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The map label for this gene is parC [H]

Identifier: 71907479

GI number: 71907479

Start: 1985806

End: 1988223

Strand: Reverse

Name: parC [H]

Synonym: Daro_1850

Alternate gene names: 71907479

Gene position: 1988223-1985806 (Counterclockwise)

Preceding gene: 71907484

Following gene: 71907474

Centisome position: 44.17

GC content: 64.43

Gene sequence:

>2418_bases
ATGACCGACCAGCTCAATCTCTTCGACCCGAACGCCAAGGCAGCCGCCACCGAACCCGAGGCGCCAGCCCTGCCTGCCAC
CGAAACACAGGAACTGGCCCCCGAACTGCCACTGGAAACCGCTGCCGAGCCAGCGCTCGAACCAGCGTCGGCCTTGCCGC
CTGATCTGCCCCCGTCGGCCACCGGCCCGGCCAGCGACATTCCCTCGCCGGCCGACTATGCCGCCCGCCGCTACCTCGAA
TACGCGATGAGCGTTGTCACCGGTCGCGCCCTTCCCTCGGCCGCCGACGGCCAGAAGCCGGTGCAGCGCCGCATCCTCTA
CGCCATGCACCGGATGGGCCTGTACAAGAGCCCGCGCCACGTCAAGTCGGCCCGCGTCGTCGGTGACGTGATCGGTAAAT
ACCATCCGCACGGCGACTCCTCGGTTTACGACGCCATGGTCCGCATGGCCCAAGACTGGAGCCTGCGCTACCCGATCGTC
GACGGCCAGGGCAATTTCGGCTCGCGCGACGGCGATAACGCCGCTGCCATGCGCTACACGGAAGCCCGCCTGACGCCGAT
TGCCGAACTGCTGCTGGCCGAGCTCGACGAAGGCACGGTTGACTGGAAGCCCAATTACGACGGCGCCAACGATGAACCCG
CCCTGCTCCCGGCCCGTCTGCCCTTTGCGCTGTTGAACGGTGCCTCCGGCATCGCCGTTGGCATGGCGACGGAAATCCCC
GCGCACAACCTGCGCGAAGTGGCGAATGCGGCGGTCAATCTGATCAGGAATCCCGATTTCGGCGAAGACGAAGTGCTGAA
ACTGATTCCAGGCCCGGACTATCCCGGCGGCGCGCAGATCATCTCGTCGCCGGAGGAAATCGCCGCCACCTACCGTAGCG
GCCGTGGCAGCCTGCGCGTGCGTGCCAAGTGGAAGATCGAAAACCTGGCCCGCGGCCAGTGGAAGCTGGTCATCACCGAA
TTGCCACCGGGCGTTTCCACCGCCACCGTGATGTCGGAAATCGAGGCCTGCTCCAACCCGGTCGCCAAGGAAAAAGCCGG
CAAGAAGGTCTTTACGCCGGAACAGCTGAATCTGAAGGCCGCCTTCCTGTCGTCCATCTCGGAAAGCGGCGTGCGCGATG
AATCGGGCAAGGAACACGCCGTCCGCCTGGTCATTGAACCGGCATCCTCGCGCCAGGGTCAGGATGATCTGGTCCGCATG
CTGCTCGCTCACACCAGCCTGGAAACCAATGCTTCGATCAACCTGACGATCCTCGGCGTCAATGGCACGCCGCGCCAGGC
CTCGCTGTACAGCATGATCGCCGAGTGGTGCCGCTTCCGGCTGACTACCGTTGAACGGCGCACCCGCCACCGCCTGACCG
CCGCTGAAAAGCGCATCCACATCCTCGAAGGCCGGCAGGCCATCCTGCTCGACATCGACCGCGTCATCAAGGTCATCCGC
GAATCGGACGATCCCAAGGCCGACCTGATGGCGCACTTCAAGCTGTCGGAAATCCAGGCTGAAGACATCCTCGAAATCCG
CCTGCGCCAGCTGGCCAGGCTGGAAGGTATCAAGATCGGTGAAGAACTGGCCAAGCTGCGCGAAGAAGCGGCCGGCCTGA
ACAAACTGCTCGATTCCGAAGAAGCCCTGCGCGCCTGCGTGGCGGCCGAAATCGAGGCCGATGCCAAGAAATACGGCGAC
GACCGCCGGACGCTGATCGAAGCCGACGCCAAGGTCACGATGTCGGACGCCAAGACAGTGTCCATCGTTGATGAACCGAC
CACGCTGATCGTCTCCAAGCACGGCTGGCTGCGTTCGCGTACCGGGCACAACATCGATCCGACGCAACTGACCTTCCGTT
CCGGCGACAGCCTGCTCGCCTGCCTGCCCTGCCGGACGGTCGATTCGCTGATCATCCTCGACCATCTCGGCCGTGCCTAT
TCCATTTCCGCCGCCGATATTCCCGGCGGCAAGGGCGATGGCGTACCGGCCACCTCGGTGGTCGACTTTCAGGATGGCGG
CAAGCTCTGTCTTGCCCTGTCCACCTCTGCCGACAAGCGCTATCTGGTCGCCGCCGACGGTGGCTACGGCTTCCGCTGCC
AGGGCAGCGACTTCCTGTCACGCGGCAAGGCTGGCAAGGCCTTCCTGACGCTGGGCGATGGCGAAGCACCAGCCATCTTC
ATGCCAGCCCCGGCTGAGGGCGAAATTGCCTGCGTCACCAAGGATGGCCGTGCGCTGGTCTTCAACATCGAGGAAGTCCG
CCTGCTGGCCAAGGGCCGTGGCCTGAAGCTGATCGACGCCGCTCCCGGCAAGACGGCACTGGAAGAGATCATTCCGGTCG
TTGATGGCGTGGCCGGCAAGCTGAAAGGCGAACGCCTGGAAATCTGCCGCGGCAACCGTGGTGGCAAGGGCAAGCCGGTA
AAGGCACCACGCAAGTAA

Upstream 100 bases:

>100_bases
CCCAGCCCGACCGTCCAGCGAATTCCCAGTCTTTAAGCCGAAACTATCGCCAGCGTGATAAATTCGCCGCCGACTCGATT
CAGGATTTAGACGCAAGACC

Downstream 100 bases:

>100_bases
ATACGCGGCGTATCTTCAAAAGTAAAAACGGGGCCAGCCAGCCCCGTTTTTCATGCGTGTTCCGCCAGATCAGGCAGCGC
TGTCCGCCGCATGCATTTCT

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 805; Mature: 804

Protein sequence:

>805_residues
MTDQLNLFDPNAKAAATEPEAPALPATETQELAPELPLETAAEPALEPASALPPDLPPSATGPASDIPSPADYAARRYLE
YAMSVVTGRALPSAADGQKPVQRRILYAMHRMGLYKSPRHVKSARVVGDVIGKYHPHGDSSVYDAMVRMAQDWSLRYPIV
DGQGNFGSRDGDNAAAMRYTEARLTPIAELLLAELDEGTVDWKPNYDGANDEPALLPARLPFALLNGASGIAVGMATEIP
AHNLREVANAAVNLIRNPDFGEDEVLKLIPGPDYPGGAQIISSPEEIAATYRSGRGSLRVRAKWKIENLARGQWKLVITE
LPPGVSTATVMSEIEACSNPVAKEKAGKKVFTPEQLNLKAAFLSSISESGVRDESGKEHAVRLVIEPASSRQGQDDLVRM
LLAHTSLETNASINLTILGVNGTPRQASLYSMIAEWCRFRLTTVERRTRHRLTAAEKRIHILEGRQAILLDIDRVIKVIR
ESDDPKADLMAHFKLSEIQAEDILEIRLRQLARLEGIKIGEELAKLREEAAGLNKLLDSEEALRACVAAEIEADAKKYGD
DRRTLIEADAKVTMSDAKTVSIVDEPTTLIVSKHGWLRSRTGHNIDPTQLTFRSGDSLLACLPCRTVDSLIILDHLGRAY
SISAADIPGGKGDGVPATSVVDFQDGGKLCLALSTSADKRYLVAADGGYGFRCQGSDFLSRGKAGKAFLTLGDGEAPAIF
MPAPAEGEIACVTKDGRALVFNIEEVRLLAKGRGLKLIDAAPGKTALEEIIPVVDGVAGKLKGERLEICRGNRGGKGKPV
KAPRK

Sequences:

