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The map label for this gene is map [H]

Identifier: 71907370

GI number: 71907370

Start: 1871636

End: 1872436

Strand: Reverse

Name: map [H]

Synonym: Daro_1740

Alternate gene names: 71907370

Gene position: 1872436-1871636 (Counterclockwise)

Preceding gene: 71907388

Following gene: 71907369

Centisome position: 41.6

GC content: 58.68

Gene sequence:

>801_bases
ATGAGCATCACCATCAAGACCCCGGAAGATATCGAAAAAATGCGAGTTGCCGGGCGTCTGGCCGGAGAGGTCCTCGACTA
CATCGAACCCTTCGTCAAGCCGGGCATCACAACCGGCGAACTGGACAAGCTCTGCCACGACCTGATGGTCAATGAGCAGG
GCTGCATCCCCGCCCCGCTGAATTACGCCCCGTCCGGCTACGCCCCCTACCCGAAATCGATCTGCACCTCCGTCAACCAG
CAAGTCTGCCACGGCGTACCGGGCGAGCGGGTATTGAAGAGCGGCGACATCATCAATCTCGACATCACGACGATCAAGGA
TGGTTATCACGGCGATACCAGCCGGATGTTTGTCGTCGGCGAAGGTTCGATCCAAGCCAAGCGCCTGTGCGAAATCACCT
TTGACTGCATGTGGCTGGGAATTTCGGTCGTCAAGCCGGGCGCCTTCCTCGGCGACATTGGTGCCGTCATCCAGAAGTAC
GCCGAGAAAAGTGGCTACTCCGTCGTCCGTGAGTTCTGCGGCCACGGCATCGGCAAGAAATTCCACGAAGACCCGCAAGT
GCTGCATTACGGCAAGCCTGGCACCGGTCCAAAACTGGAACCGGGCATGATTTTCACCATCGAACCGATGATCAATGCCG
GCAAGGCAGCGATCCGGGAAATGGCCGATGGCTGGACCATCGTCACCAAGGATCGCAGCCTGTCCGCACAATGGGAACAT
ACGGTTCTGGTGACCGAGACCGGCTACGAAGTGCTGACCCTCTCGGCTGGATGTCGCCCCAAGCCTGACTGGATCGCTTA
A

Upstream 100 bases:

>100_bases
TTGAAAACCTGTGGAGTATGCCATTTCCCGCGGCATCTGCTTTGCGAAACAGCCCCCATCATTTATCCTTCACCGTCCCC
AACGCACCATAAGAACAGCC

Downstream 100 bases:

>100_bases
TGTCCTGCGACGTCGCCGCTCTGCGGGCCGAAGTCAAGGCCAATCAAAACCAGCTGCGGCTGAATTATGAGCAAAGCAAT
GATGCCGTCGCCCTGCTCCG

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MSITIKTPEDIEKMRVAGRLAGEVLDYIEPFVKPGITTGELDKLCHDLMVNEQGCIPAPLNYAPSGYAPYPKSICTSVNQ
QVCHGVPGERVLKSGDIINLDITTIKDGYHGDTSRMFVVGEGSIQAKRLCEITFDCMWLGISVVKPGAFLGDIGAVIQKY
AEKSGYSVVREFCGHGIGKKFHEDPQVLHYGKPGTGPKLEPGMIFTIEPMINAGKAAIREMADGWTIVTKDRSLSAQWEH
TVLVTETGYEVLTLSAGCRPKPDWIA

Sequences:

>Translated_266_residues
MSITIKTPEDIEKMRVAGRLAGEVLDYIEPFVKPGITTGELDKLCHDLMVNEQGCIPAPLNYAPSGYAPYPKSICTSVNQ
QVCHGVPGERVLKSGDIINLDITTIKDGYHGDTSRMFVVGEGSIQAKRLCEITFDCMWLGISVVKPGAFLGDIGAVIQKY
AEKSGYSVVREFCGHGIGKKFHEDPQVLHYGKPGTGPKLEPGMIFTIEPMINAGKAAIREMADGWTIVTKDRSLSAQWEH
TVLVTETGYEVLTLSAGCRPKPDWIA
>Mature_265_residues
SITIKTPEDIEKMRVAGRLAGEVLDYIEPFVKPGITTGELDKLCHDLMVNEQGCIPAPLNYAPSGYAPYPKSICTSVNQQ
VCHGVPGERVLKSGDIINLDITTIKDGYHGDTSRMFVVGEGSIQAKRLCEITFDCMWLGISVVKPGAFLGDIGAVIQKYA
EKSGYSVVREFCGHGIGKKFHEDPQVLHYGKPGTGPKLEPGMIFTIEPMINAGKAAIREMADGWTIVTKDRSLSAQWEHT
VLVTETGYEVLTLSAGCRPKPDWIA

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=252, Percent_Identity=48.015873015873, Blast_Score=239, Evalue=2e-63,
Organism=Homo sapiens, GI40385867, Length=252, Percent_Identity=40.4761904761905, Blast_Score=192, Evalue=2e-49,
Organism=Escherichia coli, GI1786364, Length=255, Percent_Identity=61.9607843137255, Blast_Score=340, Evalue=6e-95,
Organism=Escherichia coli, GI1788728, Length=255, Percent_Identity=26.2745098039216, Blast_Score=81, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI71996291, Length=259, Percent_Identity=44.015444015444, Blast_Score=224, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6323273, Length=253, Percent_Identity=46.2450592885375, Blast_Score=224, Evalue=2e-59,
Organism=Drosophila melanogaster, GI21355531, Length=251, Percent_Identity=47.4103585657371, Blast_Score=226, Evalue=1e-59,
Organism=Drosophila melanogaster, GI24583427, Length=249, Percent_Identity=42.9718875502008, Blast_Score=206, Evalue=1e-53,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 29015; Mature: 28884

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSITIKTPEDIEKMRVAGRLAGEVLDYIEPFVKPGITTGELDKLCHDLMVNEQGCIPAPL
CEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCC
NYAPSGYAPYPKSICTSVNQQVCHGVPGERVLKSGDIINLDITTIKDGYHGDTSRMFVVG
CCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCEEEEEEEEECCCCCCCCCEEEEEE
EGSIQAKRLCEITFDCMWLGISVVKPGAFLGDIGAVIQKYAEKSGYSVVREFCGHGIGKK
CCCCCHHHHHHHHHHHHEECHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCH
FHEDPQVLHYGKPGTGPKLEPGMIFTIEPMINAGKAAIREMADGWTIVTKDRSLSAQWEH
HCCCCCEEECCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCE
TVLVTETGYEVLTLSAGCRPKPDWIA
EEEEEECCCEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
SITIKTPEDIEKMRVAGRLAGEVLDYIEPFVKPGITTGELDKLCHDLMVNEQGCIPAPL
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCC
NYAPSGYAPYPKSICTSVNQQVCHGVPGERVLKSGDIINLDITTIKDGYHGDTSRMFVVG
CCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCEEEEEEEEECCCCCCCCCEEEEEE
EGSIQAKRLCEITFDCMWLGISVVKPGAFLGDIGAVIQKYAEKSGYSVVREFCGHGIGKK
CCCCCHHHHHHHHHHHHEECHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCH
FHEDPQVLHYGKPGTGPKLEPGMIFTIEPMINAGKAAIREMADGWTIVTKDRSLSAQWEH
HCCCCCEEECCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCE
TVLVTETGYEVLTLSAGCRPKPDWIA
EEEEEECCCEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]