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The map label for this gene is pyrD

Identifier: 71906803

GI number: 71906803

Start: 1268223

End: 1269266

Strand: Reverse

Name: pyrD

Synonym: Daro_1164

Alternate gene names: 71906803

Gene position: 1269266-1268223 (Counterclockwise)

Preceding gene: 71906810

Following gene: 71906802

Centisome position: 28.2

GC content: 60.92

Gene sequence:

>1044_bases
ATGCTATATCCCCTGATCCGCAAATTCTTCTTCTCCCTCGACGCTGAAACCGCCCACGGTATCGGCATGAAGGGCATCGA
TCTGATGAACGCCGCCGGCCTGGCCTGCGCCGTCGCCAAGCCAGTCGCCGCCTGCCCGGTCGAAGTCATGGGCCTCAAAT
TCCCCAATCCGGTCGGCCTGGCCGCCGGTCTGGACAAGAACGGCGATCACATCGATGGCCTGGCCAAGCTCGGCTTCGGC
TTCATCGAAATCGGCACGATCACGCCGCGCCCGCAGGATGGCAACCCGAAGCCGCGCCTGTTCCGCATCCCGGAAGCGCA
AGGCATCATCAACCGGATGGGCTTCAACAACGCCGGCGTCGACAAATTGCTGGAAAACGTCCGCGCCGCCGAATTCCCGA
AAAAGGGCGGCATCCTCGGCATCAACATCGGCAAGAACGCGACGACGCCGATCGAGAAGGCCGCCGACGATTACCTGATC
TGCCTCGACAAGGTCTACAACGACGCCAGCTACGTGACGGTCAATATCTCGTCGCCGAACACCAAGAACCTGCGCGAATT
GCAGAAGGATGAGGCGCTCGATGACCTGCTGGCACAACTGAAAGCAAAACAGCTGCAACTGGCCGAGCAATACGGCAAGT
ACGTGCCGATGGCTCTGAAGATCGCTCCCGATCTCGACGACGAGCAGATCACCGCCATCGCCGATGCGCTGCGCCGCCAT
CGCTTCGATGCGGTGATCGCCACCAACACCACGCTGTCGCGCGAAGGCGTCGAAGGCATGCCGAATGCCACAGAAACAGG
CGGCCTGTCGGGCAAGCCGGTCTTCGAGAAATCAACAGCCGTGCAGAAAAAACTATCGATCGCCCTCGCCGGCGAACTTC
CGATCATCGGTGTCGGCGGCATCATGGGCGGTGAGGATGCGGCCGAGAAAATCCGCGCCGGCGCAAGCCTGGTGCAGTTC
TACAGCGGTTTCATCTACCGTGGCCCGGATCTGGTCAGCGAGGTAGCAGAAACACTGGCCCACGTCATGCGGAAATCCGT
ATAA

Upstream 100 bases:

>100_bases
TGTTTCAGACTTTAAATCAAGGCACCGGAGCAACACCATCACCGGCGCTCAAAGGATGCCGGGCAAGCGCTGACGCAATG
CGGTAAAATGTTGCCCCATC

Downstream 100 bases:

>100_bases
GCCCATTCGATCCACGCGGTTGTTTGCACTGCAACAAAGCCCGATAATTCGCACCTCAAGCTGGTTAAAACTATGAGCCA
CTATATATTCATCCTCATCG

Product: dihydroorotate oxidase A

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MLYPLIRKFFFSLDAETAHGIGMKGIDLMNAAGLACAVAKPVAACPVEVMGLKFPNPVGLAAGLDKNGDHIDGLAKLGFG
FIEIGTITPRPQDGNPKPRLFRIPEAQGIINRMGFNNAGVDKLLENVRAAEFPKKGGILGINIGKNATTPIEKAADDYLI
CLDKVYNDASYVTVNISSPNTKNLRELQKDEALDDLLAQLKAKQLQLAEQYGKYVPMALKIAPDLDDEQITAIADALRRH
RFDAVIATNTTLSREGVEGMPNATETGGLSGKPVFEKSTAVQKKLSIALAGELPIIGVGGIMGGEDAAEKIRAGASLVQF
YSGFIYRGPDLVSEVAETLAHVMRKSV

Sequences:

>Translated_347_residues
MLYPLIRKFFFSLDAETAHGIGMKGIDLMNAAGLACAVAKPVAACPVEVMGLKFPNPVGLAAGLDKNGDHIDGLAKLGFG
FIEIGTITPRPQDGNPKPRLFRIPEAQGIINRMGFNNAGVDKLLENVRAAEFPKKGGILGINIGKNATTPIEKAADDYLI
CLDKVYNDASYVTVNISSPNTKNLRELQKDEALDDLLAQLKAKQLQLAEQYGKYVPMALKIAPDLDDEQITAIADALRRH
RFDAVIATNTTLSREGVEGMPNATETGGLSGKPVFEKSTAVQKKLSIALAGELPIIGVGGIMGGEDAAEKIRAGASLVQF
YSGFIYRGPDLVSEVAETLAHVMRKSV
>Mature_347_residues
MLYPLIRKFFFSLDAETAHGIGMKGIDLMNAAGLACAVAKPVAACPVEVMGLKFPNPVGLAAGLDKNGDHIDGLAKLGFG
FIEIGTITPRPQDGNPKPRLFRIPEAQGIINRMGFNNAGVDKLLENVRAAEFPKKGGILGINIGKNATTPIEKAADDYLI
CLDKVYNDASYVTVNISSPNTKNLRELQKDEALDDLLAQLKAKQLQLAEQYGKYVPMALKIAPDLDDEQITAIADALRRH
RFDAVIATNTTLSREGVEGMPNATETGGLSGKPVFEKSTAVQKKLSIALAGELPIIGVGGIMGGEDAAEKIRAGASLVQF
YSGFIYRGPDLVSEVAETLAHVMRKSV

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI45006951, Length=340, Percent_Identity=42.6470588235294, Blast_Score=247, Evalue=1e-65,
Organism=Escherichia coli, GI1787177, Length=336, Percent_Identity=56.8452380952381, Blast_Score=380, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17509475, Length=351, Percent_Identity=41.5954415954416, Blast_Score=243, Evalue=1e-64,
Organism=Drosophila melanogaster, GI281361352, Length=361, Percent_Identity=39.8891966759003, Blast_Score=241, Evalue=5e-64,
Organism=Drosophila melanogaster, GI17137316, Length=361, Percent_Identity=39.8891966759003, Blast_Score=241, Evalue=5e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_DECAR (Q47GW1)

Other databases:

- EMBL:   CP000089
- RefSeq:   YP_284390.1
- ProteinModelPortal:   Q47GW1
- SMR:   Q47GW1
- STRING:   Q47GW1
- GeneID:   3569290
- GenomeReviews:   CP000089_GR
- KEGG:   dar:Daro_1164
- NMPDR:   fig|159087.4.peg.750
- eggNOG:   COG0167
- HOGENOM:   HBG351027
- OMA:   SYVTVNI
- ProtClustDB:   CLSK2525788
- BioCyc:   DARO159087:DARO_1164-MONOMER
- HAMAP:   MF_00225
- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01036

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.5.2

Molecular weight: Translated: 37075; Mature: 37075

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 178-178

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYPLIRKFFFSLDAETAHGIGMKGIDLMNAAGLACAVAKPVAACPVEVMGLKFPNPVGL
CCHHHHHHHHHHCCCCHHCCCCCCCCHHHHHCCHHHHHHCCHHHCCHHHCCCCCCCCCCC
AAGLDKNGDHIDGLAKLGFGFIEIGTITPRPQDGNPKPRLFRIPEAQGIINRMGFNNAGV
CCCCCCCCCHHHHHHHHCCCEEEECCCCCCCCCCCCCCCEEECCCHHHHHHHCCCCCCCH
DKLLENVRAAEFPKKGGILGINIGKNATTPIEKAADDYLICLDKVYNDASYVTVNISSPN
HHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHCCCCCEEEHHHHCCCCEEEEEEECCCC
TKNLRELQKDEALDDLLAQLKAKQLQLAEQYGKYVPMALKIAPDLDDEQITAIADALRRH
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHH
RFDAVIATNTTLSREGVEGMPNATETGGLSGKPVFEKSTAVQKKLSIALAGELPIIGVGG
HCCEEEEECCEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHEEEECCCCEEEECC
IMGGEDAAEKIRAGASLVQFYSGFIYRGPDLVSEVAETLAHVMRKSV
CCCCHHHHHHHHHHHHHHHHHHCCEECCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLYPLIRKFFFSLDAETAHGIGMKGIDLMNAAGLACAVAKPVAACPVEVMGLKFPNPVGL
CCHHHHHHHHHHCCCCHHCCCCCCCCHHHHHCCHHHHHHCCHHHCCHHHCCCCCCCCCCC
AAGLDKNGDHIDGLAKLGFGFIEIGTITPRPQDGNPKPRLFRIPEAQGIINRMGFNNAGV
CCCCCCCCCHHHHHHHHCCCEEEECCCCCCCCCCCCCCCEEECCCHHHHHHHCCCCCCCH
DKLLENVRAAEFPKKGGILGINIGKNATTPIEKAADDYLICLDKVYNDASYVTVNISSPN
HHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHCCCCCEEEHHHHCCCCEEEEEEECCCC
TKNLRELQKDEALDDLLAQLKAKQLQLAEQYGKYVPMALKIAPDLDDEQITAIADALRRH
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHH
RFDAVIATNTTLSREGVEGMPNATETGGLSGKPVFEKSTAVQKKLSIALAGELPIIGVGG
HCCEEEEECCEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHEEEECCCCEEEECC
IMGGEDAAEKIRAGASLVQFYSGFIYRGPDLVSEVAETLAHVMRKSV
CCCCHHHHHHHHHHHHHHHHHHCCEECCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA