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The map label for this gene is bcd [H]

Identifier: 71905742

GI number: 71905742

Start: 116928

End: 118100

Strand: Reverse

Name: bcd [H]

Synonym: Daro_0100

Alternate gene names: 71905742

Gene position: 118100-116928 (Counterclockwise)

Preceding gene: 71905743

Following gene: 71905741

Centisome position: 2.62

GC content: 62.23

Gene sequence:

>1173_bases
ATGAATATTCCCAGCCTCGACTTCGGCCTCGGCGAAGACATCAACCTGCTGCGCGATGCGGTGAAGGCCTTTGCCGATGC
AGAAATCGCGCCGCGCGCCGCGGAAATCGACCGCGCTAACGAATTCCCGGCCGACCTCTGGAAGAAATTCGGCGATATGG
GCCTGCTCGGCATGACGGCCGGCGAAGAGTACGGTGGCACCAACATGGGCTACCTGGCCCACATCGTGGCGCTGGAGGAA
ATCTCCCGCGCCTCGGCCTCGGTCGGTCTGTCCTACGGCGCCCACTCGAATCTGTGCGTTAACCAGATCCGCCGCAACGG
CACCGAAGCCCAGCGCCAGAAATACCTGCCCAAGCTGATCTCCGGCGAACATGTCGGCGCCTTGGCCATGTCCGAACCAA
ATGCCGGCTCCGACGTCGTCTCGATGAAGCTGAAGGCCGAGAAGAAGGGCGACCGTTACGTCCTGAACGGTTCCAAGATG
TGGATTACCAACGGCGGCGATGCCGACACACTGGTCGTCTACGCCAAGACCGACCTCAACGCCGGGGCCAAGGGCATGAC
TGCCTTCATCGTCGAAAAGGGCATGAAAGGCTTCACCCACGGCACGCACCTCGACAAGCTGGGCATGCGCGGCTCCAACA
CCTTCCCGTTGTTCTTCGACGATTGCGAAGTGCCGGAAGAAAACGTGCTGGGCGGTGTCGGCAACGGCACCAAGGTGCTG
ATGTCCGGCCTCGACTACGAACGTGCGGTCCTCTGCGGAGGCCCGCTCGGCATCATGGCCGCCTGCATGGACGTCGTCGT
ACCTTACCTGCACGAGCGCAAGCAGTTCGGCCAGGCGATCGGCGAATTCCAGCTGATGCAGGGCAAGGTCGCCGACCTCT
ATTCGACCTGGCAGGCTACCCGCGCCTACGTCTATGCCGTCGGCCGGGCCTGTGATGCGACGGACCATTCCCGCACCCTG
CGCAAGGATGCCGCCGGCGCCATTCTCTACTCGGCTGAAAAGGCAACCTGGATGGCCGGCGAAGCGATCCAGACGCTGGG
TGGCGTCGGCTACACCAACGAGTATCCAACCGGCCGCTTGTGGCGAGATGCCAAGCTCTATGAGATCGGGGCAGGCACCT
CGGAAATCCGTAGAATGCTGATTGGTCGCGAACTCTTCGCTGAAACCGCATAA

Upstream 100 bases:

>100_bases
AAGGAAACGCTTTGTGCGCTGATGCAGCAGACCATCATGGTCATGCATGGCAAAACCGAAAAGTAGTTCAAAAAATAAAC
CTGGAACGGAGACAAACCAC

Downstream 100 bases:

>100_bases
CACGCTCCTGCCGGCGCTCCGGACAGGAGCGCCGCAACATGGAGCTAAACAGCATGACCGTTACCCTACGCACCCTCACC
GCCAACGATAGCGAAGCCCT

Product: isovaleryl-CoA dehydrogenase

Products: NA

Alternate protein names: Butyryl-CoA dehydrogenase; SCAD [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MNIPSLDFGLGEDINLLRDAVKAFADAEIAPRAAEIDRANEFPADLWKKFGDMGLLGMTAGEEYGGTNMGYLAHIVALEE
ISRASASVGLSYGAHSNLCVNQIRRNGTEAQRQKYLPKLISGEHVGALAMSEPNAGSDVVSMKLKAEKKGDRYVLNGSKM
WITNGGDADTLVVYAKTDLNAGAKGMTAFIVEKGMKGFTHGTHLDKLGMRGSNTFPLFFDDCEVPEENVLGGVGNGTKVL
MSGLDYERAVLCGGPLGIMAACMDVVVPYLHERKQFGQAIGEFQLMQGKVADLYSTWQATRAYVYAVGRACDATDHSRTL
RKDAAGAILYSAEKATWMAGEAIQTLGGVGYTNEYPTGRLWRDAKLYEIGAGTSEIRRMLIGRELFAETA

Sequences:

>Translated_390_residues
MNIPSLDFGLGEDINLLRDAVKAFADAEIAPRAAEIDRANEFPADLWKKFGDMGLLGMTAGEEYGGTNMGYLAHIVALEE
ISRASASVGLSYGAHSNLCVNQIRRNGTEAQRQKYLPKLISGEHVGALAMSEPNAGSDVVSMKLKAEKKGDRYVLNGSKM
WITNGGDADTLVVYAKTDLNAGAKGMTAFIVEKGMKGFTHGTHLDKLGMRGSNTFPLFFDDCEVPEENVLGGVGNGTKVL
MSGLDYERAVLCGGPLGIMAACMDVVVPYLHERKQFGQAIGEFQLMQGKVADLYSTWQATRAYVYAVGRACDATDHSRTL
RKDAAGAILYSAEKATWMAGEAIQTLGGVGYTNEYPTGRLWRDAKLYEIGAGTSEIRRMLIGRELFAETA
>Mature_390_residues
MNIPSLDFGLGEDINLLRDAVKAFADAEIAPRAAEIDRANEFPADLWKKFGDMGLLGMTAGEEYGGTNMGYLAHIVALEE
ISRASASVGLSYGAHSNLCVNQIRRNGTEAQRQKYLPKLISGEHVGALAMSEPNAGSDVVSMKLKAEKKGDRYVLNGSKM
WITNGGDADTLVVYAKTDLNAGAKGMTAFIVEKGMKGFTHGTHLDKLGMRGSNTFPLFFDDCEVPEENVLGGVGNGTKVL
MSGLDYERAVLCGGPLGIMAACMDVVVPYLHERKQFGQAIGEFQLMQGKVADLYSTWQATRAYVYAVGRACDATDHSRTL
RKDAAGAILYSAEKATWMAGEAIQTLGGVGYTNEYPTGRLWRDAKLYEIGAGTSEIRRMLIGRELFAETA

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI226958412, Length=384, Percent_Identity=61.9791666666667, Blast_Score=487, Evalue=1e-138,
Organism=Homo sapiens, GI226958414, Length=346, Percent_Identity=64.1618497109827, Blast_Score=459, Evalue=1e-129,
Organism=Homo sapiens, GI4557233, Length=377, Percent_Identity=39.5225464190981, Blast_Score=273, Evalue=2e-73,
Organism=Homo sapiens, GI4501859, Length=373, Percent_Identity=36.4611260053619, Blast_Score=257, Evalue=2e-68,
Organism=Homo sapiens, GI21361497, Length=377, Percent_Identity=36.8700265251989, Blast_Score=229, Evalue=2e-60,
Organism=Homo sapiens, GI187960098, Length=382, Percent_Identity=35.3403141361257, Blast_Score=218, Evalue=6e-57,
Organism=Homo sapiens, GI4557231, Length=382, Percent_Identity=35.3403141361257, Blast_Score=218, Evalue=7e-57,
Organism=Homo sapiens, GI4501857, Length=376, Percent_Identity=32.9787234042553, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI76496475, Length=348, Percent_Identity=37.6436781609195, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI4557235, Length=348, Percent_Identity=37.6436781609195, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI7656849, Length=389, Percent_Identity=31.8766066838046, Blast_Score=199, Evalue=4e-51,
Organism=Homo sapiens, GI4503943, Length=390, Percent_Identity=30.5128205128205, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI7669494, Length=356, Percent_Identity=31.4606741573034, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI48976061, Length=354, Percent_Identity=25.7062146892655, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI211971008, Length=354, Percent_Identity=25.7062146892655, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI38505218, Length=279, Percent_Identity=20.7885304659498, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1786223, Length=384, Percent_Identity=28.3854166666667, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI87081958, Length=386, Percent_Identity=28.4974093264249, Blast_Score=151, Evalue=5e-38,
Organism=Escherichia coli, GI87082384, Length=266, Percent_Identity=25.5639097744361, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI87081702, Length=275, Percent_Identity=25.0909090909091, Blast_Score=68, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17538396, Length=383, Percent_Identity=61.0966057441253, Blast_Score=480, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI17506239, Length=374, Percent_Identity=34.2245989304813, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI17508101, Length=382, Percent_Identity=34.0314136125654, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17569725, Length=388, Percent_Identity=35.8247422680412, Blast_Score=236, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17534899, Length=388, Percent_Identity=35.3092783505155, Blast_Score=232, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI17570075, Length=388, Percent_Identity=35.3092783505155, Blast_Score=230, Evalue=9e-61,
Organism=Caenorhabditis elegans, GI71990804, Length=322, Percent_Identity=39.4409937888199, Blast_Score=225, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI17533517, Length=381, Percent_Identity=32.5459317585302, Blast_Score=215, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI71985184, Length=356, Percent_Identity=33.4269662921348, Blast_Score=198, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI17505929, Length=371, Percent_Identity=32.0754716981132, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=37.6623376623377, Blast_Score=175, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI71985192, Length=287, Percent_Identity=34.8432055749129, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI17551932, Length=372, Percent_Identity=30.6451612903226, Blast_Score=171, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=34.6715328467153, Blast_Score=171, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI17534353, Length=383, Percent_Identity=30.5483028720627, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17531909, Length=242, Percent_Identity=29.3388429752066, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21355753, Length=385, Percent_Identity=60.2597402597403, Blast_Score=452, Evalue=1e-127,
Organism=Drosophila melanogaster, GI21356377, Length=389, Percent_Identity=38.8174807197943, Blast_Score=276, Evalue=1e-74,
Organism=Drosophila melanogaster, GI24646207, Length=379, Percent_Identity=36.1477572559367, Blast_Score=261, Evalue=8e-70,
Organism=Drosophila melanogaster, GI24666513, Length=380, Percent_Identity=34.7368421052632, Blast_Score=235, Evalue=4e-62,
Organism=Drosophila melanogaster, GI24660351, Length=382, Percent_Identity=35.6020942408377, Blast_Score=227, Evalue=1e-59,
Organism=Drosophila melanogaster, GI281363737, Length=348, Percent_Identity=35.3448275862069, Blast_Score=201, Evalue=8e-52,
Organism=Drosophila melanogaster, GI19920834, Length=389, Percent_Identity=29.5629820051414, Blast_Score=159, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: =1.3.99.2 [H]

Molecular weight: Translated: 42110; Mature: 42110

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIPSLDFGLGEDINLLRDAVKAFADAEIAPRAAEIDRANEFPADLWKKFGDMGLLGMTA
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCHHHHHHHCCCCEEEECC
GEEYGGTNMGYLAHIVALEEISRASASVGLSYGAHSNLCVNQIRRNGTEAQRQKYLPKLI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHH
SGEHVGALAMSEPNAGSDVVSMKLKAEKKGDRYVLNGSKMWITNGGDADTLVVYAKTDLN
CCCCCCEEEECCCCCCCCEEEEEEEECCCCCEEEECCCEEEEECCCCCCEEEEEEECCCC
AGAKGMTAFIVEKGMKGFTHGTHLDKLGMRGSNTFPLFFDDCEVPEENVLGGVGNGTKVL
CCCCHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCEEECCCCCCHHHCCCCCCCCHHHH
MSGLDYERAVLCGGPLGIMAACMDVVVPYLHERKQFGQAIGEFQLMQGKVADLYSTWQAT
HHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
RAYVYAVGRACDATDHSRTLRKDAAGAILYSAEKATWMAGEAIQTLGGVGYTNEYPTGRL
HHHHHHHCCCCCCCCHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCE
WRDAKLYEIGAGTSEIRRMLIGRELFAETA
ECCCEEEEECCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNIPSLDFGLGEDINLLRDAVKAFADAEIAPRAAEIDRANEFPADLWKKFGDMGLLGMTA
CCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCHHHHHHHCCCCEEEECC
GEEYGGTNMGYLAHIVALEEISRASASVGLSYGAHSNLCVNQIRRNGTEAQRQKYLPKLI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHH
SGEHVGALAMSEPNAGSDVVSMKLKAEKKGDRYVLNGSKMWITNGGDADTLVVYAKTDLN
CCCCCCEEEECCCCCCCCEEEEEEEECCCCCEEEECCCEEEEECCCCCCEEEEEEECCCC
AGAKGMTAFIVEKGMKGFTHGTHLDKLGMRGSNTFPLFFDDCEVPEENVLGGVGNGTKVL
CCCCHHHHHHHHHCCCCCCCCCCHHHHCCCCCCCCCEEECCCCCCHHHCCCCCCCCHHHH
MSGLDYERAVLCGGPLGIMAACMDVVVPYLHERKQFGQAIGEFQLMQGKVADLYSTWQAT
HHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
RAYVYAVGRACDATDHSRTLRKDAAGAILYSAEKATWMAGEAIQTLGGVGYTNEYPTGRL
HHHHHHHCCCCCCCCHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCE
WRDAKLYEIGAGTSEIRRMLIGRELFAETA
ECCCEEEEECCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]