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The map label for this gene is groEL [H]

Identifier: 71891860

GI number: 71891860

Start: 85742

End: 87379

Strand: Direct

Name: groEL [H]

Synonym: BPEN_073

Alternate gene names: 71891860

Gene position: 85742-87379 (Clockwise)

Preceding gene: 71891859

Following gene: 71891861

Centisome position: 10.83

GC content: 39.38

Gene sequence:

>1638_bases
ATGGCAGCTAAAGATGTGAAATTTGGTAATGATGCGCGTGTAAAAATGCTGCGCGGAGTGAATGTATTGGCTGACGCAGT
GAAAGTTACTCTTGGTCCTAAAGGTAGGAATGTGGTATTGGATAAATCTTTTGGGGCACCAGTTATAACTAAAGATGGGG
TATCTGTGGCACGAGAAATTGAATTAGAAGACAAATTTGAAAATATGGGCGCTCAAATGGTGAAGGAGGTTGCTTCTAAA
GCAAATGATTCTGCGGGAGATGGAACGACAACTGCAACCGTGTTAGCTCAATCTATAGTTAATGAAGGACTCAAAGCTGT
AGCTGCTGGAATGAATCCCATGGATTTAAAACGTGGAATTGATAAGGCAGTCGTTGCAGCAGTAGAAGAATTGAAAAAAC
TATCTGTGCCTTGTTCAGATCCTAAAGCTATTGCACAAGTAGGTACTATTTCTGCAAATTCTGATGAAACTGTTGGTAAA
CTTATTGCGCAAGCAATGGATAAGGTGGGAAAAGAAGGAGTTATCACTGTAGAAGAAGGGTCGGGTTTACAAGATGAACT
AGATGTAGTTGAAGGTATGCAATTTGACCGTGGTTATCTTTCTCCTTATTTTGTTAATAAACCTGAAAGTGGTACAGTGG
AACTAGAACATCCTTTCATTTTATTAGCAGATAAAAAGATTTCTAACATTAGGGAAATGTTACCTATATTAGAATCTGTT
GCAAAGGCAGGAAAACCATTGCTTATTATTGCTGAAGATGTAGAAGGTGAAGCTTTAGCGACTTTGGTTGTAAATAATAT
GCGTGGTATAGTAAAAGTAACTGCCGTAAAGGCGCCAGGTTTTGGTGATCGACGTAAAGCTATGTTACAAGATATAGCTG
TATTGACTGCGGGTACTGTGATTTCTGAAGAAATTGGATTGGAATTGGAAAAAGCAACATTAGAAGATATGGGGCAAGCT
AAACGTGTAGTTATTACCAAAGATGCTACTACTATTATTGATGGAGTAGGTAATAAGTCCGCTATAAATAGTCGTGTAGC
ACAGATTAATCAACAACGTGATGAAGCTACTTCTGATTATGATCGTGAGAAGCTACAAGAGCGTGTTGCTAAATTAGCTG
GTGGAGTTGCAGTAATTAAAGTTGGAGCAGCTACTGAAGTAGAAATGAAAGAAAAGAAAGCGCGTGTAGAGGATGCGTTA
CATGCAACTCGTGCCGCTGTTGAAGAAGGTGTAGTTGCGGGTGGTGGTGTTGCTTTAATTCGTGTAGCTAACGCTATTAG
AAATCTATGTGGTGATAATGAAGATCAAAATGTTGGTATTAAGGTAGCTCGCCGTGCAATGGAAGCTCCTTTGCGTCAAA
TTATGGCGAACGCTGGAGAAGAACCATCAGTAATCGCTAATAACGTCAGATCAGGAGAAGGTAATACTGGTTATAATGCT
GCTACTGAAAAATATGGTAATATGATCGAGTTGGGGATTTTAGATCCTACTAAAGTAACTCGTTCTGCTTTACAATACGC
AGCATCTATTGCAGGTTTAATGATTACTACTGAATGTATGGTTACTGAATTACCTAAAGAAGATAAACCAGACTTAGGAA
ATGCAGGAGCTGGTGGTAACATGGGGGGCATGATGTAG

Upstream 100 bases:

>100_bases
GAAGTATTAATTATGTCAGAAAGCGATATCCTTGCTATCGTTGAGAAATAATTCGCGACTAACTTATTAATTGAACTTGG
AAATCTTTAAGGAAAATGAA

Downstream 100 bases:

>100_bases
TTGATATCAATTCTACTATAATCACTGAAACAAACAACCCTGATCTAATTAGATCAGGGTTGTTTGTTTCAGTGATTATA
GTAGAATGTTAATTAATTTT

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 545; Mature: 544

Protein sequence:

>545_residues
MAAKDVKFGNDARVKMLRGVNVLADAVKVTLGPKGRNVVLDKSFGAPVITKDGVSVAREIELEDKFENMGAQMVKEVASK
ANDSAGDGTTTATVLAQSIVNEGLKAVAAGMNPMDLKRGIDKAVVAAVEELKKLSVPCSDPKAIAQVGTISANSDETVGK
LIAQAMDKVGKEGVITVEEGSGLQDELDVVEGMQFDRGYLSPYFVNKPESGTVELEHPFILLADKKISNIREMLPILESV
AKAGKPLLIIAEDVEGEALATLVVNNMRGIVKVTAVKAPGFGDRRKAMLQDIAVLTAGTVISEEIGLELEKATLEDMGQA
KRVVITKDATTIIDGVGNKSAINSRVAQINQQRDEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDAL
HATRAAVEEGVVAGGGVALIRVANAIRNLCGDNEDQNVGIKVARRAMEAPLRQIMANAGEEPSVIANNVRSGEGNTGYNA
ATEKYGNMIELGILDPTKVTRSALQYAASIAGLMITTECMVTELPKEDKPDLGNAGAGGNMGGMM

Sequences:

>Translated_545_residues
MAAKDVKFGNDARVKMLRGVNVLADAVKVTLGPKGRNVVLDKSFGAPVITKDGVSVAREIELEDKFENMGAQMVKEVASK
ANDSAGDGTTTATVLAQSIVNEGLKAVAAGMNPMDLKRGIDKAVVAAVEELKKLSVPCSDPKAIAQVGTISANSDETVGK
LIAQAMDKVGKEGVITVEEGSGLQDELDVVEGMQFDRGYLSPYFVNKPESGTVELEHPFILLADKKISNIREMLPILESV
AKAGKPLLIIAEDVEGEALATLVVNNMRGIVKVTAVKAPGFGDRRKAMLQDIAVLTAGTVISEEIGLELEKATLEDMGQA
KRVVITKDATTIIDGVGNKSAINSRVAQINQQRDEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDAL
HATRAAVEEGVVAGGGVALIRVANAIRNLCGDNEDQNVGIKVARRAMEAPLRQIMANAGEEPSVIANNVRSGEGNTGYNA
ATEKYGNMIELGILDPTKVTRSALQYAASIAGLMITTECMVTELPKEDKPDLGNAGAGGNMGGMM
>Mature_544_residues
AAKDVKFGNDARVKMLRGVNVLADAVKVTLGPKGRNVVLDKSFGAPVITKDGVSVAREIELEDKFENMGAQMVKEVASKA
NDSAGDGTTTATVLAQSIVNEGLKAVAAGMNPMDLKRGIDKAVVAAVEELKKLSVPCSDPKAIAQVGTISANSDETVGKL
IAQAMDKVGKEGVITVEEGSGLQDELDVVEGMQFDRGYLSPYFVNKPESGTVELEHPFILLADKKISNIREMLPILESVA
KAGKPLLIIAEDVEGEALATLVVNNMRGIVKVTAVKAPGFGDRRKAMLQDIAVLTAGTVISEEIGLELEKATLEDMGQAK
RVVITKDATTIIDGVGNKSAINSRVAQINQQRDEATSDYDREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALH
ATRAAVEEGVVAGGGVALIRVANAIRNLCGDNEDQNVGIKVARRAMEAPLRQIMANAGEEPSVIANNVRSGEGNTGYNAA
TEKYGNMIELGILDPTKVTRSALQYAASIAGLMITTECMVTELPKEDKPDLGNAGAGGNMGGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=51.8939393939394, Blast_Score=547, Evalue=1e-155,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=51.8939393939394, Blast_Score=547, Evalue=1e-155,
Organism=Escherichia coli, GI1790586, Length=532, Percent_Identity=89.0977443609023, Blast_Score=945, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=51.9848771266541, Blast_Score=549, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=51.6587677725119, Blast_Score=214, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=53.2319391634981, Blast_Score=547, Evalue=1e-156,
Organism=Saccharomyces cerevisiae, GI6322524, Length=162, Percent_Identity=27.1604938271605, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=51.8026565464896, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=51.8026565464896, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI45550936, Length=527, Percent_Identity=50.4743833017078, Blast_Score=530, Evalue=1e-151,
Organism=Drosophila melanogaster, GI45550132, Length=527, Percent_Identity=50.4743833017078, Blast_Score=530, Evalue=1e-151,
Organism=Drosophila melanogaster, GI45550935, Length=527, Percent_Identity=50.4743833017078, Blast_Score=530, Evalue=1e-151,
Organism=Drosophila melanogaster, GI17864606, Length=553, Percent_Identity=41.9529837251356, Blast_Score=443, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24584129, Length=530, Percent_Identity=36.4150943396226, Blast_Score=332, Evalue=5e-91,
Organism=Drosophila melanogaster, GI19921262, Length=530, Percent_Identity=36.4150943396226, Blast_Score=332, Evalue=5e-91,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57462; Mature: 57331

