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The map label for this gene is trxC [H]

Identifier: 71906567

GI number: 71906567

Start: 1007053

End: 1007496

Strand: Reverse

Name: trxC [H]

Synonym: Daro_0928

Alternate gene names: 71906567

Gene position: 1007496-1007053 (Counterclockwise)

Preceding gene: 71906568

Following gene: 71906566

Centisome position: 22.38

GC content: 61.49

Gene sequence:

>444_bases
ATGTCCGAAAACCTGCACCTCGTCTGCCCGCACTGCGCTGCGGTCAATCGCATTCCAGCCGCGAAGCTGGGCGATGCGCC
GAACTGCGGCCAATGCAAGCAGCCCCTGTTCACCGGTGAACCGCTGGAACTGAACGCCGCAAACTTCGACCGCCACCTAT
CGCGCAACGATCTGCCGGTCGTCGTCGATTTCTGGGCGCCGTGGTGCGGGCCATGCCGGACGATGGCACCGACCTTCCAT
CAAGCCGCCATCGACCTCGAACCTTACGCCCGACTGGTCAAGGTCAACACCGAAGCCGAGCAACAACTGGCTGCCCGCTT
CAATATTCGCAGCATTCCCACGCTGGCTGTCTTTTTGAACGGTCGCGAAATCGCCCGCCAGAGCGGCGCGCTCGACCTCG
GATCGCTGAAACGCTGGCTACAGCCGCATCTTTACAAGTCTTAA

Upstream 100 bases:

>100_bases
ACTGGAAACCAGCGCCCGAGAAGCCTTCAAATTCGGCGCCCGGGCTTGAAATTCGTCAGATGGCACAAATATCAGGACAA
CCTGATATTTGGAGCCTGAG

Downstream 100 bases:

>100_bases
CTTCCGTCGCCGGCTGCCGTTAACAGTGTGTCGAAACACACTTCGCGGAGGCCACCATGAAAATCACCAGTGCCAGCCTG
CAGTTGGCCTCATCACACGC

Product: thioredoxin

Products: NA

Alternate protein names: Trx-2; Protein-disulfide reductase [H]

Number of amino acids: Translated: 147; Mature: 146

Protein sequence:

>147_residues
MSENLHLVCPHCAAVNRIPAAKLGDAPNCGQCKQPLFTGEPLELNAANFDRHLSRNDLPVVVDFWAPWCGPCRTMAPTFH
QAAIDLEPYARLVKVNTEAEQQLAARFNIRSIPTLAVFLNGREIARQSGALDLGSLKRWLQPHLYKS

Sequences:

>Translated_147_residues
MSENLHLVCPHCAAVNRIPAAKLGDAPNCGQCKQPLFTGEPLELNAANFDRHLSRNDLPVVVDFWAPWCGPCRTMAPTFH
QAAIDLEPYARLVKVNTEAEQQLAARFNIRSIPTLAVFLNGREIARQSGALDLGSLKRWLQPHLYKS
>Mature_146_residues
SENLHLVCPHCAAVNRIPAAKLGDAPNCGQCKQPLFTGEPLELNAANFDRHLSRNDLPVVVDFWAPWCGPCRTMAPTFHQ
AAIDLEPYARLVKVNTEAEQQLAARFNIRSIPTLAVFLNGREIARQSGALDLGSLKRWLQPHLYKS

Specific function: Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI224493972, Length=123, Percent_Identity=32.520325203252, Blast_Score=76, Evalue=8e-15,
Organism=Homo sapiens, GI42794771, Length=123, Percent_Identity=32.520325203252, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI4758304, Length=98, Percent_Identity=39.7959183673469, Blast_Score=74, Evalue=4e-14,
Organism=Escherichia coli, GI1788936, Length=140, Percent_Identity=47.1428571428571, Blast_Score=145, Evalue=1e-36,
Organism=Escherichia coli, GI87082331, Length=103, Percent_Identity=36.8932038834951, Blast_Score=82, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17507915, Length=106, Percent_Identity=33.0188679245283, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=97, Percent_Identity=31.9587628865979, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI25144092, Length=86, Percent_Identity=37.2093023255814, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17569137, Length=101, Percent_Identity=32.6732673267327, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI193209454, Length=101, Percent_Identity=32.6732673267327, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI32566189, Length=101, Percent_Identity=32.6732673267327, Blast_Score=69, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323072, Length=86, Percent_Identity=36.046511627907, Blast_Score=67, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321648, Length=88, Percent_Identity=36.3636363636364, Blast_Score=66, Evalue=2e-12,
Organism=Drosophila melanogaster, GI28573567, Length=114, Percent_Identity=35.0877192982456, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI19921434, Length=77, Percent_Identity=36.3636363636364, Blast_Score=73, Evalue=8e-14,
Organism=Drosophila melanogaster, GI18859803, Length=108, Percent_Identity=31.4814814814815, Blast_Score=66, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 16342; Mature: 16211

Theoretical pI: Translated: 8.14; Mature: 8.14

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
4.1 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSENLHLVCPHCAAVNRIPAAKLGDAPNCGQCKQPLFTGEPLELNAANFDRHLSRNDLPV
CCCCCEEEECCHHHHCCCCCHHCCCCCCCCCCCCCCCCCCCCEECCCCCHHHCCCCCCCE
VVDFWAPWCGPCRTMAPTFHQAAIDLEPYARLVKVNTEAEQQLAARFNIRSIPTLAVFLN
EEECCCCCCCCCCCCCCCHHHHHCCCCHHHEEEECCCHHHHHHHHHCCCCCCCEEEEEEC
GREIARQSGALDLGSLKRWLQPHLYKS
CHHHHHHCCCCCHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SENLHLVCPHCAAVNRIPAAKLGDAPNCGQCKQPLFTGEPLELNAANFDRHLSRNDLPV
CCCCEEEECCHHHHCCCCCHHCCCCCCCCCCCCCCCCCCCCEECCCCCHHHCCCCCCCE
VVDFWAPWCGPCRTMAPTFHQAAIDLEPYARLVKVNTEAEQQLAARFNIRSIPTLAVFLN
EEECCCCCCCCCCCCCCCHHHHHCCCCHHHEEEECCCHHHHHHHHHCCCCCCCEEEEEEC
GREIARQSGALDLGSLKRWLQPHLYKS
CHHHHHHCCCCCHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]