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The map label for this gene is hutI

Identifier: 71911583

GI number: 71911583

Start: 1730856

End: 1732121

Strand: Reverse

Name: hutI

Synonym: M5005_Spy_1770

Alternate gene names: 71911583

Gene position: 1732121-1730856 (Counterclockwise)

Preceding gene: 71911592

Following gene: 71911580

Centisome position: 94.21

GC content: 41.71

Gene sequence:

>1266_bases
ATGGTTGCTGATGTCTTATTAACACATTTTAATCAACTATTTTGTCTAAATGATCCAGGTCATCCTTTAACTGGTCAAGA
AATGAAAAAAGCCACTATCGTTGAAGATGGCTATATAGCCATCAAAGACGGCCTCATTGTGGCTCTTGGTTCTGGTGAAC
CAGATGCTGAGCTTGTCGGTACACAGACTATTATGCGTTCTTATAAAGGTAAAATTGCAACGCCTGGTATTATTGACTGT
CATACCCATTTGGTCTATGGTGGCAGTCGTGAACATGAATTTGCCAAGAAATTAGCAGGGGTGTCTTACTTGGATATTTT
AGCTCAAGGTGGTGGTATTTTAAGCACGGTGAGGGCCACTCGGTCAGCCAGCTTTGACAACCTTTATCAAAAATCCAAGA
GATTGCTAGACTACATGTTGCTTCATGGAGTGACTACTGTCGAAGCGAAAAGTGGCTACGGCCTTGATTGGGAAACAGAA
AAACGCCAACTGGATGTTGTTGCTGCTTTAGAAAAAGACCATCCCATTGATTTGGTGTCTACGTTTATGGCAGCCCATGC
GATTCCTGAAGAATACAAAGGGAATCCTAAGGCTTATCTCGATGTGATTATCAAGGATATGCTTCCTGTTGTTAAAGAGG
AAAATCTGGCAGAATTTTGTGATATTTTCTGTGAAAAAAATGTTTTTACAGCTGATGAGTCTCGCTATCTGTTAAGCAAA
GCCAAAGAAATGGGCTTCAAGCTTCGTATTCACGCAGATGAAATTGCGTCTATAGGCGGAGTTGATGTCGCAGCAGAGCT
CAGCGCAGTTAGTGCAGAGCATTTGATGATGATAACAGATGATGGTATCGCTAAGTTGATTGGTGCTGGTGTTATTGGTA
ATTTGCTTCCAGCCACCACCTTTAGTTTGATGGAAGACACTTATGCCCCTGCTCGCAAAATGATCGATGCTGGCATGGCC
ATCACCCTCTCAACAGATAGTAATCCAGGCAGTTGCCCGACTGCTAACATGCAGTTTGTGATGCAATTAGGTTGTTTTAT
GTTACGTTTAACACCGATTGAAGTCTTAAATGCTGTTACCATTAACGCGGCCTACTCTGTCAATCGTCAGGAGAGAGTTG
GTAGTTTGACAGTTGGTAAAGAAGCAGATATTGCCATTTTTGATGCCCCAAATATTGATTACCCATTTTATTTCTTTGCC
ACCAACTTGATTCACCAAGTCTATAAAAAAGGACAACTCACAGTTGACCGAGGTCGTATTCTTTAA

Upstream 100 bases:

>100_bases
TGTTACCAAAGTTGCAAAGATCGCAACTATTGAGTGGGTGAGGGGGGACTAGTAATGGCTATTAATCAGTTGACAAACGA
TGTTAAAAAAGGAGGTTTTT

Downstream 100 bases:

>100_bases
AAAATTTAAAAAAGAAGCTTTGAGCGTTAGCTCAAAACTTCTTTTAAATATGCTGTTTTATTGACGAATCAAGTAGTCAA
AGGCACCGATGGCAGCAGTA

Product: imidazolonepropionase

Products: NA

Alternate protein names: Imidazolone-5-propionate hydrolase

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MVADVLLTHFNQLFCLNDPGHPLTGQEMKKATIVEDGYIAIKDGLIVALGSGEPDAELVGTQTIMRSYKGKIATPGIIDC
HTHLVYGGSREHEFAKKLAGVSYLDILAQGGGILSTVRATRSASFDNLYQKSKRLLDYMLLHGVTTVEAKSGYGLDWETE
KRQLDVVAALEKDHPIDLVSTFMAAHAIPEEYKGNPKAYLDVIIKDMLPVVKEENLAEFCDIFCEKNVFTADESRYLLSK
AKEMGFKLRIHADEIASIGGVDVAAELSAVSAEHLMMITDDGIAKLIGAGVIGNLLPATTFSLMEDTYAPARKMIDAGMA
ITLSTDSNPGSCPTANMQFVMQLGCFMLRLTPIEVLNAVTINAAYSVNRQERVGSLTVGKEADIAIFDAPNIDYPFYFFA
TNLIHQVYKKGQLTVDRGRIL

Sequences:

>Translated_421_residues
MVADVLLTHFNQLFCLNDPGHPLTGQEMKKATIVEDGYIAIKDGLIVALGSGEPDAELVGTQTIMRSYKGKIATPGIIDC
HTHLVYGGSREHEFAKKLAGVSYLDILAQGGGILSTVRATRSASFDNLYQKSKRLLDYMLLHGVTTVEAKSGYGLDWETE
KRQLDVVAALEKDHPIDLVSTFMAAHAIPEEYKGNPKAYLDVIIKDMLPVVKEENLAEFCDIFCEKNVFTADESRYLLSK
AKEMGFKLRIHADEIASIGGVDVAAELSAVSAEHLMMITDDGIAKLIGAGVIGNLLPATTFSLMEDTYAPARKMIDAGMA
ITLSTDSNPGSCPTANMQFVMQLGCFMLRLTPIEVLNAVTINAAYSVNRQERVGSLTVGKEADIAIFDAPNIDYPFYFFA
TNLIHQVYKKGQLTVDRGRIL
>Mature_421_residues
MVADVLLTHFNQLFCLNDPGHPLTGQEMKKATIVEDGYIAIKDGLIVALGSGEPDAELVGTQTIMRSYKGKIATPGIIDC
HTHLVYGGSREHEFAKKLAGVSYLDILAQGGGILSTVRATRSASFDNLYQKSKRLLDYMLLHGVTTVEAKSGYGLDWETE
KRQLDVVAALEKDHPIDLVSTFMAAHAIPEEYKGNPKAYLDVIIKDMLPVVKEENLAEFCDIFCEKNVFTADESRYLLSK
AKEMGFKLRIHADEIASIGGVDVAAELSAVSAEHLMMITDDGIAKLIGAGVIGNLLPATTFSLMEDTYAPARKMIDAGMA
ITLSTDSNPGSCPTANMQFVMQLGCFMLRLTPIEVLNAVTINAAYSVNRQERVGSLTVGKEADIAIFDAPNIDYPFYFFA
TNLIHQVYKKGQLTVDRGRIL

Specific function: Unknown

COG id: COG1228

COG function: function code Q; Imidazolonepropionase and related amidohydrolases

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hutI family

Homologues:

Organism=Homo sapiens, GI223972677, Length=427, Percent_Identity=34.8946135831382, Blast_Score=220, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI17555004, Length=368, Percent_Identity=35.054347826087, Blast_Score=222, Evalue=3e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTI_STRP1 (P58080)

Other databases:

- EMBL:   AE004092
- EMBL:   CP000017
- RefSeq:   NP_270013.1
- RefSeq:   YP_283133.1
- ProteinModelPortal:   P58080
- SMR:   P58080
- EnsemblBacteria:   EBSTRT00000001608
- EnsemblBacteria:   EBSTRT00000027462
- GeneID:   3571134
- GeneID:   901722
- GenomeReviews:   AE004092_GR
- GenomeReviews:   CP000017_GR
- KEGG:   spy:SPy_2081
- KEGG:   spz:M5005_Spy_1770
- GeneTree:   EBGT00050000027529
- HOGENOM:   HBG686142
- OMA:   MNMACTL
- ProtClustDB:   PRK09356
- BioCyc:   SPYO160490:SPY2081-MONOMER
- BioCyc:   SPYO293653:M5005_SPY1770-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00372
- InterPro:   IPR006680
- InterPro:   IPR005920
- InterPro:   IPR011059
- TIGRFAMs:   TIGR01224

Pfam domain/function: PF01979 Amidohydro_1; SSF51338 Metalo_hydrolase

EC number: =3.5.2.7

Molecular weight: Translated: 45982; Mature: 45982

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: NA

Important sites: BINDING 90-90 BINDING 103-103 BINDING 153-153 BINDING 186-186 BINDING 254-254

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVADVLLTHFNQLFCLNDPGHPLTGQEMKKATIVEDGYIAIKDGLIVALGSGEPDAELVG
CHHHHHHHHCCCEEEECCCCCCCCCHHHHHHEEEECCEEEEECCEEEEECCCCCCHHHHH
TQTIMRSYKGKIATPGIIDCHTHLVYGGSREHEFAKKLAGVSYLDILAQGGGILSTVRAT
HHHHHHHHCCCCCCCCEEECCEEEEECCCCHHHHHHHHCCCHHHHHHHCCCCHHHHHHHH
RSASFDNLYQKSKRLLDYMLLHGVTTVEAKSGYGLDWETEKRQLDVVAALEKDHPIDLVS
HCCCHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCHHHHHHHEECCCCCCHHHHH
TFMAAHAIPEEYKGNPKAYLDVIIKDMLPVVKEENLAEFCDIFCEKNVFTADESRYLLSK
HHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHH
AKEMGFKLRIHADEIASIGGVDVAAELSAVSAEHLMMITDDGIAKLIGAGVIGNLLPATT
HHHCCEEEEEEHHHHHHCCCCCHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHH
FSLMEDTYAPARKMIDAGMAITLSTDSNPGSCPTANMQFVMQLGCFMLRLTPIEVLNAVT
HHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHEE
INAAYSVNRQERVGSLTVGKEADIAIFDAPNIDYPFYFFATNLIHQVYKKGQLTVDRGRI
EEEEEECCHHHHCCCEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEECCCCC
L
C
>Mature Secondary Structure
MVADVLLTHFNQLFCLNDPGHPLTGQEMKKATIVEDGYIAIKDGLIVALGSGEPDAELVG
CHHHHHHHHCCCEEEECCCCCCCCCHHHHHHEEEECCEEEEECCEEEEECCCCCCHHHHH
TQTIMRSYKGKIATPGIIDCHTHLVYGGSREHEFAKKLAGVSYLDILAQGGGILSTVRAT
HHHHHHHHCCCCCCCCEEECCEEEEECCCCHHHHHHHHCCCHHHHHHHCCCCHHHHHHHH
RSASFDNLYQKSKRLLDYMLLHGVTTVEAKSGYGLDWETEKRQLDVVAALEKDHPIDLVS
HCCCHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCHHHHHHHEECCCCCCHHHHH
TFMAAHAIPEEYKGNPKAYLDVIIKDMLPVVKEENLAEFCDIFCEKNVFTADESRYLLSK
HHHHHHCCCHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHH
AKEMGFKLRIHADEIASIGGVDVAAELSAVSAEHLMMITDDGIAKLIGAGVIGNLLPATT
HHHCCEEEEEEHHHHHHCCCCCHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHH
FSLMEDTYAPARKMIDAGMAITLSTDSNPGSCPTANMQFVMQLGCFMLRLTPIEVLNAVT
HHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHEE
INAAYSVNRQERVGSLTVGKEADIAIFDAPNIDYPFYFFATNLIHQVYKKGQLTVDRGRI
EEEEEECCHHHHCCCEECCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEECCCCC
L
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11296296