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKDVKFGNDARVKMLRGVNVLADAVKVTLGPKGRNVVLDKSFGAPVITKDGVSVAREI
CCCCCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCCEEECCCHHHHHHC
ELEDKFENMGAQMVKEVASKANDSAGDGTTTATVLAQSIVNEGLKAVAAGMNPMDLKRGI
CHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCH
DKAVVAAVEELKKLSVPCSDPKAIAQVGTISANSDETVGKLIAQAMDKVGKEGVITVEEG
HHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECC
SGLQDELDVVEGMQFDRGYLSPYFVNKPESGTVELEHPFILLADKKISNIREMLPILESV
CCCHHHHHHHHCCCCCCCCCCCEEECCCCCCEEEECCCEEEEECCHHHHHHHHHHHHHHH
AKAGKPLLIIAEDVEGEALATLVVNNMRGIVKVTAVKAPGFGDRRKAMLQDIAVLTAGTV
HHCCCCEEEEEECCCCHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHH
ISEEIGLELEKATLEDMGQAKRVVITKDATTIIDGVGNKSAINSRVAQINQQRDEATSDY
HHHHHCCEEHHHHHHHCCCCCEEEEECCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHH
DREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGVVAGGGVALI
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RVANAIRNLCGDNEDQNVGIKVARRAMEAPLRQIMANAGEEPSVIANNVRSGEGNTGYNA
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCH
ATEKYGNMIELGILDPTKVTRSALQYAASIAGLMITTECMVTELPKEDKPDLGNAGAGGN
HHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
MGGMM
CCCCC
>Mature Secondary Structure 
AAKDVKFGNDARVKMLRGVNVLADAVKVTLGPKGRNVVLDKSFGAPVITKDGVSVAREI
CCCCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCCEEECCCHHHHHHC
ELEDKFENMGAQMVKEVASKANDSAGDGTTTATVLAQSIVNEGLKAVAAGMNPMDLKRGI
CHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCH
DKAVVAAVEELKKLSVPCSDPKAIAQVGTISANSDETVGKLIAQAMDKVGKEGVITVEEG
HHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECC
SGLQDELDVVEGMQFDRGYLSPYFVNKPESGTVELEHPFILLADKKISNIREMLPILESV
CCCHHHHHHHHCCCCCCCCCCCEEECCCCCCEEEECCCEEEEECCHHHHHHHHHHHHHHH
AKAGKPLLIIAEDVEGEALATLVVNNMRGIVKVTAVKAPGFGDRRKAMLQDIAVLTAGTV
HHCCCCEEEEEECCCCHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHH
ISEEIGLELEKATLEDMGQAKRVVITKDATTIIDGVGNKSAINSRVAQINQQRDEATSDY
HHHHHCCEEHHHHHHHCCCCCEEEEECCCHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHH
DREKLQERVAKLAGGVAVIKVGAATEVEMKEKKARVEDALHATRAAVEEGVVAGGGVALI
HHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RVANAIRNLCGDNEDQNVGIKVARRAMEAPLRQIMANAGEEPSVIANNVRSGEGNTGYNA
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCH
ATEKYGNMIELGILDPTKVTRSALQYAASIAGLMITTECMVTELPKEDKPDLGNAGAGGN
HHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
MGGMM
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12886019 [H]