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The map label for this gene is irr [H]

Identifier: 71911538

GI number: 71911538

Start: 1689421

End: 1690074

Strand: Reverse

Name: irr [H]

Synonym: M5005_Spy_1725

Alternate gene names: 71911538

Gene position: 1690074-1689421 (Counterclockwise)

Preceding gene: 71911539

Following gene: 71911537

Centisome position: 91.92

GC content: 38.38

Gene sequence:

>654_bases
ATGTTTAAAATATTAGTAGTTGAAGATGATGATACCATCAGTCAAGTGATTTGTGAGTTTTTAAAAGCGAATAACTATGA
TCCAGATTGTGTATTTGATGGCCAAGCTGCCTTAGACAAGTGGCAGACAACGTCTTATGATCTGATTATTTTAGACATCA
TGCTCCCTTCCTTAAGTGGCTTAGAAGTGCTAAAAACAATTCGAAAGACATCAGATGTCCCTATTATTATGCTAACGGCA
TTAGATGACGAGTACACACAGCTTGTAAGCTTCAACCATTTGATTAGTGATTATGTGACCAAACCATTTTCACCACTCAT
TTTAATCAAACGTATCGAAAATGTATTACGCGTCTCTACTCCAGATGAAAAGCGCCAAATCGGAGACTTACTTGTTGATG
AGACCGAACATAGCGTCTATTGGCAAGGAACATTGGTCAAACTAACCAAAAAAGAATATGACATTATTGATTATTTAGCA
AAACGTCACCAAAAAATTGTCACCAGAGACCAATTGATGGATGACATATGGGGCTATTCTGAACTGGACACGCGTGTCCT
TGACAACCACATCAAGAACCTTCGTAAAAAAATGACGGGTATTCCCCTCAAGACAATTACAGGCATGGGCTATTTATTGG
GAGAGCGTGAGTGA

Upstream 100 bases:

>100_bases
TGAATAATCAACCAAACAAGCATAAAAGTCAAAAAGGATGACCCTTTGATGTCATCCTTAGCTGCTTGATACACTAAACG
CCAATCTAGAAAGGGAAGTT

Downstream 100 bases:

>100_bases
GACTAATCAAAAAAACCTTTTTGGTCATCAATGGCTTAATTATTGTAGTGGTTACCTCTATTTTGTTAGTGCTTTATTTT
GCAATGCCAATTTATTACAC

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MFKILVVEDDDTISQVICEFLKANNYDPDCVFDGQAALDKWQTTSYDLIILDIMLPSLSGLEVLKTIRKTSDVPIIMLTA
LDDEYTQLVSFNHLISDYVTKPFSPLILIKRIENVLRVSTPDEKRQIGDLLVDETEHSVYWQGTLVKLTKKEYDIIDYLA
KRHQKIVTRDQLMDDIWGYSELDTRVLDNHIKNLRKKMTGIPLKTITGMGYLLGERE

Sequences:

>Translated_217_residues
MFKILVVEDDDTISQVICEFLKANNYDPDCVFDGQAALDKWQTTSYDLIILDIMLPSLSGLEVLKTIRKTSDVPIIMLTA
LDDEYTQLVSFNHLISDYVTKPFSPLILIKRIENVLRVSTPDEKRQIGDLLVDETEHSVYWQGTLVKLTKKEYDIIDYLA
KRHQKIVTRDQLMDDIWGYSELDTRVLDNHIKNLRKKMTGIPLKTITGMGYLLGERE
>Mature_217_residues
MFKILVVEDDDTISQVICEFLKANNYDPDCVFDGQAALDKWQTTSYDLIILDIMLPSLSGLEVLKTIRKTSDVPIIMLTA
LDDEYTQLVSFNHLISDYVTKPFSPLILIKRIENVLRVSTPDEKRQIGDLLVDETEHSVYWQGTLVKLTKKEYDIIDYLA
KRHQKIVTRDQLMDDIWGYSELDTRVLDNHIKNLRKKMTGIPLKTITGMGYLLGERE

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788394, Length=219, Percent_Identity=32.8767123287671, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=31.1111111111111, Blast_Score=123, Evalue=7e-30,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=32.4324324324324, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI87082012, Length=216, Percent_Identity=34.7222222222222, Blast_Score=110, Evalue=5e-26,
Organism=Escherichia coli, GI1786784, Length=220, Percent_Identity=28.6363636363636, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI2367329, Length=230, Percent_Identity=32.6086956521739, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1790552, Length=216, Percent_Identity=31.4814814814815, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1789402, Length=219, Percent_Identity=24.6575342465753, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1789809, Length=230, Percent_Identity=28.2608695652174, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1786911, Length=225, Percent_Identity=30.6666666666667, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1787229, Length=222, Percent_Identity=27.9279279279279, Blast_Score=87, Evalue=9e-19,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=27.1929824561404, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI145693140, Length=237, Percent_Identity=26.5822784810127, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=26.9058295964126, Blast_Score=66, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25071; Mature: 25071

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKILVVEDDDTISQVICEFLKANNYDPDCVFDGQAALDKWQTTSYDLIILDIMLPSLSG
CEEEEEEECCCHHHHHHHHHHHCCCCCCCEEECCHHHHHHHCCCCCCEEEEEEHHCCCCH
LEVLKTIRKTSDVPIIMLTALDDEYTQLVSFNHLISDYVTKPFSPLILIKRIENVLRVST
HHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
PDEKRQIGDLLVDETEHSVYWQGTLVKLTKKEYDIIDYLAKRHQKIVTRDQLMDDIWGYS
CHHHHHHHHHHHCCCCCEEEECCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
ELDTRVLDNHIKNLRKKMTGIPLKTITGMGYLLGERE
HHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHCCCCC
>Mature Secondary Structure
MFKILVVEDDDTISQVICEFLKANNYDPDCVFDGQAALDKWQTTSYDLIILDIMLPSLSG
CEEEEEEECCCHHHHHHHHHHHCCCCCCCEEECCHHHHHHHCCCCCCEEEEEEHHCCCCH
LEVLKTIRKTSDVPIIMLTALDDEYTQLVSFNHLISDYVTKPFSPLILIKRIENVLRVST
HHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
PDEKRQIGDLLVDETEHSVYWQGTLVKLTKKEYDIIDYLAKRHQKIVTRDQLMDDIWGYS
CHHHHHHHHHHHCCCCCEEEECCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
ELDTRVLDNHIKNLRKKMTGIPLKTITGMGYLLGERE
HHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8631706; 12663927 [H]