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The map label for this gene is mtaD [H]

Identifier: 71906868

GI number: 71906868

Start: 1333443

End: 1334777

Strand: Reverse

Name: mtaD [H]

Synonym: Daro_1229

Alternate gene names: 71906868

Gene position: 1334777-1333443 (Counterclockwise)

Preceding gene: 71906927

Following gene: 71906867

Centisome position: 29.65

GC content: 57.23

Gene sequence:

>1335_bases
ATGACAACAACACCTGAAGTTATCGACCTTCTGATCGAAGCACGCTGGATTGCTGCGGTCGACCCCGACGTGGTACACAA
AAACCACGCCGTCGCCGTCAACCAAGGTCGCATTCTGGCCATCCTGCCCGCCGGCGAAGCCCGTGCCCTGTATGCGCCGA
AGAAGACCACGGTACTTCAGGACCACATCCTGATTCCCGGCCTGATCAACCTGCACACCCACGCCGCGATGAGCCTGATG
CGTGGCCTGGCCGACGACCTGCCATTGATGGAGTGGCTACAGAAACATATCTGGCCGACAGAAGCCGCCCATCTCTCGTC
GCAGTTCGTCTACGACGGCACCCGCCTCGCCTGCGCTGAAATGCTCAAAGGCGGGATTACCTGCTTCAACGACATGTACT
TTTTCCCGGAAGCTGCTGCGACGGCCGCATCCGAATTCGGCATGCGTGCAATGCTCGGCATCACCACGCTGGAGTTCCCA
ACCCCCTATGCCAGTGATGCCACCGATTACATCAACAAGGGACTGGCCGTCCGCGAAGCGTGGCACAACAATCCACTGAT
TGACTTCTGCCTGGCACCCCACGCCCCTTACACCGTGTCTGACAGCACTTTTGAACGGATTCTGACGCTCTCCGAGCAAC
TGAATCTGCCGGTGCACTGCCACATTCACGAAACACAGCAGGAAATTGACGAAAATCTTAAGCAGCACAAACTGCGACCG
CTGGCCCGCCTGCACAAACTCGGACTACTCGGCCCCAATTTCATCGGGGTCCACGCCGTCCACCTGAACGACGACGACCT
GCAACTACTCGCCGATACCGGCTGCAATATCGCCCACTGCCCCACCTCTAACCTCAAACTGGCCAGCGGCTTTGCTCCAG
TAGCGAAAATGAGACAATTTAGCATCAATGTCGGGCTAGGTACCGACGGCGCGGCAAGCAACAACCGCCTCGACCTGTTT
GGCGAAATGCGCCTGGCCTCCCTATTAGCCAAAGGACTAACCGGTGATGCCAGCGCCCTGCCAGCCAGAGAAATCCTGCG
CATGGCCACACTCTATGCCGCCCAAGCACTGGGACTCGGCAATGAAGTCGGCTCGATCACCCCGGGAAAATCAGCAGACC
TTTGTGCCGTCAGCCTGGCGGCATTGGAAACACGCCCCTGTTTCGACCCAGTGTCACACCTGATCAATGTCTCAGGCCGA
GAATCAGTTACTCACGTCTGGGTCGCCGGAAAGTGTTGCGTAGACGACAAATCTTTACTTCAGCACGACCAAAATGATTT
GGAATCTGCGATAGCACTATGGCAGAATAGTTTGGAATTCCGCCAGCGGACCTGA

Upstream 100 bases:

>100_bases
ATGTCTCACATTCGCACCGCTTGCGCGATGCCTTATTAGTTGATTCAAGCGTAATTTGCTATTTTAACACGCGACCTTCA
CCGGATAGACCCCGTTTTTC

Downstream 100 bases:

>100_bases
TCTATGGTCGTGGAGCGGGTTAAAGATTTCCAAATTTTCTTCAATGAGGGAAAACAATGATCAAAAATATCGTCAAGAAA
TCTCTGGTTCTGGCCCTGCT

Product: N-ethylammeline chlorohydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase [H]

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MTTTPEVIDLLIEARWIAAVDPDVVHKNHAVAVNQGRILAILPAGEARALYAPKKTTVLQDHILIPGLINLHTHAAMSLM
RGLADDLPLMEWLQKHIWPTEAAHLSSQFVYDGTRLACAEMLKGGITCFNDMYFFPEAAATAASEFGMRAMLGITTLEFP
TPYASDATDYINKGLAVREAWHNNPLIDFCLAPHAPYTVSDSTFERILTLSEQLNLPVHCHIHETQQEIDENLKQHKLRP
LARLHKLGLLGPNFIGVHAVHLNDDDLQLLADTGCNIAHCPTSNLKLASGFAPVAKMRQFSINVGLGTDGAASNNRLDLF
GEMRLASLLAKGLTGDASALPAREILRMATLYAAQALGLGNEVGSITPGKSADLCAVSLAALETRPCFDPVSHLINVSGR
ESVTHVWVAGKCCVDDKSLLQHDQNDLESAIALWQNSLEFRQRT

Sequences:

>Translated_444_residues
MTTTPEVIDLLIEARWIAAVDPDVVHKNHAVAVNQGRILAILPAGEARALYAPKKTTVLQDHILIPGLINLHTHAAMSLM
RGLADDLPLMEWLQKHIWPTEAAHLSSQFVYDGTRLACAEMLKGGITCFNDMYFFPEAAATAASEFGMRAMLGITTLEFP
TPYASDATDYINKGLAVREAWHNNPLIDFCLAPHAPYTVSDSTFERILTLSEQLNLPVHCHIHETQQEIDENLKQHKLRP
LARLHKLGLLGPNFIGVHAVHLNDDDLQLLADTGCNIAHCPTSNLKLASGFAPVAKMRQFSINVGLGTDGAASNNRLDLF
GEMRLASLLAKGLTGDASALPAREILRMATLYAAQALGLGNEVGSITPGKSADLCAVSLAALETRPCFDPVSHLINVSGR
ESVTHVWVAGKCCVDDKSLLQHDQNDLESAIALWQNSLEFRQRT
>Mature_443_residues
TTTPEVIDLLIEARWIAAVDPDVVHKNHAVAVNQGRILAILPAGEARALYAPKKTTVLQDHILIPGLINLHTHAAMSLMR
GLADDLPLMEWLQKHIWPTEAAHLSSQFVYDGTRLACAEMLKGGITCFNDMYFFPEAAATAASEFGMRAMLGITTLEFPT
PYASDATDYINKGLAVREAWHNNPLIDFCLAPHAPYTVSDSTFERILTLSEQLNLPVHCHIHETQQEIDENLKQHKLRPL
ARLHKLGLLGPNFIGVHAVHLNDDDLQLLADTGCNIAHCPTSNLKLASGFAPVAKMRQFSINVGLGTDGAASNNRLDLFG
EMRLASLLAKGLTGDASALPAREILRMATLYAAQALGLGNEVGSITPGKSADLCAVSLAALETRPCFDPVSHLINVSGRE
SVTHVWVAGKCCVDDKSLLQHDQNDLESAIALWQNSLEFRQRT

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=372, Percent_Identity=26.8817204301075, Blast_Score=127, Evalue=2e-29,
Organism=Escherichia coli, GI1789249, Length=330, Percent_Identity=30, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI87082177, Length=420, Percent_Identity=22.1428571428571, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17540282, Length=393, Percent_Identity=24.1730279898219, Blast_Score=96, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6319963, Length=333, Percent_Identity=24.6246246246246, Blast_Score=97, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24643849, Length=383, Percent_Identity=28.4595300261097, Blast_Score=132, Evalue=4e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 48403; Mature: 48272

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTPEVIDLLIEARWIAAVDPDVVHKNHAVAVNQGRILAILPAGEARALYAPKKTTVLQ
CCCCHHHHHHHHHHHHEEECCHHHHCCCCEEEECCCEEEEEEECCCCCEEECCCCCCEEC
DHILIPGLINLHTHAAMSLMRGLADDLPLMEWLQKHIWPTEAAHLSSQFVYDGTRLACAE
CCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHCCHHEECCHHHHHHH
MLKGGITCFNDMYFFPEAAATAASEFGMRAMLGITTLEFPTPYASDATDYINKGLAVREA
HHHCCCEEECCCEECCCHHHHHHHHHCCHHHHCEEEEECCCCCCCCHHHHHHCCCEEHHH
WHNNPLIDFCLAPHAPYTVSDSTFERILTLSEQLNLPVHCHIHETQQEIDENLKQHKLRP
HCCCCEEEEEECCCCCCEECHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHH
LARLHKLGLLGPNFIGVHAVHLNDDDLQLLADTGCNIAHCPTSNLKLASGFAPVAKMRQF
HHHHHHHCCCCCCCEEEEEEEECCCCHHEEECCCCCEEECCCCCCEECCCCHHHHHHHHE
SINVGLGTDGAASNNRLDLFGEMRLASLLAKGLTGDASALPAREILRMATLYAAQALGLG
EEEEECCCCCCCCCCCEEHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
NEVGSITPGKSADLCAVSLAALETRPCFDPVSHLINVSGRESVTHVWVAGKCCVDDKSLL
CCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEEEEECEEECCCHHHH
QHDQNDLESAIALWQNSLEFRQRT
HCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TTTPEVIDLLIEARWIAAVDPDVVHKNHAVAVNQGRILAILPAGEARALYAPKKTTVLQ
CCCHHHHHHHHHHHHEEECCHHHHCCCCEEEECCCEEEEEEECCCCCEEECCCCCCEEC
DHILIPGLINLHTHAAMSLMRGLADDLPLMEWLQKHIWPTEAAHLSSQFVYDGTRLACAE
CCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHCCHHEECCHHHHHHH
MLKGGITCFNDMYFFPEAAATAASEFGMRAMLGITTLEFPTPYASDATDYINKGLAVREA
HHHCCCEEECCCEECCCHHHHHHHHHCCHHHHCEEEEECCCCCCCCHHHHHHCCCEEHHH
WHNNPLIDFCLAPHAPYTVSDSTFERILTLSEQLNLPVHCHIHETQQEIDENLKQHKLRP
HCCCCEEEEEECCCCCCEECHHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHH
LARLHKLGLLGPNFIGVHAVHLNDDDLQLLADTGCNIAHCPTSNLKLASGFAPVAKMRQF
HHHHHHHCCCCCCCEEEEEEEECCCCHHEEECCCCCEEECCCCCCEECCCCHHHHHHHHE
SINVGLGTDGAASNNRLDLFGEMRLASLLAKGLTGDASALPAREILRMATLYAAQALGLG
EEEEECCCCCCCCCCCEEHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCC
NEVGSITPGKSADLCAVSLAALETRPCFDPVSHLINVSGRESVTHVWVAGKCCVDDKSLL
CCCCCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCEEEEEEECEEECCCHHHH
QHDQNDLESAIALWQNSLEFRQRT
HCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA