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The map label for this gene is norA [H]

Identifier: 71911388

GI number: 71911388

Start: 1535635

End: 1536831

Strand: Reverse

Name: norA [H]

Synonym: M5005_Spy_1575

Alternate gene names: 71911388

Gene position: 1536831-1535635 (Counterclockwise)

Preceding gene: 71911391

Following gene: 71911387

Centisome position: 83.59

GC content: 39.68

Gene sequence:

>1197_bases
ATGGAAGAAAAATTGTTTAACAAACATTTTGTGGCCATCACAGTAATAAACTTTATAGTCTATATGGTCTACTATCTTTT
TACAGTTATTATTGCCTTTGTGGCGACTAGAGAGCTAGGAGCTCAGACTAGCCAGGCAGGATTGGCAACAGGGATTTATA
TTCTAGGGACTTTATTAGCCCGTTTGATTTTTGGAAAGCAGTTGGAGGTGTTTGGTCGTCGTTTGGTTTTAAGAGGAGGT
GCTATTTTTTACCTCTTAACGACCTTAGCCTACTTTTATATGCCAACGATTAGCATGATGTACTTGGTTCGTTTCTTGAA
CGGATTTGGTTATGGTGTAGTATCAACTGCGACAAATACCATTGTAACAGCCTATATTCCAGCTCGTAAAAGAGGAGAAG
GAATTAATTTTTATGGCTTGTCAACCAGTCTAGCAGCAGCTATTGGCCCTTTTGTAGGAACCTTTATGTTGGATAATCTT
CATATTGATTTTCGCATGATTATTGTCTTATGTAGCGTCTTGATTGGGTGTGTGGTTGTTGGTGCTTTTGCTTTTCCAGT
CAAAAACATGTCTTTAAATGCGGAGCAATTGGCTAAAACCAAATCGTGGACTGTGGATAGTTTCATTGAGAAAAAAGCCT
TGTTTATCACTGCAATCGCCTTTTTAATGGGGATTGCCTATGCTTCAGTTTTAGGATTTCAAAAATTATACACGTCTGAA
ATTCATTTGACAACAGTAGGCGCTTATTTCTTTGTGGTCTATGCCTTAATCATTACCATCACTCGTCCAGCAATGGGACG
TTTAATGGATGCTAAAGGCGATAAATGGGTCTTGTACCCAAGTTATCTTTTTTTAGCAATGGGACTCTTCTTGCTAGGTA
GTGTATCGTCTGGAGGAAGCTATTTGCTTTCAGGAGCCTTGATTGGCTTTGGTTATGGCACTTTTATGTCTTGTGGTCAA
GCCGCCTCCATACAAGGAGTGGATGAGCACCGCTTTAATACGGCTATGTCTACTTATATGATTGGTCTTGATTTAGGTTT
AGGTGCTGGGCCTTACCTCTTGGGCTTGATTAAAGATTTGGCACTTGGTAGTGGTGTGGCTTCCTTTAGGCACTTATTCT
GGTTAGCTGCTGTGATTCCACTGATTTGTACCTTGCTTTACTTGTTAAAAACAAAGACAAGACAGGTTGTGTCTTAA

Upstream 100 bases:

>100_bases
AATGCCCTTTGATAGTAACACTTATATTATACCATTGAAATATATTATATTCTGCTTTTTTTGTAAAATGTTTATGAAAA
TAGAGAGGAGTTCATTTTCA

Downstream 100 bases:

>100_bases
GGACAAGAAAAGGAGTTTAGTCTTATACTTAAATACAAACGTATCTTAACAGCTGTAGATAGTTCCTATGAGCCGGGATT
AGCTGTGGGTAAAGCCATTA

Product: quinolone resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MEEKLFNKHFVAITVINFIVYMVYYLFTVIIAFVATRELGAQTSQAGLATGIYILGTLLARLIFGKQLEVFGRRLVLRGG
AIFYLLTTLAYFYMPTISMMYLVRFLNGFGYGVVSTATNTIVTAYIPARKRGEGINFYGLSTSLAAAIGPFVGTFMLDNL
HIDFRMIIVLCSVLIGCVVVGAFAFPVKNMSLNAEQLAKTKSWTVDSFIEKKALFITAIAFLMGIAYASVLGFQKLYTSE
IHLTTVGAYFFVVYALIITITRPAMGRLMDAKGDKWVLYPSYLFLAMGLFLLGSVSSGGSYLLSGALIGFGYGTFMSCGQ
AASIQGVDEHRFNTAMSTYMIGLDLGLGAGPYLLGLIKDLALGSGVASFRHLFWLAAVIPLICTLLYLLKTKTRQVVS

Sequences:

>Translated_398_residues
MEEKLFNKHFVAITVINFIVYMVYYLFTVIIAFVATRELGAQTSQAGLATGIYILGTLLARLIFGKQLEVFGRRLVLRGG
AIFYLLTTLAYFYMPTISMMYLVRFLNGFGYGVVSTATNTIVTAYIPARKRGEGINFYGLSTSLAAAIGPFVGTFMLDNL
HIDFRMIIVLCSVLIGCVVVGAFAFPVKNMSLNAEQLAKTKSWTVDSFIEKKALFITAIAFLMGIAYASVLGFQKLYTSE
IHLTTVGAYFFVVYALIITITRPAMGRLMDAKGDKWVLYPSYLFLAMGLFLLGSVSSGGSYLLSGALIGFGYGTFMSCGQ
AASIQGVDEHRFNTAMSTYMIGLDLGLGAGPYLLGLIKDLALGSGVASFRHLFWLAAVIPLICTLLYLLKTKTRQVVS
>Mature_398_residues
MEEKLFNKHFVAITVINFIVYMVYYLFTVIIAFVATRELGAQTSQAGLATGIYILGTLLARLIFGKQLEVFGRRLVLRGG
AIFYLLTTLAYFYMPTISMMYLVRFLNGFGYGVVSTATNTIVTAYIPARKRGEGINFYGLSTSLAAAIGPFVGTFMLDNL
HIDFRMIIVLCSVLIGCVVVGAFAFPVKNMSLNAEQLAKTKSWTVDSFIEKKALFITAIAFLMGIAYASVLGFQKLYTSE
IHLTTVGAYFFVVYALIITITRPAMGRLMDAKGDKWVLYPSYLFLAMGLFLLGSVSSGGSYLLSGALIGFGYGTFMSCGQ
AASIQGVDEHRFNTAMSTYMIGLDLGLGAGPYLLGLIKDLALGSGVASFRHLFWLAAVIPLICTLLYLLKTKTRQVVS

Specific function: Involved In Sulfonamide (Sulfathiazole) And Bicyclomycin Resistance. Probable Membrane Translocase. [C]

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43505; Mature: 43505

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure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HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]