>Translated_805_residues
MTDQLNLFDPNAKAAATEPEAPALPATETQELAPELPLETAAEPALEPASALPPDLPPSATGPASDIPSPADYAARRYLE
YAMSVVTGRALPSAADGQKPVQRRILYAMHRMGLYKSPRHVKSARVVGDVIGKYHPHGDSSVYDAMVRMAQDWSLRYPIV
DGQGNFGSRDGDNAAAMRYTEARLTPIAELLLAELDEGTVDWKPNYDGANDEPALLPARLPFALLNGASGIAVGMATEIP
AHNLREVANAAVNLIRNPDFGEDEVLKLIPGPDYPGGAQIISSPEEIAATYRSGRGSLRVRAKWKIENLARGQWKLVITE
LPPGVSTATVMSEIEACSNPVAKEKAGKKVFTPEQLNLKAAFLSSISESGVRDESGKEHAVRLVIEPASSRQGQDDLVRM
LLAHTSLETNASINLTILGVNGTPRQASLYSMIAEWCRFRLTTVERRTRHRLTAAEKRIHILEGRQAILLDIDRVIKVIR
ESDDPKADLMAHFKLSEIQAEDILEIRLRQLARLEGIKIGEELAKLREEAAGLNKLLDSEEALRACVAAEIEADAKKYGD
DRRTLIEADAKVTMSDAKTVSIVDEPTTLIVSKHGWLRSRTGHNIDPTQLTFRSGDSLLACLPCRTVDSLIILDHLGRAY
SISAADIPGGKGDGVPATSVVDFQDGGKLCLALSTSADKRYLVAADGGYGFRCQGSDFLSRGKAGKAFLTLGDGEAPAIF
MPAPAEGEIACVTKDGRALVFNIEEVRLLAKGRGLKLIDAAPGKTALEEIIPVVDGVAGKLKGERLEICRGNRGGKGKPV
KAPRK
>Mature_804_residues
TDQLNLFDPNAKAAATEPEAPALPATETQELAPELPLETAAEPALEPASALPPDLPPSATGPASDIPSPADYAARRYLEY
AMSVVTGRALPSAADGQKPVQRRILYAMHRMGLYKSPRHVKSARVVGDVIGKYHPHGDSSVYDAMVRMAQDWSLRYPIVD
GQGNFGSRDGDNAAAMRYTEARLTPIAELLLAELDEGTVDWKPNYDGANDEPALLPARLPFALLNGASGIAVGMATEIPA
HNLREVANAAVNLIRNPDFGEDEVLKLIPGPDYPGGAQIISSPEEIAATYRSGRGSLRVRAKWKIENLARGQWKLVITEL
PPGVSTATVMSEIEACSNPVAKEKAGKKVFTPEQLNLKAAFLSSISESGVRDESGKEHAVRLVIEPASSRQGQDDLVRML
LAHTSLETNASINLTILGVNGTPRQASLYSMIAEWCRFRLTTVERRTRHRLTAAEKRIHILEGRQAILLDIDRVIKVIRE
SDDPKADLMAHFKLSEIQAEDILEIRLRQLARLEGIKIGEELAKLREEAAGLNKLLDSEEALRACVAAEIEADAKKYGDD
RRTLIEADAKVTMSDAKTVSIVDEPTTLIVSKHGWLRSRTGHNIDPTQLTFRSGDSLLACLPCRTVDSLIILDHLGRAYS
ISAADIPGGKGDGVPATSVVDFQDGGKLCLALSTSADKRYLVAADGGYGFRCQGSDFLSRGKAGKAFLTLGDGEAPAIFM
PAPAEGEIACVTKDGRALVFNIEEVRLLAKGRGLKLIDAAPGKTALEEIIPVVDGVAGKLKGERLEICRGNRGGKGKPVK
APRK

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=256, Percent_Identity=29.6875, Blast_Score=87, Evalue=9e-17,
Organism=Homo sapiens, GI19913408, Length=256, Percent_Identity=27.34375, Blast_Score=85, Evalue=3e-16,
Organism=Escherichia coli, GI1789396, Length=746, Percent_Identity=43.1635388739946, Blast_Score=565, Evalue=1e-162,
Organism=Escherichia coli, GI1788562, Length=766, Percent_Identity=34.0731070496084, Blast_Score=365, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17535065, Length=177, Percent_Identity=33.3333333333333, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI212645845, Length=417, Percent_Identity=24.9400479616307, Blast_Score=83, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI212645657, Length=176, Percent_Identity=31.8181818181818, Blast_Score=77, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI115534553, Length=170, Percent_Identity=30, Blast_Score=72, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=288, Percent_Identity=28.4722222222222, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI17136538, Length=265, Percent_Identity=26.7924528301887, Blast_Score=89, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 86759; Mature: 86628

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDQLNLFDPNAKAAATEPEAPALPATETQELAPELPLETAAEPALEPASALPPDLPPSA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCHHCCCCCCCCHHCCCCCCCCCC
TGPASDIPSPADYAARRYLEYAMSVVTGRALPSAADGQKPVQRRILYAMHRMGLYKSPRH
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHH
VKSARVVGDVIGKYHPHGDSSVYDAMVRMAQDWSLRYPIVDGQGNFGSRDGDNAAAMRYT
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEECEEECCCCCCCCCCCCCHHHEEEH
EARLTPIAELLLAELDEGTVDWKPNYDGANDEPALLPARLPFALLNGASGIAVGMATEIP
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEECCCCCHHHHCCCCCEEEEEECCCC
AHNLREVANAAVNLIRNPDFGEDEVLKLIPGPDYPGGAQIISSPEEIAATYRSGRGSLRV
HHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHCCCHHHHHHHHHCCCCCEEE
RAKWKIENLARGQWKLVITELPPGVSTATVMSEIEACSNPVAKEKAGKKVFTPEQLNLKA
EEEEEHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCHHH
AFLSSISESGVRDESGKEHAVRLVIEPASSRQGQDDLVRMLLAHTSLETNASINLTILGV
HHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEEC
NGTPRQASLYSMIAEWCRFRLTTVERRTRHRLTAAEKRIHILEGRQAILLDIDRVIKVIR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEEHHHHHHHHH
ESDDPKADLMAHFKLSEIQAEDILEIRLRQLARLEGIKIGEELAKLREEAAGLNKLLDSE
CCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCHH
EALRACVAAEIEADAKKYGDDRRTLIEADAKVTMSDAKTVSIVDEPTTLIVSKHGWLRSR
HHHHHHHHHHHHHHHHHCCCCHHEEEECCCEEEECCCCEEEEECCCEEEEEECCCCEECC
TGHNIDPTQLTFRSGDSLLACLPCRTVDSLIILDHLGRAYSISAADIPGGKGDGVPATSV
CCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEE
VDFQDGGKLCLALSTSADKRYLVAADGGYGFRCQGSDFLSRGKAGKAFLTLGDGEAPAIF
EEECCCCCEEEEEECCCCCEEEEEECCCCCEEECCHHHHHCCCCCCEEEEECCCCCCEEE
MPAPAEGEIACVTKDGRALVFNIEEVRLLAKGRGLKLIDAAPGKTALEEIIPVVDGVAGK
ECCCCCCCEEEEECCCCEEEEEHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCHHHH
LKGERLEICRGNRGGKGKPVKAPRK
CCCCEEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TDQLNLFDPNAKAAATEPEAPALPATETQELAPELPLETAAEPALEPASALPPDLPPSA
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCHHCCCCCCCCHHCCCCCCCCCC
TGPASDIPSPADYAARRYLEYAMSVVTGRALPSAADGQKPVQRRILYAMHRMGLYKSPRH
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHH
VKSARVVGDVIGKYHPHGDSSVYDAMVRMAQDWSLRYPIVDGQGNFGSRDGDNAAAMRYT
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEECEEECCCCCCCCCCCCCHHHEEEH
EARLTPIAELLLAELDEGTVDWKPNYDGANDEPALLPARLPFALLNGASGIAVGMATEIP
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEECCCCCHHHHCCCCCEEEEEECCCC
AHNLREVANAAVNLIRNPDFGEDEVLKLIPGPDYPGGAQIISSPEEIAATYRSGRGSLRV
HHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHCCCHHHHHHHHHCCCCCEEE
RAKWKIENLARGQWKLVITELPPGVSTATVMSEIEACSNPVAKEKAGKKVFTPEQLNLKA
EEEEEHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCCCHHH
AFLSSISESGVRDESGKEHAVRLVIEPASSRQGQDDLVRMLLAHTSLETNASINLTILGV
HHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEEEC
NGTPRQASLYSMIAEWCRFRLTTVERRTRHRLTAAEKRIHILEGRQAILLDIDRVIKVIR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEEHHHHHHHHH
ESDDPKADLMAHFKLSEIQAEDILEIRLRQLARLEGIKIGEELAKLREEAAGLNKLLDSE
CCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCHH
EALRACVAAEIEADAKKYGDDRRTLIEADAKVTMSDAKTVSIVDEPTTLIVSKHGWLRSR
HHHHHHHHHHHHHHHHHCCCCHHEEEECCCEEEECCCCEEEEECCCEEEEEECCCCEECC
TGHNIDPTQLTFRSGDSLLACLPCRTVDSLIILDHLGRAYSISAADIPGGKGDGVPATSV
CCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCEE
VDFQDGGKLCLALSTSADKRYLVAADGGYGFRCQGSDFLSRGKAGKAFLTLGDGEAPAIF
EEECCCCCEEEEEECCCCCEEEEEECCCCCEEECCHHHHHCCCCCCEEEEECCCCCCEEE
MPAPAEGEIACVTKDGRALVFNIEEVRLLAKGRGLKLIDAAPGKTALEEIIPVVDGVAGK
ECCCCCCCEEEEECCCCEEEEEHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHCCHHHH
LKGERLEICRGNRGGKGKPVKAPRK
CCCCEEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7830580 [H]