACGGCATGGCATGGCTGGCCCAGTCGGCGATGTTCCTGCTGCTGGGCCTGCTGGTGGCACCGCACC
GGATCTGGGAGGTGGCATTGCCCGCCATCGCGGTGGCGGCCTTTCTGATGTTCGTAGCCCGGCCGGCGGCCGTATTCCTC
GCGCTGCTGCCCTTCCGGCTGAGCGTCGGGGAAAAGGGGTTCATTGCGTGGATGGGGCTGCGCGGCGCGGTACCCATCGT
GCTGTCGCTGTTCCCGCTGCTGCGCGGCTTGCCGGAGTCCGGCCTGATTTTTCGCATCGCGTTCGCCGTGGTGCTGGCGA
GCCTGCTGCTGCAGGGAACGACGGTGGCGCCTGCCGCGCGGCTGGCCCGCGTGCTGCGCCCCGGCTTTCCCGAGCCGCTC
GCGCGCTCGCGTTTGCGTGGCACGCACGGCCCGACACTGGAGGTCATGCAGTTCCGGGTCGGTGCCAACGCCCCTGTGGA
AAACGTTCGGGCCGATCAGCTGGAACTGCCGCCCAAATGCCGGTTGCTGACCGTGGCGCGCGACGACGCGCTCGCGCCGC
ACGACCAGACCGTGCTGCGTGCCGGCGATACGGTGTCGGTCCTGGCGCCCGCTACAGTGGTGCCCAGACTGGCGGCGCTG
TTCCAGGCGGCGGGCCCGGCCCCGGCGTGGGAGCAAGTCACGCATGATTTCCTGATTTCCGGCGATGCGTTCCTGCGCGA
TCTGGCGGCGCTCTACGGCGAGCGCGCGTTGACCGCTGCTGAAAGTCCGCTGACGCTGGCCGACGCCATGCAGGCCGCCT
TCGTTTCGCCGCCGGTTGAAGGCGACAGCGTCGTGATCGCCGGGCTGCATCTGACTGCCGCGCGCATGGAAGGGCCGCGC
ATTGTGCAGGTCGGCCTGTTGCTGCCGCGCACTGAAGGTGCCACCGGCACGCGGCGCTGGGGCATCTGGCGCAAGCGCCA
GGCCTAG

Upstream 100 bases:

>100_bases
TCGGACAGGTCGGACCCCGCCTCGAAAGGTGGCGACCGCGGCACTGGCTGTAAGGTGCTGAAAGGTTGCGAAAGATGGCG
TTAGATAGAAAGGACTCCCT

Downstream 100 bases:

>100_bases
TCCGCGGACGTCAGTCGACCTTAGCGCCCGACACGCGCACGATCTGCGCGTACTTCTTCAGCTCGCGCTGTACCAGCGCG
CCGAACTGCTCCGGCGTGGT

Product: transporter-associated region:TrkA-C:Sodium/hydrogen exchanger

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 588; Mature: 588

Protein sequence:

>588_residues
MESVDHVILIGAVVMSLGIVVGAFSARAGVPFLLVFLAVGMLAGVDGPGGIRFSNTWLSFLVGNLALAVILLDGGLRTSY
ATFRVALRPSLALATVGVLVTAGLVGLFSASVLGIDWKLGLLLGAIVGSTDAAAVFSLLHSSGIRLKDRVASVLEIESGI
NDPMAIFLTLTLMEWIAAPDGLTPLALAMRLGVQFGVGAVLGVGLGLCLASVLERIEVAEGLHAILICSGGALIFAITQT
LGGSGFLAVYLAGMLVGNRDRAVTSDTMRAMDGMAWLAQSAMFLLLGLLVAPHRIWEVALPAIAVAAFLMFVARPAAVFL
ALLPFRLSVGEKGFIAWMGLRGAVPIVLSLFPLLRGLPESGLIFRIAFAVVLASLLLQGTTVAPAARLARVLRPGFPEPL
ARSRLRGTHGPTLEVMQFRVGANAPVENVRADQLELPPKCRLLTVARDDALAPHDQTVLRAGDTVSVLAPATVVPRLAAL
FQAAGPAPAWEQVTHDFLISGDAFLRDLAALYGERALTAAESPLTLADAMQAAFVSPPVEGDSVVIAGLHLTAARMEGPR
IVQVGLLLPRTEGATGTRRWGIWRKRQA

Sequences:

>Translated_588_residues
MESVDHVILIGAVVMSLGIVVGAFSARAGVPFLLVFLAVGMLAGVDGPGGIRFSNTWLSFLVGNLALAVILLDGGLRTSY
ATFRVALRPSLALATVGVLVTAGLVGLFSASVLGIDWKLGLLLGAIVGSTDAAAVFSLLHSSGIRLKDRVASVLEIESGI
NDPMAIFLTLTLMEWIAAPDGLTPLALAMRLGVQFGVGAVLGVGLGLCLASVLERIEVAEGLHAILICSGGALIFAITQT
LGGSGFLAVYLAGMLVGNRDRAVTSDTMRAMDGMAWLAQSAMFLLLGLLVAPHRIWEVALPAIAVAAFLMFVARPAAVFL
ALLPFRLSVGEKGFIAWMGLRGAVPIVLSLFPLLRGLPESGLIFRIAFAVVLASLLLQGTTVAPAARLARVLRPGFPEPL
ARSRLRGTHGPTLEVMQFRVGANAPVENVRADQLELPPKCRLLTVARDDALAPHDQTVLRAGDTVSVLAPATVVPRLAAL
FQAAGPAPAWEQVTHDFLISGDAFLRDLAALYGERALTAAESPLTLADAMQAAFVSPPVEGDSVVIAGLHLTAARMEGPR
IVQVGLLLPRTEGATGTRRWGIWRKRQA
>Mature_588_residues
MESVDHVILIGAVVMSLGIVVGAFSARAGVPFLLVFLAVGMLAGVDGPGGIRFSNTWLSFLVGNLALAVILLDGGLRTSY
ATFRVALRPSLALATVGVLVTAGLVGLFSASVLGIDWKLGLLLGAIVGSTDAAAVFSLLHSSGIRLKDRVASVLEIESGI
NDPMAIFLTLTLMEWIAAPDGLTPLALAMRLGVQFGVGAVLGVGLGLCLASVLERIEVAEGLHAILICSGGALIFAITQT
LGGSGFLAVYLAGMLVGNRDRAVTSDTMRAMDGMAWLAQSAMFLLLGLLVAPHRIWEVALPAIAVAAFLMFVARPAAVFL
ALLPFRLSVGEKGFIAWMGLRGAVPIVLSLFPLLRGLPESGLIFRIAFAVVLASLLLQGTTVAPAARLARVLRPGFPEPL
ARSRLRGTHGPTLEVMQFRVGANAPVENVRADQLELPPKCRLLTVARDDALAPHDQTVLRAGDTVSVLAPATVVPRLAAL
FQAAGPAPAWEQVTHDFLISGDAFLRDLAALYGERALTAAESPLTLADAMQAAFVSPPVEGDSVVIAGLHLTAARMEGPR
IVQVGLLLPRTEGATGTRRWGIWRKRQA

Specific function: Participates in control of cell volume in low-osmolarity conditions [H]

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI87081854, Length=576, Percent_Identity=42.8819444444444, Blast_Score=386, Evalue=1e-108,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170 [H]

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C [H]

EC number: NA

Molecular weight: Translated: 61545; Mature: 61545

Theoretical pI: Translated: 8.89; Mature: 8.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESVDHVILIGAVVMSLGIVVGAFSARAGVPFLLVFLAVGMLAGVDGPGGIRFSNTWLSF
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHH
LVGNLALAVILLDGGLRTSYATFRVALRPSLALATVGVLVTAGLVGLFSASVLGIDWKLG
HHHHHHHHHHHCCCCCCCCHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
LLLGAIVGSTDAAAVFSLLHSSGIRLKDRVASVLEIESGINDPMAIFLTLTLMEWIAAPD
HHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
GLTPLALAMRLGVQFGVGAVLGVGLGLCLASVLERIEVAEGLHAILICSGGALIFAITQT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEHHH
LGGSGFLAVYLAGMLVGNRDRAVTSDTMRAMDGMAWLAQSAMFLLLGLLVAPHRIWEVAL
CCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
PAIAVAAFLMFVARPAAVFLALLPFRLSVGEKGFIAWMGLRGAVPIVLSLFPLLRGLPES
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCC
GLIFRIAFAVVLASLLLQGTTVAPAARLARVLRPGFPEPLARSRLRGTHGPTLEVMQFRV
CHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHHEEC
GANAPVENVRADQLELPPKCRLLTVARDDALAPHDQTVLRAGDTVSVLAPATVVPRLAAL
CCCCCHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHCCCCCEEECCCHHHHHHHHHH
FQAAGPAPAWEQVTHDFLISGDAFLRDLAALYGERALTAAESPLTLADAMQAAFVSPPVE
HHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHCCCCCC
GDSVVIAGLHLTAARMEGPRIVQVGLLLPRTEGATGTRRWGIWRKRQA
CCCEEEEEEEEEHHHCCCCEEEEEEEEEECCCCCCCCHHCCCCCCCCC
>Mature Secondary Structure
MESVDHVILIGAVVMSLGIVVGAFSARAGVPFLLVFLAVGMLAGVDGPGGIRFSNTWLSF
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCEEHHHHHHH
LVGNLALAVILLDGGLRTSYATFRVALRPSLALATVGVLVTAGLVGLFSASVLGIDWKLG
HHHHHHHHHHHCCCCCCCCHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
LLLGAIVGSTDAAAVFSLLHSSGIRLKDRVASVLEIESGINDPMAIFLTLTLMEWIAAPD
HHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
GLTPLALAMRLGVQFGVGAVLGVGLGLCLASVLERIEVAEGLHAILICSGGALIFAITQT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEHHH
LGGSGFLAVYLAGMLVGNRDRAVTSDTMRAMDGMAWLAQSAMFLLLGLLVAPHRIWEVAL
CCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
PAIAVAAFLMFVARPAAVFLALLPFRLSVGEKGFIAWMGLRGAVPIVLSLFPLLRGLPES
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCC
GLIFRIAFAVVLASLLLQGTTVAPAARLARVLRPGFPEPLARSRLRGTHGPTLEVMQFRV
CHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHHHEEC
GANAPVENVRADQLELPPKCRLLTVARDDALAPHDQTVLRAGDTVSVLAPATVVPRLAAL
CCCCCHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHCCCCCEEECCCHHHHHHHHHH
FQAAGPAPAWEQVTHDFLISGDAFLRDLAALYGERALTAAESPLTLADAMQAAFVSPPVE
HHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHHHCCCCCC
GDSVVIAGLHLTAARMEGPRIVQVGLLLPRTEGATGTRRWGIWRKRQA
CCCEEEEEEEEEHHHCCCCEEEEEEEEEECCCCCCCCHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA