Click here to switch to the map view.

The map label for this gene is flp [H]

Identifier: 71907575

GI number: 71907575

Start: 2098362

End: 2100128

Strand: Reverse

Name: flp [H]

Synonym: Daro_1946

Alternate gene names: 71907575

Gene position: 2100128-2098362 (Counterclockwise)

Preceding gene: 71907591

Following gene: 71907574

Centisome position: 46.66

GC content: 56.88

Gene sequence:

>1767_bases
ATGAATCACCGCCTCGCCCCACTCCTTGCCGGTGTCGTTCTTTTGCTCAGCGGCTGCGCCACGCCTCCACCCGCATCACA
AAACGACGTCCGCGGCGACTATGGCCATACACAGAAACACCTGGCCTGGCTGATCGACCGTGAGATGGCGCAAAACGAAA
TCACCGGAATCAGCATCGCGTTGGTCGATAACCAGCAGGTTGTGTGGCAACAAGGCTTCGGTTACGCCGATCTGGAAAAC
AAGACACCGGCGACACCAGAAACGATCTATCGAGCCGGCTCCATCGCCAAGGTATTTACCGCTGCCGCCACCATGCAACT
GGCCGAACAGGGCAAACTCGACATCGACAACCCCCTGGCGTCTGCGCTGCCCGAATTCTCGATCAAGAGCCGCTTTCCCA
ATGCCGCCCCGGTGACACCGCGCAACATCATGTCTCACCACTCCGGGCTGCCATCGAATTTCCTGCGCGGTCTCTTCGTT
CGCGATCCTGATCGCTTCGACTCGGTGGTTGAGGCCATCCACGACGAACATCTCGCCTTTCCACCCAACTACGTTTTTTC
CTATTCAAATCTCGGCGTGGCGCTGCTTGGCGCAGCAATCCAGAAGGTCAGTGGCGAAGCCTTCGATATTTACATGCATA
ACCACCTCTTCCTGCCACTAGGCATGCCCCAGAGCAGTTTCGCCCAACGCCCGATCGCCAAGACCTACGATCGCAACAAG
GAGAGCGAGGCTTTCTCGCTGCGCGACATGCCGGCCGCTAATCTGCTGAGCAATGTCGTTGACCTGAGCCAGTTCATGAA
AATGCAGTTTGCCGACGGCAAGTCAGGCAAATATCAAGTGCTATCCGCAGCCTCCCTGCACGAGATGGTACGCATCCAGA
ACAAGGATTTCCCGCTAACCTTCAAGCAATACGTCGGCCTCGGCTGGATGATGAGCGGCATCGACATTCCCGGCGGTGGC
CCGGTGGCCAGTCACGGCGGCTCACTGCCCGATTCGCACAGCATGATGGCCATCTTGCCGGAGCACAAACTGGGGGTTGT
CGTTCTTTCCAACTCAGCCACCTCGCATGTCGCCGTCTCGAAAATCGCTACCGAGGCCCTACGCCTGATGCTGGAAGCCA
AGACCGGCATTCGCCAAAACCCGGAACCACCAGTCCGTGCCGCCGAGCGCGCACCAAGCTCCGAAGAGTTGCGCCAGTTC
GACGGCAATTTCGACACGATGGTCGGACTAGCCAGAATCAGCACAAAATCCGGTCAAATAGACGTTGACGCCGCCGGCCA
CCAATTCCGCCTGGTGCCACATGAAGATGGGCTGCTAACGATCAAATACAAGCTTCTCGGCATGCTGCCAGTGCGCGTTG
GAGCTTTCGAGGACATCCACCTATCGATGGCCAATGTCAACGGGCGCCAGATCATCGTTGGAAGAATTGGAAACGAATCG
CTGATCTTCGGTGAAAAACTAAAACCCTCGGTCATTCCCGAGCGATTCCGGCAAAATCTTGGCAATTACGAAATCGTCGG
CAAGATTGATGGCCCATCGCCTGACAGGCTTTTGCTCAAGGAAGACCATGGCATGCTGATCGGCGAAGCCCACTTTCCCG
AGGTTCCCGATCTGTTGTTGAGGATCGCTTTCCTGCCGGTATCCGACAACGAAGTGATTACCGCTGGCCTGGGTACCAGC
CGGGGCGATACACTACGCCTGATCGAAGCGGGCAATGAAGCCATGCTGGGCTTTTCCGGCATTCAAATGCGCAAGAAACT
GAACTAA

Upstream 100 bases:

>100_bases
TTTAAAATACTCGACTGAATTTGTCAGCTATTTTCCCCGAAGACAAGCAGTGGTATCTGTTTATAATCCATTGCCATTGC
AGCGAAAGCTCCCCCCTTTG

Downstream 100 bases:

>100_bases
AAAATGAACGAATTACATCTTGAACTGAAGACTTTCATTATCGAAACGATGAATCTCGAAGACATCACGCCGGCAGATAT
CGATGACGAAGCGCTGCTTT

Product: Beta-lactamase

Products: A Substituted Beta- Amino Acid. [C]

Alternate protein names: FmtA-like protein [H]

Number of amino acids: Translated: 588; Mature: 588

Protein sequence:

>588_residues
MNHRLAPLLAGVVLLLSGCATPPPASQNDVRGDYGHTQKHLAWLIDREMAQNEITGISIALVDNQQVVWQQGFGYADLEN
KTPATPETIYRAGSIAKVFTAAATMQLAEQGKLDIDNPLASALPEFSIKSRFPNAAPVTPRNIMSHHSGLPSNFLRGLFV
RDPDRFDSVVEAIHDEHLAFPPNYVFSYSNLGVALLGAAIQKVSGEAFDIYMHNHLFLPLGMPQSSFAQRPIAKTYDRNK
ESEAFSLRDMPAANLLSNVVDLSQFMKMQFADGKSGKYQVLSAASLHEMVRIQNKDFPLTFKQYVGLGWMMSGIDIPGGG
PVASHGGSLPDSHSMMAILPEHKLGVVVLSNSATSHVAVSKIATEALRLMLEAKTGIRQNPEPPVRAAERAPSSEELRQF
DGNFDTMVGLARISTKSGQIDVDAAGHQFRLVPHEDGLLTIKYKLLGMLPVRVGAFEDIHLSMANVNGRQIIVGRIGNES
LIFGEKLKPSVIPERFRQNLGNYEIVGKIDGPSPDRLLLKEDHGMLIGEAHFPEVPDLLLRIAFLPVSDNEVITAGLGTS
RGDTLRLIEAGNEAMLGFSGIQMRKKLN

Sequences:

>Translated_588_residues
MNHRLAPLLAGVVLLLSGCATPPPASQNDVRGDYGHTQKHLAWLIDREMAQNEITGISIALVDNQQVVWQQGFGYADLEN
KTPATPETIYRAGSIAKVFTAAATMQLAEQGKLDIDNPLASALPEFSIKSRFPNAAPVTPRNIMSHHSGLPSNFLRGLFV
RDPDRFDSVVEAIHDEHLAFPPNYVFSYSNLGVALLGAAIQKVSGEAFDIYMHNHLFLPLGMPQSSFAQRPIAKTYDRNK
ESEAFSLRDMPAANLLSNVVDLSQFMKMQFADGKSGKYQVLSAASLHEMVRIQNKDFPLTFKQYVGLGWMMSGIDIPGGG
PVASHGGSLPDSHSMMAILPEHKLGVVVLSNSATSHVAVSKIATEALRLMLEAKTGIRQNPEPPVRAAERAPSSEELRQF
DGNFDTMVGLARISTKSGQIDVDAAGHQFRLVPHEDGLLTIKYKLLGMLPVRVGAFEDIHLSMANVNGRQIIVGRIGNES
LIFGEKLKPSVIPERFRQNLGNYEIVGKIDGPSPDRLLLKEDHGMLIGEAHFPEVPDLLLRIAFLPVSDNEVITAGLGTS
RGDTLRLIEAGNEAMLGFSGIQMRKKLN
>Mature_588_residues
MNHRLAPLLAGVVLLLSGCATPPPASQNDVRGDYGHTQKHLAWLIDREMAQNEITGISIALVDNQQVVWQQGFGYADLEN
KTPATPETIYRAGSIAKVFTAAATMQLAEQGKLDIDNPLASALPEFSIKSRFPNAAPVTPRNIMSHHSGLPSNFLRGLFV
RDPDRFDSVVEAIHDEHLAFPPNYVFSYSNLGVALLGAAIQKVSGEAFDIYMHNHLFLPLGMPQSSFAQRPIAKTYDRNK
ESEAFSLRDMPAANLLSNVVDLSQFMKMQFADGKSGKYQVLSAASLHEMVRIQNKDFPLTFKQYVGLGWMMSGIDIPGGG
PVASHGGSLPDSHSMMAILPEHKLGVVVLSNSATSHVAVSKIATEALRLMLEAKTGIRQNPEPPVRAAERAPSSEELRQF
DGNFDTMVGLARISTKSGQIDVDAAGHQFRLVPHEDGLLTIKYKLLGMLPVRVGAFEDIHLSMANVNGRQIIVGRIGNES
LIFGEKLKPSVIPERFRQNLGNYEIVGKIDGPSPDRLLLKEDHGMLIGEAHFPEVPDLLLRIAFLPVSDNEVITAGLGTS
RGDTLRLIEAGNEAMLGFSGIQMRKKLN

Specific function: Its precise function is unknown. Has no penicillin- binding activity and is not involved in methicillin resistance [H]

COG id: COG1680

COG function: function code V; Beta-lactamase class C and other penicillin binding proteins

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI26051231, Length=95, Percent_Identity=42.1052631578947, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI26051233, Length=95, Percent_Identity=42.1052631578947, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1790593, Length=342, Percent_Identity=22.8070175438596, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI87082101, Length=374, Percent_Identity=23.7967914438503, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1786574, Length=321, Percent_Identity=23.3644859813084, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI115533026, Length=351, Percent_Identity=26.7806267806268, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17550934, Length=331, Percent_Identity=25.9818731117825, Blast_Score=97, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001466 [H]

