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The map label for this gene is mtlR [H]

Identifier: 71911477

GI number: 71911477

Start: 1620126

End: 1622186

Strand: Reverse

Name: mtlR [H]

Synonym: M5005_Spy_1664

Alternate gene names: 71911477

Gene position: 1622186-1620126 (Counterclockwise)

Preceding gene: 71911478

Following gene: 71911476

Centisome position: 88.23

GC content: 40.76

Gene sequence:

>2061_bases
ATGCTATCTCATGAGCTCATCAGAAACTATCAACTCTTTTCTAAATATAAAGGACATTCACTGGAGGCATTTGAATCCAT
TTTAAAGGCAAGCAAACGTCATATACTGGCAGATATTGCTAAAATCAATGACACGTTGTCACTCTATCAGTTACCCCTTA
TTGCTCTGGACAGGCAGCTGGTTTATCCGCCAGACCTTACTGAAAAGGACTTGTTGAATCGCATGCTACCTACCTTAGAC
GACTATCTCTTTCAAGATGAGCGTCTGGATATGATTATCATTTACATCATGATGGCTAAAGAATTTATCTCCATTAACCA
CTTGGAAAGCTTGTTACGGCTCAGCAGAAATTCTGTTATTGCTGATTTAAACTTGGTGCGTGATCGGGTACAAGCTTTTC
AGGTAACTTTAGCTTACAATCGCCAGGATGGTTATTTTTTTGAAGGAGAACCCTTAGCCTTGCGGCGTCTCTTAGAATCA
GCGGTCAGTTCTCTTTTGCAAGTCACATCTGGACCTTGGGTGTTCAGTTACTTATTGCATGAACTTGGTTTGCCCGACCA
GAAAAAGGTGATGGCAGCAACGTTGGAGGAACTGAGCAGGGAGAACCACTTAACTTTTATTTCGGAGAAATTGAGGGATT
TGATTTATTTTTTCTGCCTTCTCGCTCATCGACCATTTTCACGGAACGTAAGGGCTGAAGCAGTGGATACTTTTCCTTTA
GCTTCGCCAGCTGTTGAAACGATGGTGGACCAGTTATTGGTCAACTTCCCCAGTCTAACCGAAGAAAAATATTTGGTTCA
ATCTAGGTTACTTGGTTGTATCCAAGGTGACTTAGAGTTAGTCTTTCAGCAACCTATTTATGACATTATGGAGGAAATCA
TCAATTCGGTGGCGGTTAACACGGGATTGTCTATCACCGATACCCCAGAACTTCGTCAGAACCTATACAGTCACCTTTTG
CCAGCTTATTACCGACTTTACTACGACATTAACTTGACCAATCCTTTGAAGGAACAAATCAAACAAGATTATGAATCTCT
CTTTTACTTGGTCAAGCGCAGCCTTTCTCCTCTAGAAAAACAATTGGGGAAATCAGTTAATGAAGATGAGGTTGCTTATT
TTACCATTCATTTTGGGAGATGGTTGCAGGCCCCTAAGAAGAGGCCAAGCAATCAGCTGGTAGCCTTATCTGTTTGCCCT
AATGGCATTAGTTCGTCTCTGATGTTGGAGGCAACCTTGAAGGAACTTTTTCCACAGCTACAGTTTATTAGGATTCACCA
GCTGGACAAAATAAAGTTGTTGGATCCAGCATCCTTTGATTTGATTTTTTCAACAGTAGCTTTTGACTGTGCTAAACCTG
TTTATGTGACGCAAGCTTTGATGGGACCTGTTGAAAAAATGATGTTGAAAAAGATGGTCTGTGATGACTTTCATCTTCCC
TTGTCAGAGCAATTCGCTTTGGATGATCTGTTGAGTATTATTCATAAACATACCACGATTACTAATAAAGAAGGACTTGT
TAGTGATTTATCCCGTTACCTGATTGGTAACCATTTAACGATTGAAAAAGGAGGTCTAGGACTATTGGACTTGTTAACAG
CAGATTTTATTAGGCAGGCTGATGCTGTTTCGGATTGGCAGGAAGCGATTCGTTTGGCTGCTCAGCCTTTACTAGAACAC
CAGATGATTGAAACATCTTATATCGATGGCATGATTGATTCGGTCAATGAGCTTGGGGCCTATATTGTTTTAGCCCCTAA
GGTGGCTGTTCCTCATGCGGCGCCTGAAAAAGGAACGCGGCAGTTAGGCATGTCTCTCTTACAACTAAAAGAACCTGTCA
GCTTTGATTTGAAGCAAGAAGGTGATCCAGACAAGCAAGTGCAATTGATTTTTGTTTTGTCTGCTGTGGATTCTAGTTCA
CATTTGAAGGCTTTGCAGGAACTGTCGTTGATTTTAGATGATGATGAACATATTGAGCAATTAATTGAGGCTAAGAATAC
TGAGGAAATAATGAGTCTGATTAGCCATATGATTGAAAAAGGAGACGAATCACATGATTAA

