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The map label for this gene is gmhA

Identifier: 71906141

GI number: 71906141

Start: 562530

End: 563120

Strand: Reverse

Name: gmhA

Synonym: Daro_0501

Alternate gene names: 71906141

Gene position: 563120-562530 (Counterclockwise)

Preceding gene: 71906142

Following gene: 71906140

Centisome position: 12.51

GC content: 61.08

Gene sequence:

>591_bases
ATGGATCTCATCGCCCGCGTTGCCAAGAATTTCGAAGACAGCGCCCAAACCAAGCTGAACGCCGTCGACATGATGGCTGC
CCCGATTGCTGCCGCCATCGAGACTATGACCAACTGCCTGATCAACGGCGGCAAGATTCTCGCCTGCGGCAACGGCGGCT
CGGCCGGCGATTCGCAGCATTTCGCCGCTGAACTGATCGGCCGCTTCGAGGCCGAGCGTCAGGAACTGGCCGCCATCGCG
CTGACCACCGACAGCTCGATCCTGACCGCCATCGGCAATGACTATTCGTTCAACCAGATTTTCTCCAAGCAGGTGCGCGG
CCTCGGCCATTCTGGCGACATCCTGCTGGCCATTTCCACCTCCGGCAATTCCGGCAACATCATCGAAGCCATCAAGGCCG
CCCACGAACACGACATGCACGTGATCGCGCTGACCGGCAAGGGCGGCGGCCAGATCGGCGAAATGCTGCGCGACGCCGAT
ATTCATCTCTGCGTACCGGCCGACCGGACGGCGCGCATTCAGGAAACCCACCTGCTCGTCATCCATTGCCTGTGCGATGG
CATCGATGCGCTTTTACTGGGAGTCGAATGA

Upstream 100 bases:

>100_bases
TGAGCGACAACAAAAATCCATGGCAACGGGTGGCGTTCGAAGTGTTCGTGGAGCTGTGAGGTAGAATGCTTCGATCTACA
GCCTTAAACCTTTGAACGAT

Downstream 100 bases:

>100_bases
TGCAAAAAGCCAAACTCAGCCTGGCTGCCCTGCTGATGATTGCCGCCCTGCCCGCCTTGCAGGGCTGCGTTGAAGCCGCC
CTGCTCGGCACTGCGGCCGC

Product: phosphoheptose isomerase

Products: NA

Alternate protein names: Sedoheptulose 7-phosphate isomerase

Number of amino acids: Translated: 196; Mature: 196

Protein sequence:

>196_residues
MDLIARVAKNFEDSAQTKLNAVDMMAAPIAAAIETMTNCLINGGKILACGNGGSAGDSQHFAAELIGRFEAERQELAAIA
LTTDSSILTAIGNDYSFNQIFSKQVRGLGHSGDILLAISTSGNSGNIIEAIKAAHEHDMHVIALTGKGGGQIGEMLRDAD
IHLCVPADRTARIQETHLLVIHCLCDGIDALLLGVE

Sequences:

>Translated_196_residues
MDLIARVAKNFEDSAQTKLNAVDMMAAPIAAAIETMTNCLINGGKILACGNGGSAGDSQHFAAELIGRFEAERQELAAIA
LTTDSSILTAIGNDYSFNQIFSKQVRGLGHSGDILLAISTSGNSGNIIEAIKAAHEHDMHVIALTGKGGGQIGEMLRDAD
IHLCVPADRTARIQETHLLVIHCLCDGIDALLLGVE
>Mature_196_residues
MDLIARVAKNFEDSAQTKLNAVDMMAAPIAAAIETMTNCLINGGKILACGNGGSAGDSQHFAAELIGRFEAERQELAAIA
LTTDSSILTAIGNDYSFNQIFSKQVRGLGHSGDILLAISTSGNSGNIIEAIKAAHEHDMHVIALTGKGGGQIGEMLRDAD
IHLCVPADRTARIQETHLLVIHCLCDGIDALLLGVE

Specific function: Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate

COG id: COG0279

COG function: function code G; Phosphoheptose isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain

Homologues:

Organism=Escherichia coli, GI1789539, Length=188, Percent_Identity=49.468085106383, Blast_Score=195, Evalue=2e-51,
Organism=Escherichia coli, GI1786416, Length=152, Percent_Identity=51.3157894736842, Blast_Score=138, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GMHA_DECAR (Q47IS3)

Other databases:

- EMBL:   CP000089
- RefSeq:   YP_283728.1
- ProteinModelPortal:   Q47IS3
- SMR:   Q47IS3
- STRING:   Q47IS3
- GeneID:   3569975
- GenomeReviews:   CP000089_GR
- KEGG:   dar:Daro_0501
- NMPDR:   fig|159087.4.peg.85
- eggNOG:   COG0279
- HOGENOM:   HBG671955
- OMA:   HDREMIV
- ProtClustDB:   PRK13936
- BioCyc:   DARO159087:DARO_0501-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00067
- InterPro:   IPR020620
- InterPro:   IPR001347

Pfam domain/function: PF01380 SIS

EC number: =5.3.1.28

Molecular weight: Translated: 20577; Mature: 20577

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS51464 SIS

Important sites: BINDING 64-64 BINDING 124-124 BINDING 174-174

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLIARVAKNFEDSAQTKLNAVDMMAAPIAAAIETMTNCLINGGKILACGNGGSAGDSQH
CCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHH
FAAELIGRFEAERQELAAIALTTDSSILTAIGNDYSFNQIFSKQVRGLGHSGDILLAIST
HHHHHHHHHHHHHHHEEEEEEECCCCEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEEEC
SGNSGNIIEAIKAAHEHDMHVIALTGKGGGQIGEMLRDADIHLCVPADRTARIQETHLLV
CCCCCCHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHCCCEEEEECCCCCCCHHHHHHHH
IHCLCDGIDALLLGVE
HHHHHCCHHHEEEECC
>Mature Secondary Structure
MDLIARVAKNFEDSAQTKLNAVDMMAAPIAAAIETMTNCLINGGKILACGNGGSAGDSQH
CCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCHH
FAAELIGRFEAERQELAAIALTTDSSILTAIGNDYSFNQIFSKQVRGLGHSGDILLAIST
HHHHHHHHHHHHHHHEEEEEEECCCCEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEEEC
SGNSGNIIEAIKAAHEHDMHVIALTGKGGGQIGEMLRDADIHLCVPADRTARIQETHLLV
CCCCCCHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHCCCEEEEECCCCCCCHHHHHHHH
IHCLCDGIDALLLGVE
HHHHHCCHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA