| Definition | Streptococcus pyogenes MGAS5005 chromosome, complete genome. |
|---|---|
| Accession | NC_007297 |
| Length | 1,838,554 |
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The map label for this gene is polA [H]
Identifier: 71909973
GI number: 71909973
Start: 172134
End: 174776
Strand: Direct
Name: polA [H]
Synonym: M5005_Spy_0159
Alternate gene names: 71909973
Gene position: 172134-174776 (Clockwise)
Preceding gene: 71909972
Following gene: 71909974
Centisome position: 9.36
GC content: 42.41
Gene sequence:
>2643_bases ATGGAAAACAAGAATAAATTACTATTAATTGATGGCTCCTCTGTTGCCTTTCGTGCCTTTTTTGCCCTTTACAATCAAAT TGACCGCTTTAAAAATCATAGCGGTCTCCATACCAATGCCATTTATGGCTTTCATTTGATGCTAGACCACATGATGAAAA GAGTCCGGCCTACTCACGTGCTGGTGGCTTTTGATGCGGGCAAAACCACCTTCCGAACAGAAATGTATGCCGATTATAAG GCGGGTCGCGCTAAAACCCCAGATGAATTTCGTGAGCAGTTTTCTTATATTCGTGAGATGTTGACAGCCCTTGGGATTGC TTATTATGAGTTGGAACACTACGAAGCAGACGATATTATCGGGACGCTTGATAAAATGGCGGAGCGCACAGAAGTGCCTT TTGATGTGACCATTGTCAGTGGTGATAAAGATTTGATCCAGTTAACTGACGAAAATACCGTGGTTGAAATTTCTAAAAAA GGGGTTGCCGAATTTGAAGAATTCACACCGGCTTACCTCATGGAAAAAATGGGCTTGACGCCAAACCAGTTTATTGACCT CAAAGCCTTGATGGGAGATAAATCGGATAACATTCCTGGAGTGACAAAAATTGGAGAAAAAACAGGCCTTAAGCTCCTTC ATGAATTTGGTAGTTTGGAAGGCATTTACGAGCATATTGATGGATTCAAGACCTCAAAAATGAAAGAAAACTTGATCAAT GACCGTGACCAAGCTTTCCTATCTAAAACGCTCGCCACTATCAATACAGCATCTCCTATCACAATTGGCTTAGATGATAT TGTCTACAATGGTCCAGATGTTGCTAGCCTCTCTCAATTTTACGATGAGATGGATTTTGTGCAACTCAAGAAAGGTCTTG CTAGCCAGATGCCTCAAGAGCCAGTAGCTGTCATTTCCTATCAAGAAGTGACCAATGTGTCTGCTGATTTGTTTAGCGCA GAAGACATCTTCTACTTTGAAACGCTTCGGGATAATTACCATCGTGAGGCCATCATTGGTTTTGCTTGGGGACATGGTGA GCAGATTTACGCATCCACAGACCTTAGCCTATTAGCGACGGATAGTTTTAAGCAGGTCTTCCAAAAACCCATTGCCACTT ATGATTTTAAACGTAGCAAGGTCTTGTTGAGCCACTTAGGAATTGAGTTGGTAGCACCTAGCTATGATGCTAGACTAGCT AATTACCTTCTGTCAACTGTAGAAGACAATGAGCTTAGCACCATTGCCCGCATTTTTACTGACATCTCTTTGGAAGAAGA CGATACGGTCTATGGTAAAGGTGCTAAACGGGCTGTTCCTGATAAAGACGTCTTACTAGAACACTTAGCTCGTAAGGTCA AAGTATTATTAGATAGCAAGTCTCAAATGCTAGACAAGCTCACTGCCCATGAGCAACTAGACCTCTATCAGAATATTGAA TTGCCTTTGGCTAATGTCCTTGCTAAAATGGAAATTGAAGGGATCAAGGTTAATAGGGCGACTTTGCAAGATATGGCAGA GCAAAACAAGGTCATTATTGAAGCGCTCACCCAAGAGATTTATGATATGGCTGGCCAAGAATTTAACATTAATTCGCCTA AACAGCTGGGCAGTATCTTGTTTGAGAAGATGCAACTACCTCTTGAGATGACTAAGAAGACCAAAACAGGTTATTCTACA GCTGTTGATGTTTTGGAACGTTTGGCACCGATTGCTCCAATTGTGGCTAAAATTTTGGATTACCGCCAGATTACTAAATT GCAATCCACCTATGTGATTGGTTTACAGGATTATATTCTGGCTGATGGCAAGATTCATACCCGCTATGTGCAGGATCTCA CCCAGACAGGGCGTTTGTCTAGTGTGGACCCTAATCTTCAAAACATTCCCATTCGTTTGGAACAGGGGCGTTTGATTCGT AAGGCCTTTACCCCATCTCATGAAGATGCCGTCTTGTTGAGTTCAGATTACTCACAGATTGAATTGCGCGTGCTAGCACA TATTTCAGGGGATGAGCATTTGATTGCTGCCTTTAATGAAGGGGCAGACATTCATACCTCAACGGCTATGCGTGTGTTTG GGATTGACAAGGCAGCAGATGTTACTGCCAATGACCGCCGTAATGCCAAGGCTGTTAACTTTGGAATTGTGTATGGGATT TCTGATTTTGGTTTGTCAAATAACCTTGGTATCACCCGTAAACAGTCCAAGTCTTACATTGATACCTATTTTGAACGCTA TCCTGGGATTAAAGCCTATATGGAAAATGTGGTGCGTGAGGCTAAAGACAAGGGCTATGTAGAGACCCTCTTTAAGCGTC GCCGTGAATTACCGGATATCAACTCTCGTAATTTCAACGTTCGCTCTTTTGCGGAGCGTACAGCCATCAACTCGCCCATT CAAGGAAGCGCAGCTGATATTCTCAAAATCGCTATGATTAATCTGGATAAGGCCTTGCAAGCAGGTGGTTTTAGAGCTAA AATGCTGCTTCAAGTGCATGATGAAATCGTTTTGGAAGTGCCAAATGATGAGTTGACTGCTATAAAAAAACTTGTCAAAG ACACCATGGAAGCTGCTGTTGATTTAGCTGTTCCTTTATGTGTCGATGAAAGTACTGGGCAGAGCTGGTACGAAGCCAAA TAA
Upstream 100 bases:
>100_bases TCTAGGAATTTTCCTAGGCTTTTTAGGTTAACCATTTACTTATCAGCAAAACCAATGGCTTAAAGGAGAAAAGCCCGTCC CTCTGTGTTATAATAAGGCT
Downstream 100 bases:
>100_bases GTTTTCTTACTTGTTATTTCTCATTTTGACAACTTATGTTATAATAAACTAAAAAATTGTAGGAGAAGTCATGAAGCTGC TTTGAGCTTTTTGACGGATA
Product: DNA polymerase I
Products: NA
Alternate protein names: POL I [H]
Number of amino acids: Translated: 880; Mature: 880
Protein sequence:
>880_residues MENKNKLLLIDGSSVAFRAFFALYNQIDRFKNHSGLHTNAIYGFHLMLDHMMKRVRPTHVLVAFDAGKTTFRTEMYADYK AGRAKTPDEFREQFSYIREMLTALGIAYYELEHYEADDIIGTLDKMAERTEVPFDVTIVSGDKDLIQLTDENTVVEISKK GVAEFEEFTPAYLMEKMGLTPNQFIDLKALMGDKSDNIPGVTKIGEKTGLKLLHEFGSLEGIYEHIDGFKTSKMKENLIN DRDQAFLSKTLATINTASPITIGLDDIVYNGPDVASLSQFYDEMDFVQLKKGLASQMPQEPVAVISYQEVTNVSADLFSA EDIFYFETLRDNYHREAIIGFAWGHGEQIYASTDLSLLATDSFKQVFQKPIATYDFKRSKVLLSHLGIELVAPSYDARLA NYLLSTVEDNELSTIARIFTDISLEEDDTVYGKGAKRAVPDKDVLLEHLARKVKVLLDSKSQMLDKLTAHEQLDLYQNIE LPLANVLAKMEIEGIKVNRATLQDMAEQNKVIIEALTQEIYDMAGQEFNINSPKQLGSILFEKMQLPLEMTKKTKTGYST AVDVLERLAPIAPIVAKILDYRQITKLQSTYVIGLQDYILADGKIHTRYVQDLTQTGRLSSVDPNLQNIPIRLEQGRLIR KAFTPSHEDAVLLSSDYSQIELRVLAHISGDEHLIAAFNEGADIHTSTAMRVFGIDKAADVTANDRRNAKAVNFGIVYGI SDFGLSNNLGITRKQSKSYIDTYFERYPGIKAYMENVVREAKDKGYVETLFKRRRELPDINSRNFNVRSFAERTAINSPI QGSAADILKIAMINLDKALQAGGFRAKMLLQVHDEIVLEVPNDELTAIKKLVKDTMEAAVDLAVPLCVDESTGQSWYEAK
Sequences:
>Translated_880_residues MENKNKLLLIDGSSVAFRAFFALYNQIDRFKNHSGLHTNAIYGFHLMLDHMMKRVRPTHVLVAFDAGKTTFRTEMYADYK AGRAKTPDEFREQFSYIREMLTALGIAYYELEHYEADDIIGTLDKMAERTEVPFDVTIVSGDKDLIQLTDENTVVEISKK GVAEFEEFTPAYLMEKMGLTPNQFIDLKALMGDKSDNIPGVTKIGEKTGLKLLHEFGSLEGIYEHIDGFKTSKMKENLIN DRDQAFLSKTLATINTASPITIGLDDIVYNGPDVASLSQFYDEMDFVQLKKGLASQMPQEPVAVISYQEVTNVSADLFSA EDIFYFETLRDNYHREAIIGFAWGHGEQIYASTDLSLLATDSFKQVFQKPIATYDFKRSKVLLSHLGIELVAPSYDARLA NYLLSTVEDNELSTIARIFTDISLEEDDTVYGKGAKRAVPDKDVLLEHLARKVKVLLDSKSQMLDKLTAHEQLDLYQNIE LPLANVLAKMEIEGIKVNRATLQDMAEQNKVIIEALTQEIYDMAGQEFNINSPKQLGSILFEKMQLPLEMTKKTKTGYST AVDVLERLAPIAPIVAKILDYRQITKLQSTYVIGLQDYILADGKIHTRYVQDLTQTGRLSSVDPNLQNIPIRLEQGRLIR KAFTPSHEDAVLLSSDYSQIELRVLAHISGDEHLIAAFNEGADIHTSTAMRVFGIDKAADVTANDRRNAKAVNFGIVYGI SDFGLSNNLGITRKQSKSYIDTYFERYPGIKAYMENVVREAKDKGYVETLFKRRRELPDINSRNFNVRSFAERTAINSPI QGSAADILKIAMINLDKALQAGGFRAKMLLQVHDEIVLEVPNDELTAIKKLVKDTMEAAVDLAVPLCVDESTGQSWYEAK >Mature_880_residues MENKNKLLLIDGSSVAFRAFFALYNQIDRFKNHSGLHTNAIYGFHLMLDHMMKRVRPTHVLVAFDAGKTTFRTEMYADYK AGRAKTPDEFREQFSYIREMLTALGIAYYELEHYEADDIIGTLDKMAERTEVPFDVTIVSGDKDLIQLTDENTVVEISKK GVAEFEEFTPAYLMEKMGLTPNQFIDLKALMGDKSDNIPGVTKIGEKTGLKLLHEFGSLEGIYEHIDGFKTSKMKENLIN DRDQAFLSKTLATINTASPITIGLDDIVYNGPDVASLSQFYDEMDFVQLKKGLASQMPQEPVAVISYQEVTNVSADLFSA EDIFYFETLRDNYHREAIIGFAWGHGEQIYASTDLSLLATDSFKQVFQKPIATYDFKRSKVLLSHLGIELVAPSYDARLA NYLLSTVEDNELSTIARIFTDISLEEDDTVYGKGAKRAVPDKDVLLEHLARKVKVLLDSKSQMLDKLTAHEQLDLYQNIE LPLANVLAKMEIEGIKVNRATLQDMAEQNKVIIEALTQEIYDMAGQEFNINSPKQLGSILFEKMQLPLEMTKKTKTGYST AVDVLERLAPIAPIVAKILDYRQITKLQSTYVIGLQDYILADGKIHTRYVQDLTQTGRLSSVDPNLQNIPIRLEQGRLIR KAFTPSHEDAVLLSSDYSQIELRVLAHISGDEHLIAAFNEGADIHTSTAMRVFGIDKAADVTANDRRNAKAVNFGIVYGI SDFGLSNNLGITRKQSKSYIDTYFERYPGIKAYMENVVREAKDKGYVETLFKRRRELPDINSRNFNVRSFAERTAINSPI QGSAADILKIAMINLDKALQAGGFRAKMLLQVHDEIVLEVPNDELTAIKKLVKDTMEAAVDLAVPLCVDESTGQSWYEAK
Specific function: In addition to polymerase activity, this DNA polymerase exhibits 3' to 5' and 5' to 3' exonuclease activity [H]
COG id: COG0749
COG function: function code L; DNA polymerase I - 3'-5' exonuclease and polymerase domains
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 5'-3' exonuclease domain [H]
Homologues:
Organism=Homo sapiens, GI112420958, Length=478, Percent_Identity=31.5899581589958, Blast_Score=223, Evalue=8e-58, Organism=Homo sapiens, GI139394648, Length=699, Percent_Identity=27.0386266094421, Blast_Score=217, Evalue=4e-56, Organism=Escherichia coli, GI1790294, Length=941, Percent_Identity=37.8320935175345, Blast_Score=532, Evalue=1e-152, Organism=Escherichia coli, GI226510970, Length=211, Percent_Identity=30.8056872037915, Blast_Score=108, Evalue=2e-24, Organism=Caenorhabditis elegans, GI86563272, Length=394, Percent_Identity=29.1878172588832, Blast_Score=169, Evalue=7e-42, Organism=Drosophila melanogaster, GI17933644, Length=439, Percent_Identity=32.3462414578588, Blast_Score=228, Evalue=1e-59,
Paralogues:
None
Copy number: 400 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002562 - InterPro: IPR020046 - InterPro: IPR020045 - InterPro: IPR002421 - InterPro: IPR020047 - InterPro: IPR019760 - InterPro: IPR001098 - InterPro: IPR018320 - InterPro: IPR002298 - InterPro: IPR008918 - InterPro: IPR012337 [H]
Pfam domain/function: PF01367 5_3_exonuc; PF02739 5_3_exonuc_N; PF00476 DNA_pol_A [H]
EC number: =2.7.7.7 [H]
Molecular weight: Translated: 99040; Mature: 99040
Theoretical pI: Translated: 5.09; Mature: 5.09
Prosite motif: PS00447 DNA_POLYMERASE_A
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.1 %Cys (Translated Protein) 2.7 %Met (Translated Protein) 2.8 %Cys+Met (Translated Protein) 0.1 %Cys (Mature Protein) 2.7 %Met (Mature Protein) 2.8 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MENKNKLLLIDGSSVAFRAFFALYNQIDRFKNHSGLHTNAIYGFHLMLDHMMKRVRPTHV CCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCEE LVAFDAGKTTFRTEMYADYKAGRAKTPDEFREQFSYIREMLTALGIAYYELEHYEADDII EEEEECCCCEEEHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH GTLDKMAERTEVPFDVTIVSGDKDLIQLTDENTVVEISKKGVAEFEEFTPAYLMEKMGLT HHHHHHHHHCCCCEEEEEEECCCCEEEECCCCEEEEECCCCHHHHHHCCHHHHHHHHCCC PNQFIDLKALMGDKSDNIPGVTKIGEKTGLKLLHEFGSLEGIYEHIDGFKTSKMKENLIN CCHHEEHHHHHCCCCCCCCCCHHCCHHHHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHC DRDQAFLSKTLATINTASPITIGLDDIVYNGPDVASLSQFYDEMDFVQLKKGLASQMPQE CHHHHHHHHHHHHHCCCCCEEEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC PVAVISYQEVTNVSADLFSAEDIFYFETLRDNYHREAIIGFAWGHGEQIYASTDLSLLAT CEEEEEHHHHHCCHHHHCCCCHHHHHHHHHCCCCCEEEEEEEECCCCEEEEECCCEEEEC DSFKQVFQKPIATYDFKRSKVLLSHLGIELVAPSYDARLANYLLSTVEDNELSTIARIFT HHHHHHHHCCHHHCCCHHHHHHHHHCCEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHH DISLEEDDTVYGKGAKRAVPDKDVLLEHLARKVKVLLDSKSQMLDKLTAHEQLDLYQNIE HCCCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC LPLANVLAKMEIEGIKVNRATLQDMAEQNKVIIEALTQEIYDMAGQEFNINSPKQLGSIL CCHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH FEKMQLPLEMTKKTKTGYSTAVDVLERLAPIAPIVAKILDYRQITKLQSTYVIGLQDYIL HHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEHHHEE ADGKIHTRYVQDLTQTGRLSSVDPNLQNIPIRLEQGRLIRKAFTPSHEDAVLLSSDYSQI ECCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCHHHHHCCCCCCCEEEEECCCCCE ELRVLAHISGDEHLIAAFNEGADIHTSTAMRVFGIDKAADVTANDRRNAKAVNFGIVYGI EEEEEEEECCCCEEEEEECCCCCEECCCEEEEEECCCCCCCCCCCCCCCEEEEEEEEEEE SDFGLSNNLGITRKQSKSYIDTYFERYPGIKAYMENVVREAKDKGYVETLFKRRRELPDI CCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCC NSRNFNVRSFAERTAINSPIQGSAADILKIAMINLDKALQAGGFRAKMLLQVHDEIVLEV CCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCEEEEEC PNDELTAIKKLVKDTMEAAVDLAVPLCVDESTGQSWYEAK CCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCC >Mature Secondary Structure MENKNKLLLIDGSSVAFRAFFALYNQIDRFKNHSGLHTNAIYGFHLMLDHMMKRVRPTHV CCCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCEE LVAFDAGKTTFRTEMYADYKAGRAKTPDEFREQFSYIREMLTALGIAYYELEHYEADDII EEEEECCCCEEEHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH GTLDKMAERTEVPFDVTIVSGDKDLIQLTDENTVVEISKKGVAEFEEFTPAYLMEKMGLT HHHHHHHHHCCCCEEEEEEECCCCEEEECCCCEEEEECCCCHHHHHHCCHHHHHHHHCCC PNQFIDLKALMGDKSDNIPGVTKIGEKTGLKLLHEFGSLEGIYEHIDGFKTSKMKENLIN CCHHEEHHHHHCCCCCCCCCCHHCCHHHHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHC DRDQAFLSKTLATINTASPITIGLDDIVYNGPDVASLSQFYDEMDFVQLKKGLASQMPQE CHHHHHHHHHHHHHCCCCCEEEEHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC PVAVISYQEVTNVSADLFSAEDIFYFETLRDNYHREAIIGFAWGHGEQIYASTDLSLLAT CEEEEEHHHHHCCHHHHCCCCHHHHHHHHHCCCCCEEEEEEEECCCCEEEEECCCEEEEC DSFKQVFQKPIATYDFKRSKVLLSHLGIELVAPSYDARLANYLLSTVEDNELSTIARIFT HHHHHHHHCCHHHCCCHHHHHHHHHCCEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHH DISLEEDDTVYGKGAKRAVPDKDVLLEHLARKVKVLLDSKSQMLDKLTAHEQLDLYQNIE HCCCCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC LPLANVLAKMEIEGIKVNRATLQDMAEQNKVIIEALTQEIYDMAGQEFNINSPKQLGSIL CCHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH FEKMQLPLEMTKKTKTGYSTAVDVLERLAPIAPIVAKILDYRQITKLQSTYVIGLQDYIL HHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEHHHEE ADGKIHTRYVQDLTQTGRLSSVDPNLQNIPIRLEQGRLIRKAFTPSHEDAVLLSSDYSQI ECCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCHHHHHCCCCCCCEEEEECCCCCE ELRVLAHISGDEHLIAAFNEGADIHTSTAMRVFGIDKAADVTANDRRNAKAVNFGIVYGI EEEEEEEECCCCEEEEEECCCCCEECCCEEEEEECCCCCCCCCCCCCCCEEEEEEEEEEE SDFGLSNNLGITRKQSKSYIDTYFERYPGIKAYMENVVREAKDKGYVETLFKRRRELPDI CCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCC NSRNFNVRSFAERTAINSPIQGSAADILKIAMINLDKALQAGGFRAKMLLQVHDEIVLEV CCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCEEEEEC PNDELTAIKKLVKDTMEAAVDLAVPLCVDESTGQSWYEAK CCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11463916 [H]