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The map label for this gene is ffh [H]

Identifier: 71891959

GI number: 71891959

Start: 225699

End: 227060

Strand: Direct

Name: ffh [H]

Synonym: BPEN_178

Alternate gene names: 71891959

Gene position: 225699-227060 (Clockwise)

Preceding gene: 71891958

Following gene: 71891960

Centisome position: 28.51

GC content: 28.56

Gene sequence:

>1362_bases
ATGTTTAAAAAATTATCCAATAAAATATCACAATCAATACGCAATATTGTTGGTTCTGGGCGTTTAACAGAAAACAATAT
TAAAGAAACTTTAAATATGGTTAAGATTGCCTTACTAGAAGGAGATGTAGCATTACCTGTAGTACACGGTTTTGTTAATA
CAGTTAAAGAAGGTATAATAGGAAGCGATATAAACAAACATTTAACTCCAGGTCAAGAATTTATTAAAATTATGCATGCC
TCTTTAGTAAAAATTATGGGAGAAGGATCCAATGATTTAAATTTAAATACTCAAACACCATCAATAATATTAATAGTAGG
TGCACAAGGTTCTGGAAAAACTACTACTACCGGAAAACTTGCGAAATTTTTGAAAATTAAAAAAAATAAAAAAATATTAG
TAGCGTCAACTGACGTATATAGACCGGCAGGCGTGCAACAATTAAAATCGTTGATAAAATCTGAAGATATAATTTTTTTT
GAAGATTGTAATGTTCGGAATAAGCCCATTGATATACTGAAAGCAGCATCCATTGTATCAAGATCATTATCTTATGATGT
TTTGTTAATAGATACTGCTGGTTGTTTAGAAACAGATGATAGTTTGCTTTCAGAACTAGCTGAAATGCATAGCTGTGTTA
ATCCAATAGAAACTTTATTCATTGTAGATTCTATGATTGGACAAGTAGCTATTAATAGTATAAATGTGTTCAATAAAACT
TTGCCATTAACCGGAATTATTTTAACTAAGTTAGATGGGGATTCACGTGGAGGAGTGGCTTTATCTATTAAATATCTTAC
CGGAAAACCTATAAAATTCATAGGAACAGGAGAAAAAATTGATGCATTAGAGCCTTTCAATTCATACAGAATAGCTGGAC
GCATACTTGGAATGGGCGATATACTTTCGTTAATCGAAGATATTGATAACCAATCAAAATGGGTTAAAGAAAAAAAATAT
ATTAATAAAAACAGTGTAGACTTTAATTTATATGATTTTTTAGGTTATATAAAACAAATACGTAGTATGGGAGGAATTAA
TAAAATAATAGGTAAATTACCTCTTAATTTAGGAGTAAACTTAGATAATATTCAATCATATACACATGACAATACATTCA
TACGTATGGAAGCCATAATTAACTCTATGACTGTGAAAGAACGTATGAATCCAAAAATAATTACTGGATCTAGAAAAAAA
CGTATTGCTAATGGATCTGGAGTACATGTACAAGATGTCACAAAGTTACTAAACACGTTTAATCATATACGTATTACAAT
ACAGAAAATAAATAAAAATGAAATATTTCAAATGATACGTACATTAAAAAACAAAATATCATCTAAATTTACAATTAATT
AA

Upstream 100 bases:

>100_bases
CAATGAAAAACTAAAAATATTAAAGATTGTGTTTATTCTAACTTAGTATGAATAAATAATAAATTTGTTCGTGTGTTTGC
TTTGATTTTGAGCCATAAAG

Downstream 100 bases:

>100_bases
AAAATATTTTATTTTGTTGAAATCGGTAGATATATTCATGCTCTTTATTACGCGAGTCTGTTGGTTTTTTGGTTATTAAT
TGAAGGTTATACACTTATGG

Product: 4.5S-RNP protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 453; Mature: 453

Protein sequence:

>453_residues
MFKKLSNKISQSIRNIVGSGRLTENNIKETLNMVKIALLEGDVALPVVHGFVNTVKEGIIGSDINKHLTPGQEFIKIMHA
SLVKIMGEGSNDLNLNTQTPSIILIVGAQGSGKTTTTGKLAKFLKIKKNKKILVASTDVYRPAGVQQLKSLIKSEDIIFF
EDCNVRNKPIDILKAASIVSRSLSYDVLLIDTAGCLETDDSLLSELAEMHSCVNPIETLFIVDSMIGQVAINSINVFNKT
LPLTGIILTKLDGDSRGGVALSIKYLTGKPIKFIGTGEKIDALEPFNSYRIAGRILGMGDILSLIEDIDNQSKWVKEKKY
INKNSVDFNLYDFLGYIKQIRSMGGINKIIGKLPLNLGVNLDNIQSYTHDNTFIRMEAIINSMTVKERMNPKIITGSRKK
RIANGSGVHVQDVTKLLNTFNHIRITIQKINKNEIFQMIRTLKNKISSKFTIN

Sequences:

