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The map label for this gene is macA [H]

Identifier: 71907303

GI number: 71907303

Start: 1798600

End: 1799790

Strand: Reverse

Name: macA [H]

Synonym: Daro_1673

Alternate gene names: 71907303

Gene position: 1799790-1798600 (Counterclockwise)

Preceding gene: 71907304

Following gene: 71907302

Centisome position: 39.99

GC content: 60.37

Gene sequence:

>1191_bases
ATGAAACCCAGCCAGGTCATTAGCCGAAAGCTTGGACTCGGGCTTTTTGCCGCAATGCTTGTCGTTGGATTTGGCGTGAT
TGTCGCCCGCTCAGGTCCGTTATCTCCCATCCAGGTCACCACACTCCGTGTGGAGTCGGGGTCGCTGTCATCAGCGATAT
TTGGTATTGGCACGGTCGAAGCCCGCCGTAGTTATTTCATTGGCCCAACGGCTGCGGGGCGCGTCAAATCTGTGCATGCG
GATGTGGGCGAAACGGTCAAGGCCAGGCAGTTGCTGGCGGAAATCGACCCTGTGGACCTGGATGAGCGCCTTCGTTCGAC
AGAAGCCGCTTATGCCCGGGCTGCCAGTGCCGTCATCGCCGCCGAAGCACAACGAAAAGATGCGATAGCCAGACGGCAAC
TCGCCGAGCTAAATGCCAAACGCTATCGCGACCTGGGTGGAAAGAATTTCGTCAGCCCCAGCGCAGTGGAAGGCAAGCAG
CAGGAACTTGATTCGGCTCAGGCAGCACTTGAGGCCAGTGAGGCCAACCTACTGGGCGCCCGCCAAGAGCAACTTCGGCT
GAAAGCTGACCAGGATGGCATCCGCCAACAACGTGGCAACCTTCGTCTGCTGGCCCCGCGGGATGGCCTAGTGATTAGCC
GCGACGCGGAACCAGGTTCGACGGTCATTGCCGGCCAGGCGGTCCTCCGCCTTGTTGAGCCTGACAGTCTCTGGGTCAAG
GCCCGCCTCGACCAGGGGCGCTCGCGCGGCCTGGCCGTAGGACAAGCCGCAGATATTGTGTTGCGCAGCAATGTCTCTAC
GCCCCTCCCTGGAAAGGTGGCGCGCATCGAGCCGGTGAGTGACAGCGTCACGGAGGAGCGCATCGCTCAAATCGCATTCG
AGCGCATCCCAGAAGGACTGAGCGTTGGCGAGATGACCGAAGTGACGGTGAAGACCGGTGAAGCTAAATCCGGGTTGCTG
CTTCCGAATGCCGCCATCAAACAGATGCCCCAAGGCAGCGGTGTCTGGAAGCTCAAGGACGGCAAGCCAAGCCTGACCCC
GGTGAAGCTGGGCAGCAACAGCCTTGATGGCAACGTACAGATTCTCGACGGCTTGGTTGCAGGCGACGAGGTGGTCATTC
ATAGCGAGCGCGACCTCAACGAGGGCGCCCGCATCAAGGTCGTCAACCAACTCGTGGGGAAACCGAAGTGA

Upstream 100 bases:

>100_bases
GTTTGGTGATGCAGTCCATGCTCGTTGGCGTCTCACCTGATACCGAAGAGCCGGTACTTGGCGTTCTACACCTCTACCTT
GCCGGCCTGAGAGCCAAATC

Downstream 100 bases:

>100_bases
TTAGCCTAGCCGGGCGGGACATCCTGCACTCCTGGTCAAAATTCGTCCTGACCGGTATCGGCCTGGGTTTGTTGATTGGT
GTAACTCTGACCATGGCTGG

Product: secretion protein HlyD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MKPSQVISRKLGLGLFAAMLVVGFGVIVARSGPLSPIQVTTLRVESGSLSSAIFGIGTVEARRSYFIGPTAAGRVKSVHA
DVGETVKARQLLAEIDPVDLDERLRSTEAAYARAASAVIAAEAQRKDAIARRQLAELNAKRYRDLGGKNFVSPSAVEGKQ
QELDSAQAALEASEANLLGARQEQLRLKADQDGIRQQRGNLRLLAPRDGLVISRDAEPGSTVIAGQAVLRLVEPDSLWVK
ARLDQGRSRGLAVGQAADIVLRSNVSTPLPGKVARIEPVSDSVTEERIAQIAFERIPEGLSVGEMTEVTVKTGEAKSGLL
LPNAAIKQMPQGSGVWKLKDGKPSLTPVKLGSNSLDGNVQILDGLVAGDEVVIHSERDLNEGARIKVVNQLVGKPK

Sequences:

>Translated_396_residues
MKPSQVISRKLGLGLFAAMLVVGFGVIVARSGPLSPIQVTTLRVESGSLSSAIFGIGTVEARRSYFIGPTAAGRVKSVHA
DVGETVKARQLLAEIDPVDLDERLRSTEAAYARAASAVIAAEAQRKDAIARRQLAELNAKRYRDLGGKNFVSPSAVEGKQ
QELDSAQAALEASEANLLGARQEQLRLKADQDGIRQQRGNLRLLAPRDGLVISRDAEPGSTVIAGQAVLRLVEPDSLWVK
ARLDQGRSRGLAVGQAADIVLRSNVSTPLPGKVARIEPVSDSVTEERIAQIAFERIPEGLSVGEMTEVTVKTGEAKSGLL
LPNAAIKQMPQGSGVWKLKDGKPSLTPVKLGSNSLDGNVQILDGLVAGDEVVIHSERDLNEGARIKVVNQLVGKPK
>Mature_396_residues
MKPSQVISRKLGLGLFAAMLVVGFGVIVARSGPLSPIQVTTLRVESGSLSSAIFGIGTVEARRSYFIGPTAAGRVKSVHA
DVGETVKARQLLAEIDPVDLDERLRSTEAAYARAASAVIAAEAQRKDAIARRQLAELNAKRYRDLGGKNFVSPSAVEGKQ
QELDSAQAALEASEANLLGARQEQLRLKADQDGIRQQRGNLRLLAPRDGLVISRDAEPGSTVIAGQAVLRLVEPDSLWVK
ARLDQGRSRGLAVGQAADIVLRSNVSTPLPGKVARIEPVSDSVTEERIAQIAFERIPEGLSVGEMTEVTVKTGEAKSGLL
LPNAAIKQMPQGSGVWKLKDGKPSLTPVKLGSNSLDGNVQILDGLVAGDEVVIHSERDLNEGARIKVVNQLVGKPK

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=367, Percent_Identity=28.0653950953678, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI87082036, Length=378, Percent_Identity=26.7195767195767, Blast_Score=73, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42065; Mature: 42065

Theoretical pI: Translated: 10.20; Mature: 10.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPSQVISRKLGLGLFAAMLVVGFGVIVARSGPLSPIQVTTLRVESGSLSSAIFGIGTVE
CCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCEEEEEEEEECCCCCHHHHCCCCHH
ARRSYFIGPTAAGRVKSVHADVGETVKARQLLAEIDPVDLDERLRSTEAAYARAASAVIA
HCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
AEAQRKDAIARRQLAELNAKRYRDLGGKNFVSPSAVEGKQQELDSAQAALEASEANLLGA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
RQEQLRLKADQDGIRQQRGNLRLLAPRDGLVISRDAEPGSTVIAGQAVLRLVEPDSLWVK
CHHHHEECCCHHHHHHHCCCEEEEECCCCEEEECCCCCCCEEEECHHHHEEECCCCEEEE
ARLDQGRSRGLAVGQAADIVLRSNVSTPLPGKVARIEPVSDSVTEERIAQIAFERIPEGL
EECCCCCCCCEEECCHHCEEEECCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCC
SVGEMTEVTVKTGEAKSGLLLPNAAIKQMPQGSGVWKLKDGKPSLTPVKLGSNSLDGNVQ
CCCCEEEEEEECCCCCCCEECCCHHHHHCCCCCCEEEEECCCCCCCEEEECCCCCCCCEE
ILDGLVAGDEVVIHSERDLNEGARIKVVNQLVGKPK
EEEEEECCCEEEEECCCCCCCCCEEEEEHHHHCCCC
>Mature Secondary Structure
MKPSQVISRKLGLGLFAAMLVVGFGVIVARSGPLSPIQVTTLRVESGSLSSAIFGIGTVE
CCHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCEEEEEEEEECCCCCHHHHCCCCHH
ARRSYFIGPTAAGRVKSVHADVGETVKARQLLAEIDPVDLDERLRSTEAAYARAASAVIA
HCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
AEAQRKDAIARRQLAELNAKRYRDLGGKNFVSPSAVEGKQQELDSAQAALEASEANLLGA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
RQEQLRLKADQDGIRQQRGNLRLLAPRDGLVISRDAEPGSTVIAGQAVLRLVEPDSLWVK
CHHHHEECCCHHHHHHHCCCEEEEECCCCEEEECCCCCCCEEEECHHHHEEECCCCEEEE
ARLDQGRSRGLAVGQAADIVLRSNVSTPLPGKVARIEPVSDSVTEERIAQIAFERIPEGL
EECCCCCCCCEEECCHHCEEEECCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCCC
SVGEMTEVTVKTGEAKSGLLLPNAAIKQMPQGSGVWKLKDGKPSLTPVKLGSNSLDGNVQ
CCCCEEEEEEECCCCCCCEECCCHHHHHCCCCCCEEEEECCCCCCCEEEECCCCCCCCEE
ILDGLVAGDEVVIHSERDLNEGARIKVVNQLVGKPK
EEEEEECCCEEEEECCCCCCCCCEEEEEHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]