Pfam domain/function: PF00144 Beta-lactamase [H]

EC number: 3.5.2.6 [C]

Molecular weight: Translated: 64172; Mature: 64172

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHRLAPLLAGVVLLLSGCATPPPASQNDVRGDYGHTQKHLAWLIDREMAQNEITGISIA
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEE
LVDNQQVVWQQGFGYADLENKTPATPETIYRAGSIAKVFTAAATMQLAEQGKLDIDNPLA
EECCCEEEECCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHH
SALPEFSIKSRFPNAAPVTPRNIMSHHSGLPSNFLRGLFVRDPDRFDSVVEAIHDEHLAF
HHCCCCHHHHCCCCCCCCCHHHHHHHCCCCCHHHHCCEECCCCHHHHHHHHHHHHCCCCC
PPNYVFSYSNLGVALLGAAIQKVSGEAFDIYMHNHLFLPLGMPQSSFAQRPIAKTYDRNK
CCCCEEEECCCCHHHHHHHHHHHCCCEEEEEEECEEEEEECCCHHHHHCCCCHHHHCCCC
ESEAFSLRDMPAANLLSNVVDLSQFMKMQFADGKSGKYQVLSAASLHEMVRIQNKDFPLT
CCCCEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHCCCCCCEE
FKQYVGLGWMMSGIDIPGGGPVASHGGSLPDSHSMMAILPEHKLGVVVLSNSATSHVAVS
HHHHCCCCEEEECEECCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEEECCCCCHHHHH
KIATEALRLMLEAKTGIRQNPEPPVRAAERAPSSEELRQFDGNFDTMVGLARISTKSGQI
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCHHHHHHHCCCHHHHHHHHHEECCCCCE
DVDAAGHQFRLVPHEDGLLTIKYKLLGMLPVRVGAFEDIHLSMANVNGRQIIVGRIGNES
EEECCCCEEEEEECCCCEEEEEEEECCCCHHHCCCCCEEEEEEECCCCCEEEEEECCCCC
LIFGEKLKPSVIPERFRQNLGNYEIVGKIDGPSPDRLLLKEDHGMLIGEAHFPEVPDLLL
EEECCCCCCCCCHHHHHHCCCCEEEEEEECCCCCCEEEEECCCCEEEECCCCCCHHHHHH
RIAFLPVSDNEVITAGLGTSRGDTLRLIEAGNEAMLGFSGIQMRKKLN
HHEEEECCCCCEEEECCCCCCCCEEEEEECCCCEEEECCCHHHHHCCC
>Mature Secondary Structure
MNHRLAPLLAGVVLLLSGCATPPPASQNDVRGDYGHTQKHLAWLIDREMAQNEITGISIA
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEE
LVDNQQVVWQQGFGYADLENKTPATPETIYRAGSIAKVFTAAATMQLAEQGKLDIDNPLA
EECCCEEEECCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHH
SALPEFSIKSRFPNAAPVTPRNIMSHHSGLPSNFLRGLFVRDPDRFDSVVEAIHDEHLAF
HHCCCCHHHHCCCCCCCCCHHHHHHHCCCCCHHHHCCEECCCCHHHHHHHHHHHHCCCCC
PPNYVFSYSNLGVALLGAAIQKVSGEAFDIYMHNHLFLPLGMPQSSFAQRPIAKTYDRNK
CCCCEEEECCCCHHHHHHHHHHHCCCEEEEEEECEEEEEECCCHHHHHCCCCHHHHCCCC
ESEAFSLRDMPAANLLSNVVDLSQFMKMQFADGKSGKYQVLSAASLHEMVRIQNKDFPLT
CCCCEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHHHHHCCCCCCEE
FKQYVGLGWMMSGIDIPGGGPVASHGGSLPDSHSMMAILPEHKLGVVVLSNSATSHVAVS
HHHHCCCCEEEECEECCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEEECCCCCHHHHH
KIATEALRLMLEAKTGIRQNPEPPVRAAERAPSSEELRQFDGNFDTMVGLARISTKSGQI
HHHHHHHHHHHHHHHCCCCCCCCCCHHHHCCCCHHHHHHHCCCHHHHHHHHHEECCCCCE
DVDAAGHQFRLVPHEDGLLTIKYKLLGMLPVRVGAFEDIHLSMANVNGRQIIVGRIGNES
EEECCCCEEEEEECCCCEEEEEEEECCCCHHHCCCCCEEEEEEECCCCCEEEEEECCCCC
LIFGEKLKPSVIPERFRQNLGNYEIVGKIDGPSPDRLLLKEDHGMLIGEAHFPEVPDLLL
EEECCCCCCCCCHHHHHHCCCCEEEEEEECCCCCCEEEEECCCCEEEECCCCCCHHHHHH
RIAFLPVSDNEVITAGLGTSRGDTLRLIEAGNEAMLGFSGIQMRKKLN
HHEEEECCCCCEEEECCCCCCCCEEEEEECCCCEEEECCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Beta-Lactam; H2O [C]

Specific reaction: A Beta-Lactam + H2O = A Substituted Beta- Amino Acid. [C]

General reaction: Carboxylic acid amide hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA