Click here to switch to the map view.

The map label for this gene is atoC [H]

Identifier: 71908199

GI number: 71908199

Start: 2784466

End: 2785872

Strand: Reverse

Name: atoC [H]

Synonym: Daro_2585

Alternate gene names: 71908199

Gene position: 2785872-2784466 (Counterclockwise)

Preceding gene: 71908201

Following gene: 71908198

Centisome position: 61.89

GC content: 49.47

Gene sequence:

>1407_bases
ATGGTTGGAGATCGTGAATTGGCACACATACTTATTGTCGATGATGACTTGGCGATATGCCAGACACTGAAATCTCATTT
TCAAAAAAACGCTTTTCAAGTGTCGCTGGCTAATACGGCGGAAGCAGGAATTACTATCGCTCTTTCAAGCAATATTGACG
CCATCATCTCGGACATTCGCCTGCCTGCAAAAGGAGGCCTTGACCTTTTGCGCGAGGTCAAAGCGCTAAAGCCAGAACTA
CCGATCATTATGATTACAGCGTTCCATAATATGGAGATGACGGTGGCGGCGATGCAATGCGGGGCTATGGACTACGTTCC
AAAGCCCATCGACCTCCCGGAATTGGACGCAGCGGTTAATAGAGCTCTCTTTGCTTCCAGTCGTTCAGACCATGTGACAG
GAGAACCGCTGATCATTGGAGCGACAGATGTAAGCCCAACACAAATTGTGGGTCAATCATTTGCCATGAAAGAGGTCTAC
AAAAGCATCGCACTTGTGGCGCAGAGCAGGGTGACGGCCTTGATTCTCGGAGAGTCTGGCACGGGGAAAGAGTTGGTTGC
CCGTGCAATACACAACGCAAGTGCCGAACGGGATATGCCTTTTATTGCGGTCAACTGTGCCGCTTTGGTTGACTCTCTCC
TTGAGAGTGAACTGTTCGGCCATGAGCGAGGTGCTTTCACTGGCGCCGTCAATGCGCACAAAGGAAAAGTCGAGCAAGTA
GGGGAGGGGACGTTGTTCTTGGACGAGGTCGCCGAGTTGACCCCCCTTATCCAAGGCAAACTACTGCGTATCCTAGAGGC
ACGAGAATATAGTCCAGTAGGCAGTGCACAAGTTAAAAAAAGCAAGGCCAGATTCATAGCGGCAACAAACGTAGACTTGC
AAGCAAGGGTTGCCTCCGGCGAGTTTCGCGAAGATCTTTTTTACCGCCTCAACGTTGCTTCCATCAACCTACCGCCTTTG
CGAGAACGGCAAGGAGACATGCCAAGATTGATCGATTTCCTTCTTCGGAAGATCAATCGTGACCTACGTAAAAACATACG
TAGAGTGTCTGGTGAAGCTATGGCTTGCCTCAATGCCTTCGCATGGCCTGGCAATGTTCGGCAACTTGACAATGTACTCA
TGAAAGCTGCGGTAATGGAACGCGGCGACACTCTCACCATTGACCGTCTTCCGCCTGAAATAAAATGCTCACGAATGCCA
GCATCAGCATTAGAGATCGATACTTCCATGCCGAAAGACCTTCTTTCACTTCGGGAGTTAGAAAAAAATCACATCGTGCG
CGTGCTGCAAAGAACCGGTTGGCATAAAGGACAGGCCTGTGAAATTCTTGATATTTCTCGTCCTAAGCTTGAGCGACGTA
TCCATGAATTTAATCTCAGCCCTCCTGATCGTCCTAGCGACGATTGA

Upstream 100 bases:

>100_bases
TCTAGCCCATAGAAAATTAGTTCTACCCATCCAGTGGTTCGAGCAACGCTCCGTCCCGATGGGTGTTCTCTTAAGGGTTT
GAAGGATGTCGGGGGTAAAA

Downstream 100 bases:

>100_bases
GTGACTTGCATATTCCGCAGAGTTTCTGGTCGAAATTCTCAAGTTCTTCGTCGCTGGCGACGTGAGCGACTGGCTCTGCA
CTAGCAACTGGTCAAGCCGT

Product: helix-turn-helix, Fis-type

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MVGDRELAHILIVDDDLAICQTLKSHFQKNAFQVSLANTAEAGITIALSSNIDAIISDIRLPAKGGLDLLREVKALKPEL
PIIMITAFHNMEMTVAAMQCGAMDYVPKPIDLPELDAAVNRALFASSRSDHVTGEPLIIGATDVSPTQIVGQSFAMKEVY
KSIALVAQSRVTALILGESGTGKELVARAIHNASAERDMPFIAVNCAALVDSLLESELFGHERGAFTGAVNAHKGKVEQV
GEGTLFLDEVAELTPLIQGKLLRILEAREYSPVGSAQVKKSKARFIAATNVDLQARVASGEFREDLFYRLNVASINLPPL
RERQGDMPRLIDFLLRKINRDLRKNIRRVSGEAMACLNAFAWPGNVRQLDNVLMKAAVMERGDTLTIDRLPPEIKCSRMP
ASALEIDTSMPKDLLSLRELEKNHIVRVLQRTGWHKGQACEILDISRPKLERRIHEFNLSPPDRPSDD

Sequences:

>Translated_468_residues
MVGDRELAHILIVDDDLAICQTLKSHFQKNAFQVSLANTAEAGITIALSSNIDAIISDIRLPAKGGLDLLREVKALKPEL
PIIMITAFHNMEMTVAAMQCGAMDYVPKPIDLPELDAAVNRALFASSRSDHVTGEPLIIGATDVSPTQIVGQSFAMKEVY
KSIALVAQSRVTALILGESGTGKELVARAIHNASAERDMPFIAVNCAALVDSLLESELFGHERGAFTGAVNAHKGKVEQV
GEGTLFLDEVAELTPLIQGKLLRILEAREYSPVGSAQVKKSKARFIAATNVDLQARVASGEFREDLFYRLNVASINLPPL
RERQGDMPRLIDFLLRKINRDLRKNIRRVSGEAMACLNAFAWPGNVRQLDNVLMKAAVMERGDTLTIDRLPPEIKCSRMP
ASALEIDTSMPKDLLSLRELEKNHIVRVLQRTGWHKGQACEILDISRPKLERRIHEFNLSPPDRPSDD
>Mature_468_residues
MVGDRELAHILIVDDDLAICQTLKSHFQKNAFQVSLANTAEAGITIALSSNIDAIISDIRLPAKGGLDLLREVKALKPEL
PIIMITAFHNMEMTVAAMQCGAMDYVPKPIDLPELDAAVNRALFASSRSDHVTGEPLIIGATDVSPTQIVGQSFAMKEVY
KSIALVAQSRVTALILGESGTGKELVARAIHNASAERDMPFIAVNCAALVDSLLESELFGHERGAFTGAVNAHKGKVEQV
GEGTLFLDEVAELTPLIQGKLLRILEAREYSPVGSAQVKKSKARFIAATNVDLQARVASGEFREDLFYRLNVASINLPPL
RERQGDMPRLIDFLLRKINRDLRKNIRRVSGEAMACLNAFAWPGNVRQLDNVLMKAAVMERGDTLTIDRLPPEIKCSRMP
ASALEIDTSMPKDLLSLRELEKNHIVRVLQRTGWHKGQACEILDISRPKLERRIHEFNLSPPDRPSDD

