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The map label for this gene is dnaX [H]

Identifier: 161611258

GI number: 161611258

Start: 2320157

End: 2322349

Strand: Reverse

Name: dnaX [H]

Synonym: Reut_A2112

Alternate gene names: 161611258

Gene position: 2322349-2320157 (Counterclockwise)

Preceding gene: 73541801

Following gene: 73541799

Centisome position: 61.01

GC content: 70.45

Gene sequence:

>2193_bases
ATGAGTTATCAAGTTCTAGCGCGCAAATGGCGCCCCAGGGATTTCACCACGCTGGTCGGCCAGGAGCACGTGGTCCGCGC
GCTCACGCACGCGCTGGAACAGCAACGGCTCCACCACGCCTACCTGTTCACCGGCACGCGCGGGGTCGGCAAGACCACGC
TGTCCCGGATCCTGGCCAAGGCCCTCAACTGTACCGGTGCTGACGGCAACGGCGGCATCACGGCGCAGCCGTGCGGCCAG
TGCAAGGCATGCACCGAAATCGATAGCGGCCGCTTCGTCGACTATATCGAGATGGACGCGGCCTCGAACCGCGGCGTCGA
CGAAATGGCGCAGCTGCTGGACAAGGCGGTGTACGCGCCGACGGCGGGGCGCTTCAAGGTCTACATGATCGATGAAGTGC
ACATGCTGACCAACCACGCCTTCAACGCGATGCTGAAGACGCTGGAGGAGCCGCCCGGCCACGTCAAGTTCATCCTGGCC
ACGACCGACCCGCAGAAGATTCCGGTCACGGTGTTGTCGCGCTGCCTGCAGTTCAATCTCAAGCAGATGCCGCCCGCGCA
GATCGTGTCCCACCTGGACAATATCCTCGGGCAGGAAGGCATCGGCCATGACGGCAATGCGCTGCGGCTGCTGGCCCAGG
CGGCCCACGGCTCGATGCGCGACGCGCTGTCGCTGACCGACCAGGCCATTGCCTACAGCGCCGGCGAGGTGTCCGAGGAA
GCCGTGCGCGGCATGCTCGGCGCAATCGACCAGGGTTATCTCGTGCAATTGCTCGACGCGCTGGCAGCCGAGGACGGCGC
CGCGCTGATCGGCATTGCCGACGCCATGGCCGACCGCAGCCTGTCGTTCGCCGGCGCGCTGCAGGACCTTGGCTCGCTGC
TGCACAAGATCGCACTGGCCCAGGCCGTACCGGCTTCGGTGCAGGACGAATGGCCGGAAGCTGGCGATGTGCGCCGTCTG
GCGGGCGTGTTCGATGCGCAGGAAGTCCAGCTCTTCTACCAGATCGCGAACCTTGGCCGCAGCGAGTTGGCGCTGGCGCC
TGACGAGTACGCTGGTTTCACCATGACGCTGCTGCGTATGCTGGCGTTCCGCCCGTCGTCGACGCCGGAACCGCTGCCTG
CATCAGCGCCGGGGCAGGGCGGTGGCGCTACGCCGCGTGCCCGTACTGTGGCAGCGTCCGCGCCGGTCGTGGCTGAACCC
GTGGCGCGCTACGCGGAATCTGCTGCGTCGCCGACGCCTGCCCCTGCGCCCGCTCCGGCAGCGCAGGCCCCTGCGGTGGC
TGCGCCGGCCAGGCAGGACGCTGGTGGGGATGCACCGATGTCGCCTGCCCGGGCCGCCCTCGCGGCAGCGCGGCAGGCTT
CCGCCGCTCGCGGCGGTGGTAGTGGTAGCGGCCGGGCGCTTGCCGCGGCGCCGATGTCGACCCCGGCAGGCGGTGCCGCA
CGCCAGCCGGCCCAGCCGCTGCGCGCGCCGGCACCCGCCGCCGCCGCGTCGCGCCCTGCGCCTGCGCCCACGGCAAGGCC
GGTGCCGCCGGCCGCAGCGCCTGCACCGGCCCGCAAGCCCGCCCCGCAAGCCGAAAGTGCCCCGCCGTGGGAGGCGTCGG
GCGGCAGTGACATCCCTCCGTGGGAAGACCTGCCTCCTGACCTGCCGGTCTTTGGCCCCTATGACAACGAGCCCGTGAGC
CTGCCGACGAAGGCAGCAGCGCCGGCGCGCGCGTCGAAGCCGGAAGCTCCGGCCCCCGAGGCGCCCCGCCCGCGGCCTGT
GGCAAAGGCTGTTCCGCCGCGTCCGCCCGCAGCTGCGGAAGACGGTACGCCGCCGGTGTTCACGGGGGAGTGGCCTACGC
TGGCCGCCAACCTGCCGCTCAAGGGCCTGCCGCAGCAGTTGGCCTACCAGAGCGAACTGACCCAGGTGGTCGGGCGTACC
TTCAACCTGCGTATTCCAGTTGCGGCGCTCGGCGAAAACGGCGTTGCCGAGCGCCTGCAGCAAGTGCTGTCGGACCACTT
CGGTGTGCCGGTGCGCGTGCAGTGCGAAATCGGCGCGGTCTCCGAGACGGCCGCCGCGGCCGATGCGCAGGCCCGTGCCG
AGCGCCAGCGCGAGGCGGAGGCCAACATCGAAGCCGACCCGTTCGTGCAAGGCCTGCTGCGTGACTTTGGCGGCCAGATC
GTGCCGGGCTCGATCCAGCCGCGCGTGGCCTGA

Upstream 100 bases:

>100_bases
ACCGGGCCCGGCGCTAGCCCAGTCGGCGCCAAGGCTGGCGGGGGCGGCGGTTGCCGTGGCGGCCGCCGTCGCGGCCCCGC
CTTTTGCTACAATCGCCGGC

Downstream 100 bases:

>100_bases
ATTTTCCGGGCCGCGCGGGGCGCGGCCTTCCAACCGCTTTCTATCGAATCCAGGAGCATTCCATCATGATGAAAGGTCAA
CTGGCCGGGCTGATGAAGCA

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 730; Mature: 729

Protein sequence:

>730_residues
MSYQVLARKWRPRDFTTLVGQEHVVRALTHALEQQRLHHAYLFTGTRGVGKTTLSRILAKALNCTGADGNGGITAQPCGQ
CKACTEIDSGRFVDYIEMDAASNRGVDEMAQLLDKAVYAPTAGRFKVYMIDEVHMLTNHAFNAMLKTLEEPPGHVKFILA
TTDPQKIPVTVLSRCLQFNLKQMPPAQIVSHLDNILGQEGIGHDGNALRLLAQAAHGSMRDALSLTDQAIAYSAGEVSEE
AVRGMLGAIDQGYLVQLLDALAAEDGAALIGIADAMADRSLSFAGALQDLGSLLHKIALAQAVPASVQDEWPEAGDVRRL
AGVFDAQEVQLFYQIANLGRSELALAPDEYAGFTMTLLRMLAFRPSSTPEPLPASAPGQGGGATPRARTVAASAPVVAEP
VARYAESAASPTPAPAPAPAAQAPAVAAPARQDAGGDAPMSPARAALAAARQASAARGGGSGSGRALAAAPMSTPAGGAA
RQPAQPLRAPAPAAAASRPAPAPTARPVPPAAAPAPARKPAPQAESAPPWEASGGSDIPPWEDLPPDLPVFGPYDNEPVS
LPTKAAAPARASKPEAPAPEAPRPRPVAKAVPPRPPAAAEDGTPPVFTGEWPTLAANLPLKGLPQQLAYQSELTQVVGRT
FNLRIPVAALGENGVAERLQQVLSDHFGVPVRVQCEIGAVSETAAAADAQARAERQREAEANIEADPFVQGLLRDFGGQI
VPGSIQPRVA

Sequences:

>Translated_730_residues
MSYQVLARKWRPRDFTTLVGQEHVVRALTHALEQQRLHHAYLFTGTRGVGKTTLSRILAKALNCTGADGNGGITAQPCGQ
CKACTEIDSGRFVDYIEMDAASNRGVDEMAQLLDKAVYAPTAGRFKVYMIDEVHMLTNHAFNAMLKTLEEPPGHVKFILA
TTDPQKIPVTVLSRCLQFNLKQMPPAQIVSHLDNILGQEGIGHDGNALRLLAQAAHGSMRDALSLTDQAIAYSAGEVSEE
AVRGMLGAIDQGYLVQLLDALAAEDGAALIGIADAMADRSLSFAGALQDLGSLLHKIALAQAVPASVQDEWPEAGDVRRL
AGVFDAQEVQLFYQIANLGRSELALAPDEYAGFTMTLLRMLAFRPSSTPEPLPASAPGQGGGATPRARTVAASAPVVAEP
VARYAESAASPTPAPAPAPAAQAPAVAAPARQDAGGDAPMSPARAALAAARQASAARGGGSGSGRALAAAPMSTPAGGAA
RQPAQPLRAPAPAAAASRPAPAPTARPVPPAAAPAPARKPAPQAESAPPWEASGGSDIPPWEDLPPDLPVFGPYDNEPVS
LPTKAAAPARASKPEAPAPEAPRPRPVAKAVPPRPPAAAEDGTPPVFTGEWPTLAANLPLKGLPQQLAYQSELTQVVGRT
FNLRIPVAALGENGVAERLQQVLSDHFGVPVRVQCEIGAVSETAAAADAQARAERQREAEANIEADPFVQGLLRDFGGQI
VPGSIQPRVA
>Mature_729_residues
SYQVLARKWRPRDFTTLVGQEHVVRALTHALEQQRLHHAYLFTGTRGVGKTTLSRILAKALNCTGADGNGGITAQPCGQC
KACTEIDSGRFVDYIEMDAASNRGVDEMAQLLDKAVYAPTAGRFKVYMIDEVHMLTNHAFNAMLKTLEEPPGHVKFILAT
TDPQKIPVTVLSRCLQFNLKQMPPAQIVSHLDNILGQEGIGHDGNALRLLAQAAHGSMRDALSLTDQAIAYSAGEVSEEA
VRGMLGAIDQGYLVQLLDALAAEDGAALIGIADAMADRSLSFAGALQDLGSLLHKIALAQAVPASVQDEWPEAGDVRRLA
GVFDAQEVQLFYQIANLGRSELALAPDEYAGFTMTLLRMLAFRPSSTPEPLPASAPGQGGGATPRARTVAASAPVVAEPV
ARYAESAASPTPAPAPAPAAQAPAVAAPARQDAGGDAPMSPARAALAAARQASAARGGGSGSGRALAAAPMSTPAGGAAR
QPAQPLRAPAPAAAASRPAPAPTARPVPPAAAPAPARKPAPQAESAPPWEASGGSDIPPWEDLPPDLPVFGPYDNEPVSL
PTKAAAPARASKPEAPAPEAPRPRPVAKAVPPRPPAAAEDGTPPVFTGEWPTLAANLPLKGLPQQLAYQSELTQVVGRTF
NLRIPVAALGENGVAERLQQVLSDHFGVPVRVQCEIGAVSETAAAADAQARAERQREAEANIEADPFVQGLLRDFGGQIV
PGSIQPRVA

Specific function: The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=332, Percent_Identity=23.1927710843373, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI194306571, Length=330, Percent_Identity=22.7272727272727, Blast_Score=73, Evalue=1e-12,
Organism=Homo sapiens, GI194306567, Length=330, Percent_Identity=22.7272727272727, Blast_Score=73, Evalue=1e-12,
Organism=Escherichia coli, GI1786676, Length=373, Percent_Identity=53.887399463807, Blast_Score=403, Evalue=1e-113,
Organism=Escherichia coli, GI1787341, Length=173, Percent_Identity=31.2138728323699, Blast_Score=66, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6324039, Length=246, Percent_Identity=25.2032520325203, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI18859927, Length=264, Percent_Identity=24.2424242424242, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022001
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12168 DNA_pol3_tau_4; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 75839; Mature: 75707

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYQVLARKWRPRDFTTLVGQEHVVRALTHALEQQRLHHAYLFTGTRGVGKTTLSRILAK
CCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHH
ALNCTGADGNGGITAQPCGQCKACTEIDSGRFVDYIEMDAASNRGVDEMAQLLDKAVYAP
HHCCCCCCCCCCCCCCCCCCCHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCC
TAGRFKVYMIDEVHMLTNHAFNAMLKTLEEPPGHVKFILATTDPQKIPVTVLSRCLQFNL
CCCCEEEEEECHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHCC
KQMPPAQIVSHLDNILGQEGIGHDGNALRLLAQAAHGSMRDALSLTDQAIAYSAGEVSEE
CCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHH
AVRGMLGAIDQGYLVQLLDALAAEDGAALIGIADAMADRSLSFAGALQDLGSLLHKIALA
HHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
QAVPASVQDEWPEAGDVRRLAGVFDAQEVQLFYQIANLGRSELALAPDEYAGFTMTLLRM
HHCCCCHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCHHEEECCHHHCHHHHHHHHH
LAFRPSSTPEPLPASAPGQGGGATPRARTVAASAPVVAEPVARYAESAASPTPAPAPAPA
HHCCCCCCCCCCCCCCCCCCCCCCCCHHEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCC
AQAPAVAAPARQDAGGDAPMSPARAALAAARQASAARGGGSGSGRALAAAPMSTPAGGAA
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCC
RQPAQPLRAPAPAAAASRPAPAPTARPVPPAAAPAPARKPAPQAESAPPWEASGGSDIPP
CCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
WEDLPPDLPVFGPYDNEPVSLPTKAAAPARASKPEAPAPEAPRPRPVAKAVPPRPPAAAE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DGTPPVFTGEWPTLAANLPLKGLPQQLAYQSELTQVVGRTFNLRIPVAALGENGVAERLQ
CCCCCEECCCCCCEECCCCCCCCHHHHHHHHHHHHHHCCCEEEEECHHCCCCCHHHHHHH
QVLSDHFGVPVRVQCEIGAVSETAAAADAQARAERQREAEANIEADPFVQGLLRDFGGQI
HHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCEE
VPGSIQPRVA
CCCCCCCCCC
>Mature Secondary Structure 
SYQVLARKWRPRDFTTLVGQEHVVRALTHALEQQRLHHAYLFTGTRGVGKTTLSRILAK
CHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHH
ALNCTGADGNGGITAQPCGQCKACTEIDSGRFVDYIEMDAASNRGVDEMAQLLDKAVYAP
HHCCCCCCCCCCCCCCCCCCCHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCC
TAGRFKVYMIDEVHMLTNHAFNAMLKTLEEPPGHVKFILATTDPQKIPVTVLSRCLQFNL
CCCCEEEEEECHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHCC
KQMPPAQIVSHLDNILGQEGIGHDGNALRLLAQAAHGSMRDALSLTDQAIAYSAGEVSEE
CCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHHH
AVRGMLGAIDQGYLVQLLDALAAEDGAALIGIADAMADRSLSFAGALQDLGSLLHKIALA
HHHHHHHHCCCHHHHHHHHHHHCCCCCEEEEHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
QAVPASVQDEWPEAGDVRRLAGVFDAQEVQLFYQIANLGRSELALAPDEYAGFTMTLLRM
HHCCCCHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCHHEEECCHHHCHHHHHHHHH
LAFRPSSTPEPLPASAPGQGGGATPRARTVAASAPVVAEPVARYAESAASPTPAPAPAPA
HHCCCCCCCCCCCCCCCCCCCCCCCCHHEEECCCCHHHHHHHHHHHHCCCCCCCCCCCCC
AQAPAVAAPARQDAGGDAPMSPARAALAAARQASAARGGGSGSGRALAAAPMSTPAGGAA
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCC
RQPAQPLRAPAPAAAASRPAPAPTARPVPPAAAPAPARKPAPQAESAPPWEASGGSDIPP
CCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
WEDLPPDLPVFGPYDNEPVSLPTKAAAPARASKPEAPAPEAPRPRPVAKAVPPRPPAAAE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DGTPPVFTGEWPTLAANLPLKGLPQQLAYQSELTQVVGRTFNLRIPVAALGENGVAERLQ
CCCCCEECCCCCCEECCCCCCCCHHHHHHHHHHHHHHCCCEEEEECHHCCCCCHHHHHHH
QVLSDHFGVPVRVQCEIGAVSETAAAADAQARAERQREAEANIEADPFVQGLLRDFGGQI
HHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCEE
VPGSIQPRVA
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3534795; 3018672; 9278503; 2186364; 2187190; 2181440; 1575709 [H]