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The map label for this gene is menB [H]

Identifier: 71907247

GI number: 71907247

Start: 1734524

End: 1735348

Strand: Reverse

Name: menB [H]

Synonym: Daro_1616

Alternate gene names: 71907247

Gene position: 1735348-1734524 (Counterclockwise)

Preceding gene: 71907248

Following gene: 71907246

Centisome position: 38.55

GC content: 61.58

Gene sequence:

>825_bases
ATGACCAACAGCATCCGCTGGCATAGCGCCCATATCTATTCCGACATCCTCTACGAAACCAGCGAGGGGATTGCCAAGAT
CACCATCAACCGGCCGGAACGGCGCAATGCCTTCCGCCCGGAGACCGTCAGTGAATTGATCGATGCCTTTCACCGTGCCC
ATCACGACAACGCTATTGGCGCCATCATCCTGACCGGTGCCGGCAACGAAGCCTTCTGCTCTGGTGGTGATCAAAAGGTG
CGCGGCGAAGAAGGCTATATTGACGAAGGTGGCACGCCGCACCTGAACGTCCTCGATCTGCAAATGCAGATTCGCCGCCT
GCCCAAGCCTGTCGTCGCCATGGTCGCCGGCTACGCGATCGGTGGCGGCCATGTGCTGCACCTTGTTTGCGACCTTTCTA
TCGCTGCCGACAACGCCCGCTTCGGCCAGACCGGACCGCGCGTCGGCAGTTTCGATGCCGGCCTTGGCGCGGGGCTGATG
GCACGCACCATTGGACTGAAACGAGCCAAAGAGGTCTGGCTGCTCTGCCGCCAGTACGATGCCACCACTGCACTCGACTG
GGGCTTGGTCAATGCCGTCGTTCCCGTCGAAAAGCTGGAAGCCGAAACCGTGGCCTGGTGCCGCGATATGCTGCAACTGT
CGCCGATGGCACTGCGCATGATCAAGGCCGGCTTCAACGCCGATACCGACGGCCTGGCTGGCATCCAAGAACTTGCCGGC
AACGCCACCGGCCTCTTCTACATGAGCGAGGAAGGGCAGGAAGGCCGCAATGCCTGGCTCGAACGCCGGCCACCCGATTT
TGGCAAGTACCGCAAGCGGCCGTGA

Upstream 100 bases:

>100_bases
GCAAACTGGAAGCGCCGGCCATCCAGTCACGGCAAGGCAGATCAATTCCGTCAAGCCCGGCTGACGATATACTTCGGCCA
TTGCAATCCAATGCCGAATC

Downstream 100 bases:

>100_bases
ACATCGCTGCAGCCGACTGGCAGCCCTACCAGCTCCCGTTAAATCGGCCTTGGCAAACCAGCCGGGGAACATTATTCGAG
CGTTGCGGCCGCCTGCTTCG

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 274; Mature: 273

Protein sequence:

>274_residues
MTNSIRWHSAHIYSDILYETSEGIAKITINRPERRNAFRPETVSELIDAFHRAHHDNAIGAIILTGAGNEAFCSGGDQKV
RGEEGYIDEGGTPHLNVLDLQMQIRRLPKPVVAMVAGYAIGGGHVLHLVCDLSIAADNARFGQTGPRVGSFDAGLGAGLM
ARTIGLKRAKEVWLLCRQYDATTALDWGLVNAVVPVEKLEAETVAWCRDMLQLSPMALRMIKAGFNADTDGLAGIQELAG
NATGLFYMSEEGQEGRNAWLERRPPDFGKYRKRP

Sequences:

>Translated_274_residues
MTNSIRWHSAHIYSDILYETSEGIAKITINRPERRNAFRPETVSELIDAFHRAHHDNAIGAIILTGAGNEAFCSGGDQKV
RGEEGYIDEGGTPHLNVLDLQMQIRRLPKPVVAMVAGYAIGGGHVLHLVCDLSIAADNARFGQTGPRVGSFDAGLGAGLM
ARTIGLKRAKEVWLLCRQYDATTALDWGLVNAVVPVEKLEAETVAWCRDMLQLSPMALRMIKAGFNADTDGLAGIQELAG
NATGLFYMSEEGQEGRNAWLERRPPDFGKYRKRP
>Mature_273_residues
TNSIRWHSAHIYSDILYETSEGIAKITINRPERRNAFRPETVSELIDAFHRAHHDNAIGAIILTGAGNEAFCSGGDQKVR
GEEGYIDEGGTPHLNVLDLQMQIRRLPKPVVAMVAGYAIGGGHVLHLVCDLSIAADNARFGQTGPRVGSFDAGLGAGLMA
RTIGLKRAKEVWLLCRQYDATTALDWGLVNAVVPVEKLEAETVAWCRDMLQLSPMALRMIKAGFNADTDGLAGIQELAGN
ATGLFYMSEEGQEGRNAWLERRPPDFGKYRKRP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=244, Percent_Identity=31.5573770491803, Blast_Score=107, Evalue=9e-24,
Organism=Homo sapiens, GI31542718, Length=246, Percent_Identity=32.1138211382114, Blast_Score=95, Evalue=6e-20,
Organism=Homo sapiens, GI45643119, Length=213, Percent_Identity=26.7605633802817, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI260275230, Length=213, Percent_Identity=26.7605633802817, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI260274832, Length=213, Percent_Identity=26.7605633802817, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4757966, Length=226, Percent_Identity=25.6637168141593, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI51538581, Length=226, Percent_Identity=25.6637168141593, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI25453481, Length=226, Percent_Identity=25.6637168141593, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI51538573, Length=226, Percent_Identity=25.6637168141593, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4502327, Length=263, Percent_Identity=28.5171102661597, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI213417737, Length=210, Percent_Identity=25.7142857142857, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI157694516, Length=210, Percent_Identity=25.7142857142857, Blast_Score=68, Evalue=9e-12,
Organism=Escherichia coli, GI1788597, Length=273, Percent_Identity=67.7655677655678, Blast_Score=380, Evalue=1e-107,
Organism=Escherichia coli, GI1787659, Length=259, Percent_Identity=28.1853281853282, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1787660, Length=259, Percent_Identity=32.046332046332, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI87082183, Length=256, Percent_Identity=28.515625, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI221142681, Length=214, Percent_Identity=30.8411214953271, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1788682, Length=177, Percent_Identity=27.683615819209, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17554946, Length=249, Percent_Identity=29.718875502008, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI25145438, Length=246, Percent_Identity=30.0813008130081, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17540714, Length=220, Percent_Identity=27.2727272727273, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17560910, Length=169, Percent_Identity=33.1360946745562, Blast_Score=87, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17535521, Length=215, Percent_Identity=28.8372093023256, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17549921, Length=207, Percent_Identity=24.6376811594203, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI20129971, Length=260, Percent_Identity=29.6153846153846, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24653477, Length=260, Percent_Identity=29.6153846153846, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24653139, Length=283, Percent_Identity=27.9151943462898, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21357171, Length=186, Percent_Identity=36.0215053763441, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI19922422, Length=267, Percent_Identity=24.3445692883895, Blast_Score=71, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24650670, Length=184, Percent_Identity=29.8913043478261, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 30001; Mature: 29869

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNSIRWHSAHIYSDILYETSEGIAKITINRPERRNAFRPETVSELIDAFHRAHHDNAIG
CCCCCEEHHHHHHHHHHHHCCCCEEEEEECCCHHCCCCCCHHHHHHHHHHHHHCCCCCEE
AIILTGAGNEAFCSGGDQKVRGEEGYIDEGGTPHLNVLDLQMQIRRLPKPVVAMVAGYAI
EEEEECCCCCCEECCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHCCHHHHHHHHHHCC
GGGHVLHLVCDLSIAADNARFGQTGPRVGSFDAGLGAGLMARTIGLKRAKEVWLLCRQYD
CCCCEEEEEEHHHEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
ATTALDWGLVNAVVPVEKLEAETVAWCRDMLQLSPMALRMIKAGFNADTDGLAGIQELAG
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCHHHHHHHHCC
NATGLFYMSEEGQEGRNAWLERRPPDFGKYRKRP
CCEEEEEECCCCCCHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TNSIRWHSAHIYSDILYETSEGIAKITINRPERRNAFRPETVSELIDAFHRAHHDNAIG
CCCCEEHHHHHHHHHHHHCCCCEEEEEECCCHHCCCCCCHHHHHHHHHHHHHCCCCCEE
AIILTGAGNEAFCSGGDQKVRGEEGYIDEGGTPHLNVLDLQMQIRRLPKPVVAMVAGYAI
EEEEECCCCCCEECCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHCCHHHHHHHHHHCC
GGGHVLHLVCDLSIAADNARFGQTGPRVGSFDAGLGAGLMARTIGLKRAKEVWLLCRQYD
CCCCEEEEEEHHHEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
ATTALDWGLVNAVVPVEKLEAETVAWCRDMLQLSPMALRMIKAGFNADTDGLAGIQELAG
CCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCCCHHHHHHHHCC
NATGLFYMSEEGQEGRNAWLERRPPDFGKYRKRP
CCEEEEEECCCCCCHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]