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The map label for this gene is ispE [H]

Identifier: 71909889

GI number: 71909889

Start: 87235

End: 87393

Strand: Direct

Name: ispE [H]

Synonym: M5005_Spy_0075

Alternate gene names: 71909889

Gene position: 87235-87393 (Clockwise)

Preceding gene: 71909888

Following gene: 71909890

Centisome position: 4.74

GC content: 43.4

Gene sequence:

>159_bases
ATGATGGATATTGGTATACCGATTGGTAGTGATGTGCCTTATTGCTTGCTTTCAGGTTGTGCCCAAGTCACTGGTAAAGG
TGAAGTGGTTTGTCGCATTTTGGGGCTGTTATCGTCTTGGGTGGTTTTGGTTAAACCAGATTTTGGTATCTCGACTTGA

Upstream 100 bases:

>100_bases
AAGCGGATTCCCATGTGTGCTGGTATGGGAGGAGGTTCTAGCGATGCTGTTACTATCAGAGCATTAAATCAGATGGCTCC
TTACTCTTAGCCGAAAAGAT

Downstream 100 bases:

>100_bases
ACATTTTTTCTAGATATTAATTGTAAAATCATTTCAAGAGTGTCTACTACTCATTTGGTTGCGGCGATTGAAGCGGGTAA
CTATAATGATGGGATATTGA

Product: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

Products: NA

Alternate protein names: CMK; 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase [H]

Number of amino acids: Translated: 52; Mature: 52

Protein sequence:

>52_residues
MMDIGIPIGSDVPYCLLSGCAQVTGKGEVVCRILGLLSSWVVLVKPDFGIST

Sequences:

>Translated_52_residues
MMDIGIPIGSDVPYCLLSGCAQVTGKGEVVCRILGLLSSWVVLVKPDFGIST
>Mature_52_residues
MMDIGIPIGSDVPYCLLSGCAQVTGKGEVVCRILGLLSSWVVLVKPDFGIST

Specific function: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol [H]

COG id: COG1947

COG function: function code I; 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. IspE subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR000870
- InterPro:   IPR004424
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.148 [H]

Molecular weight: Translated: 5440; Mature: 5440

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
9.6 %Cys+Met (Translated Protein)
5.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
9.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDIGIPIGSDVPYCLLSGCAQVTGKGEVVCRILGLLSSWVVLVKPDFGIST
CCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCEEEECCCCCCCC
>Mature Secondary Structure
MMDIGIPIGSDVPYCLLSGCAQVTGKGEVVCRILGLLSSWVVLVKPDFGIST
CCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA