Click here to switch to the map view.

The map label for this gene is thrC [H]

Identifier: 71908001

GI number: 71908001

Start: 2567391

End: 2568818

Strand: Reverse

Name: thrC [H]

Synonym: Daro_2382

Alternate gene names: 71908001

Gene position: 2568818-2567391 (Counterclockwise)

Preceding gene: 71908002

Following gene: 71908000

Centisome position: 57.07

GC content: 58.61

Gene sequence:

>1428_bases
ATGCGCTATCTCTCGACCCGCGGTCACGCCGCGCCCCAGGCTTTCTGCGACATTCTCCTTGGTGGCCTGGCCCCGGATGG
TGGTCTCTACCTCCCGGAAAGCTACCCGCAGATCAGCCGAGCCGAACTTGATGCCTGGCGCCAACTGTCGTATGCCGATC
TGGCTTATGAGATCCTGTCCAAGTTCATCACCGATATTCCGGCAGCCGATCTGAAGGCGCTGGTCGCCAAGACCTACACT
GCCAAGGTTTATTGCCATACCCGCAACGGGGGGGATGCTGCCCAGATCACGCCGCTGACCAAGCTGGAAGACGGCCTCTA
CACTCAGGAACTGTCCAACGGCCCGACGCTGGCCTTCAAGGATATGGCCATGCAGTTGCTCGGCAACCTGTTTGAGTACG
TGCTCGACAAGCGTGGTGAGTCGATCAACATCCTTGGCGCGACTTCCGGCGACACCGGTTCGGCGGCCGAGTACGCCATG
CGCGGCAAGCACAACGTCAAGGTCTTCATGCTCTCGCCGGATGGCAAGATGAGCGCCTTCCAGCGCGCCCAGATGTATTC
GCTGCAGGATGCCAACATCTTCAACATTGCCGTCACCGGCATGTTCGACGACGCGCAGGATATCGTGAAGGCTGTCTCGA
ATGACGCTGCGTTCAAGGCCAAGTACAAGATTGGCGCCGTCAATTCGATCAATTGGGCACGGGTCGCTGCACAGATTGTC
TATTACTTCCAAGGCTACTTCCTGGCTACCCGGTCGAACGACGAGCAGGTCGCTTTCGCCGTGCCGTCGGGTAATTTCGG
CAATATCTGCGCCGGCCACATCGCTCGCCAGATGGGCTTGCCAATCGCCCGTCTCGTTTTGGCCACCAATGAAAACGACG
TGCTCGACGAGTTTTTCCGCACCGGTGTCTATCGTCCGCGTACCTCGGCTGAAACCAGCATTACTTCCAGCCCGTCGATG
GATATTTCCAAGGCCTCCAATTTCGAGCGCTTTGTGTTCGACCTGGTCGGCCGTGATCCGGCTGTCGTCAAGGAGTTGTG
GGCCAAAGTGGACAAGGGGCAGGCTTTCGATCTGTCGGCAACGGCCTTCTGGAAAAACATGCCGAAATTCGGGTTTGTGT
CTGGCAAGAGCACGCACATCGACCGCATCAACACGATCCGTTTTGCGCAAGGCCGCTATAACGTGATGCTCGACACCCAT
ACCGCCGATGGCCTGAAGGTGGCGCTTGAGCATCGTCTGCCGAATGTGCCGATGATTGTTCTGGAAACTGCTCAGCCGGC
CAAGTTCGAGGAAACGATTCGTGAGGCACTGGGCACCGAGCCGGTTCGTCCAGCTGATCTGGCGGGTATCGAGAACCTGC
CACAGCGCGTCGTGGTCATGGCGCCGGATGTGGAGGCCATCAAGCAGTTCCTCGTCGAGCGAGTGTGA

Upstream 100 bases:

>100_bases
CCTGCGGATTGGCACTCTTTATCGTTGCGCTCGTCCAAGCCGTGCGCATGCATCGCTCGACGCGGTAAAATCGCAGTTTT
TCGCTTTTCAGGTTTCCGCC

Downstream 100 bases:

>100_bases
GTTTCGACCACGAAGCGCACTGGTCTGCCCGCTATCGTGATGTGGGGGACGAATACTTGTTCGGCACGGCGCCGAACAAG
TTCCTGGCTTCTCAGGCGGA

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 475; Mature: 475

Protein sequence:

>475_residues
MRYLSTRGHAAPQAFCDILLGGLAPDGGLYLPESYPQISRAELDAWRQLSYADLAYEILSKFITDIPAADLKALVAKTYT
AKVYCHTRNGGDAAQITPLTKLEDGLYTQELSNGPTLAFKDMAMQLLGNLFEYVLDKRGESINILGATSGDTGSAAEYAM
RGKHNVKVFMLSPDGKMSAFQRAQMYSLQDANIFNIAVTGMFDDAQDIVKAVSNDAAFKAKYKIGAVNSINWARVAAQIV
YYFQGYFLATRSNDEQVAFAVPSGNFGNICAGHIARQMGLPIARLVLATNENDVLDEFFRTGVYRPRTSAETSITSSPSM
DISKASNFERFVFDLVGRDPAVVKELWAKVDKGQAFDLSATAFWKNMPKFGFVSGKSTHIDRINTIRFAQGRYNVMLDTH
TADGLKVALEHRLPNVPMIVLETAQPAKFEETIREALGTEPVRPADLAGIENLPQRVVVMAPDVEAIKQFLVERV

Sequences:

>Translated_475_residues
MRYLSTRGHAAPQAFCDILLGGLAPDGGLYLPESYPQISRAELDAWRQLSYADLAYEILSKFITDIPAADLKALVAKTYT
AKVYCHTRNGGDAAQITPLTKLEDGLYTQELSNGPTLAFKDMAMQLLGNLFEYVLDKRGESINILGATSGDTGSAAEYAM
RGKHNVKVFMLSPDGKMSAFQRAQMYSLQDANIFNIAVTGMFDDAQDIVKAVSNDAAFKAKYKIGAVNSINWARVAAQIV
YYFQGYFLATRSNDEQVAFAVPSGNFGNICAGHIARQMGLPIARLVLATNENDVLDEFFRTGVYRPRTSAETSITSSPSM
DISKASNFERFVFDLVGRDPAVVKELWAKVDKGQAFDLSATAFWKNMPKFGFVSGKSTHIDRINTIRFAQGRYNVMLDTH
TADGLKVALEHRLPNVPMIVLETAQPAKFEETIREALGTEPVRPADLAGIENLPQRVVVMAPDVEAIKQFLVERV
>Mature_475_residues
MRYLSTRGHAAPQAFCDILLGGLAPDGGLYLPESYPQISRAELDAWRQLSYADLAYEILSKFITDIPAADLKALVAKTYT
AKVYCHTRNGGDAAQITPLTKLEDGLYTQELSNGPTLAFKDMAMQLLGNLFEYVLDKRGESINILGATSGDTGSAAEYAM
RGKHNVKVFMLSPDGKMSAFQRAQMYSLQDANIFNIAVTGMFDDAQDIVKAVSNDAAFKAKYKIGAVNSINWARVAAQIV
YYFQGYFLATRSNDEQVAFAVPSGNFGNICAGHIARQMGLPIARLVLATNENDVLDEFFRTGVYRPRTSAETSITSSPSM
DISKASNFERFVFDLVGRDPAVVKELWAKVDKGQAFDLSATAFWKNMPKFGFVSGKSTHIDRINTIRFAQGRYNVMLDTH
TADGLKVALEHRLPNVPMIVLETAQPAKFEETIREALGTEPVRPADLAGIENLPQRVVVMAPDVEAIKQFLVERV

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI149193323, Length=469, Percent_Identity=32.1961620469083, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI153792148, Length=469, Percent_Identity=30.9168443496802, Blast_Score=200, Evalue=3e-51,
Organism=Escherichia coli, GI1786185, Length=474, Percent_Identity=29.746835443038, Blast_Score=198, Evalue=7e-52,
Organism=Saccharomyces cerevisiae, GI6319901, Length=477, Percent_Identity=40.8805031446541, Blast_Score=311, Evalue=1e-85,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 52290; Mature: 52290

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYLSTRGHAAPQAFCDILLGGLAPDGGLYLPESYPQISRAELDAWRQLSYADLAYEILS
CCCCCCCCCCCHHHHHHHHHHCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
KFITDIPAADLKALVAKTYTAKVYCHTRNGGDAAQITPLTKLEDGLYTQELSNGPTLAFK
HHHHCCCHHHHHHHHHHEEEEEEEEEECCCCCCEEECCHHHHHCCCHHHHHCCCCCCHHH
DMAMQLLGNLFEYVLDKRGESINILGATSGDTGSAAEYAMRGKHNVKVFMLSPDGKMSAF
HHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHCCCCCEEEEEECCCCCHHHH
QRAQMYSLQDANIFNIAVTGMFDDAQDIVKAVSNDAAFKAKYKIGAVNSINWARVAAQIV
HHHHHHCCCCCCEEEEEEEECCCCHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHH
YYFQGYFLATRSNDEQVAFAVPSGNFGNICAGHIARQMGLPIARLVLATNENDVLDEFFR
HHHCCEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHH
TGVYRPRTSAETSITSSPSMDISKASNFERFVFDLVGRDPAVVKELWAKVDKGQAFDLSA
CCCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHHHCCCCCEEECHH
TAFWKNMPKFGFVSGKSTHIDRINTIRFAQGRYNVMLDTHTADGLKVALEHRLPNVPMIV
HHHHHCCCCCEECCCCCCCCCCCEEEEEECCCEEEEEECCCCCCHHHHHHHCCCCCCEEE
LETAQPAKFEETIREALGTEPVRPADLAGIENLPQRVVVMAPDVEAIKQFLVERV
EECCCCCHHHHHHHHHHCCCCCCCHHHHCHHCCCCEEEEECCCHHHHHHHHHHCC
>Mature Secondary Structure
MRYLSTRGHAAPQAFCDILLGGLAPDGGLYLPESYPQISRAELDAWRQLSYADLAYEILS
CCCCCCCCCCCHHHHHHHHHHCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
KFITDIPAADLKALVAKTYTAKVYCHTRNGGDAAQITPLTKLEDGLYTQELSNGPTLAFK
HHHHCCCHHHHHHHHHHEEEEEEEEEECCCCCCEEECCHHHHHCCCHHHHHCCCCCCHHH
DMAMQLLGNLFEYVLDKRGESINILGATSGDTGSAAEYAMRGKHNVKVFMLSPDGKMSAF
HHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHCCCCCEEEEEECCCCCHHHH
QRAQMYSLQDANIFNIAVTGMFDDAQDIVKAVSNDAAFKAKYKIGAVNSINWARVAAQIV
HHHHHHCCCCCCEEEEEEEECCCCHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHH
YYFQGYFLATRSNDEQVAFAVPSGNFGNICAGHIARQMGLPIARLVLATNENDVLDEFFR
HHHCCEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHH
TGVYRPRTSAETSITSSPSMDISKASNFERFVFDLVGRDPAVVKELWAKVDKGQAFDLSA
CCCCCCCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHCCCHHHHHHHHHHCCCCCEEECHH
TAFWKNMPKFGFVSGKSTHIDRINTIRFAQGRYNVMLDTHTADGLKVALEHRLPNVPMIV
HHHHHCCCCCEECCCCCCCCCCCEEEEEECCCEEEEEECCCCCCHHHHHHHCCCCCCEEE
LETAQPAKFEETIREALGTEPVRPADLAGIENLPQRVVVMAPDVEAIKQFLVERV
EECCCCCHHHHHHHHHHCCCCCCCHHHHCHHCCCCEEEEECCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8117070 [H]