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The map label for this gene is hpt

Identifier: 71909826

GI number: 71909826

Start: 12211

End: 12753

Strand: Direct

Name: hpt

Synonym: M5005_Spy_0012

Alternate gene names: 71909826

Gene position: 12211-12753 (Clockwise)

Preceding gene: 71909825

Following gene: 71909827

Centisome position: 0.66

GC content: 30.39

Gene sequence:

>543_bases
ATGCTCGAGCAAGATATTCAAAAAATTCTTTACTCTGAAAATGATATTATTCGGAAAACTAAAAAATTAGGAGAACAATT
AACAAAAGATTATCAAGAAAAAAATCCGCTTATGATTGGTGTATTAAAAGGATCAGTTCCTTTTATGGCAGAACTAATGA
AACACATCGATACTCATGTTGAAATTGATTTTATGGTAGTATCAAGTTATCATGGCGGTACATCTAGCAGTGGTGAAGTT
AAAATTTTAAAAGATGTAGATACCAATATTGAAGGAAGAGATATCATAATTGTTGAAGATATTATTGACACCGGTCGCAC
CTTAAAATATTTACGAGATATGTTTAAGTACCGTAAAGCTAATACTATCAAAATTGCAACACTGTTTGATAAACCTGAAG
GTCGTGTTGTTAAAATTGAAGCAGATTATGTTTGTTACAATATTCCAAATGAATTTATCGTAGGCTTTGGTTTAGATTAC
GCAGAAAATTATCGCAATCTTCCTTACGTAGGTGTATTAAAAGAAGAAGTCTATTCAAAATAG

Upstream 100 bases:

>100_bases
TTTGTATTGATAGGTAATAAAACTTATTTGAGAAAAGCTTGTAAACATGATATAATGTTGGCTAAACTGTATATTGATAA
ATTAGAAAAAGGGTGACAGC

Downstream 100 bases:

>100_bases
AAAAAGGTCAATGTTTACTGTATGAAAAATAATAAAAATAATGGTTTTGTTAAAAATTCTTTTATATATATATTGATGAT
TATTGTTGTCATCACAGGAT

Product: hypoxanthine-guanine phosphoribosyltransferase

Products: NA

Alternate protein names: HGPRT; HGPRTase

Number of amino acids: Translated: 180; Mature: 180

Protein sequence:

>180_residues
MLEQDIQKILYSENDIIRKTKKLGEQLTKDYQEKNPLMIGVLKGSVPFMAELMKHIDTHVEIDFMVVSSYHGGTSSSGEV
KILKDVDTNIEGRDIIIVEDIIDTGRTLKYLRDMFKYRKANTIKIATLFDKPEGRVVKIEADYVCYNIPNEFIVGFGLDY
AENYRNLPYVGVLKEEVYSK

Sequences:

>Translated_180_residues
MLEQDIQKILYSENDIIRKTKKLGEQLTKDYQEKNPLMIGVLKGSVPFMAELMKHIDTHVEIDFMVVSSYHGGTSSSGEV
KILKDVDTNIEGRDIIIVEDIIDTGRTLKYLRDMFKYRKANTIKIATLFDKPEGRVVKIEADYVCYNIPNEFIVGFGLDY
AENYRNLPYVGVLKEEVYSK
>Mature_180_residues
MLEQDIQKILYSENDIIRKTKKLGEQLTKDYQEKNPLMIGVLKGSVPFMAELMKHIDTHVEIDFMVVSSYHGGTSSSGEV
KILKDVDTNIEGRDIIIVEDIIDTGRTLKYLRDMFKYRKANTIKIATLFDKPEGRVVKIEADYVCYNIPNEFIVGFGLDY
AENYRNLPYVGVLKEEVYSK

Specific function: This Enzyme Acts Exclusively On Hypoxanthine; It Does Not Act On Guanine (By Similarity). [C]

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI9910262, Length=182, Percent_Identity=31.8681318681319, Blast_Score=100, Evalue=9e-22,
Organism=Homo sapiens, GI4504483, Length=182, Percent_Identity=30.2197802197802, Blast_Score=99, Evalue=3e-21,
Organism=Escherichia coli, GI87081689, Length=166, Percent_Identity=42.1686746987952, Blast_Score=158, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17510817, Length=178, Percent_Identity=29.7752808988764, Blast_Score=86, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HPRT_STRP3 (Q8P321)

Other databases:

- EMBL:   BA000034
- EMBL:   AE014074
- RefSeq:   NP_663815.1
- RefSeq:   NP_801274.1
- ProteinModelPortal:   Q8P321
- SMR:   Q8P321
- EnsemblBacteria:   EBSTRT00000034925
- EnsemblBacteria:   EBSTRT00000036499
- GeneID:   1008325
- GeneID:   1066447
- GenomeReviews:   AE014074_GR
- GenomeReviews:   BA000034_GR
- KEGG:   spg:SpyM3_0011
- KEGG:   sps:SPs0012
- GeneTree:   EBGT00050000028142
- HOGENOM:   HBG536385
- OMA:   INAHYAD
- ProtClustDB:   CLSK883890
- BioCyc:   SPYO193567:SPS0012-MONOMER
- BioCyc:   SPYO198466:SPYM3_0011-MONOMER
- GO:   GO:0005737
- InterPro:   IPR005904
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01203

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.8

Molecular weight: Translated: 20725; Mature: 20725

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEQDIQKILYSENDIIRKTKKLGEQLTKDYQEKNPLMIGVLKGSVPFMAELMKHIDTHV
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCE
EIDFMVVSSYHGGTSSSGEVKILKDVDTNIEGRDIIIVEDIIDTGRTLKYLRDMFKYRKA
EEEEEEEEECCCCCCCCCCEEEEEECCCCCCCCEEEEEHHHHCCCHHHHHHHHHHHHCCC
NTIKIATLFDKPEGRVVKIEADYVCYNIPNEFIVGFGLDYAENYRNLPYVGVLKEEVYSK
CEEEEEEEEECCCCCEEEEEECEEEEECCCCEEEECCCCHHHHCCCCCEEEHHHHHHCCC
>Mature Secondary Structure
MLEQDIQKILYSENDIIRKTKKLGEQLTKDYQEKNPLMIGVLKGSVPFMAELMKHIDTHV
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCE
EIDFMVVSSYHGGTSSSGEVKILKDVDTNIEGRDIIIVEDIIDTGRTLKYLRDMFKYRKA
EEEEEEEEECCCCCCCCCCEEEEEECCCCCCCCEEEEEHHHHCCCHHHHHHHHHHHHCCC
NTIKIATLFDKPEGRVVKIEADYVCYNIPNEFIVGFGLDYAENYRNLPYVGVLKEEVYSK
CEEEEEEEEECCCCCEEEEEECEEEEECCCCEEEECCCCHHHHCCCCCEEEHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12799345; 12122206