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The map label for this gene is parC [H]

Identifier: 71893388

GI number: 71893388

Start: 33802

End: 36342

Strand: Reverse

Name: parC [H]

Synonym: MHJ_0029

Alternate gene names: 71893388

Gene position: 36342-33802 (Counterclockwise)

Preceding gene: 71893389

Following gene: 71893387

Centisome position: 4.05

GC content: 28.26

Gene sequence:

>2541_bases
ATGAATAAAAGTCTTGATTCAGTAATTAATTCCCAGCTAGAAAAAATTTTAGCAGAAAAATTTATCCGTTATTCAAAATA
TGTAATTCAACAACGGGCAATTCCAGATGTCAAAGACGGCCTAAAACCGGTTCAGAGGCGAATTCTTTATTCAATGTGAC
AGTTGGGGCTAAAAAATAGTAAAAATTACAAAAAATCTGCTAGAGTTGTCGGTGATGTAATCGGAAAATATCATCCTCAT
GGTGATTCTTCAATCTATGATGCTCTTGTCAGACTTGCCCAGGAATGAAAAATGAATTCTCCGCTTGTGGAAATGCACGG
AAATAAAGGGTCAATTGATGACGATCCACCTGCCGCGATGCGATATACAGAGGTTAGATTGGCTGAAATTAGTGAGCATT
TACTTGAATTAATTTCGAAAAATGTTGTAAGTTTTTGCCCTAATTTTGATGATAGTGAAAAAGAACCAACAATTTTACCT
GCAATTTTCCCAAATTTATTAATAAATGGGGCAATTGGAATTGCAAGTGGATTTGCAACTGAAATCCCCCCGCATAATTT
AGGCGAAGTGATCGATGCAGCAATTTTGATGATTAAAAATCCAGGAATTACAATTGAAGAAATTTCTACTATAATTTTAG
GTCCTGATTTTCCAACAGGCGGAATTGTTTATGGAAAATCAGGTATTTTTGATGCTTTCAAAACTGGAAAAGGCAAAATA
AAAATAAGCTCTGATTATAAAATTTTCGAAAAAAATGGGCAAAATGTAATTGAAATTACCTCGATTCCTTTTGGAATTTC
AAAGTCAAGTTTAATCGAAGAAATTGATGACATTCGTTTTGATGTAAAAATTTATGGGATTAAAAATGTAATTGATCAAT
CCGATCAAAATGGAGTTTCCATTTTGATCGAACTCGAACAGGACGGAAATCCTGACCTAATTATTAATTATCTACTACAA
AAAACTCATCTACAAATACATTATTCTTATAATTCCGTTGCAATTTGTGATAATTCACCAAAACTTTTGTCAATCAAGGA
GATGATTTTTTACTATCTTGAGCATTTAAGAAAAATTAAGCTTGCCGAATTTAATTTTGAACTTTACAAAAATAAAAAAA
GATTAGAAATTATTACTGGGTTTCTCAAAGTTGCCGATATTACTGACGAAGTTATTAAGGTTATTCGCGCATCTGATAAT
TCAAAAGTTGGGGTAGTTAATGATTTAATTAAATTTTTTAACTTTAGCCAAACCCAAGCAGAGGCAATTGCATCAATGCG
TTTATACCGTCTTTCGAAAATTGAGCAGCAAATTTACCTTGAAGAATCAAAAAATTTAGAAAAAAACATTACTAAGTTCA
AAAAACTTATTGAAAATAAAGATGAATTTGATAAAAATTTAATAAATATGTTAACTGATTTTAAAAAACATCACGGAAAA
CCGCGAAAAACTAGGATAATTGACTCTGATATTAAGATAAAAATTAACAAAGATGAATTAGTAAAAGATGAGTTTTTTTA
TTTTTGAATAACAAAATCGGGACTTTATAAAAAATTAGATATAAAAAATTCTCTCCCTGATGAAATAGAAAAAACTCAGC
TTCCAAATGGAGATTTTTTCATTTTTCAAGGTATAATTAACCAAAAACAAAAAGCAGTTTTTCTAACTAATAAAGGGGAA
ATAGCAATTTTAGCTGTGCATCAAATTCCTGAATTAAATCTGAAAAACTCACCTAATAATTTAAAAATAACTTTAGGAAT
CCCAAATAATCAACAAATTTTAAGTGTTTTTTTTGCTGATAGTTTTGAAAGTAGTCAATTTTTAATTTTTATTTCCAAAT
TCAGTTTTGCTAAAAGAATGAATTTGGACCAATTAATGAAAATTAAGCAAAAAAAATTACAAAATATCTTTCGATTCAAG
GAAGGTGATGAGCTAATTAGTGTTTTTTTAGAAGAAAAATTAAAAAATATTGTTCTAATTACCACACAAAACCGCGCTCT
AAAAATGAGTATATCAGAAATTCCAATTTATACTAGAAATTCCACAGGTATAAAAATTTTCAGACACCGAAAAAATGAAT
TTATCAGTGCCAGTCAAACTATTGAAAGCTCAGAATCACTTGCAGTTATTGACTTTAATTCACAGTTTGAAAAAATTAAT
ACTGAAAATTTGTTTTTTGGAAATAAAATTCTTACTCCAAAAAACTTTAAAACAAAGCTTGATTTTTCCCTGAGCCCAAA
AAGCATAATAATTTATAACGAAAATTTGCAAATTTTTGAATTTGGAGAAGGATTAAAAATTTTTAGTTTAAATGATTTTA
GAAAGCTAAAAACTAATCAAAAAAAAGATTATAAATTCTTTTTACCAAATATTCAATCGGGAAAAAACCACATAAAAAAC
AACAACTTTTTGCTAAAAAGCAATTCTAATGATCAAAATTCTATATCAAAAAATGACTCAACTTTAGAAGAAAAACTTCG
GAAAGTAAGTGAAATTGATATTGATTTAATTCTGAAAAAAATAGAAAAGGATGACAAATAA

