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The map label for this gene is czcC [H]

Identifier: 71907874

GI number: 71907874

Start: 2440339

End: 2441649

Strand: Reverse

Name: czcC [H]

Synonym: Daro_2254

Alternate gene names: 71907874

Gene position: 2441649-2440339 (Counterclockwise)

Preceding gene: 71907875

Following gene: 71907873

Centisome position: 54.25

GC content: 64.15

Gene sequence:

>1311_bases
ATGTTGTTCGACACCCCTGCCGGGGAGCGCGGCTTGCTGCGTCGTCTCGGCATGCTGGCGGGGCTATTCCTCGCTGGCAG
CAGTGCTTTCGCAGCCGGCCCGCTAACCCTGGACGAAGCCTGGCGCTTGGCGGAAACCGCCAACCCGACCCTGCGCGCCG
CCCGTGCCAACCTCGATGCTGCTGAAGGCCAGTTGCGGGATGCTTCCGGGCTCCTTTACAACAACCCGCAGCTTTCGACT
GACCAGACCCGTCGTCGCGTGCCCCAGGCTGGTTTGCCGGACAACCGATTTCATGAGCAGACGCTAGGTGTTTCGCAGAC
CTTCGAGATCGCGGGACAGGCCGGTTACCGGCGCGAGGCCGCCGGCCGAGACCTGGCCGCCGTCACCGCGAATATCGATG
AAGTCCGCCGTTTGGTGCGCGCCGAAGTCGAGCAGCGCTTCTATCGGGTGCTGGTCCTGCAACGCCGTATCGAGACCGAA
CGGGAGGCTCTGGCCGCCGTCACTGATGCCGCTGCGGCGGTTAGAAAGCGTGTAGCAGCCGGTGAAGACAGCCGGCTCGA
TGGCAATCTGGCGATGGTCGAAGCCGAGCGCGGCCACAACCAACTCGCCGTCCTGGACGAACAACTCCTCCAGGCACGTG
CGGAACTCAGTGCTGCGCTGCAACTGCCCATCACTGCCTTGCCGGAGACGACCGGCGAATTGCGGGCAGCACCAACCGTC
GCCACCTTGGAAACGTTGCAGGCTTCGGCCCGTGAACGGCCATTGCTGCGTTCGTTGGAACACCGGGAACAAGCGGCCCG
CAACCGGCTGGGCCTTGAACGCTCCGCCGCCTACCCAGATGTCACCGTTGGCCTGAGTGCCGGCCGGGAAGCCCCTTACG
ATGCCCGTGAGCAATTTATCCGTCTGACCATCTCGGTGCCGTTGCCCCTGTTTCGCCGAAATGGCGCAGGAATCGGCAAG
GCGACAACGGAACTGACCCAGGCTGAGATCGAACGGCAAAGCAGCGAGCGCGATGTGATGGCCCAGGTGAATGCCCTCTG
GCAACGCATGGAGAGTCTGCAAAGTCGCGTCAAACGCCTTACCGAGTCGGTCCTGCCGGCTCTCGACGAGAACCGCCGCC
TGTCATCCACCGCCTACCGGGCTGGCGAGATTGGCCTGCTGCAACTGCTGCTGGTCAATCGCCAGTTGCTGGATGCCCGA
CGCGACTACCTCGATGCCCTCGGCGACTTTATCCAGACCCGCATTGCCCTAGAGCAAACGGCCGGCTGGCCCGTCGCTCA
AGCCAACCCATCCCCCGAGAAAAACAAATGA

Upstream 100 bases:

>100_bases
TTTCGTCCACCCCGAAACACCTTTCAAGCCTAAACCGACATCGTTCGTCAGCGGATGCCTCATGGCAGTCCGTTTCTTCA
TCGCTTGAAAGGTTTCTCCC

Downstream 100 bases:

>100_bases
CCCGCATCCTCCCGACAACCCTCTTGGCCCTCTCGCTGGTGCTGGTCGCCTGCGGTCGTAACGCGCCTGAGAGCAGCACC
GTGACGGAAAAGCCCGCCGC

Product: Outer membrane efflux protein

Products: NA

Alternate protein names: Cation efflux system protein CzcC [H]

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MLFDTPAGERGLLRRLGMLAGLFLAGSSAFAAGPLTLDEAWRLAETANPTLRAARANLDAAEGQLRDASGLLYNNPQLST
DQTRRRVPQAGLPDNRFHEQTLGVSQTFEIAGQAGYRREAAGRDLAAVTANIDEVRRLVRAEVEQRFYRVLVLQRRIETE
REALAAVTDAAAAVRKRVAAGEDSRLDGNLAMVEAERGHNQLAVLDEQLLQARAELSAALQLPITALPETTGELRAAPTV
ATLETLQASARERPLLRSLEHREQAARNRLGLERSAAYPDVTVGLSAGREAPYDAREQFIRLTISVPLPLFRRNGAGIGK
ATTELTQAEIERQSSERDVMAQVNALWQRMESLQSRVKRLTESVLPALDENRRLSSTAYRAGEIGLLQLLLVNRQLLDAR
RDYLDALGDFIQTRIALEQTAGWPVAQANPSPEKNK

Sequences:

>Translated_436_residues
MLFDTPAGERGLLRRLGMLAGLFLAGSSAFAAGPLTLDEAWRLAETANPTLRAARANLDAAEGQLRDASGLLYNNPQLST
DQTRRRVPQAGLPDNRFHEQTLGVSQTFEIAGQAGYRREAAGRDLAAVTANIDEVRRLVRAEVEQRFYRVLVLQRRIETE
REALAAVTDAAAAVRKRVAAGEDSRLDGNLAMVEAERGHNQLAVLDEQLLQARAELSAALQLPITALPETTGELRAAPTV
ATLETLQASARERPLLRSLEHREQAARNRLGLERSAAYPDVTVGLSAGREAPYDAREQFIRLTISVPLPLFRRNGAGIGK
ATTELTQAEIERQSSERDVMAQVNALWQRMESLQSRVKRLTESVLPALDENRRLSSTAYRAGEIGLLQLLLVNRQLLDAR
RDYLDALGDFIQTRIALEQTAGWPVAQANPSPEKNK
>Mature_436_residues
MLFDTPAGERGLLRRLGMLAGLFLAGSSAFAAGPLTLDEAWRLAETANPTLRAARANLDAAEGQLRDASGLLYNNPQLST
DQTRRRVPQAGLPDNRFHEQTLGVSQTFEIAGQAGYRREAAGRDLAAVTANIDEVRRLVRAEVEQRFYRVLVLQRRIETE
REALAAVTDAAAAVRKRVAAGEDSRLDGNLAMVEAERGHNQLAVLDEQLLQARAELSAALQLPITALPETTGELRAAPTV
ATLETLQASARERPLLRSLEHREQAARNRLGLERSAAYPDVTVGLSAGREAPYDAREQFIRLTISVPLPLFRRNGAGIGK
ATTELTQAEIERQSSERDVMAQVNALWQRMESLQSRVKRLTESVLPALDENRRLSSTAYRAGEIGLLQLLLVNRQLLDAR
RDYLDALGDFIQTRIALEQTAGWPVAQANPSPEKNK

Specific function: CzcC protein appears to modify the specificity of the system, perhaps by acting on the CzcB protein. When the CzcC protein is added to CzcA and CzcB, the efflux system gains specificity for cadmium and cobalt [H]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 47958; Mature: 47958

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFDTPAGERGLLRRLGMLAGLFLAGSSAFAAGPLTLDEAWRLAETANPTLRAARANLDA
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCCH
AEGQLRDASGLLYNNPQLSTDQTRRRVPQAGLPDNRFHEQTLGVSQTFEIAGQAGYRREA
HCCCCCCCCCCEECCCCCCCHHHHHHCCCCCCCCCHHHHHHCCCHHHHHHHCCCCCCHHH
AGRDLAAVTANIDEVRRLVRAEVEQRFYRVLVLQRRIETEREALAAVTDAAAAVRKRVAA
CCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GEDSRLDGNLAMVEAERGHNQLAVLDEQLLQARAELSAALQLPITALPETTGELRAAPTV
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCHHCCCHH
ATLETLQASARERPLLRSLEHREQAARNRLGLERSAAYPDVTVGLSAGREAPYDAREQFI
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHCCCCCEEEECCCCCCCCHHHHHHHE
RLTISVPLPLFRRNGAGIGKATTELTQAEIERQSSERDVMAQVNALWQRMESLQSRVKRL
EEEEECCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TESVLPALDENRRLSSTAYRAGEIGLLQLLLVNRQLLDARRDYLDALGDFIQTRIALEQT
HHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGWPVAQANPSPEKNK
CCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLFDTPAGERGLLRRLGMLAGLFLAGSSAFAAGPLTLDEAWRLAETANPTLRAARANLDA
CCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCCH
AEGQLRDASGLLYNNPQLSTDQTRRRVPQAGLPDNRFHEQTLGVSQTFEIAGQAGYRREA
HCCCCCCCCCCEECCCCCCCHHHHHHCCCCCCCCCHHHHHHCCCHHHHHHHCCCCCCHHH
AGRDLAAVTANIDEVRRLVRAEVEQRFYRVLVLQRRIETEREALAAVTDAAAAVRKRVAA
CCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GEDSRLDGNLAMVEAERGHNQLAVLDEQLLQARAELSAALQLPITALPETTGELRAAPTV
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCHHCCCHH
ATLETLQASARERPLLRSLEHREQAARNRLGLERSAAYPDVTVGLSAGREAPYDAREQFI
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHCCCCCEEEECCCCCCCCHHHHHHHE
RLTISVPLPLFRRNGAGIGKATTELTQAEIERQSSERDVMAQVNALWQRMESLQSRVKRL
EEEEECCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TESVLPALDENRRLSSTAYRAGEIGLLQLLLVNRQLLDARRDYLDALGDFIQTRIALEQT
HHHHHHHCCCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGWPVAQANPSPEKNK
CCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2678100; 7766206 [H]