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=459, Percent_Identity=41.8300653594771, Blast_Score=334, Evalue=6e-93,
Organism=Escherichia coli, GI1790437, Length=441, Percent_Identity=40.1360544217687, Blast_Score=330, Evalue=2e-91,
Organism=Escherichia coli, GI1790299, Length=469, Percent_Identity=38.8059701492537, Blast_Score=298, Evalue=6e-82,
Organism=Escherichia coli, GI1788905, Length=458, Percent_Identity=36.6812227074236, Blast_Score=270, Evalue=2e-73,
Organism=Escherichia coli, GI87082117, Length=293, Percent_Identity=43.6860068259386, Blast_Score=236, Evalue=3e-63,
Organism=Escherichia coli, GI1789087, Length=240, Percent_Identity=49.5833333333333, Blast_Score=235, Evalue=5e-63,
Organism=Escherichia coli, GI1789233, Length=323, Percent_Identity=39.6284829721362, Blast_Score=221, Evalue=7e-59,
Organism=Escherichia coli, GI87082152, Length=240, Percent_Identity=45.4166666666667, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI87081872, Length=312, Percent_Identity=38.4615384615385, Blast_Score=191, Evalue=9e-50,
Organism=Escherichia coli, GI1786524, Length=323, Percent_Identity=36.5325077399381, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1787583, Length=239, Percent_Identity=38.9121338912134, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1789828, Length=295, Percent_Identity=30.8474576271186, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI87081858, Length=295, Percent_Identity=30.1694915254237, Blast_Score=129, Evalue=3e-31,
Organism=Escherichia coli, GI1786784, Length=114, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1789809, Length=132, Percent_Identity=28.7878787878788, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1786911, Length=117, Percent_Identity=30.7692307692308, Blast_Score=62, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51500; Mature: 51500

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVGDRELAHILIVDDDLAICQTLKSHFQKNAFQVSLANTAEAGITIALSSNIDAIISDIR
CCCCCCEEEEEEECCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCCHHHHHHHCC
LPAKGGLDLLREVKALKPELPIIMITAFHNMEMTVAAMQCGAMDYVPKPIDLPELDAAVN
CCCCCCHHHHHHHHHHCCCCCEEEEEEECCCEEEEHHHHCCCCCCCCCCCCCCHHHHHHH
RALFASSRSDHVTGEPLIIGATDVSPTQIVGQSFAMKEVYKSIALVAQSRVTALILGESG
HHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCC
TGKELVARAIHNASAERDMPFIAVNCAALVDSLLESELFGHERGAFTGAVNAHKGKVEQV
CCHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCHHHC
GEGTLFLDEVAELTPLIQGKLLRILEAREYSPVGSAQVKKSKARFIAATNVDLQARVASG
CCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCEEEEEECCCEEEEECCC
EFREDLFYRLNVASINLPPLRERQGDMPRLIDFLLRKINRDLRKNIRRVSGEAMACLNAF
HHHHHHHEEEEEEEECCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
AWPGNVRQLDNVLMKAAVMERGDTLTIDRLPPEIKCSRMPASALEIDTSMPKDLLSLREL
CCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCEECCCCCHHHHCCCCCCHHHHHHHHH
EKNHIVRVLQRTGWHKGQACEILDISRPKLERRIHEFNLSPPDRPSDD
HHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MVGDRELAHILIVDDDLAICQTLKSHFQKNAFQVSLANTAEAGITIALSSNIDAIISDIR
CCCCCCEEEEEEECCCHHHHHHHHHHHHCCCEEEEECCCCCCCEEEEECCCHHHHHHHCC
LPAKGGLDLLREVKALKPELPIIMITAFHNMEMTVAAMQCGAMDYVPKPIDLPELDAAVN
CCCCCCHHHHHHHHHHCCCCCEEEEEEECCCEEEEHHHHCCCCCCCCCCCCCCHHHHHHH
RALFASSRSDHVTGEPLIIGATDVSPTQIVGQSFAMKEVYKSIALVAQSRVTALILGESG
HHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCC
TGKELVARAIHNASAERDMPFIAVNCAALVDSLLESELFGHERGAFTGAVNAHKGKVEQV
CCHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCHHHC
GEGTLFLDEVAELTPLIQGKLLRILEAREYSPVGSAQVKKSKARFIAATNVDLQARVASG
CCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCEEEEEECCCEEEEECCC
EFREDLFYRLNVASINLPPLRERQGDMPRLIDFLLRKINRDLRKNIRRVSGEAMACLNAF
HHHHHHHEEEEEEEECCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
AWPGNVRQLDNVLMKAAVMERGDTLTIDRLPPEIKCSRMPASALEIDTSMPKDLLSLREL
CCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCCCEECCCCCHHHHCCCCCCHHHHHHHHH
EKNHIVRVLQRTGWHKGQACEILDISRPKLERRIHEFNLSPPDRPSDD
HHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]