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The map label for this gene is yegE [H]

Identifier: 71905775

GI number: 71905775

Start: 147199

End: 149283

Strand: Reverse

Name: yegE [H]

Synonym: Daro_0133

Alternate gene names: 71905775

Gene position: 149283-147199 (Counterclockwise)

Preceding gene: 71905776

Following gene: 71905772

Centisome position: 3.32

GC content: 60.86

Gene sequence:

>2085_bases
ATGAATCGTCTCACCCTCCGCCATCGCCTGCTGTTGCTAACGCTGCTCCCCAGCACGTTAATTGCCATCGCCCTGGTCAC
TTATTTCACCTTCAGCGGCATCAAGACGCTGGAAGGTGAACTTCGCCTCAAGGGCATGGCCACCGTCCGCTACCTGGCTC
CGATCAGCGAATACGGAATCATCGCGGGTCAGGTTGAAGGGCTGCACGGGCTAGCCCAAGCTACCGTCCAGGAATCCGGC
GTCAAGGCGGCCATCGTCGTTAATCAGAAAGGCCGCACTATCGCCGTTAGTGGCCGGGTTTCACTGGCGGCTGACGAGCT
TCGCCAGATTCTGAGCGAACCCAAGCAAGTCGCCGAAACCGACCAATGGATCGCCTTTGGCGCACCGGTAAAACGCTCGA
TGAGCGACACCGACCAGCTCTTTGAAACCAATGCCGGCAAGCCCGCCATTCCCGAAGTCATCGGTCACGTCTTTGTCGAG
TTCGACAAGACCGAGTTGGCCAACAAGCAACGCCAGCTCCTGCAGCGCGGCTTGGTCATCGTCCTCCTGGGTTTGCTCGT
ACTCGCTGCCATGGCCATCGCCATGGCGGACAATCTGGCCAAGCCCGTCATGCGCCTGGTTCAGGCCGTGAAAGACATGT
CGTCCGGCCGGCTGGACACCCGTGTGCCAGCCAGCTCCAGTGGTGAACTCGGCGTCCTCGAAAATGGCTTCAACGAAATG
GCGGCAAAGATCGAGGAAGTGCATCACTCGATGCAGACCCGGATCGAGGAGGCTACCGCCCAACTCGCCTTCCAGGCTCG
CCACGACGCACTAACCGGCCTGCTCAACCGGCGAGAATTCGAGCACCGCCTGGAAAAAGCACTGGCCAGCGTTCAGGCCG
GCGGTGACGAATTTGCCATCCTGTTCCTCGACCTCGACCGATTCAAGCAGGTCAATGACACCTGTGGCTATCTGGCCGGC
GACGAACTGCTACGCCAGATGGCGCTGCTCTTCCAGGGCCGCTTGCGCGAGGAAGACACTTTGGCTCGACTGGGCGGTGA
CGAATTCAGCATCATGCTGGCCAACTGCACCGGCGCGCGCGCCTTGCAAGTCGCCGATGACATTTGCGGCCTTGCCGCCG
CCTATCGCTTTATCTGGCAGGACAAGGTTTTCGCCATCGGCGCCAGCGTTGGCATCACCACGGTCAACCGCAAGGTGCGC
AACATCAACGAAATCCTCGCCGCCGGCGATGCCGCCTGCCATCGCGCCAAAGAAAGCGGCCGCAACCGTGTCTGCGAACA
AGAAGTGACCTTCAATCAGGAACGCCGCCATGAAGCCAGCAATTGGGCCAGTCGCATTGCCAATGCCCTCTCCGAGGACC
GGTTGCTGGTCGAGGCAGTGCCCTTGCGCGCCCTCCAGCACGCTGCCAGCGGACATGTCGTCGAACTGACGGCTCGCCTC
AACGAGCCTGGCCAGCCCCCAGTCGCCCTCGCCGCACTGATCGACGCAGCCGAACGCTATGACCTGGCGCCCGCCATCGA
CCGACGCCTGATCGATACCGCCATCGCGGCGCAGGCGCGCGCCAAACGTCAGCATCGCAACCTGTATTGCCTAGTGCCGC
TCTCACGTAGCTCGATCAGCAGCCGGGAAACAATCGACTACATCGCCCGCAGCCTGTCCAGCCAGAACATGGCCGGCAAC
AAACTCTGCTTCATGTTTTCCGAAGACATCCTGACCCATCTGACCAGTCAGGCCATGGAATTCTCTCGCCAAGTACATAC
CCTTGGTTGCCAGATTGGTCTGGACGATTTTGGTGGGGGGCTATCGTCTTTCAGCCACCTGCGCAGCATCACCCCCAGCC
ACGTCAAGCTGAGCCGCAGCCTGACCCGGGATCTTGGTGGCAACCGGGCGTCTACCGCCTTGCTGCGGGCAGTTCAGGAA
ATTACGGCGGACCAGCACATCCGTTCGATCGCCGAAGACATCGACGATCTGGATACGCTGGAACAACTCAAGGATCTCGG
GATCGATTACGCGCAGGGCAAGGCCATCGCGCCCAACGAGCCCTTCGAAGTCTGGTTTGAAGGCGCTGTCATGCGCTCAG
GCTAG

Upstream 100 bases:

>100_bases
TTGCCATTGCCATCAATCCAAATGTTGCACAGGCACTGGGACTCAACATTCCCGATGAAGCGTCGCTACGACGCGCCATC
CTTGCTGACAGGGATGCACG

Downstream 100 bases:

>100_bases
ATCTGACTCAGGCCATCAGAAATCAAGCCGCAGACTGACCCACTGCCGCCGATCAACAATACGGTCAGACGGTTCTGCAT
TCCATTTGTACTCGTTGTGC

Product: diguanylate cyclase/phosphodiesterase

Products: NA

Alternate protein names: DGC [H]

Number of amino acids: Translated: 694; Mature: 694

Protein sequence:

>694_residues
MNRLTLRHRLLLLTLLPSTLIAIALVTYFTFSGIKTLEGELRLKGMATVRYLAPISEYGIIAGQVEGLHGLAQATVQESG
VKAAIVVNQKGRTIAVSGRVSLAADELRQILSEPKQVAETDQWIAFGAPVKRSMSDTDQLFETNAGKPAIPEVIGHVFVE
FDKTELANKQRQLLQRGLVIVLLGLLVLAAMAIAMADNLAKPVMRLVQAVKDMSSGRLDTRVPASSSGELGVLENGFNEM
AAKIEEVHHSMQTRIEEATAQLAFQARHDALTGLLNRREFEHRLEKALASVQAGGDEFAILFLDLDRFKQVNDTCGYLAG
DELLRQMALLFQGRLREEDTLARLGGDEFSIMLANCTGARALQVADDICGLAAAYRFIWQDKVFAIGASVGITTVNRKVR
NINEILAAGDAACHRAKESGRNRVCEQEVTFNQERRHEASNWASRIANALSEDRLLVEAVPLRALQHAASGHVVELTARL
NEPGQPPVALAALIDAAERYDLAPAIDRRLIDTAIAAQARAKRQHRNLYCLVPLSRSSISSRETIDYIARSLSSQNMAGN
KLCFMFSEDILTHLTSQAMEFSRQVHTLGCQIGLDDFGGGLSSFSHLRSITPSHVKLSRSLTRDLGGNRASTALLRAVQE
ITADQHIRSIAEDIDDLDTLEQLKDLGIDYAQGKAIAPNEPFEVWFEGAVMRSG

Sequences:

>Translated_694_residues
MNRLTLRHRLLLLTLLPSTLIAIALVTYFTFSGIKTLEGELRLKGMATVRYLAPISEYGIIAGQVEGLHGLAQATVQESG
VKAAIVVNQKGRTIAVSGRVSLAADELRQILSEPKQVAETDQWIAFGAPVKRSMSDTDQLFETNAGKPAIPEVIGHVFVE
FDKTELANKQRQLLQRGLVIVLLGLLVLAAMAIAMADNLAKPVMRLVQAVKDMSSGRLDTRVPASSSGELGVLENGFNEM
AAKIEEVHHSMQTRIEEATAQLAFQARHDALTGLLNRREFEHRLEKALASVQAGGDEFAILFLDLDRFKQVNDTCGYLAG
DELLRQMALLFQGRLREEDTLARLGGDEFSIMLANCTGARALQVADDICGLAAAYRFIWQDKVFAIGASVGITTVNRKVR
NINEILAAGDAACHRAKESGRNRVCEQEVTFNQERRHEASNWASRIANALSEDRLLVEAVPLRALQHAASGHVVELTARL
NEPGQPPVALAALIDAAERYDLAPAIDRRLIDTAIAAQARAKRQHRNLYCLVPLSRSSISSRETIDYIARSLSSQNMAGN
KLCFMFSEDILTHLTSQAMEFSRQVHTLGCQIGLDDFGGGLSSFSHLRSITPSHVKLSRSLTRDLGGNRASTALLRAVQE
ITADQHIRSIAEDIDDLDTLEQLKDLGIDYAQGKAIAPNEPFEVWFEGAVMRSG
>Mature_694_residues
MNRLTLRHRLLLLTLLPSTLIAIALVTYFTFSGIKTLEGELRLKGMATVRYLAPISEYGIIAGQVEGLHGLAQATVQESG
VKAAIVVNQKGRTIAVSGRVSLAADELRQILSEPKQVAETDQWIAFGAPVKRSMSDTDQLFETNAGKPAIPEVIGHVFVE
FDKTELANKQRQLLQRGLVIVLLGLLVLAAMAIAMADNLAKPVMRLVQAVKDMSSGRLDTRVPASSSGELGVLENGFNEM
AAKIEEVHHSMQTRIEEATAQLAFQARHDALTGLLNRREFEHRLEKALASVQAGGDEFAILFLDLDRFKQVNDTCGYLAG
DELLRQMALLFQGRLREEDTLARLGGDEFSIMLANCTGARALQVADDICGLAAAYRFIWQDKVFAIGASVGITTVNRKVR
NINEILAAGDAACHRAKESGRNRVCEQEVTFNQERRHEASNWASRIANALSEDRLLVEAVPLRALQHAASGHVVELTARL
NEPGQPPVALAALIDAAERYDLAPAIDRRLIDTAIAAQARAKRQHRNLYCLVPLSRSSISSRETIDYIARSLSSQNMAGN
KLCFMFSEDILTHLTSQAMEFSRQVHTLGCQIGLDDFGGGLSSFSHLRSITPSHVKLSRSLTRDLGGNRASTALLRAVQE
ITADQHIRSIAEDIDDLDTLEQLKDLGIDYAQGKAIAPNEPFEVWFEGAVMRSG

Specific function: Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria [H]

COG id: COG2199

COG function: function code T; FOG: GGDEF domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PAS (PER-ARNT-SIM) domains [H]

Homologues:

Organism=Escherichia coli, GI1788381, Length=432, Percent_Identity=29.6296296296296, Blast_Score=170, Evalue=3e-43,
Organism=Escherichia coli, GI1787541, Length=528, Percent_Identity=27.0833333333333, Blast_Score=139, Evalue=8e-34,
Organism=Escherichia coli, GI87081881, Length=179, Percent_Identity=35.195530726257, Blast_Score=97, Evalue=4e-21,
Organism=Escherichia coli, GI1786584, Length=177, Percent_Identity=28.8135593220339, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1787262, Length=169, Percent_Identity=32.5443786982249, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI87081921, Length=464, Percent_Identity=21.551724137931, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI145693134, Length=162, Percent_Identity=33.3333333333333, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI87082007, Length=167, Percent_Identity=31.7365269461078, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1788956, Length=198, Percent_Identity=33.3333333333333, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1787802, Length=226, Percent_Identity=26.1061946902655, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI1787816, Length=171, Percent_Identity=29.2397660818713, Blast_Score=76, Evalue=9e-15,
Organism=Escherichia coli, GI1788085, Length=171, Percent_Identity=27.4853801169591, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1789149, Length=267, Percent_Identity=23.5955056179775, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788849, Length=242, Percent_Identity=23.5537190082645, Blast_Score=73, Evalue=7e-14,
Organism=Escherichia coli, GI87081974, Length=100, Percent_Identity=37, Blast_Score=71, Evalue=3e-13,
Organism=Escherichia coli, GI87081977, Length=165, Percent_Identity=29.6969696969697, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR007895
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013656
- InterPro:   IPR013655 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF05231 MASE1; PF08447 PAS_3; PF08448 PAS_4 [H]

EC number: =2.7.7.65 [H]

Molecular weight: Translated: 75998; Mature: 75998

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS50885 HAMP ; PS50883 EAL ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRLTLRHRLLLLTLLPSTLIAIALVTYFTFSGIKTLEGELRLKGMATVRYLAPISEYGI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCEEHHHHHHHHHHHHHHCCE
IAGQVEGLHGLAQATVQESGVKAAIVVNQKGRTIAVSGRVSLAADELRQILSEPKQVAET
EEHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEECCCHHHHHHHHHHHHHCHHHHHCC
DQWIAFGAPVKRSMSDTDQLFETNAGKPAIPEVIGHVFVEFDKTELANKQRQLLQRGLVI
CCEEEECCCHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
VLLGLLVLAAMAIAMADNLAKPVMRLVQAVKDMSSGRLDTRVPASSSGELGVLENGFNEM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCHHHH
AAKIEEVHHSMQTRIEEATAQLAFQARHDALTGLLNRREFEHRLEKALASVQAGGDEFAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
LFLDLDRFKQVNDTCGYLAGDELLRQMALLFQGRLREEDTLARLGGDEFSIMLANCTGAR
EEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEEEEECCCCH
ALQVADDICGLAAAYRFIWQDKVFAIGASVGITTVNRKVRNINEILAAGDAACHRAKESG
HHHHHHHHHHHHHHHHHHHHCHHHEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
RNRVCEQEVTFNQERRHEASNWASRIANALSEDRLLVEAVPLRALQHAASGHVVELTARL
HCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEEEC
NEPGQPPVALAALIDAAERYDLAPAIDRRLIDTAIAAQARAKRQHRNLYCLVPLSRSSIS
CCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCC
SRETIDYIARSLSSQNMAGNKLCFMFSEDILTHLTSQAMEFSRQVHTLGCQIGLDDFGGG
HHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCEECCHHCCCH
LSSFSHLRSITPSHVKLSRSLTRDLGGNRASTALLRAVQEITADQHIRSIAEDIDDLDTL
HHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQLKDLGIDYAQGKAIAPNEPFEVWFEGAVMRSG
HHHHHCCCCCCCCCCCCCCCCHHHHCCCEEECCC
>Mature Secondary Structure
MNRLTLRHRLLLLTLLPSTLIAIALVTYFTFSGIKTLEGELRLKGMATVRYLAPISEYGI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCEEHHHHHHHHHHHHHHCCE
IAGQVEGLHGLAQATVQESGVKAAIVVNQKGRTIAVSGRVSLAADELRQILSEPKQVAET
EEHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEEEECCCHHHHHHHHHHHHHCHHHHHCC
DQWIAFGAPVKRSMSDTDQLFETNAGKPAIPEVIGHVFVEFDKTELANKQRQLLQRGLVI
CCEEEECCCHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
VLLGLLVLAAMAIAMADNLAKPVMRLVQAVKDMSSGRLDTRVPASSSGELGVLENGFNEM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCHHHH
AAKIEEVHHSMQTRIEEATAQLAFQARHDALTGLLNRREFEHRLEKALASVQAGGDEFAI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
LFLDLDRFKQVNDTCGYLAGDELLRQMALLFQGRLREEDTLARLGGDEFSIMLANCTGAR
EEEEHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEEEEECCCCH
ALQVADDICGLAAAYRFIWQDKVFAIGASVGITTVNRKVRNINEILAAGDAACHRAKESG
HHHHHHHHHHHHHHHHHHHHCHHHEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
RNRVCEQEVTFNQERRHEASNWASRIANALSEDRLLVEAVPLRALQHAASGHVVELTARL
HCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEEEC
NEPGQPPVALAALIDAAERYDLAPAIDRRLIDTAIAAQARAKRQHRNLYCLVPLSRSSIS
CCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCC
SRETIDYIARSLSSQNMAGNKLCFMFSEDILTHLTSQAMEFSRQVHTLGCQIGLDDFGGG
HHHHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCEECCHHCCCH
LSSFSHLRSITPSHVKLSRSLTRDLGGNRASTALLRAVQEITADQHIRSIAEDIDDLDTL
HHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQLKDLGIDYAQGKAIAPNEPFEVWFEGAVMRSG
HHHHHCCCCCCCCCCCCCCCCHHHHCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 6094528; 7984428 [H]