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The map label for this gene is lysC [H]

Identifier: 71908131

GI number: 71908131

Start: 2711801

End: 2713021

Strand: Reverse

Name: lysC [H]

Synonym: Daro_2515

Alternate gene names: 71908131

Gene position: 2713021-2711801 (Counterclockwise)

Preceding gene: 71908132

Following gene: 71908125

Centisome position: 60.27

GC content: 56.67

Gene sequence:

>1221_bases
ATGGCGTTGATTGTTCAAAAATACGGCGGCACGTCGGTCGGTAACCCCGAGCGCATCAAAAACGTCGCCAAACGCGTTGC
CAAGTTCCAGGCCCAAGGGCATCAGGTCGTTGTCGTTGTTTCCGCGATGAGCGGCGAAACCAACAAGCTGATTGCACTGG
CCAAGGAAGTCCAGGCCAATCCCGATCCGCGCGAACTGGATGCGATCATGTCAACCGGCGAACAGGTCACTACTGGCCTG
CTTTCCATGGCATTGATGGACATTGGCTGCAAGGCCAAGAGTTACACCGGTGGCCAGGTCAAGGTGCTCACTGACAGCAC
CCATACCAAGGCACGCATCCTGTCGATTGACGAAGCCAACATGCGGCGCGATCTCGATGCCGGCTATGTGATCGTTGTTG
CCGGCTTCCAGGGCGTCGATGCCAACGGCAATATCACCACGCTCGGTCGTGGTGGTTCCGACACCTCTGGCGTGGCGCTG
GCTGCTGCCCTGAAGGCAGATGAGTGCCAGATTTACACCGACGTCGATGGTGTCTACACGACCGATCCGCGTGTCGTGCC
TGAAGCCAAGAAGCTCGACACCATCACCTTCGAAGAGATGCTGGAAATGGCCAGTCTCGGTTCCAAGGTGCTGCAGATTC
GCTCCGTCGAATTCGCCGGCAAGTACAAGGTCAAACTACGCGTTCTTTCCAGCTTCCAGGATGAAGGGGAAGGCACGCTG
ATCACTGTTGAGGAAGACAAAAACATGGAACAACCGATCATCTCCGGTATCGCCTTCAATCGCGACGAAGCCAAGCTGAC
CATGCTCGGCGTTCCGGATACCCCGGGCATCGCCTATCAAATTCTCGGTGCCATCGCCGATGCCAACATCGATGTCGACA
TGATCATCCAGAACGTTGGCCACGACGGCACGACTGACTTCTCCTTCACCGTCAATCGTGGCGAGTTCGCCAAGGCCAAG
GAAATTCTTGAAGGCGTCAAGGCCAAGCTGGGTGCTCGCGAGATCACCGGTGACAACAAGATCTGCAAGGTCTCCGCTGT
CGGCGTCGGCATGCGCTCCCATCCGGGCGTGGCCAGCCAGATGTTCAAGGCACTGGCTGATGAGGGCATCAACATCCAGA
TGATCTCCACCTCCGAGATCAAGATTTCCGTCGTTCTCGACGAAAAATATCTGGAACTGGCCGTTCGCGTGCTGCATCGG
ACTTTCGGTCTCGATCAGTAA

Upstream 100 bases:

>100_bases
GGGTTTATGGTGGCAAGTACTGATTTCTTTAGAAAAAGAACCGGGTGGGGTAAAATCCCGCCCTCTTTTTCATGTTTCCA
ACGTTTAACCGGACAAATCC

Downstream 100 bases:

>100_bases
GTTTGACCAAAGGGCGCGGAGGCTATATCATCCGCGCCTCGTTGAAGGTTCGGAGACGTGGCCGAGAGGTCGAAGGCACT
CCCCTGCTAAGGGAGCATGC

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MALIVQKYGGTSVGNPERIKNVAKRVAKFQAQGHQVVVVVSAMSGETNKLIALAKEVQANPDPRELDAIMSTGEQVTTGL
LSMALMDIGCKAKSYTGGQVKVLTDSTHTKARILSIDEANMRRDLDAGYVIVVAGFQGVDANGNITTLGRGGSDTSGVAL
AAALKADECQIYTDVDGVYTTDPRVVPEAKKLDTITFEEMLEMASLGSKVLQIRSVEFAGKYKVKLRVLSSFQDEGEGTL
ITVEEDKNMEQPIISGIAFNRDEAKLTMLGVPDTPGIAYQILGAIADANIDVDMIIQNVGHDGTTDFSFTVNRGEFAKAK
EILEGVKAKLGAREITGDNKICKVSAVGVGMRSHPGVASQMFKALADEGINIQMISTSEIKISVVLDEKYLELAVRVLHR
TFGLDQ

Sequences:

>Translated_406_residues
MALIVQKYGGTSVGNPERIKNVAKRVAKFQAQGHQVVVVVSAMSGETNKLIALAKEVQANPDPRELDAIMSTGEQVTTGL
LSMALMDIGCKAKSYTGGQVKVLTDSTHTKARILSIDEANMRRDLDAGYVIVVAGFQGVDANGNITTLGRGGSDTSGVAL
AAALKADECQIYTDVDGVYTTDPRVVPEAKKLDTITFEEMLEMASLGSKVLQIRSVEFAGKYKVKLRVLSSFQDEGEGTL
ITVEEDKNMEQPIISGIAFNRDEAKLTMLGVPDTPGIAYQILGAIADANIDVDMIIQNVGHDGTTDFSFTVNRGEFAKAK
EILEGVKAKLGAREITGDNKICKVSAVGVGMRSHPGVASQMFKALADEGINIQMISTSEIKISVVLDEKYLELAVRVLHR
TFGLDQ
>Mature_405_residues
ALIVQKYGGTSVGNPERIKNVAKRVAKFQAQGHQVVVVVSAMSGETNKLIALAKEVQANPDPRELDAIMSTGEQVTTGLL
SMALMDIGCKAKSYTGGQVKVLTDSTHTKARILSIDEANMRRDLDAGYVIVVAGFQGVDANGNITTLGRGGSDTSGVALA
AALKADECQIYTDVDGVYTTDPRVVPEAKKLDTITFEEMLEMASLGSKVLQIRSVEFAGKYKVKLRVLSSFQDEGEGTLI
TVEEDKNMEQPIISGIAFNRDEAKLTMLGVPDTPGIAYQILGAIADANIDVDMIIQNVGHDGTTDFSFTVNRGEFAKAKE
ILEGVKAKLGAREITGDNKICKVSAVGVGMRSHPGVASQMFKALADEGINIQMISTSEIKISVVLDEKYLELAVRVLHRT
FGLDQ

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=296, Percent_Identity=33.1081081081081, Blast_Score=148, Evalue=6e-37,
Organism=Escherichia coli, GI1790455, Length=345, Percent_Identity=29.5652173913043, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1790376, Length=288, Percent_Identity=24.6527777777778, Blast_Score=66, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320893, Length=396, Percent_Identity=28.030303030303, Blast_Score=122, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 43517; Mature: 43386

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALIVQKYGGTSVGNPERIKNVAKRVAKFQAQGHQVVVVVSAMSGETNKLIALAKEVQAN
CEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHEEHHHHCCC
PDPRELDAIMSTGEQVTTGLLSMALMDIGCKAKSYTGGQVKVLTDSTHTKARILSIDEAN
CCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCEEEEEEECHHH
MRRDLDAGYVIVVAGFQGVDANGNITTLGRGGSDTSGVALAAALKADECQIYTDVDGVYT
HHHCCCCCEEEEEECCCCCCCCCCEEEECCCCCCCCCEEEEEEECCCCEEEEECCCCEEE
TDPRVVPEAKKLDTITFEEMLEMASLGSKVLQIRSVEFAGKYKVKLRVLSSFQDEGEGTL
CCCCCCCCHHHCCCCCHHHHHHHHHCCHHHEEEEEEEECCCEEEEEEEEHHHCCCCCCEE
ITVEEDKNMEQPIISGIAFNRDEAKLTMLGVPDTPGIAYQILGAIADANIDVDMIIQNVG
EEEECCCCCCCHHHHCEEECCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHCC
HDGTTDFSFTVNRGEFAKAKEILEGVKAKLGAREITGDNKICKVSAVGVGMRSHPGVASQ
CCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCEEECCCCCEEEEEEEECCCCCCCCHHHH
MFKALADEGINIQMISTSEIKISVVLDEKYLELAVRVLHRTFGLDQ
HHHHHHCCCCEEEEEECCCEEEEEEECHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ALIVQKYGGTSVGNPERIKNVAKRVAKFQAQGHQVVVVVSAMSGETNKLIALAKEVQAN
EEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHEEHHHHCCC
PDPRELDAIMSTGEQVTTGLLSMALMDIGCKAKSYTGGQVKVLTDSTHTKARILSIDEAN
CCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCEEEEEEECHHH
MRRDLDAGYVIVVAGFQGVDANGNITTLGRGGSDTSGVALAAALKADECQIYTDVDGVYT
HHHCCCCCEEEEEECCCCCCCCCCEEEECCCCCCCCCEEEEEEECCCCEEEEECCCCEEE
TDPRVVPEAKKLDTITFEEMLEMASLGSKVLQIRSVEFAGKYKVKLRVLSSFQDEGEGTL
CCCCCCCCHHHCCCCCHHHHHHHHHCCHHHEEEEEEEECCCEEEEEEEEHHHCCCCCCEE
ITVEEDKNMEQPIISGIAFNRDEAKLTMLGVPDTPGIAYQILGAIADANIDVDMIIQNVG
EEEECCCCCCCHHHHCEEECCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCHHHHHHHCC
HDGTTDFSFTVNRGEFAKAKEILEGVKAKLGAREITGDNKICKVSAVGVGMRSHPGVASQ
CCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCEEECCCCCEEEEEEEECCCCCCCCHHHH
MFKALADEGINIQMISTSEIKISVVLDEKYLELAVRVLHRTFGLDQ
HHHHHHCCCCEEEEEECCCEEEEEEECHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]