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The map label for this gene is relA [H]

Identifier: 71911499

GI number: 71911499

Start: 1646213

End: 1648432

Strand: Reverse

Name: relA [H]

Synonym: M5005_Spy_1686

Alternate gene names: 71911499

Gene position: 1648432-1646213 (Counterclockwise)

Preceding gene: 71911500

Following gene: 71911498

Centisome position: 89.66

GC content: 44.28

Gene sequence:

>2220_bases
ATGGCAAAAATAATGAACGTAACAGGAGAAGAAGTCATTGCCTTAGCGGCCACCTATATGACCAAGGCTGATGTGGCTTT
TGTGGCAAAGGCTTTAGCATATGCAACAGCGGCCCATTTCTACCAAGTGAGAAAGTCAGGCGAACCCTATATCGTCCATC
CGATTCAGGTGGCGGGGATTCTGGCTGATTTGCATCTGGATGCTGTGACAGTTGCTTGTGGCTTTTTACATGATGTCGTA
GAAGATACGGATATTACCTTAGATGAGATCGAAGCAGACTTTGGCCATGATGCTCGTGATATCGTTGATGGTGTCACCAA
GTTAGGTAAAGTTGAGTACAAATCTCATGAGGAGCAACTCGCCGAAAACCATCGCAAAATGCTGATGGCTATGTCCAAAG
ATATTCGCGTGATTTTGGTGAAATTGGCTGACCGCCTGCATAATATGCGCACCCTCAAACATTTGCGCAAGGACAAACAA
GAGCGCATTTCGCGCGAAACCATGGAAATCTATGCCCCCTTGGCGCATCGTTTGGGGATTAGTCGCATCAAATGGGAACT
AGAAGATTTGGCTTTTCGTTACCTCAATGAAACCGAATTTTACAAAATTTCCCATATGATGAAAGAAAAACGTCGCGAGC
GTGAAGCTTTGGTAGAGGCTATTGTCAGTAAGGTCAAAACCTATACGACACAACAAGGGTTGTTTGGAGATGTGTATGGC
CGACCAAAACACATTTATTCGATTTATCGGAAAATGCGGGACAAAAAGAAACGATTCGATCAGATTTTTGATCTGATTGC
CATTCGTTGTGTCATGGAAACGCAAAGCGATGTCTATGCTATGGTTGGCTATATTCATGAGCTTTGGCGTCCCATGCCAG
GCCGCTTCAAGGATTATATTGCAGCTCCTAAAGCTAATGGCTACCAGTCTATTCATACCACCGTGTATGGGCCAAAAGGA
CCTATTGAGATTCAAATCAGAACTAAGGACATGCATCAAGTGGCTGAGTACGGGGTTGCTGCTCACTGGGCTTATAAAAA
AGGCGTGCGTGGTAAGGTCAATCAAGCTGAGCAAGCCGTTGGCATGAACTGGATCAAAGAGCTGGTAGAATTGCAAGATG
CCTCAAATGGCGATGCAGTGGACTTTGTGGATTCGGTCAAAGAAGACATTTTTTCTGAACGGATTTATGTCTTTACACCG
ACAGGGGCCGTTCAGGAGTTACCAAAAGAATCAGGTCCTATTGATTTTGCTTATGCGATCCATACGCAAATCGGTGAAAA
AGCAACAGGTGCCAAAGTCAATGGACGTATGGTTCCTCTCACTGCCAAGTTAAAAACAGGAGATGTGGTTGAAATCATCA
CCAATGCCAATTCCTTTGGCCCTAGTCGAGACTGGGTAAAACTGGTCAAAACCAATAAGGCTCGCAACAAAATTCGTCAG
TTCTTTAAAAATCAAGACAAGGAATTGTCAGTGAATAAAGGCCGTGATTTGTTGGTGTCTTATTTTCAAGAGCAGGGCTA
CGTTGCCAATAAATACCTTGACAAAAAACGCATTGAAGCCATCCTTCCAAAAGTCAGTGTGAAGAGCGAAGAATCACTCT
ATGCAGCCGTTGGGTTTGGTGACATTAGTCCTATCAGTGTCTTTAACAAGTTAACCGAAAAAGAGCGCCGTGAAGAAGAA
AGGGCCAAGGCTAAAGCAGAAGCTGAAGAATTGGTTAAGGGCGGTGAGGTCAAACACGAAAACAAAGATGTGCTCAAGGT
TCGCAGTGAAAATGGAGTCATTATCCAAGGAGCATCAGGCCTCTTGATGCGGATTGCCAAGTGTTGTAATCCTGTACCTG
GTGATCCTATTGACGGCTACATTACCAAAGGGCGTGGCATTGCGATTCACAGATCGGACTGTCATAACATTAAGAGTCAA
GATGGCTACCAAGAACGCTTGATTGAGGTCGAGTGGGATTTGGACAATTCGAGTAAAGATTATCAGGCTGAAATTGATAT
CTATGGGCTCAATCGTAGTGGTCTGCTTAATGATGTGCTCCAAATTTTATCAAACTCAACCAAGAGCATATCGACAGTCA
ATGCTCAGCCGACCAAGGACATGAAGTTTGCTAATATTCACGTGAGCTTTGGCATTCCAAATCTGACGCATCTGACCACT
GTTGTCGAAAAAATCAAGGCAGTTCCAGATGTTTATAGCGTGAAGCGGACCAATGGCTAA

Upstream 100 bases:

>100_bases
AAGAAAAGGTCACACTAAGCGCTTTCTTAGCAGATTCTGCCTTTTGCTTTTGTGTGTAAAGTGTTAAAATAGGGAAAAGA
AATGCTAGATGAGGAACGAA

Downstream 100 bases:

>100_bases
GAAAGGATAAAAACATGAAACTTGTCTTGCAACGGGTCAAAGAGGCCTCTGTTTCTATTGATGGGAAAATTGCTGGCGCT
ATTAATCAAGGGTTGTTGTT

Product: GTP pyrophosphokinase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase

Products: NA

Alternate protein names: GTP pyrophosphokinase; (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; Stringent response-like protein; ppGpp synthase I; Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase; Penta-phosphate guanosine-3'-pyrophosphohydrolase; (ppGpp)ase [H]

Number of amino acids: Translated: 739; Mature: 738

Protein sequence:

>739_residues
MAKIMNVTGEEVIALAATYMTKADVAFVAKALAYATAAHFYQVRKSGEPYIVHPIQVAGILADLHLDAVTVACGFLHDVV
EDTDITLDEIEADFGHDARDIVDGVTKLGKVEYKSHEEQLAENHRKMLMAMSKDIRVILVKLADRLHNMRTLKHLRKDKQ
ERISRETMEIYAPLAHRLGISRIKWELEDLAFRYLNETEFYKISHMMKEKRREREALVEAIVSKVKTYTTQQGLFGDVYG
RPKHIYSIYRKMRDKKKRFDQIFDLIAIRCVMETQSDVYAMVGYIHELWRPMPGRFKDYIAAPKANGYQSIHTTVYGPKG
PIEIQIRTKDMHQVAEYGVAAHWAYKKGVRGKVNQAEQAVGMNWIKELVELQDASNGDAVDFVDSVKEDIFSERIYVFTP
TGAVQELPKESGPIDFAYAIHTQIGEKATGAKVNGRMVPLTAKLKTGDVVEIITNANSFGPSRDWVKLVKTNKARNKIRQ
FFKNQDKELSVNKGRDLLVSYFQEQGYVANKYLDKKRIEAILPKVSVKSEESLYAAVGFGDISPISVFNKLTEKERREEE
RAKAKAEAEELVKGGEVKHENKDVLKVRSENGVIIQGASGLLMRIAKCCNPVPGDPIDGYITKGRGIAIHRSDCHNIKSQ
DGYQERLIEVEWDLDNSSKDYQAEIDIYGLNRSGLLNDVLQILSNSTKSISTVNAQPTKDMKFANIHVSFGIPNLTHLTT
VVEKIKAVPDVYSVKRTNG

Sequences:

>Translated_739_residues
MAKIMNVTGEEVIALAATYMTKADVAFVAKALAYATAAHFYQVRKSGEPYIVHPIQVAGILADLHLDAVTVACGFLHDVV
EDTDITLDEIEADFGHDARDIVDGVTKLGKVEYKSHEEQLAENHRKMLMAMSKDIRVILVKLADRLHNMRTLKHLRKDKQ
ERISRETMEIYAPLAHRLGISRIKWELEDLAFRYLNETEFYKISHMMKEKRREREALVEAIVSKVKTYTTQQGLFGDVYG
RPKHIYSIYRKMRDKKKRFDQIFDLIAIRCVMETQSDVYAMVGYIHELWRPMPGRFKDYIAAPKANGYQSIHTTVYGPKG
PIEIQIRTKDMHQVAEYGVAAHWAYKKGVRGKVNQAEQAVGMNWIKELVELQDASNGDAVDFVDSVKEDIFSERIYVFTP
TGAVQELPKESGPIDFAYAIHTQIGEKATGAKVNGRMVPLTAKLKTGDVVEIITNANSFGPSRDWVKLVKTNKARNKIRQ
FFKNQDKELSVNKGRDLLVSYFQEQGYVANKYLDKKRIEAILPKVSVKSEESLYAAVGFGDISPISVFNKLTEKERREEE
RAKAKAEAEELVKGGEVKHENKDVLKVRSENGVIIQGASGLLMRIAKCCNPVPGDPIDGYITKGRGIAIHRSDCHNIKSQ
DGYQERLIEVEWDLDNSSKDYQAEIDIYGLNRSGLLNDVLQILSNSTKSISTVNAQPTKDMKFANIHVSFGIPNLTHLTT
VVEKIKAVPDVYSVKRTNG
>Mature_738_residues
AKIMNVTGEEVIALAATYMTKADVAFVAKALAYATAAHFYQVRKSGEPYIVHPIQVAGILADLHLDAVTVACGFLHDVVE
DTDITLDEIEADFGHDARDIVDGVTKLGKVEYKSHEEQLAENHRKMLMAMSKDIRVILVKLADRLHNMRTLKHLRKDKQE
RISRETMEIYAPLAHRLGISRIKWELEDLAFRYLNETEFYKISHMMKEKRREREALVEAIVSKVKTYTTQQGLFGDVYGR
PKHIYSIYRKMRDKKKRFDQIFDLIAIRCVMETQSDVYAMVGYIHELWRPMPGRFKDYIAAPKANGYQSIHTTVYGPKGP
IEIQIRTKDMHQVAEYGVAAHWAYKKGVRGKVNQAEQAVGMNWIKELVELQDASNGDAVDFVDSVKEDIFSERIYVFTPT
GAVQELPKESGPIDFAYAIHTQIGEKATGAKVNGRMVPLTAKLKTGDVVEIITNANSFGPSRDWVKLVKTNKARNKIRQF
FKNQDKELSVNKGRDLLVSYFQEQGYVANKYLDKKRIEAILPKVSVKSEESLYAAVGFGDISPISVFNKLTEKERREEER
AKAKAEAEELVKGGEVKHENKDVLKVRSENGVIIQGASGLLMRIAKCCNPVPGDPIDGYITKGRGIAIHRSDCHNIKSQD
GYQERLIEVEWDLDNSSKDYQAEIDIYGLNRSGLLNDVLQILSNSTKSISTVNAQPTKDMKFANIHVSFGIPNLTHLTTV
VEKIKAVPDVYSVKRTNG

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes both the formation of pppGpp wh

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=139, Percent_Identity=39.568345323741, Blast_Score=71, Evalue=4e-12,
Organism=Escherichia coli, GI1790082, Length=729, Percent_Identity=40.0548696844993, Blast_Score=550, Evalue=1e-157,
Organism=Escherichia coli, GI1789147, Length=698, Percent_Identity=36.2464183381089, Blast_Score=471, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI25143118, Length=137, Percent_Identity=37.956204379562, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5; =3.1.7.2 [H]

Molecular weight: Translated: 83532; Mature: 83401

Theoretical pI: Translated: 9.03; Mature: 9.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIMNVTGEEVIALAATYMTKADVAFVAKALAYATAAHFYQVRKSGEPYIVHPIQVAGI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHH
LADLHLDAVTVACGFLHDVVEDTDITLDEIEADFGHDARDIVDGVTKLGKVEYKSHEEQL
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHH
AENHRKMLMAMSKDIRVILVKLADRLHNMRTLKHLRKDKQERISRETMEIYAPLAHRLGI
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
SRIKWELEDLAFRYLNETEFYKISHMMKEKRREREALVEAIVSKVKTYTTQQGLFGDVYG
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
RPKHIYSIYRKMRDKKKRFDQIFDLIAIRCVMETQSDVYAMVGYIHELWRPMPGRFKDYI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
AAPKANGYQSIHTTVYGPKGPIEIQIRTKDMHQVAEYGVAAHWAYKKGVRGKVNQAEQAV
CCCCCCCCCEEEEEEECCCCCEEEEEECCHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHH
GMNWIKELVELQDASNGDAVDFVDSVKEDIFSERIYVFTPTGAVQELPKESGPIDFAYAI
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCEEEECCCHHHHHCCCCCCCCEEEEEE
HTQIGEKATGAKVNGRMVPLTAKLKTGDVVEIITNANSFGPSRDWVKLVKTNKARNKIRQ
HHHHCCCCCCCCCCCEEEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
FFKNQDKELSVNKGRDLLVSYFQEQGYVANKYLDKKRIEAILPKVSVKSEESLYAAVGFG
HHCCCCCEEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCC
DISPISVFNKLTEKERREEERAKAKAEAEELVKGGEVKHENKDVLKVRSENGVIIQGASG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCEEEECCCH
LLMRIAKCCNPVPGDPIDGYITKGRGIAIHRSDCHNIKSQDGYQERLIEVEWDLDNSSKD
HHHHHHHHCCCCCCCCCCCEEECCCCEEEECCHHCCCCCCCCHHHCEEEEEECCCCCCCC
YQAEIDIYGLNRSGLLNDVLQILSNSTKSISTVNAQPTKDMKFANIHVSFGIPNLTHLTT
EEEEEEEEECCCCCHHHHHHHHHCCCCCCEEECCCCCCCCCEEEEEEEEECCCCHHHHHH
VVEKIKAVPDVYSVKRTNG
HHHHHHHCCCHHHHCCCCC
>Mature Secondary Structure 
AKIMNVTGEEVIALAATYMTKADVAFVAKALAYATAAHFYQVRKSGEPYIVHPIQVAGI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHH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HHHHHHHCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8232196 [H]