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The map label for this gene is capA [H]

Identifier: 71910445

GI number: 71910445

Start: 635907

End: 637199

Strand: Direct

Name: capA [H]

Synonym: M5005_Spy_0632

Alternate gene names: 71910445

Gene position: 635907-637199 (Clockwise)

Preceding gene: 71910444

Following gene: 71910446

Centisome position: 34.59

GC content: 37.12

Gene sequence:

>1293_bases
ATGATACTATTGAAAAGCCTCTATAAGGGCTTTTTTGCTGCAATGAAGGAGGAAAATTTTGAGGCAAGATGTTATAATAG
AGAAAAAGGAGGGTGTGTCTTGATTAAAACTATGCAATACAAAAAAACGATGGCAACAGTTGTTGCTCTTATCGTCGCAC
TTTTGCTATTTGGCTTGATTTATGATTTACTTGGGGTTCAAAAAAATGAGCTAGCAGCTCAAAAATCTGCTCAGCCAAAG
GTCAAAACAGCGCGTGTTGTAGCTAATGGCGACATTTTAATTCATGATATTCTCTACATGAGTGCTAGAAAAGCTGACGA
TACCTATGATTTCACTCCTTATTTTGAATATGTTAAGGACTGGATTAGCGGTGCTGACTTAGCTATTGGAGATTATGAAG
GGACCATTAGCCCAGATTATCCCTTAGCAGGCTATCCCTTATTCAATGCTCCAGAAGAGATTGCAGGTGCTCTGAAAAAT
ACTGGCTATGATGTAGTCGATTTAGCCCATAATCATATCTTAGATTCCCAATTAGACGGTGCCCTTAACACTAAAAAGGT
TTTTCATCAATTAGGTATAGACAGTATTGGCATCTATGACAAGGATCGTTCAAAAGAATCCTTCTTAATTAAAAATGTCA
ATGGTATCAAAATTGCAATTTTAGGTTATTCTTATGGTTATAACGGCATGGAGGCCACACTTAGCCAAGAAGACTATGAG
AAACACATGTCTGATTTAGATGAAGCTAAGATAAAAAAAGAACTTCAGCTAGCTGAAAAAAAGGCTGACGTGACCATTGT
TATGCCACAAATGGGAACAGAATATGCCTTAGAACCGACAGCAGAACAAAAAGAACTTTACCACAAAATGATTGATTGGG
GAGCTGACGTCGTCCTAGGAGGCCATCCGCATGTTATTGAACCTTCAGAGACAGTTATAAAAGGTAGGCAAAAGAAATTC
ATTATTTACTCTATGGGAAATTTTATTTCAAATCAGCGGCTTGAAACCGTAGATGATATCTGGACTGAGCGTGGCCTATT
GATGGACCTTACTTTTGAGAAAAAAGATAACAAAACAAAAATTAAAACAGTTGAGGCCCATCCAACCATGGTTTTAGCCA
AAGGTAAAGGCATTGTGGGTAAAGAAGGTTTTGAACTATACAATTATCGAACAATGGTTTTAGAAGATTTTATCAAAGGT
GGAAAATACCACGACAAGATTGATGAGGAAACCAAAGCAAAAGTAGCACTTGCCTATCAGGAAATTAATGATTTAGTTAA
CCTGAAATGGTAA

Upstream 100 bases:

>100_bases
ACAGAAATCACACCTGAAATCGTCAATGATGAGGTTGAAAATCTCATTGATGCTTTACTTTAAAAGAAAAGATCAAGTGT
AAATCTTTTAGTAGTCAGTA

Downstream 100 bases:

>100_bases
CGTTTGGTGGTTTAGCATCTAACGATAAAAAATAGAGATTAAACTTAATTTTTCCTTGATAAAAAGCAGTTATGGTGCTA
AAATAGTAACGTTGACTAAA

Product: capsule biosynthesis protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MILLKSLYKGFFAAMKEENFEARCYNREKGGCVLIKTMQYKKTMATVVALIVALLLFGLIYDLLGVQKNELAAQKSAQPK
VKTARVVANGDILIHDILYMSARKADDTYDFTPYFEYVKDWISGADLAIGDYEGTISPDYPLAGYPLFNAPEEIAGALKN
TGYDVVDLAHNHILDSQLDGALNTKKVFHQLGIDSIGIYDKDRSKESFLIKNVNGIKIAILGYSYGYNGMEATLSQEDYE
KHMSDLDEAKIKKELQLAEKKADVTIVMPQMGTEYALEPTAEQKELYHKMIDWGADVVLGGHPHVIEPSETVIKGRQKKF
IIYSMGNFISNQRLETVDDIWTERGLLMDLTFEKKDNKTKIKTVEAHPTMVLAKGKGIVGKEGFELYNYRTMVLEDFIKG
GKYHDKIDEETKAKVALAYQEINDLVNLKW

Sequences:

>Translated_430_residues
MILLKSLYKGFFAAMKEENFEARCYNREKGGCVLIKTMQYKKTMATVVALIVALLLFGLIYDLLGVQKNELAAQKSAQPK
VKTARVVANGDILIHDILYMSARKADDTYDFTPYFEYVKDWISGADLAIGDYEGTISPDYPLAGYPLFNAPEEIAGALKN
TGYDVVDLAHNHILDSQLDGALNTKKVFHQLGIDSIGIYDKDRSKESFLIKNVNGIKIAILGYSYGYNGMEATLSQEDYE
KHMSDLDEAKIKKELQLAEKKADVTIVMPQMGTEYALEPTAEQKELYHKMIDWGADVVLGGHPHVIEPSETVIKGRQKKF
IIYSMGNFISNQRLETVDDIWTERGLLMDLTFEKKDNKTKIKTVEAHPTMVLAKGKGIVGKEGFELYNYRTMVLEDFIKG
GKYHDKIDEETKAKVALAYQEINDLVNLKW
>Mature_430_residues
MILLKSLYKGFFAAMKEENFEARCYNREKGGCVLIKTMQYKKTMATVVALIVALLLFGLIYDLLGVQKNELAAQKSAQPK
VKTARVVANGDILIHDILYMSARKADDTYDFTPYFEYVKDWISGADLAIGDYEGTISPDYPLAGYPLFNAPEEIAGALKN
TGYDVVDLAHNHILDSQLDGALNTKKVFHQLGIDSIGIYDKDRSKESFLIKNVNGIKIAILGYSYGYNGMEATLSQEDYE
KHMSDLDEAKIKKELQLAEKKADVTIVMPQMGTEYALEPTAEQKELYHKMIDWGADVVLGGHPHVIEPSETVIKGRQKKF
IIYSMGNFISNQRLETVDDIWTERGLLMDLTFEKKDNKTKIKTVEAHPTMVLAKGKGIVGKEGFELYNYRTMVLEDFIKG
GKYHDKIDEETKAKVALAYQEINDLVNLKW

Specific function: Essential for the synthesis of the polyglutamate capsule of B.anthracis which is one of the principal virulence factors during anthrax infection. May form a polyglutamyl synthetase complex together with proteins CapB and CapC [H]

COG id: COG2843

COG function: function code M; Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation)

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CapA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019079 [H]

Pfam domain/function: PF09587 PGA_cap [H]

EC number: NA

Molecular weight: Translated: 48538; Mature: 48538

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILLKSLYKGFFAAMKEENFEARCYNREKGGCVLIKTMQYKKTMATVVALIVALLLFGLI
CCCHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHH
YDLLGVQKNELAAQKSAQPKVKTARVVANGDILIHDILYMSARKADDTYDFTPYFEYVKD
HHHHCCCHHHHHHHHCCCCCCEEEEEEECCCEEEHHHHHHHHCCCCCCCCCCHHHHHHHH
WISGADLAIGDYEGTISPDYPLAGYPLFNAPEEIAGALKNTGYDVVDLAHNHILDSQLDG
HHCCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
ALNTKKVFHQLGIDSIGIYDKDRSKESFLIKNVNGIKIAILGYSYGYNGMEATLSQEDYE
CCHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCEEEEEEEEECCCCCCCHHCCHHHHH
KHMSDLDEAKIKKELQLAEKKADVTIVMPQMGTEYALEPTAEQKELYHKMIDWGADVVLG
HHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEC
GHPHVIEPSETVIKGRQKKFIIYSMGNFISNQRLETVDDIWTERGLLMDLTFEKKDNKTK
CCCCEECCCHHHHCCCCCEEEEEECCCHHCCCCHHHHHHHHHCCCEEEEEEECCCCCCCE
IKTVEAHPTMVLAKGKGIVGKEGFELYNYRTMVLEDFIKGGKYHDKIDEETKAKVALAYQ
EEEEECCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
EINDLVNLKW
HHHHHHCCCC
>Mature Secondary Structure
MILLKSLYKGFFAAMKEENFEARCYNREKGGCVLIKTMQYKKTMATVVALIVALLLFGLI
CCCHHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHH
YDLLGVQKNELAAQKSAQPKVKTARVVANGDILIHDILYMSARKADDTYDFTPYFEYVKD
HHHHCCCHHHHHHHHCCCCCCEEEEEEECCCEEEHHHHHHHHCCCCCCCCCCHHHHHHHH
WISGADLAIGDYEGTISPDYPLAGYPLFNAPEEIAGALKNTGYDVVDLAHNHILDSQLDG
HHCCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
ALNTKKVFHQLGIDSIGIYDKDRSKESFLIKNVNGIKIAILGYSYGYNGMEATLSQEDYE
CCHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCEEEEEEEEECCCCCCCHHCCHHHHH
KHMSDLDEAKIKKELQLAEKKADVTIVMPQMGTEYALEPTAEQKELYHKMIDWGADVVLG
HHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEC
GHPHVIEPSETVIKGRQKKFIIYSMGNFISNQRLETVDDIWTERGLLMDLTFEKKDNKTK
CCCCEECCCHHHHCCCCCEEEEEECCCHHCCCCHHHHHHHHHCCCEEEEEEECCCCCCCE
IKTVEAHPTMVLAKGKGIVGKEGFELYNYRTMVLEDFIKGGKYHDKIDEETKAKVALAYQ
EEEEECCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
EINDLVNLKW
HHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2536679; 10475962; 12004073 [H]