Upstream 100 bases:

>100_bases
TTAATGGGGGAAAGAGCTGATCTAAGAAAGAGCTGAATTGAAAAAAACGTTAATTTTTCCCTTGAAGACAAATTTATTGA
AAATTTAAAGGAAACAATTT

Downstream 100 bases:

>100_bases
TGGATAAAAATTTTTATAAAAATTCATTAAATATTTTTAATTCTAATTTTTCAATGAAAGCAAATTTGTCAGAAAAAGAC
AAATTTTATGCTGATTTTTG

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 846; Mature: 846

Protein sequence:

>846_residues
MNKSLDSVINSQLEKILAEKFIRYSKYVIQQRAIPDVKDGLKPVQRRILYSMWQLGLKNSKNYKKSARVVGDVIGKYHPH
GDSSIYDALVRLAQEWKMNSPLVEMHGNKGSIDDDPPAAMRYTEVRLAEISEHLLELISKNVVSFCPNFDDSEKEPTILP
AIFPNLLINGAIGIASGFATEIPPHNLGEVIDAAILMIKNPGITIEEISTIILGPDFPTGGIVYGKSGIFDAFKTGKGKI
KISSDYKIFEKNGQNVIEITSIPFGISKSSLIEEIDDIRFDVKIYGIKNVIDQSDQNGVSILIELEQDGNPDLIINYLLQ
KTHLQIHYSYNSVAICDNSPKLLSIKEMIFYYLEHLRKIKLAEFNFELYKNKKRLEIITGFLKVADITDEVIKVIRASDN
SKVGVVNDLIKFFNFSQTQAEAIASMRLYRLSKIEQQIYLEESKNLEKNITKFKKLIENKDEFDKNLINMLTDFKKHHGK
PRKTRIIDSDIKIKINKDELVKDEFFYFWITKSGLYKKLDIKNSLPDEIEKTQLPNGDFFIFQGIINQKQKAVFLTNKGE
IAILAVHQIPELNLKNSPNNLKITLGIPNNQQILSVFFADSFESSQFLIFISKFSFAKRMNLDQLMKIKQKKLQNIFRFK
EGDELISVFLEEKLKNIVLITTQNRALKMSISEIPIYTRNSTGIKIFRHRKNEFISASQTIESSESLAVIDFNSQFEKIN
TENLFFGNKILTPKNFKTKLDFSLSPKSIIIYNENLQIFEFGEGLKIFSLNDFRKLKTNQKKDYKFFLPNIQSGKNHIKN
NNFLLKSNSNDQNSISKNDSTLEEKLRKVSEIDIDLILKKIEKDDK

Sequences:

>Translated_846_residues
MNKSLDSVINSQLEKILAEKFIRYSKYVIQQRAIPDVKDGLKPVQRRILYSM*QLGLKNSKNYKKSARVVGDVIGKYHPH
GDSSIYDALVRLAQE*KMNSPLVEMHGNKGSIDDDPPAAMRYTEVRLAEISEHLLELISKNVVSFCPNFDDSEKEPTILP
AIFPNLLINGAIGIASGFATEIPPHNLGEVIDAAILMIKNPGITIEEISTIILGPDFPTGGIVYGKSGIFDAFKTGKGKI
KISSDYKIFEKNGQNVIEITSIPFGISKSSLIEEIDDIRFDVKIYGIKNVIDQSDQNGVSILIELEQDGNPDLIINYLLQ
KTHLQIHYSYNSVAICDNSPKLLSIKEMIFYYLEHLRKIKLAEFNFELYKNKKRLEIITGFLKVADITDEVIKVIRASDN
SKVGVVNDLIKFFNFSQTQAEAIASMRLYRLSKIEQQIYLEESKNLEKNITKFKKLIENKDEFDKNLINMLTDFKKHHGK
PRKTRIIDSDIKIKINKDELVKDEFFYF*ITKSGLYKKLDIKNSLPDEIEKTQLPNGDFFIFQGIINQKQKAVFLTNKGE
IAILAVHQIPELNLKNSPNNLKITLGIPNNQQILSVFFADSFESSQFLIFISKFSFAKRMNLDQLMKIKQKKLQNIFRFK
EGDELISVFLEEKLKNIVLITTQNRALKMSISEIPIYTRNSTGIKIFRHRKNEFISASQTIESSESLAVIDFNSQFEKIN
TENLFFGNKILTPKNFKTKLDFSLSPKSIIIYNENLQIFEFGEGLKIFSLNDFRKLKTNQKKDYKFFLPNIQSGKNHIKN
NNFLLKSNSNDQNSISKNDSTLEEKLRKVSEIDIDLILKKIEKDDK
>Mature_846_residues
MNKSLDSVINSQLEKILAEKFIRYSKYVIQQRAIPDVKDGLKPVQRRILYSM*QLGLKNSKNYKKSARVVGDVIGKYHPH
GDSSIYDALVRLAQE*KMNSPLVEMHGNKGSIDDDPPAAMRYTEVRLAEISEHLLELISKNVVSFCPNFDDSEKEPTILP
AIFPNLLINGAIGIASGFATEIPPHNLGEVIDAAILMIKNPGITIEEISTIILGPDFPTGGIVYGKSGIFDAFKTGKGKI
KISSDYKIFEKNGQNVIEITSIPFGISKSSLIEEIDDIRFDVKIYGIKNVIDQSDQNGVSILIELEQDGNPDLIINYLLQ
KTHLQIHYSYNSVAICDNSPKLLSIKEMIFYYLEHLRKIKLAEFNFELYKNKKRLEIITGFLKVADITDEVIKVIRASDN
SKVGVVNDLIKFFNFSQTQAEAIASMRLYRLSKIEQQIYLEESKNLEKNITKFKKLIENKDEFDKNLINMLTDFKKHHGK
PRKTRIIDSDIKIKINKDELVKDEFFYF*ITKSGLYKKLDIKNSLPDEIEKTQLPNGDFFIFQGIINQKQKAVFLTNKGE
IAILAVHQIPELNLKNSPNNLKITLGIPNNQQILSVFFADSFESSQFLIFISKFSFAKRMNLDQLMKIKQKKLQNIFRFK
EGDELISVFLEEKLKNIVLITTQNRALKMSISEIPIYTRNSTGIKIFRHRKNEFISASQTIESSESLAVIDFNSQFEKIN
TENLFFGNKILTPKNFKTKLDFSLSPKSIIIYNENLQIFEFGEGLKIFSLNDFRKLKTNQKKDYKFFLPNIQSGKNHIKN
NNFLLKSNSNDQNSISKNDSTLEEKLRKVSEIDIDLILKKIEKDDK

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=180, Percent_Identity=30, Blast_Score=77, Evalue=5e-14,
Organism=Homo sapiens, GI19913406, Length=174, Percent_Identity=31.0344827586207, Blast_Score=74, Evalue=5e-13,
Organism=Escherichia coli, GI1788562, Length=715, Percent_Identity=30.7692307692308, Blast_Score=367, Evalue=1e-102,
Organism=Escherichia coli, GI1789396, Length=662, Percent_Identity=30.8157099697885, Blast_Score=299, Evalue=4e-82,
Organism=Caenorhabditis elegans, GI17535065, Length=173, Percent_Identity=31.2138728323699, Blast_Score=76, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI212645845, Length=260, Percent_Identity=31.5384615384615, Blast_Score=76, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6324241, Length=247, Percent_Identity=27.5303643724696, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005741 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 96497; Mature: 96497

Theoretical pI: Translated: 9.64; Mature: 9.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKSLDSVINSQLEKILAEKFIRYSKYVIQQRAIPDVKDGLKPVQRRILYSMQLGLKNSK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCC
NYKKSARVVGDVIGKYHPHGDSSIYDALVRLAQEKMNSPLVEMHGNKGSIDDDPPAAMRY
CHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCHHHH
TEVRLAEISEHLLELISKNVVSFCPNFDDSEKEPTILPAIFPNLLINGAIGIASGFATEI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHCCHHHCCCCCCCC
PPHNLGEVIDAAILMIKNPGITIEEISTIILGPDFPTGGIVYGKSGIFDAFKTGKGKIKI
CCCCHHHHHHHHEEEECCCCCCHHHCCEEEECCCCCCCCEEECCCCCHHHHHCCCCEEEE
SSDYKIFEKNGQNVIEITSIPFGISKSSLIEEIDDIRFDVKIYGIKNVIDQSDQNGVSIL
CCCCEEEECCCCCEEEEEECCCCCCHHHHHHHHHHCEEEEEEEEEHHHHCCCCCCCEEEE
IELEQDGNPDLIINYLLQKTHLQIHYSYNSVAICDNSPKLLSIKEMIFYYLEHLRKIKLA
EEECCCCCCCHHHHHHHHCEEEEEEEECCEEEEECCCCCEEHHHHHHHHHHHHHHHHHHH
EFNFELYKNKKRLEIITGFLKVADITDEVIKVIRASDNSKVGVVNDLIKFFNFSQTQAEA
EECHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHH
IASMRLYRLSKIEQQIYLEESKNLEKNITKFKKLIENKDEFDKNLINMLTDFKKHHGKPR
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCC
KTRIIDSDIKIKINKDELVKDEFFYFITKSGLYKKLDIKNSLPDEIEKTQLPNGDFFIFQ
CEEEECCCEEEEECHHHHHHHHEEEEEECCCCEEEECCCCCCCCHHHHHCCCCCCEEEEE
GIINQKQKAVFLTNKGEIAILAVHQIPELNLKNSPNNLKITLGIPNNQQILSVFFADSFE
CCCCCCCCEEEEECCCCEEEEEEECCCCCCCCCCCCCEEEEEECCCCCCEEEEEEECCCC
SSQFLIFISKFSFAKRMNLDQLMKIKQKKLQNIFRFKEGDELISVFLEEKLKNIVLITTQ
CCEEEEEEECHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCEEEEEEC
NRALKMSISEIPIYTRNSTGIKIFRHRKNEFISASQTIESSESLAVIDFNSQFEKINTEN
CCEEEEEHHHCCEEECCCCCEEEEEECCCHHHHHHHHHCCCCCEEEEECCCHHHHCCCCC
LFFGNKILTPKNFKTKLDFSLSPKSIIIYNENLQIFEFGEGLKIFSLNDFRKLKTNQKKD
EEECCEECCCCCCCEEEEECCCCCEEEEECCCEEEEEECCCEEEEECCHHHHHHCCCCCC
YKFFLPNIQSGKNHIKNNNFLLKSNSNDQNSISKNDSTLEEKLRKVSEIDIDLILKKIEK
EEEECCCCCCCHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHC
DDK
CCC
>Mature Secondary Structure
MNKSLDSVINSQLEKILAEKFIRYSKYVIQQRAIPDVKDGLKPVQRRILYSMQLGLKNSK
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCC
NYKKSARVVGDVIGKYHPHGDSSIYDALVRLAQEKMNSPLVEMHGNKGSIDDDPPAAMRY
CHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCHHHH
TEVRLAEISEHLLELISKNVVSFCPNFDDSEKEPTILPAIFPNLLINGAIGIASGFATEI
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHHHHCCHHHCCCCCCCC
PPHNLGEVIDAAILMIKNPGITIEEISTIILGPDFPTGGIVYGKSGIFDAFKTGKGKIKI
CCCCHHHHHHHHEEEECCCCCCHHHCCEEEECCCCCCCCEEECCCCCHHHHHCCCCEEEE
SSDYKIFEKNGQNVIEITSIPFGISKSSLIEEIDDIRFDVKIYGIKNVIDQSDQNGVSIL
CCCCEEEECCCCCEEEEEECCCCCCHHHHHHHHHHCEEEEEEEEEHHHHCCCCCCCEEEE
IELEQDGNPDLIINYLLQKTHLQIHYSYNSVAICDNSPKLLSIKEMIFYYLEHLRKIKLA
EEECCCCCCCHHHHHHHHCEEEEEEEECCEEEEECCCCCEEHHHHHHHHHHHHHHHHHHH
EFNFELYKNKKRLEIITGFLKVADITDEVIKVIRASDNSKVGVVNDLIKFFNFSQTQAEA
EECHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHH
IASMRLYRLSKIEQQIYLEESKNLEKNITKFKKLIENKDEFDKNLINMLTDFKKHHGKPR
HHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCC
KTRIIDSDIKIKINKDELVKDEFFYFITKSGLYKKLDIKNSLPDEIEKTQLPNGDFFIFQ
CEEEECCCEEEEECHHHHHHHHEEEEEECCCCEEEECCCCCCCCHHHHHCCCCCCEEEEE
GIINQKQKAVFLTNKGEIAILAVHQIPELNLKNSPNNLKITLGIPNNQQILSVFFADSFE
CCCCCCCCEEEEECCCCEEEEEEECCCCCCCCCCCCCEEEEEECCCCCCEEEEEEECCCC
SSQFLIFISKFSFAKRMNLDQLMKIKQKKLQNIFRFKEGDELISVFLEEKLKNIVLITTQ
CCEEEEEEECHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCEEEEEEC
NRALKMSISEIPIYTRNSTGIKIFRHRKNEFISASQTIESSESLAVIDFNSQFEKINTEN
CCEEEEEHHHCCEEECCCCCEEEEEECCCHHHHHHHHHCCCCCEEEEECCCHHHHCCCCC
LFFGNKILTPKNFKTKLDFSLSPKSIIIYNENLQIFEFGEGLKIFSLNDFRKLKTNQKKD
EEECCEECCCCCCCEEEEECCCCCEEEEECCCEEEEEECCCEEEEECCHHHHHHCCCCCC
YKFFLPNIQSGKNHIKNNNFLLKSNSNDQNSISKNDSTLEEKLRKVSEIDIDLILKKIEK
EEEECCCCCCCHHHCCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHC
DDK
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8763932; 11463916; 8891124; 8913454 [H]