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The map label for this gene is fsr [H]

Identifier: 71907514

GI number: 71907514

Start: 2025249

End: 2026457

Strand: Reverse

Name: fsr [H]

Synonym: Daro_1885

Alternate gene names: 71907514

Gene position: 2026457-2025249 (Counterclockwise)

Preceding gene: 71907518

Following gene: 71907511

Centisome position: 45.02

GC content: 64.02

Gene sequence:

>1209_bases
ATGACGACCGCTACCCTGCCCGCGCCCCAGCGCAGCGACATTGAAGTCATTTCGGTGATCGGCTTCGTCCATGGCGTGTC
CCATTTCTTCCACCTCTTGCTGCCGCCACTGTTTCCTTGGCTGATGGCGGAGTTCGGGCTCAGTTTCACCGCCATCGGCA
CCACGATGACCGTGTTTTTCATCGTCTCCGGCATCGGTCAGGCCAGTGCCGGTTTTCTGGTTGACCGCTTCGGGGCTGCG
CGAGTGCTCGGGGCCGGCATCAGTTGCTTTGCCCTGGCCGGCGTGCTGCTCTATTTCGCCACCGGCTATCCAATGCTGAT
TGCCGTCGCCGCGTTGGCCGGCTTGGGTAATTGCGTCTTTCACCCAGCTGACTTCACGGTCCTCAACCGCCACGTCTCGC
AACAACGCCTTGGCCATGCCTTCTCCGCCCATGGGCTATCCGGCAATCTCGGCTGGGCGGCCGCTCCGGTCTATATCACC
GGCCTCGCCACCGCCTATGGCTGGCGGACAGCGGCGCTCGGCGCCAGCGCCGTGGCCATCGCCGCACTGGCCCTGCTGTT
CTGGCGGCGAGAAGCGCTGACCGACCCGGTCGAACATCACACTGAGAAGGCTAGCGAACCGGCGGGAACCACCTTCGCCT
TCCTGAGTTCGCGGGCTGTCTGGCTGTGCTTCCTGTTCTTCCTGCTGATCACTGCGGCTTTCGGCACCATCCAGAACTTC
GCCAGCCCGATTTTGCAGGCGCTCTACGGCTTATCCATCACCACAGCTGCACTGGCGCTGTCGACCTATCTGGTCGGCGG
TGCCGCCGGCATCGTCCTCGGTGGCTTTCTCGCCCAGAAAGGCGAGCATGATCACCTGATCGCCGGCGCACTGGGCGTGG
CCGCCCTGCTCGCCATCCTGCTGGCCGCTGGCATCATGCCGGCCTGGAGCATCCTGCCGCTGATGGCCGGCATTGGTTTT
TGTACCGGTACCGCCGGGCCGTCGCGCGACCTGCTGGTGCGCCGTGCCGCCACAGCCCGCTTTGGCAAGGCCGCCTACGG
ACGGGTCTATGGCTTCGTCTATTCCGGTCTGGACCTCGGCCTGGCCATGGCACCGGTGATTTTTGGCGGGCTGATGGATG
CACGACACTTCAGCGAAGTGCTGGTCGGCATCGCCATCCTGCAATTCCTCGCCATTTTCAGCGCCTTGCGCGTTGGCAAG
GCCGTTTAA

Upstream 100 bases:

>100_bases
GTCTGTCTGCATTGCGATAATTTTTGTCCGAATATCGCACCACGGTCAATGGGTCGTAAAGCTAGACTGTAATCCTTAAC
GTTTTACTCGGACTTTATCC

Downstream 100 bases:

>100_bases
CCCTACAACCCCCGCGCCCAGGCCGGCCGCAAATGGGCCGCTTCGGGCGCCGAAATGGCCTCGCGCACCTGCTGCAACAG
GCGTTCCTTGTCTGCGCCGA

Product: major facilitator transporter

Products: fosmidomycin [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 402; Mature: 401

Protein sequence:

>402_residues
MTTATLPAPQRSDIEVISVIGFVHGVSHFFHLLLPPLFPWLMAEFGLSFTAIGTTMTVFFIVSGIGQASAGFLVDRFGAA
RVLGAGISCFALAGVLLYFATGYPMLIAVAALAGLGNCVFHPADFTVLNRHVSQQRLGHAFSAHGLSGNLGWAAAPVYIT
GLATAYGWRTAALGASAVAIAALALLFWRREALTDPVEHHTEKASEPAGTTFAFLSSRAVWLCFLFFLLITAAFGTIQNF
ASPILQALYGLSITTAALALSTYLVGGAAGIVLGGFLAQKGEHDHLIAGALGVAALLAILLAAGIMPAWSILPLMAGIGF
CTGTAGPSRDLLVRRAATARFGKAAYGRVYGFVYSGLDLGLAMAPVIFGGLMDARHFSEVLVGIAILQFLAIFSALRVGK
AV

Sequences:

>Translated_402_residues
MTTATLPAPQRSDIEVISVIGFVHGVSHFFHLLLPPLFPWLMAEFGLSFTAIGTTMTVFFIVSGIGQASAGFLVDRFGAA
RVLGAGISCFALAGVLLYFATGYPMLIAVAALAGLGNCVFHPADFTVLNRHVSQQRLGHAFSAHGLSGNLGWAAAPVYIT
GLATAYGWRTAALGASAVAIAALALLFWRREALTDPVEHHTEKASEPAGTTFAFLSSRAVWLCFLFFLLITAAFGTIQNF
ASPILQALYGLSITTAALALSTYLVGGAAGIVLGGFLAQKGEHDHLIAGALGVAALLAILLAAGIMPAWSILPLMAGIGF
CTGTAGPSRDLLVRRAATARFGKAAYGRVYGFVYSGLDLGLAMAPVIFGGLMDARHFSEVLVGIAILQFLAIFSALRVGK
AV
>Mature_401_residues
TTATLPAPQRSDIEVISVIGFVHGVSHFFHLLLPPLFPWLMAEFGLSFTAIGTTMTVFFIVSGIGQASAGFLVDRFGAAR
VLGAGISCFALAGVLLYFATGYPMLIAVAALAGLGNCVFHPADFTVLNRHVSQQRLGHAFSAHGLSGNLGWAAAPVYITG
LATAYGWRTAALGASAVAIAALALLFWRREALTDPVEHHTEKASEPAGTTFAFLSSRAVWLCFLFFLLITAAFGTIQNFA
SPILQALYGLSITTAALALSTYLVGGAAGIVLGGFLAQKGEHDHLIAGALGVAALLAILLAAGIMPAWSILPLMAGIGFC
TGTAGPSRDLLVRRAATARFGKAAYGRVYGFVYSGLDLGLAMAPVIFGGLMDARHFSEVLVGIAILQFLAIFSALRVGKA
V

Specific function: Confers the resistance against fosmidomycin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786686, Length=297, Percent_Identity=29.2929292929293, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI87082310, Length=377, Percent_Identity=26.790450928382, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 41878; Mature: 41746

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTATLPAPQRSDIEVISVIGFVHGVSHFFHLLLPPLFPWLMAEFGLSFTAIGTTMTVFF
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
IVSGIGQASAGFLVDRFGAARVLGAGISCFALAGVLLYFATGYPMLIAVAALAGLGNCVF
HHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEE
HPADFTVLNRHVSQQRLGHAFSAHGLSGNLGWAAAPVYITGLATAYGWRTAALGASAVAI
CCCCHHHHHHHHHHHHHCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AALALLFWRREALTDPVEHHTEKASEPAGTTFAFLSSRAVWLCFLFFLLITAAFGTIQNF
HHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASPILQALYGLSITTAALALSTYLVGGAAGIVLGGFLAQKGEHDHLIAGALGVAALLAIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
LAAGIMPAWSILPLMAGIGFCTGTAGPSRDLLVRRAATARFGKAAYGRVYGFVYSGLDLG
HHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAMAPVIFGGLMDARHFSEVLVGIAILQFLAIFSALRVGKAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TTATLPAPQRSDIEVISVIGFVHGVSHFFHLLLPPLFPWLMAEFGLSFTAIGTTMTVFF
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
IVSGIGQASAGFLVDRFGAARVLGAGISCFALAGVLLYFATGYPMLIAVAALAGLGNCVF
HHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEE
HPADFTVLNRHVSQQRLGHAFSAHGLSGNLGWAAAPVYITGLATAYGWRTAALGASAVAI
CCCCHHHHHHHHHHHHHCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AALALLFWRREALTDPVEHHTEKASEPAGTTFAFLSSRAVWLCFLFFLLITAAFGTIQNF
HHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASPILQALYGLSITTAALALSTYLVGGAAGIVLGGFLAQKGEHDHLIAGALGVAALLAIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
LAAGIMPAWSILPLMAGIGFCTGTAGPSRDLLVRRAATARFGKAAYGRVYGFVYSGLDLG
HHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LAMAPVIFGGLMDARHFSEVLVGIAILQFLAIFSALRVGKAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: fosmidomycin [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: fosmidomycin [Cytoplasm] + Proton [Periplasm] = fosmidomycin [Periplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8917080; 9278503 [H]