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The map label for this gene is fadD [C]

Identifier: 71907974

GI number: 71907974

Start: 2539039

End: 2540871

Strand: Reverse

Name: fadD [C]

Synonym: Daro_2355

Alternate gene names: 71907974

Gene position: 2540871-2539039 (Counterclockwise)

Preceding gene: 71907975

Following gene: 71907973

Centisome position: 56.45

GC content: 61.32

Gene sequence:

>1833_bases
ATGAGCATGGAACTGGAAAACCTGACCCTGCCGCAGATGCTGCGTCAGCGCGCCCAGCAGCAGCCGAACCGGGTTGCCAT
CCGGCAAAAGGATTTCGGTATCTGGAACCCGATCAGCTGGGACGACTACTACCGCCGCGCTGGCCATTTTGGTCTCGGCC
TGTGCGCGCTGGGTGTCCAGCCAGGCGGCCACATCGGCGTCATTTCCGAGAACCGTGTCGAATGGGTGCTGGCCCAGATG
GGCGCCGGCCTGGTCGGTGCAGTGACGGTCGGTGTTTATCCGACCAGTCCGACCAATGAAGTCTCCTACGTGCTGGAGCA
CGCCGATATCGATGTGGTGATCTGCGAGGACCAGGAGCAGAGCGACAAGGTGCTGGCGGCCATCGACAGCCTGCCGCGTC
TGCGCAAGATCGTCGTCATGGAAGAGAAGGGGCTGCGCAACACGCCGGCCGAATTTCGCGACAAGGTGCTGGCATTTTCC
GAAGTTGAAGCTCTGGGCGTCGATTACGAAGCCGTGCATCGCACCCTGATCGACGAGGTGCTGGCCAAACAGTCGCTCGA
CGATATCGGCCTGATGATCTACACCTCCGGTTCGACCGGCAAGCCGAAGGGGGCGATGATCAGCTACGGCAACATCCGCG
CCGTGGCGCCGGGCATCATCGAACGCCTCGGCCTCGACGAACATTCCCGGCATCTGTCCTACCTCCCACTGTGTCATGTG
GCGGAGCAGATGCTGACGACCTTCACGCCGATCTATCTCGGCTCGCAGGTCAATTTCGGCGAATCGCTGCGCACCGTGCA
GGAAGACCTGCGCGAAGTGGCACCGACGCTATTCCTCGGCGTGCCGCGCATCTGGGAGAAGCTGCATGCCTCGATCAGTA
TCCGCATTCATGAAACCGGGCGTTTTCGTCGCTGGCTGTTCGACAAGGCTCTGGTGGCCTGCGAGACCTTTGCCTGCAAG
GCGGTGCACCAGCGCACGCTGGGCGAAAAGCTGACCTTCGGTTTCTACTATGTGCTGATTCTGCGCGCCCTGCAGAACTA
CATCGGCCTGCGCAACGCCAAGGTCGCGCTGACCGGTGCGGCGCCGATTTCACCAGCGATCATCAGCTTCTTCCGGGCGC
TTGGCGTACCGCTGGTCGAGGTCTATGGCCTGACCGAATCGAGCGGCATGATCTTTGGCCAGCGTCTCGACCATGTGCAA
CTCGGCACGGTCGGCGCGGCGATCAGCGGTATCGATTACCGCATTGCCGAGACCGGCGAACTGCAGGTCAGGGGCGGGGC
CGTGTTTGCCGGCTATTACAAGAATGCCGAGGCCACTGCCGCGTCGATCCGCGATGGCTGGCTGCACACCGGCGACGTGG
TCAGGGAACTCGATGGCGATATCAAGATCGTCGATCGCCTGAAGGACATCATGATCACGGCCGGCGGCAAGAACCTGACG
CCGTCGGAGATCGAGAATGGCATGAAGGCCAGTCCGTACATCAAGGAGTGCATCGTCGTCGCCGACGGCCGGAATTTCGT
CGCGGCGCTGATCCAGATCGACTTCGAAACGGTCGGCAAATGGGCCGAGCGCAATCGCATGGCCTTCACGCATTTCCGCT
CACTGGTCGAAAGCCCGCAGGTCCGGGAGCTGGTTGCCGAGGAGATCAACAAGGCCAACGCCAAGCTGGCCCAGGTTTCG
CAAATCCGGAAATTCCATTTGTTGACCAAGGAGCTGGATCACGACGATGGCGAAGTCACTGCGACCATGAAGGTCCGCCG
CAGCAGCATCTACAAGACCTACGAGAAGGAAATCGAGGCGATGTACGGCAAGGGAGGGCTGGCCAATGCCTGA

Upstream 100 bases:

>100_bases
ATCAGGATGTCCGCGAGTTCTACCTCGGCATGGGCCATGGCGGCGAAATGAAGAGTTTTCGCGATATCAAGCATTACAAA
CGGCGTAAACGGTGGCTGTC

Downstream 100 bases:

>100_bases
TGGCGCAATTCTGATCAGCCGGGAGGGAGGCATCGCCACACTGACCCTCAATCGCCCGGCCAGCCGCAACCTGCTCGACA
TGGAGATGGCGTTGGCCCTG

Product: AMP-dependent synthetase and ligase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase; LACS [H]

Number of amino acids: Translated: 610; Mature: 609

Protein sequence:

>610_residues
MSMELENLTLPQMLRQRAQQQPNRVAIRQKDFGIWNPISWDDYYRRAGHFGLGLCALGVQPGGHIGVISENRVEWVLAQM
GAGLVGAVTVGVYPTSPTNEVSYVLEHADIDVVICEDQEQSDKVLAAIDSLPRLRKIVVMEEKGLRNTPAEFRDKVLAFS
EVEALGVDYEAVHRTLIDEVLAKQSLDDIGLMIYTSGSTGKPKGAMISYGNIRAVAPGIIERLGLDEHSRHLSYLPLCHV
AEQMLTTFTPIYLGSQVNFGESLRTVQEDLREVAPTLFLGVPRIWEKLHASISIRIHETGRFRRWLFDKALVACETFACK
AVHQRTLGEKLTFGFYYVLILRALQNYIGLRNAKVALTGAAPISPAIISFFRALGVPLVEVYGLTESSGMIFGQRLDHVQ
LGTVGAAISGIDYRIAETGELQVRGGAVFAGYYKNAEATAASIRDGWLHTGDVVRELDGDIKIVDRLKDIMITAGGKNLT
PSEIENGMKASPYIKECIVVADGRNFVAALIQIDFETVGKWAERNRMAFTHFRSLVESPQVRELVAEEINKANAKLAQVS
QIRKFHLLTKELDHDDGEVTATMKVRRSSIYKTYEKEIEAMYGKGGLANA

Sequences:

>Translated_610_residues
MSMELENLTLPQMLRQRAQQQPNRVAIRQKDFGIWNPISWDDYYRRAGHFGLGLCALGVQPGGHIGVISENRVEWVLAQM
GAGLVGAVTVGVYPTSPTNEVSYVLEHADIDVVICEDQEQSDKVLAAIDSLPRLRKIVVMEEKGLRNTPAEFRDKVLAFS
EVEALGVDYEAVHRTLIDEVLAKQSLDDIGLMIYTSGSTGKPKGAMISYGNIRAVAPGIIERLGLDEHSRHLSYLPLCHV
AEQMLTTFTPIYLGSQVNFGESLRTVQEDLREVAPTLFLGVPRIWEKLHASISIRIHETGRFRRWLFDKALVACETFACK
AVHQRTLGEKLTFGFYYVLILRALQNYIGLRNAKVALTGAAPISPAIISFFRALGVPLVEVYGLTESSGMIFGQRLDHVQ
LGTVGAAISGIDYRIAETGELQVRGGAVFAGYYKNAEATAASIRDGWLHTGDVVRELDGDIKIVDRLKDIMITAGGKNLT
PSEIENGMKASPYIKECIVVADGRNFVAALIQIDFETVGKWAERNRMAFTHFRSLVESPQVRELVAEEINKANAKLAQVS
QIRKFHLLTKELDHDDGEVTATMKVRRSSIYKTYEKEIEAMYGKGGLANA
>Mature_609_residues
SMELENLTLPQMLRQRAQQQPNRVAIRQKDFGIWNPISWDDYYRRAGHFGLGLCALGVQPGGHIGVISENRVEWVLAQMG
AGLVGAVTVGVYPTSPTNEVSYVLEHADIDVVICEDQEQSDKVLAAIDSLPRLRKIVVMEEKGLRNTPAEFRDKVLAFSE
VEALGVDYEAVHRTLIDEVLAKQSLDDIGLMIYTSGSTGKPKGAMISYGNIRAVAPGIIERLGLDEHSRHLSYLPLCHVA
EQMLTTFTPIYLGSQVNFGESLRTVQEDLREVAPTLFLGVPRIWEKLHASISIRIHETGRFRRWLFDKALVACETFACKA
VHQRTLGEKLTFGFYYVLILRALQNYIGLRNAKVALTGAAPISPAIISFFRALGVPLVEVYGLTESSGMIFGQRLDHVQL
GTVGAAISGIDYRIAETGELQVRGGAVFAGYYKNAEATAASIRDGWLHTGDVVRELDGDIKIVDRLKDIMITAGGKNLTP
SEIENGMKASPYIKECIVVADGRNFVAALIQIDFETVGKWAERNRMAFTHFRSLVESPQVRELVAEEINKANAKLAQVSQ
IRKFHLLTKELDHDDGEVTATMKVRRSSIYKTYEKEIEAMYGKGGLANA

Specific function: Esterification, Concomitant With Transport, Of Exogenous Long-Chain Fatty Acids Into Metabolically Active CoA Thioesters For Subsequent Degradation Or Incorporation Into Phospholipids. [C]

COG id: COG1022

COG function: function code I; Long-chain acyl-CoA synthetases (AMP-forming)

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI83745141, Length=629, Percent_Identity=27.9809220985692, Blast_Score=262, Evalue=7e-70,
Organism=Homo sapiens, GI27477105, Length=603, Percent_Identity=28.1923714759536, Blast_Score=231, Evalue=2e-60,
Organism=Homo sapiens, GI57165410, Length=599, Percent_Identity=27.0450751252087, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI42794760, Length=601, Percent_Identity=26.4559068219634, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI42794758, Length=601, Percent_Identity=26.4559068219634, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI42794756, Length=601, Percent_Identity=26.4559068219634, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI40807491, Length=569, Percent_Identity=27.768014059754, Blast_Score=198, Evalue=1e-50,
Organism=Homo sapiens, GI57165412, Length=599, Percent_Identity=26.8781302170284, Blast_Score=195, Evalue=9e-50,
Organism=Homo sapiens, GI42794754, Length=631, Percent_Identity=26.3074484944533, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI42794752, Length=631, Percent_Identity=26.3074484944533, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI12669909, Length=635, Percent_Identity=24.7244094488189, Blast_Score=177, Evalue=4e-44,
Organism=Homo sapiens, GI4758332, Length=641, Percent_Identity=24.6489859594384, Blast_Score=176, Evalue=4e-44,
Organism=Escherichia coli, GI1788107, Length=477, Percent_Identity=23.0607966457023, Blast_Score=85, Evalue=2e-17,
Organism=Escherichia coli, GI145693145, Length=329, Percent_Identity=25.2279635258359, Blast_Score=79, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17510401, Length=605, Percent_Identity=27.4380165289256, Blast_Score=206, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17556552, Length=596, Percent_Identity=26.006711409396, Blast_Score=197, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17541856, Length=600, Percent_Identity=25.6666666666667, Blast_Score=185, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17564090, Length=573, Percent_Identity=25.4799301919721, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI25147511, Length=633, Percent_Identity=24.1706161137441, Blast_Score=158, Evalue=9e-39,
Organism=Caenorhabditis elegans, GI193204819, Length=626, Percent_Identity=24.1214057507987, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17553312, Length=575, Percent_Identity=22.7826086956522, Blast_Score=136, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI17558820, Length=477, Percent_Identity=24.9475890985325, Blast_Score=128, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI32563687, Length=481, Percent_Identity=24.7401247401247, Blast_Score=126, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17560308, Length=636, Percent_Identity=24.2138364779874, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI133901848, Length=217, Percent_Identity=23.5023041474654, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17559526, Length=167, Percent_Identity=33.5329341317365, Blast_Score=80, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6320852, Length=596, Percent_Identity=24.1610738255034, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6322182, Length=542, Percent_Identity=24.5387453874539, Blast_Score=134, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6323903, Length=607, Percent_Identity=23.0642504118616, Blast_Score=132, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6324893, Length=551, Percent_Identity=23.4119782214156, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI17933690, Length=636, Percent_Identity=27.6729559748428, Blast_Score=240, Evalue=2e-63,
Organism=Drosophila melanogaster, GI281366413, Length=622, Percent_Identity=29.0996784565916, Blast_Score=232, Evalue=7e-61,
Organism=Drosophila melanogaster, GI24666501, Length=622, Percent_Identity=29.0996784565916, Blast_Score=231, Evalue=8e-61,
Organism=Drosophila melanogaster, GI24666497, Length=622, Percent_Identity=29.0996784565916, Blast_Score=231, Evalue=8e-61,
Organism=Drosophila melanogaster, GI19921316, Length=662, Percent_Identity=27.190332326284, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI62471679, Length=630, Percent_Identity=24.9206349206349, Blast_Score=169, Evalue=8e-42,
Organism=Drosophila melanogaster, GI62471683, Length=630, Percent_Identity=24.9206349206349, Blast_Score=169, Evalue=8e-42,
Organism=Drosophila melanogaster, GI62471685, Length=630, Percent_Identity=24.9206349206349, Blast_Score=169, Evalue=8e-42,
Organism=Drosophila melanogaster, GI24586636, Length=630, Percent_Identity=24.9206349206349, Blast_Score=169, Evalue=8e-42,
Organism=Drosophila melanogaster, GI62471681, Length=630, Percent_Identity=24.9206349206349, Blast_Score=168, Evalue=8e-42,
Organism=Drosophila melanogaster, GI62471687, Length=630, Percent_Identity=24.9206349206349, Blast_Score=168, Evalue=8e-42,
Organism=Drosophila melanogaster, GI24586634, Length=630, Percent_Identity=24.9206349206349, Blast_Score=168, Evalue=8e-42,
Organism=Drosophila melanogaster, GI22026970, Length=630, Percent_Identity=24.9206349206349, Blast_Score=168, Evalue=8e-42,
Organism=Drosophila melanogaster, GI62471689, Length=630, Percent_Identity=24.9206349206349, Blast_Score=168, Evalue=9e-42,
Organism=Drosophila melanogaster, GI24581924, Length=498, Percent_Identity=24.4979919678715, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI21355181, Length=466, Percent_Identity=24.2489270386266, Blast_Score=89, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 67609; Mature: 67477

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00455 AMP_BINDING ; PS00290 IG_MHC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMELENLTLPQMLRQRAQQQPNRVAIRQKDFGIWNPISWDDYYRRAGHFGLGLCALGVQ
CCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHCCCCCCEEEEECCC
PGGHIGVISENRVEWVLAQMGAGLVGAVTVGVYPTSPTNEVSYVLEHADIDVVICEDQEQ
CCCCEEEECCCHHHHHHHHHCCCEEEEEEEEEECCCCCCHHHHHEEECCEEEEEECCCCC
SDKVLAAIDSLPRLRKIVVMEEKGLRNTPAEFRDKVLAFSEVEALGVDYEAVHRTLIDEV
HHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LAKQSLDDIGLMIYTSGSTGKPKGAMISYGNIRAVAPGIIERLGLDEHSRHLSYLPLCHV
HHHCCCCCCCEEEEECCCCCCCCCCEEECCCCEECCHHHHHHCCCCHHHCCCCCCHHHHH
AEQMLTTFTPIYLGSQVNFGESLRTVQEDLREVAPTLFLGVPRIWEKLHASISIRIHETG
HHHHHHHHCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCEEEEEEECCC
RFRRWLFDKALVACETFACKAVHQRTLGEKLTFGFYYVLILRALQNYIGLRNAKVALTGA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECC
APISPAIISFFRALGVPLVEVYGLTESSGMIFGQRLDHVQLGTVGAAISGIDYRIAETGE
CCCCHHHHHHHHHHCCCEEEEECCCCCCCCEECCCCCEEEECCHHHHHCCCEEEEECCCE
LQVRGGAVFAGYYKNAEATAASIRDGWLHTGDVVRELDGDIKIVDRLKDIMITAGGKNLT
EEEECCEEEEEECCCCCHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHEEECCCCCCC
PSEIENGMKASPYIKECIVVADGRNFVAALIQIDFETVGKWAERNRMAFTHFRSLVESPQ
HHHHHCCCCCCCCHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCH
VRELVAEEINKANAKLAQVSQIRKFHLLTKELDHDDGEVTATMKVRRSSIYKTYEKEIEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHH
MYGKGGLANA
HHCCCCCCCC
>Mature Secondary Structure 
SMELENLTLPQMLRQRAQQQPNRVAIRQKDFGIWNPISWDDYYRRAGHFGLGLCALGVQ
CCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHCCCCCCEEEEECCC
PGGHIGVISENRVEWVLAQMGAGLVGAVTVGVYPTSPTNEVSYVLEHADIDVVICEDQEQ
CCCCEEEECCCHHHHHHHHHCCCEEEEEEEEEECCCCCCHHHHHEEECCEEEEEECCCCC
SDKVLAAIDSLPRLRKIVVMEEKGLRNTPAEFRDKVLAFSEVEALGVDYEAVHRTLIDEV
HHHHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
LAKQSLDDIGLMIYTSGSTGKPKGAMISYGNIRAVAPGIIERLGLDEHSRHLSYLPLCHV
HHHCCCCCCCEEEEECCCCCCCCCCEEECCCCEECCHHHHHHCCCCHHHCCCCCCHHHHH
AEQMLTTFTPIYLGSQVNFGESLRTVQEDLREVAPTLFLGVPRIWEKLHASISIRIHETG
HHHHHHHHCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCEEEEEEECCC
RFRRWLFDKALVACETFACKAVHQRTLGEKLTFGFYYVLILRALQNYIGLRNAKVALTGA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECC
APISPAIISFFRALGVPLVEVYGLTESSGMIFGQRLDHVQLGTVGAAISGIDYRIAETGE
CCCCHHHHHHHHHHCCCEEEEECCCCCCCCEECCCCCEEEECCHHHHHCCCEEEEECCCE
LQVRGGAVFAGYYKNAEATAASIRDGWLHTGDVVRELDGDIKIVDRLKDIMITAGGKNLT
EEEECCEEEEEECCCCCHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHEEECCCCCCC
PSEIENGMKASPYIKECIVVADGRNFVAALIQIDFETVGKWAERNRMAFTHFRSLVESPQ
HHHHHCCCCCCCCHHEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCH
VRELVAEEINKANAKLAQVSQIRKFHLLTKELDHDDGEVTATMKVRRSSIYKTYEKEIEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHH
MYGKGGLANA
HHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]