Upstream 100 bases:

>100_bases
GAGTCCAATTGCAGTCAAAAATGACATGAGACAATTGGACTCAATTTATCTTGAAAATGAAAACGCTTCATTTTATACTG
ACATTATAGGAGGAGATGAC

Downstream 100 bases:

>100_bases
AATTGTAACGGTTTGTGGAAACGGTATTGGTAGTAGCTTGTTACTTCGCATGAAAGTAGAAGCTATCGCCTCTAGTTTGG
GTATTGATGTGGATGCAGAA

Product: PTS system, mannitol (cryptic)-specific IIA component

Products: NA

Alternate protein names: Mannitol operon transcriptional activator; Mtl operon transcriptional activator; Putative phosphotransferase enzyme IIB component; Putative PTS system EIIB component; Putative phosphotransferase enzyme IIA component; Putative PTS system EIIA component [H]

Number of amino acids: Translated: 686; Mature: 686

Protein sequence:

>686_residues
MLSHELIRNYQLFSKYKGHSLEAFESILKASKRHILADIAKINDTLSLYQLPLIALDRQLVYPPDLTEKDLLNRMLPTLD
DYLFQDERLDMIIIYIMMAKEFISINHLESLLRLSRNSVIADLNLVRDRVQAFQVTLAYNRQDGYFFEGEPLALRRLLES
AVSSLLQVTSGPWVFSYLLHELGLPDQKKVMAATLEELSRENHLTFISEKLRDLIYFFCLLAHRPFSRNVRAEAVDTFPL
ASPAVETMVDQLLVNFPSLTEEKYLVQSRLLGCIQGDLELVFQQPIYDIMEEIINSVAVNTGLSITDTPELRQNLYSHLL
PAYYRLYYDINLTNPLKEQIKQDYESLFYLVKRSLSPLEKQLGKSVNEDEVAYFTIHFGRWLQAPKKRPSNQLVALSVCP
NGISSSLMLEATLKELFPQLQFIRIHQLDKIKLLDPASFDLIFSTVAFDCAKPVYVTQALMGPVEKMMLKKMVCDDFHLP
LSEQFALDDLLSIIHKHTTITNKEGLVSDLSRYLIGNHLTIEKGGLGLLDLLTADFIRQADAVSDWQEAIRLAAQPLLEH
QMIETSYIDGMIDSVNELGAYIVLAPKVAVPHAAPEKGTRQLGMSLLQLKEPVSFDLKQEGDPDKQVQLIFVLSAVDSSS
HLKALQELSLILDDDEHIEQLIEAKNTEEIMSLISHMIEKGDESHD

Sequences:

>Translated_686_residues
MLSHELIRNYQLFSKYKGHSLEAFESILKASKRHILADIAKINDTLSLYQLPLIALDRQLVYPPDLTEKDLLNRMLPTLD
DYLFQDERLDMIIIYIMMAKEFISINHLESLLRLSRNSVIADLNLVRDRVQAFQVTLAYNRQDGYFFEGEPLALRRLLES
AVSSLLQVTSGPWVFSYLLHELGLPDQKKVMAATLEELSRENHLTFISEKLRDLIYFFCLLAHRPFSRNVRAEAVDTFPL
ASPAVETMVDQLLVNFPSLTEEKYLVQSRLLGCIQGDLELVFQQPIYDIMEEIINSVAVNTGLSITDTPELRQNLYSHLL
PAYYRLYYDINLTNPLKEQIKQDYESLFYLVKRSLSPLEKQLGKSVNEDEVAYFTIHFGRWLQAPKKRPSNQLVALSVCP
NGISSSLMLEATLKELFPQLQFIRIHQLDKIKLLDPASFDLIFSTVAFDCAKPVYVTQALMGPVEKMMLKKMVCDDFHLP
LSEQFALDDLLSIIHKHTTITNKEGLVSDLSRYLIGNHLTIEKGGLGLLDLLTADFIRQADAVSDWQEAIRLAAQPLLEH
QMIETSYIDGMIDSVNELGAYIVLAPKVAVPHAAPEKGTRQLGMSLLQLKEPVSFDLKQEGDPDKQVQLIFVLSAVDSSS
HLKALQELSLILDDDEHIEQLIEAKNTEEIMSLISHMIEKGDESHD
>Mature_686_residues
MLSHELIRNYQLFSKYKGHSLEAFESILKASKRHILADIAKINDTLSLYQLPLIALDRQLVYPPDLTEKDLLNRMLPTLD
DYLFQDERLDMIIIYIMMAKEFISINHLESLLRLSRNSVIADLNLVRDRVQAFQVTLAYNRQDGYFFEGEPLALRRLLES
AVSSLLQVTSGPWVFSYLLHELGLPDQKKVMAATLEELSRENHLTFISEKLRDLIYFFCLLAHRPFSRNVRAEAVDTFPL
ASPAVETMVDQLLVNFPSLTEEKYLVQSRLLGCIQGDLELVFQQPIYDIMEEIINSVAVNTGLSITDTPELRQNLYSHLL
PAYYRLYYDINLTNPLKEQIKQDYESLFYLVKRSLSPLEKQLGKSVNEDEVAYFTIHFGRWLQAPKKRPSNQLVALSVCP
NGISSSLMLEATLKELFPQLQFIRIHQLDKIKLLDPASFDLIFSTVAFDCAKPVYVTQALMGPVEKMMLKKMVCDDFHLP
LSEQFALDDLLSIIHKHTTITNKEGLVSDLSRYLIGNHLTIEKGGLGLLDLLTADFIRQADAVSDWQEAIRLAAQPLLEH
QMIETSYIDGMIDSVNELGAYIVLAPKVAVPHAAPEKGTRQLGMSLLQLKEPVSFDLKQEGDPDKQVQLIFVLSAVDSSS
HLKALQELSLILDDDEHIEQLIEAKNTEEIMSLISHMIEKGDESHD

Specific function: Positively regulates the expression of the mtlAFD operon involved in the uptake and catabolism of mannitol [H]

COG id: COG3711

COG function: function code K; Transcriptional antiterminator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIB type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI2367359, Length=139, Percent_Identity=30.9352517985612, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI1790755, Length=140, Percent_Identity=28.5714285714286, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1789302, Length=105, Percent_Identity=40.9523809523809, Blast_Score=78, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013196
- InterPro:   IPR007737
- InterPro:   IPR011608
- InterPro:   IPR016152
- InterPro:   IPR002178
- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR011991 [H]

Pfam domain/function: PF08279 HTH_11; PF05043 Mga; PF00874 PRD; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 78164; Mature: 78164

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00372 PTS_EIIA_TYPE_2_HIS ; PS51094 PTS_EIIA_TYPE_2 ; PS51099 PTS_EIIB_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSHELIRNYQLFSKYKGHSLEAFESILKASKRHILADIAKINDTLSLYQLPLIALDRQL
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
VYPPDLTEKDLLNRMLPTLDDYLFQDERLDMIIIYIMMAKEFISINHLESLLRLSRNSVI
ECCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
ADLNLVRDRVQAFQVTLAYNRQDGYFFEGEPLALRRLLESAVSSLLQVTSGPWVFSYLLH
HHHHHHHHHHHHHHEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
ELGLPDQKKVMAATLEELSRENHLTFISEKLRDLIYFFCLLAHRPFSRNVRAEAVDTFPL
HCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCC
ASPAVETMVDQLLVNFPSLTEEKYLVQSRLLGCIQGDLELVFQQPIYDIMEEIINSVAVN
CCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TGLSITDTPELRQNLYSHLLPAYYRLYYDINLTNPLKEQIKQDYESLFYLVKRSLSPLEK
CCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
QLGKSVNEDEVAYFTIHFGRWLQAPKKRPSNQLVALSVCPNGISSSLMLEATLKELFPQL
HHCCCCCCCCEEEEEEEHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHH
QFIRIHQLDKIKLLDPASFDLIFSTVAFDCAKPVYVTQALMGPVEKMMLKKMVCDDFHLP
HHHHHHCCCCEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
LSEQFALDDLLSIIHKHTTITNKEGLVSDLSRYLIGNHLTIEKGGLGLLDLLTADFIRQA
CHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHH
DAVSDWQEAIRLAAQPLLEHQMIETSYIDGMIDSVNELGAYIVLAPKVAVPHAAPEKGTR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCEECCCCCCCCHHH
QLGMSLLQLKEPVSFDLKQEGDPDKQVQLIFVLSAVDSSSHLKALQELSLILDDDEHIEQ
HHHHHHHHHCCCCCCCCCCCCCCCHHEEEEEEEECCCCHHHHHHHHHHHHHCCCHHHHHH
LIEAKNTEEIMSLISHMIEKGDESHD
HHHCCCHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLSHELIRNYQLFSKYKGHSLEAFESILKASKRHILADIAKINDTLSLYQLPLIALDRQL
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
VYPPDLTEKDLLNRMLPTLDDYLFQDERLDMIIIYIMMAKEFISINHLESLLRLSRNSVI
ECCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHH
ADLNLVRDRVQAFQVTLAYNRQDGYFFEGEPLALRRLLESAVSSLLQVTSGPWVFSYLLH
HHHHHHHHHHHHHHEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
ELGLPDQKKVMAATLEELSRENHLTFISEKLRDLIYFFCLLAHRPFSRNVRAEAVDTFPL
HCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCC
ASPAVETMVDQLLVNFPSLTEEKYLVQSRLLGCIQGDLELVFQQPIYDIMEEIINSVAVN
CCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TGLSITDTPELRQNLYSHLLPAYYRLYYDINLTNPLKEQIKQDYESLFYLVKRSLSPLEK
CCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
QLGKSVNEDEVAYFTIHFGRWLQAPKKRPSNQLVALSVCPNGISSSLMLEATLKELFPQL
HHCCCCCCCCEEEEEEEHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHH
QFIRIHQLDKIKLLDPASFDLIFSTVAFDCAKPVYVTQALMGPVEKMMLKKMVCDDFHLP
HHHHHHCCCCEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCC
LSEQFALDDLLSIIHKHTTITNKEGLVSDLSRYLIGNHLTIEKGGLGLLDLLTADFIRQA
CHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHH
DAVSDWQEAIRLAAQPLLEHQMIETSYIDGMIDSVNELGAYIVLAPKVAVPHAAPEKGTR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCEECCCCCCCCHHH
QLGMSLLQLKEPVSFDLKQEGDPDKQVQLIFVLSAVDSSSHLKALQELSLILDDDEHIEQ
HHHHHHHHHCCCCCCCCCCCCCCCHHEEEEEEEECCCCHHHHHHHHHHHHHCCCHHHHHH
LIEAKNTEEIMSLISHMIEKGDESHD
HHHCCCHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]