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The map label for this gene is arsA [H]

Identifier: 71908250

GI number: 71908250

Start: 2836143

End: 2837915

Strand: Reverse

Name: arsA [H]

Synonym: Daro_2637

Alternate gene names: 71908250

Gene position: 2837915-2836143 (Counterclockwise)

Preceding gene: 71908251

Following gene: 71908249

Centisome position: 63.05

GC content: 60.46

Gene sequence:

>1773_bases
ATGAAATTCCTTGAACAGCCGCCGCGCTATCTGTTTTTCACCGGCAAAGGCGGGGTGGGTAAAACCTCGATCGCTTGCGC
CACCGCAATCCAGTTGGCCGAAGCCGGACAGCGCGTTCTGCTGGTCAGCACCGATCCGGCTTCCAATGTTGGCCAGGTGT
TTGGCGTGGACATCGGTAACCGAATTGTCGGTATCGAGGCTGTTCCGGGTTTGTTCGCGCTTGAAATCGACCCGCAGGCA
GCGGCCCAGGCCTATCGGGACCGGATTGTCGGTCCGGTGCGTGGCGTATTGCCGGAAGCCGTTGTGAAGGGGATTGAGGA
ACAACTGTCGGGCGCATGCACGACGGAAATTGCCGCATTCGACGAGTTCACCGCGCTGCTGACCGATTCAGCGCTGGTTG
CCGGCTACGATCACATCATTTTCGATACCGCGCCGACCGGCCATACCATTCGCCTGCTGCAATTGCCCGGGGCATGGACT
GGCTTCCTTGAAGAGGGCAAAGGCGATGCTTCCTGTCTGGGGCCTTTGGCTGGTCTGGAAAAGCAACGTACCCAGTACAA
GTCTGCGGTAGAAGCGTTGGCCGATCCCGTACGGACACGGCTGATCCTGGTTGCCCGCGCCCAGGCCGCGACCTTGCGCG
AGGTTTCCCGGACACATGAAGAACTGGCCGGCATCGGTCTCAAGCAGCAGTATCTGGTGATCAATGGTGTCCTGCCTGAG
TCTGCCGTGGGCAGCGATCTGCTGGCCAAAGCCATCTACAACCGTGAGCAGGCTGCCTTGCTTGAGATCCCGGCGGTTCT
GAAAGCCTTGCCCATCGACCAGGTCGGTTTGAAGCCGTTCAACCTGGTCGGTCTGGATGCGCTTCGGAAGTTGCTGGTCG
CCAGTGTTTTTGATGCGGCATCGGATATTCCTGCTGCGACGGTGCTCCCTGAAGTTCCAAGCCTGGCCGTGCTGGTAGAC
GGTATTGCTGCCGATGGTCATGGACTGGTCATGCTGATGGGCAAGGGCGGGGTTGGCAAAACGACGCTGGCTGCAGCCGT
CGCCGTCGAACTGGCCAGCCGTGGTTTGCCGGTTCATCTGACGACCTCAGATCCGGCCGCGCATTTGTCGGAAACCCTGG
CCGGCAGTCTTGAGCATCTGACCGTCAGCCGTATCGACCCGCAGGCCGAAACCGAGCGTTATCGTCAGCATGTTTTGGAG
AGCAAAGGAGCGACGCTGGATGCCCAGGGCAGGGCGCTGCTGGAGGAAGATCTGCGCTCGCCCTGTACCGAGGAAATTGC
CGTCTTCCAGGCTTTCTCCCGAGTCATCCGCGAAGCCGGCAAGAAATTCGTCGTCATGGATACGGCGCCCACCGGCCACA
CCTTGTTGCTGCTTGATGCGACCGGTGCCTATCACCGCGAAATCGCCCGTCAGATGAGCGGCAAGGACATGCACTACACC
ACGCCGATGATGCAGTTGCAGGACGCCAAACAGACCAAGGTGCTGATTGCGACGCTGGCCGAAACGACGCCGGTGCTTGA
AGCCGCCAACCTGCAATCGGATTTGCGCCGGGCCGGCATCGAGCCCTGGGCCTGGGTCATCAATAACAGCGTCGCGGCAG
TGCAGTCGTCCTCTCCGTTACTGCGCCAACGCGCCGTCAATGAACTGGCCCAGATCGACCTGGTGGCGCATACCCATGCT
GTACGTTACGCAGTTGTTCCGCTGATCCAGGATGAGCCGGTTGGCGTCGAGCGTTTGCGCGCTCTGGCCAATTGCCATCC
TGTGACAGCCTGA

Upstream 100 bases:

>100_bases
GCGCGCTGGGCAAAAATGGAAGCTGCAGCGGTCGACGCAGTATCGCCGGCCAAAAGCTGTTGCAGCGGTTCCAAGTGCTG
CTAACCAAATAAGGGTCGCC

Downstream 100 bases:

>100_bases
TCGAGATAAATCATGAGTGAAGTTACCAAAAAACTATCCTTCCTCGACCGTTACCTGACGGTCTGGATTTTCGCCGCCAT
GGCGCTGGGTATCGGTCTTG

Product: anion-transporting ATPase

Products: NA

Alternate protein names: Arsenical resistance ATPase; Arsenite-translocating ATPase; Arsenite-transporting ATPase [H]

Number of amino acids: Translated: 590; Mature: 590

Protein sequence:

>590_residues
MKFLEQPPRYLFFTGKGGVGKTSIACATAIQLAEAGQRVLLVSTDPASNVGQVFGVDIGNRIVGIEAVPGLFALEIDPQA
AAQAYRDRIVGPVRGVLPEAVVKGIEEQLSGACTTEIAAFDEFTALLTDSALVAGYDHIIFDTAPTGHTIRLLQLPGAWT
GFLEEGKGDASCLGPLAGLEKQRTQYKSAVEALADPVRTRLILVARAQAATLREVSRTHEELAGIGLKQQYLVINGVLPE
SAVGSDLLAKAIYNREQAALLEIPAVLKALPIDQVGLKPFNLVGLDALRKLLVASVFDAASDIPAATVLPEVPSLAVLVD
GIAADGHGLVMLMGKGGVGKTTLAAAVAVELASRGLPVHLTTSDPAAHLSETLAGSLEHLTVSRIDPQAETERYRQHVLE
SKGATLDAQGRALLEEDLRSPCTEEIAVFQAFSRVIREAGKKFVVMDTAPTGHTLLLLDATGAYHREIARQMSGKDMHYT
TPMMQLQDAKQTKVLIATLAETTPVLEAANLQSDLRRAGIEPWAWVINNSVAAVQSSSPLLRQRAVNELAQIDLVAHTHA
VRYAVVPLIQDEPVGVERLRALANCHPVTA

Sequences:

>Translated_590_residues
MKFLEQPPRYLFFTGKGGVGKTSIACATAIQLAEAGQRVLLVSTDPASNVGQVFGVDIGNRIVGIEAVPGLFALEIDPQA
AAQAYRDRIVGPVRGVLPEAVVKGIEEQLSGACTTEIAAFDEFTALLTDSALVAGYDHIIFDTAPTGHTIRLLQLPGAWT
GFLEEGKGDASCLGPLAGLEKQRTQYKSAVEALADPVRTRLILVARAQAATLREVSRTHEELAGIGLKQQYLVINGVLPE
SAVGSDLLAKAIYNREQAALLEIPAVLKALPIDQVGLKPFNLVGLDALRKLLVASVFDAASDIPAATVLPEVPSLAVLVD
GIAADGHGLVMLMGKGGVGKTTLAAAVAVELASRGLPVHLTTSDPAAHLSETLAGSLEHLTVSRIDPQAETERYRQHVLE
SKGATLDAQGRALLEEDLRSPCTEEIAVFQAFSRVIREAGKKFVVMDTAPTGHTLLLLDATGAYHREIARQMSGKDMHYT
TPMMQLQDAKQTKVLIATLAETTPVLEAANLQSDLRRAGIEPWAWVINNSVAAVQSSSPLLRQRAVNELAQIDLVAHTHA
VRYAVVPLIQDEPVGVERLRALANCHPVTA
>Mature_590_residues
MKFLEQPPRYLFFTGKGGVGKTSIACATAIQLAEAGQRVLLVSTDPASNVGQVFGVDIGNRIVGIEAVPGLFALEIDPQA
AAQAYRDRIVGPVRGVLPEAVVKGIEEQLSGACTTEIAAFDEFTALLTDSALVAGYDHIIFDTAPTGHTIRLLQLPGAWT
GFLEEGKGDASCLGPLAGLEKQRTQYKSAVEALADPVRTRLILVARAQAATLREVSRTHEELAGIGLKQQYLVINGVLPE
SAVGSDLLAKAIYNREQAALLEIPAVLKALPIDQVGLKPFNLVGLDALRKLLVASVFDAASDIPAATVLPEVPSLAVLVD
GIAADGHGLVMLMGKGGVGKTTLAAAVAVELASRGLPVHLTTSDPAAHLSETLAGSLEHLTVSRIDPQAETERYRQHVLE
SKGATLDAQGRALLEEDLRSPCTEEIAVFQAFSRVIREAGKKFVVMDTAPTGHTLLLLDATGAYHREIARQMSGKDMHYT
TPMMQLQDAKQTKVLIATLAETTPVLEAANLQSDLRRAGIEPWAWVINNSVAAVQSSSPLLRQRAVNELAQIDLVAHTHA
VRYAVVPLIQDEPVGVERLRALANCHPVTA

Specific function: Anion-transporting ATPase. Catalyzes the extrusion of the oxyanions arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces resistance to the toxic agents [H]

COG id: COG0003

COG function: function code P; Oxyanion-translocating ATPase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the arsA ATPase family [H]

Homologues:

Organism=Homo sapiens, GI50428938, Length=254, Percent_Identity=28.3464566929134, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17557003, Length=268, Percent_Identity=29.4776119402985, Blast_Score=85, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320103, Length=241, Percent_Identity=28.2157676348548, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24586297, Length=256, Percent_Identity=28.125, Blast_Score=77, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016300
- InterPro:   IPR003593
- InterPro:   IPR003348 [H]

Pfam domain/function: NA

EC number: =3.6.3.16 [H]

Molecular weight: Translated: 62756; Mature: 62756

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFLEQPPRYLFFTGKGGVGKTSIACATAIQLAEAGQRVLLVSTDPASNVGQVFGVDIGN
CCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEECCC
RIVGIEAVPGLFALEIDPQAAAQAYRDRIVGPVRGVLPEAVVKGIEEQLSGACTTEIAAF
EEEEEEECCCEEEEEECHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
DEFTALLTDSALVAGYDHIIFDTAPTGHTIRLLQLPGAWTGFLEEGKGDASCLGPLAGLE
HHHHHHHHCCHHHCCCCEEEEECCCCCCEEEEEECCCCHHHHHHCCCCCHHHHHHHHHHH
KQRTQYKSAVEALADPVRTRLILVARAQAATLREVSRTHEELAGIGLKQQYLVINGVLPE
HHHHHHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCC
SAVGSDLLAKAIYNREQAALLEIPAVLKALPIDQVGLKPFNLVGLDALRKLLVASVFDAA
HHCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCEECHHHHHHHHHHHHHHHH
SDIPAATVLPEVPSLAVLVDGIAADGHGLVMLMGKGGVGKTTLAAAVAVELASRGLPVHL
CCCCCHHHCCCCCCCEEEEECEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEE
TTSDPAAHLSETLAGSLEHLTVSRIDPQAETERYRQHVLESKGATLDAQGRALLEEDLRS
ECCCHHHHHHHHHHCCHHHEEEECCCCHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHCC
PCTEEIAVFQAFSRVIREAGKKFVVMDTAPTGHTLLLLDATGAYHREIARQMSGKDMHYT
CHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCHHHHHHHHHHCCCCCEEE
TPMMQLQDAKQTKVLIATLAETTPVLEAANLQSDLRRAGIEPWAWVINNSVAAVQSSSPL
CHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEHHHCCCCEEECCCCHH
LRQRAVNELAQIDLVAHTHAVRYAVVPLIQDEPVGVERLRALANCHPVTA
HHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKFLEQPPRYLFFTGKGGVGKTSIACATAIQLAEAGQRVLLVSTDPASNVGQVFGVDIGN
CCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEEECCC
RIVGIEAVPGLFALEIDPQAAAQAYRDRIVGPVRGVLPEAVVKGIEEQLSGACTTEIAAF
EEEEEEECCCEEEEEECHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
DEFTALLTDSALVAGYDHIIFDTAPTGHTIRLLQLPGAWTGFLEEGKGDASCLGPLAGLE
HHHHHHHHCCHHHCCCCEEEEECCCCCCEEEEEECCCCHHHHHHCCCCCHHHHHHHHHHH
KQRTQYKSAVEALADPVRTRLILVARAQAATLREVSRTHEELAGIGLKQQYLVINGVLPE
HHHHHHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCC
SAVGSDLLAKAIYNREQAALLEIPAVLKALPIDQVGLKPFNLVGLDALRKLLVASVFDAA
HHCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCEECHHHHHHHHHHHHHHHH
SDIPAATVLPEVPSLAVLVDGIAADGHGLVMLMGKGGVGKTTLAAAVAVELASRGLPVHL
CCCCCHHHCCCCCCCEEEEECEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCEEEE
TTSDPAAHLSETLAGSLEHLTVSRIDPQAETERYRQHVLESKGATLDAQGRALLEEDLRS
ECCCHHHHHHHHHHCCHHHEEEECCCCHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHCC
PCTEEIAVFQAFSRVIREAGKKFVVMDTAPTGHTLLLLDATGAYHREIARQMSGKDMHYT
CHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCHHHHHHHHHHCCCCCEEE
TPMMQLQDAKQTKVLIATLAETTPVLEAANLQSDLRRAGIEPWAWVINNSVAAVQSSSPL
CHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEHHHCCCCEEECCCCHH
LRQRAVNELAQIDLVAHTHAVRYAVVPLIQDEPVGVERLRALANCHPVTA
HHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3021763; 1704144 [H]