>Translated_453_residues
MFKKLSNKISQSIRNIVGSGRLTENNIKETLNMVKIALLEGDVALPVVHGFVNTVKEGIIGSDINKHLTPGQEFIKIMHA
SLVKIMGEGSNDLNLNTQTPSIILIVGAQGSGKTTTTGKLAKFLKIKKNKKILVASTDVYRPAGVQQLKSLIKSEDIIFF
EDCNVRNKPIDILKAASIVSRSLSYDVLLIDTAGCLETDDSLLSELAEMHSCVNPIETLFIVDSMIGQVAINSINVFNKT
LPLTGIILTKLDGDSRGGVALSIKYLTGKPIKFIGTGEKIDALEPFNSYRIAGRILGMGDILSLIEDIDNQSKWVKEKKY
INKNSVDFNLYDFLGYIKQIRSMGGINKIIGKLPLNLGVNLDNIQSYTHDNTFIRMEAIINSMTVKERMNPKIITGSRKK
RIANGSGVHVQDVTKLLNTFNHIRITIQKINKNEIFQMIRTLKNKISSKFTIN
>Mature_453_residues
MFKKLSNKISQSIRNIVGSGRLTENNIKETLNMVKIALLEGDVALPVVHGFVNTVKEGIIGSDINKHLTPGQEFIKIMHA
SLVKIMGEGSNDLNLNTQTPSIILIVGAQGSGKTTTTGKLAKFLKIKKNKKILVASTDVYRPAGVQQLKSLIKSEDIIFF
EDCNVRNKPIDILKAASIVSRSLSYDVLLIDTAGCLETDDSLLSELAEMHSCVNPIETLFIVDSMIGQVAINSINVFNKT
LPLTGIILTKLDGDSRGGVALSIKYLTGKPIKFIGTGEKIDALEPFNSYRIAGRILGMGDILSLIEDIDNQSKWVKEKKY
INKNSVDFNLYDFLGYIKQIRSMGGINKIIGKLPLNLGVNLDNIQSYTHDNTFIRMEAIINSMTVKERMNPKIITGSRKK
RIANGSGVHVQDVTKLLNTFNHIRITIQKINKNEIFQMIRTLKNKISSKFTIN

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=445, Percent_Identity=29.438202247191, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI226371618, Length=369, Percent_Identity=30.0813008130081, Blast_Score=161, Evalue=9e-40,
Organism=Homo sapiens, GI89061728, Length=130, Percent_Identity=35.3846153846154, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI23308697, Length=315, Percent_Identity=23.4920634920635, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI295424842, Length=315, Percent_Identity=23.4920634920635, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI1788963, Length=452, Percent_Identity=51.1061946902655, Blast_Score=473, Evalue=1e-134,
Organism=Escherichia coli, GI1789874, Length=233, Percent_Identity=32.1888412017167, Blast_Score=123, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17539958, Length=435, Percent_Identity=29.4252873563218, Blast_Score=164, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI193206261, Length=304, Percent_Identity=25, Blast_Score=100, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6325345, Length=394, Percent_Identity=28.9340101522843, Blast_Score=148, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6320498, Length=308, Percent_Identity=24.6753246753247, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17647949, Length=435, Percent_Identity=26.4367816091954, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24641198, Length=305, Percent_Identity=23.9344262295082, Blast_Score=96, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 50146; Mature: 50146

Theoretical pI: Translated: 10.22; Mature: 10.22

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKKLSNKISQSIRNIVGSGRLTENNIKETLNMVKIALLEGDVALPVVHGFVNTVKEGII
CCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHCCC
GSDINKHLTPGQEFIKIMHASLVKIMGEGSNDLNLNTQTPSIILIVGAQGSGKTTTTGKL
CCCCHHCCCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCEEEEEEECCCCCCCCCHHHH
AKFLKIKKNKKILVASTDVYRPAGVQQLKSLIKSEDIIFFEDCNVRNKPIDILKAASIVS
HHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHH
RSLSYDVLLIDTAGCLETDDSLLSELAEMHSCVNPIETLFIVDSMIGQVAINSINVFNKT
HCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LPLTGIILTKLDGDSRGGVALSIKYLTGKPIKFIGTGEKIDALEPFNSYRIAGRILGMGD
CCCEEEEEEEECCCCCCCEEEEEEEECCCCEEEEECCCCCCCCCCCCCCCHHHHEECHHH
ILSLIEDIDNQSKWVKEKKYINKNSVDFNLYDFLGYIKQIRSMGGINKIIGKLPLNLGVN
HHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCC
LDNIQSYTHDNTFIRMEAIINSMTVKERMNPKIITGSRKKRIANGSGVHVQDVTKLLNTF
HHHHHHHCCCCCEEEHHHHHHHHHHHHHCCCCEEECCHHHHCCCCCCCCHHHHHHHHHCC
NHIRITIQKINKNEIFQMIRTLKNKISSKFTIN
CEEEEEEEECCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MFKKLSNKISQSIRNIVGSGRLTENNIKETLNMVKIALLEGDVALPVVHGFVNTVKEGII
CCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHCCC
GSDINKHLTPGQEFIKIMHASLVKIMGEGSNDLNLNTQTPSIILIVGAQGSGKTTTTGKL
CCCCHHCCCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCEEEEEEECCCCCCCCCHHHH
AKFLKIKKNKKILVASTDVYRPAGVQQLKSLIKSEDIIFFEDCNVRNKPIDILKAASIVS
HHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHH
RSLSYDVLLIDTAGCLETDDSLLSELAEMHSCVNPIETLFIVDSMIGQVAINSINVFNKT
HCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LPLTGIILTKLDGDSRGGVALSIKYLTGKPIKFIGTGEKIDALEPFNSYRIAGRILGMGD
CCCEEEEEEEECCCCCCCEEEEEEEECCCCEEEEECCCCCCCCCCCCCCCHHHHEECHHH
ILSLIEDIDNQSKWVKEKKYINKNSVDFNLYDFLGYIKQIRSMGGINKIIGKLPLNLGVN
HHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCC
LDNIQSYTHDNTFIRMEAIINSMTVKERMNPKIITGSRKKRIANGSGVHVQDVTKLLNTF
HHHHHHHCCCCCEEEHHHHHHHHHHHHHCCCCEEECCHHHHCCCCCCCCHHHHHHHHHCC
NHIRITIQKINKNEIFQMIRTLKNKISSKFTIN
CEEEEEEEECCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]