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The map label for this gene is fabG [H]

Identifier: 71910172

GI number: 71910172

Start: 364175

End: 364882

Strand: Direct

Name: fabG [H]

Synonym: M5005_Spy_0359

Alternate gene names: 71910172

Gene position: 364175-364882 (Clockwise)

Preceding gene: 71910171

Following gene: 71910173

Centisome position: 19.81

GC content: 43.93

Gene sequence:

>708_bases
TTGAGGTCAATGACTAAAGTTGTTTTAGTGACGGGCTGTGCTAGTGGGATTGGTTATGCACAGGCCCGCTATTTTTTGAA
ACAAGGGCATCACGTATATGGTGTGGATAAGTCGGATAAACCGGACTTAAGCGGTAACTTTCACTTTATCAAATTGGATT
TATCCTCTGAGTTAGCCCCACTATTTAAAGTGGTCCCCAGTGTTGATATTTTGTGTAATACTGCAGGGATTTTAGATGCC
TACAAGCCACTTTTAGACGTCAGTGATGAAGAAGTGGAACACCTATTTGATATTAATTTTTTTGCGACGGTGAAGTTAAC
ACGTCATTATCTTAGACGTATGGTGGAAAAGCAGTCAGGTGTTATCATCAATATGTGCTCAATAGCAAGTTTTATAGCGG
GTGGCGGTGGTGTTGCCTATACGAGTTCTAAGCATGCCCTTGCGGGATTCACGCGCCAGCTGGCTTTGGATTACGCCAAA
GATCAGATTCACATTTTTGGTATAGCACCAGGTGCTGTCAAAACCGCTATGACGGCTAACGATTTTGAGCCTGGTGGCTT
AGCAGACTGGGTAGCTCGTGAGACGCCAATTGGGCGTTGGACTAAACCAGATGAAGTTGCTGAATTAACGGGATTTCTTG
CTTCAGGAAAAGCGAGATCAATGCAAGGCGAGATTGTCAAAATTGACGGTGGCTGGACTTTGAAATGA

Upstream 100 bases:

>100_bases
CTACAGGCGACGCCTTATTTTCTGATTCATGTTACTGGTGCAGGTGAAGGTTTTTCCATGTGGGCACCGACACCATGTGA
TGTGTTAGCAGAGGATTGGA

Downstream 100 bases:

>100_bases
TCACATGCCTTAGCTTGAGCTGGCGCAGTAAGCCCTAGAGGTGTGATGAGTCAAACAGTCAAAGGAGATGAACAAATGAA
ATTAGCGGTTTTGGGGACAG

Product: 3-ketoacyl-(acyl-carrier-protein) reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MRSMTKVVLVTGCASGIGYAQARYFLKQGHHVYGVDKSDKPDLSGNFHFIKLDLSSELAPLFKVVPSVDILCNTAGILDA
YKPLLDVSDEEVEHLFDINFFATVKLTRHYLRRMVEKQSGVIINMCSIASFIAGGGGVAYTSSKHALAGFTRQLALDYAK
DQIHIFGIAPGAVKTAMTANDFEPGGLADWVARETPIGRWTKPDEVAELTGFLASGKARSMQGEIVKIDGGWTLK

Sequences:

>Translated_235_residues
MRSMTKVVLVTGCASGIGYAQARYFLKQGHHVYGVDKSDKPDLSGNFHFIKLDLSSELAPLFKVVPSVDILCNTAGILDA
YKPLLDVSDEEVEHLFDINFFATVKLTRHYLRRMVEKQSGVIINMCSIASFIAGGGGVAYTSSKHALAGFTRQLALDYAK
DQIHIFGIAPGAVKTAMTANDFEPGGLADWVARETPIGRWTKPDEVAELTGFLASGKARSMQGEIVKIDGGWTLK
>Mature_235_residues
MRSMTKVVLVTGCASGIGYAQARYFLKQGHHVYGVDKSDKPDLSGNFHFIKLDLSSELAPLFKVVPSVDILCNTAGILDA
YKPLLDVSDEEVEHLFDINFFATVKLTRHYLRRMVEKQSGVIINMCSIASFIAGGGGVAYTSSKHALAGFTRQLALDYAK
DQIHIFGIAPGAVKTAMTANDFEPGGLADWVARETPIGRWTKPDEVAELTGFLASGKARSMQGEIVKIDGGWTLK

Specific function: Reduces cyclopentanol to cyclopentanone. The enzyme also shows considerable activity toward cyclohexanol [H]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=242, Percent_Identity=28.9256198347107, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI40254992, Length=243, Percent_Identity=28.3950617283951, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI66933014, Length=176, Percent_Identity=29.5454545454545, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI4758504, Length=253, Percent_Identity=28.0632411067194, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI15277342, Length=257, Percent_Identity=26.4591439688716, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI7705925, Length=236, Percent_Identity=26.271186440678, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI5031737, Length=247, Percent_Identity=27.9352226720648, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI87082100, Length=250, Percent_Identity=31.6, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI87082160, Length=245, Percent_Identity=29.7959183673469, Blast_Score=103, Evalue=7e-24,
Organism=Escherichia coli, GI1790717, Length=241, Percent_Identity=28.2157676348548, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1787335, Length=242, Percent_Identity=30.9917355371901, Blast_Score=101, Evalue=3e-23,
Organism=Escherichia coli, GI1789208, Length=244, Percent_Identity=27.4590163934426, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1788459, Length=248, Percent_Identity=27.4193548387097, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1787820, Length=191, Percent_Identity=31.9371727748691, Blast_Score=81, Evalue=5e-17,
Organism=Escherichia coli, GI1786701, Length=189, Percent_Identity=31.7460317460317, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI2367175, Length=245, Percent_Identity=28.1632653061224, Blast_Score=77, Evalue=8e-16,
Organism=Escherichia coli, GI1786812, Length=242, Percent_Identity=26.8595041322314, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1789378, Length=250, Percent_Identity=26.4, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI2367365, Length=235, Percent_Identity=29.7872340425532, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1787905, Length=246, Percent_Identity=28.8617886178862, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17561402, Length=246, Percent_Identity=29.6747967479675, Blast_Score=97, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI71994604, Length=251, Percent_Identity=31.0756972111554, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71994600, Length=248, Percent_Identity=29.0322580645161, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17538182, Length=251, Percent_Identity=30.6772908366534, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17560676, Length=242, Percent_Identity=26.8595041322314, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI25147288, Length=244, Percent_Identity=25.8196721311475, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17555706, Length=242, Percent_Identity=27.6859504132231, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI115534694, Length=241, Percent_Identity=26.9709543568465, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI193204405, Length=266, Percent_Identity=30.0751879699248, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17560332, Length=266, Percent_Identity=27.0676691729323, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562990, Length=257, Percent_Identity=26.0700389105058, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17562908, Length=261, Percent_Identity=29.5019157088123, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17551412, Length=266, Percent_Identity=26.6917293233083, Blast_Score=67, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6323882, Length=194, Percent_Identity=28.8659793814433, Blast_Score=73, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6322226, Length=216, Percent_Identity=29.1666666666667, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=167, Percent_Identity=31.1377245508982, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24639444, Length=244, Percent_Identity=29.5081967213115, Blast_Score=104, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24643142, Length=239, Percent_Identity=30.9623430962343, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI23397609, Length=246, Percent_Identity=30.0813008130081, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17737361, Length=255, Percent_Identity=30.1960784313725, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21355319, Length=245, Percent_Identity=26.9387755102041, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI21358495, Length=225, Percent_Identity=27.1111111111111, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28571526, Length=250, Percent_Identity=26.8, Blast_Score=64, Evalue=6e-11,
Organism=Drosophila melanogaster, GI281364892, Length=195, Percent_Identity=28.2051282051282, Blast_Score=64, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.163 [H]

Molecular weight: Translated: 25558; Mature: 25558

Theoretical pI: Translated: 7.63; Mature: 7.63

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSMTKVVLVTGCASGIGYAQARYFLKQGHHVYGVDKSDKPDLSGNFHFIKLDLSSELAP
CCCCEEEEEEEECCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCCCEEEEEEECCCHHHH
LFKVVPSVDILCNTAGILDAYKPLLDVSDEEVEHLFDINFFATVKLTRHYLRRMVEKQSG
HHHHHCCHHEEECCHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCC
VIINMCSIASFIAGGGGVAYTSSKHALAGFTRQLALDYAKDQIHIFGIAPGAVKTAMTAN
EEEEHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHCCCC
DFEPGGLADWVARETPIGRWTKPDEVAELTGFLASGKARSMQGEIVKIDGGWTLK
CCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCEECC
>Mature Secondary Structure
MRSMTKVVLVTGCASGIGYAQARYFLKQGHHVYGVDKSDKPDLSGNFHFIKLDLSSELAP
CCCCEEEEEEEECCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCCCEEEEEEECCCHHHH
LFKVVPSVDILCNTAGILDAYKPLLDVSDEEVEHLFDINFFATVKLTRHYLRRMVEKQSG
HHHHHCCHHEEECCHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCC
VIINMCSIASFIAGGGGVAYTSSKHALAGFTRQLALDYAKDQIHIFGIAPGAVKTAMTAN
EEEEHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHCCCC
DFEPGGLADWVARETPIGRWTKPDEVAELTGFLASGKARSMQGEIVKIDGGWTLK
CCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEECCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12406764 [H]