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The map label for this gene is gyrB [H]

Identifier: 71891809

GI number: 71891809

Start: 16575

End: 18989

Strand: Direct

Name: gyrB [H]

Synonym: BPEN_016

Alternate gene names: 71891809

Gene position: 16575-18989 (Clockwise)

Preceding gene: 71891808

Following gene: 71891810

Centisome position: 2.09

GC content: 33.08

Gene sequence:

>2415_bases
ATGTTGAGTGCTTATGATTCTTCAAGTATTAAGATCTTAAAAGGGTTGGATGCAGTACGAAAACGTCCTGGGATGTATAT
TGGAGATACTGACGATGGAACAGGATTGCACCACATGGTATTTGAGGTAGTAGATAATGCTATTGATGAAGCTATTTCGG
GGTATTGTAAAAAAATAGTAGTAATAATTCATCAGGATCATTCAGTATCGGTTCAGGATGATGGACGCGGTATTCCCACG
GGTATACATGAAGAAGAAGGAGTATCTGCGGCTGAAGTTATTATGACTATATTGCACGCTGGAGGTAAATTTGACAATAG
TAATTACAAAGTATCAGGAGGATTACATGGTGTTGGAGTATCAGTAGTAAACGCATTGTCGGAGAGATTAGAGTTAGTAA
TAAAAAGAGATTTTAAAACCTACAAACAGGTTTATTGTGAAGGAAGACCGTTATCACCTTTAGAAATTATAGGCGATAGC
AAACATAGTGGCACCATAGTGCGATTTTGGCCAAGTCTTAAAACGTTTACGGGTAAGACTGAGTTTCAATATGATATTTT
AGCTAGACGTTTTAGAGAATTATCATTTTTAAATTCTGGAATCGTAATTATTTTGCGTGATTGTCGTAACAATAAAGAAG
AAAATTTTCATTGTGCAGGTGGAGTGAAAGCTTTTGTAAAATATTTGAGTGTCAATAAAACACCAATTCATCCTAATATA
TTTTATTACTTAGGTAATAAGGGGGAAATTAGTATAGAGGTTGCATTACAATGGAACGATAACTTTCAAGAAAAGATATA
TTCTTTCACTAACAATATCCCTCAACGGGATGGAGGGACTCATTTAGCAGGATTAAGAGCTGCTATTACAAGAACAATGC
ATTTTTATATGGATAAAGAAGGATATAATAGAAAAGTTAAGGTTGTAACCATAGGAGACGATGCTAGAGAAGGACTTGTT
GCTATATTATCTATTAAAATACCGGATCCAAAATTTTCTTCTCAAACTAAAGATAAATTGGTGTCATCAGAGGTGAAAAC
TGCCGTTGAGTCATTAGTTTATGAAAAGTTAATAGAATTTTTTTTAGAAAACCCAATAGATTCTAAGAATATAATAAATA
AAGTTATAGGGGCTGCTCGTGCTCGAGAAGCAGCGAGAAAAATTAGAGATTTGACACGTCGTAAGGGTTTGTCAGAGTTT
TCAACACTTCCAGGTAAATTAGCTGATTGTCAAGAAAAAAATCCAGTTTATTCTGAACTATATTTGGTAGAAGGAGATTC
TGCTGGTGGTTCTGCAAAACAGGGTAGAAATCGTAAAAATCAAGCAATATTACCGCTTAAAGGGAAAATCTTGAATGTAG
AAAAAGCACGTTTCGATAAAATGTTGACTTCTCAAGAAGTAATGACATTAATTACTGCTCTTGGATGTGGCATTGGTCCA
AATGAATATAATCCAGATAAATTGAGATACCACAATATCATAGTCATGACGGATGCAGATGTTGACGGCGCGCATATTCG
GACTTTGTTATTGACTTTTTTTTATCGCCAGATGCCAGAAATTATTGAAAGAGGACATATATTTATCGCGCAACCTCCTT
TATATAAAGTTCAGAAAGGACGCCAAGAACGATATCTTAAAGATGAAGAGGCAATGAGTAAATATCAAATATCAATAGCA
GTAGGAAGTTCTCGTTTTTACATTAATCCTGATACGCCTCCTTTGAAAGGAAAAATATTGGAACAATTAGTTTTTGAATA
TTATTTAATACAAAAAATTATTGTTCGTATGGAACATCAATTTCCCAAGATACTATTGAATAGATTAATTTATCATTCAG
TTTTATCTGAGGAACAATGTTATTGTTATGAAAGCGTTAAAATATGGATGAGATCTTTAGTTGACTCTTTGAGTAGTTTT
GAAGAATATGGCAGTAGTTACGATTTTGTTATTTTAAAACATCATGAGAATGAATATTTTGAACCCATATTACGGATACG
AACATATGGAATCAACATAGATTATGTATTAAGTATTGATTTTATTAAAAGTCATGAATATAAAAAACTAGTATCTTTTG
GAATGCAAATGAATGAATTGTTTCTTTCAGACGCATATATAGAATATGGGATATATCGTAAACAGGTACATTCTTTTGAT
CAAGCAATGGAATGGCTTATGCAAGAATCTAGAAAAGGATTAGTAATACAACGTTATAAAGGATTAGGTGAAATGAATCC
AGATCAATTATGGGAAACAACTATGAACCCAAAAAACAGATGTATGTTGCGTGTCACAATAAAAGATGCGATAGAAGCTG
ATCATTTATTTACCACACTCATGGGTGATTTAGTTGAACCAAGACGTGCATTTATTGAAAAGAACGCGTTAAAAGCAACA
AATGTAGATTACTAA

Upstream 100 bases:

>100_bases
ATTTGGTAAATGTAATAGTTCGATTGGAGTTATCTTTGGTTATATGTATTTTTGAAAAAATTAGTTCATATTATATGTGT
ATTTATACAGGAATAAGATC

Downstream 100 bases:

>100_bases
ATTATAAAGATAATTTTTTTTATATGAATTTTATATAGAAAAATGGTTTCGTGAGTCAATAGATTGTTATTATGTAATTA
TGTATTGATATTATAGGCGC

Product: DNA gyrase, subunit B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 804; Mature: 804

Protein sequence:

>804_residues
MLSAYDSSSIKILKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEAISGYCKKIVVIIHQDHSVSVQDDGRGIPT
GIHEEEGVSAAEVIMTILHAGGKFDNSNYKVSGGLHGVGVSVVNALSERLELVIKRDFKTYKQVYCEGRPLSPLEIIGDS
KHSGTIVRFWPSLKTFTGKTEFQYDILARRFRELSFLNSGIVIILRDCRNNKEENFHCAGGVKAFVKYLSVNKTPIHPNI
FYYLGNKGEISIEVALQWNDNFQEKIYSFTNNIPQRDGGTHLAGLRAAITRTMHFYMDKEGYNRKVKVVTIGDDAREGLV
AILSIKIPDPKFSSQTKDKLVSSEVKTAVESLVYEKLIEFFLENPIDSKNIINKVIGAARAREAARKIRDLTRRKGLSEF
STLPGKLADCQEKNPVYSELYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLTSQEVMTLITALGCGIGP
NEYNPDKLRYHNIIVMTDADVDGAHIRTLLLTFFYRQMPEIIERGHIFIAQPPLYKVQKGRQERYLKDEEAMSKYQISIA
VGSSRFYINPDTPPLKGKILEQLVFEYYLIQKIIVRMEHQFPKILLNRLIYHSVLSEEQCYCYESVKIWMRSLVDSLSSF
EEYGSSYDFVILKHHENEYFEPILRIRTYGINIDYVLSIDFIKSHEYKKLVSFGMQMNELFLSDAYIEYGIYRKQVHSFD
QAMEWLMQESRKGLVIQRYKGLGEMNPDQLWETTMNPKNRCMLRVTIKDAIEADHLFTTLMGDLVEPRRAFIEKNALKAT
NVDY

Sequences:

>Translated_804_residues
MLSAYDSSSIKILKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEAISGYCKKIVVIIHQDHSVSVQDDGRGIPT
GIHEEEGVSAAEVIMTILHAGGKFDNSNYKVSGGLHGVGVSVVNALSERLELVIKRDFKTYKQVYCEGRPLSPLEIIGDS
KHSGTIVRFWPSLKTFTGKTEFQYDILARRFRELSFLNSGIVIILRDCRNNKEENFHCAGGVKAFVKYLSVNKTPIHPNI
FYYLGNKGEISIEVALQWNDNFQEKIYSFTNNIPQRDGGTHLAGLRAAITRTMHFYMDKEGYNRKVKVVTIGDDAREGLV
AILSIKIPDPKFSSQTKDKLVSSEVKTAVESLVYEKLIEFFLENPIDSKNIINKVIGAARAREAARKIRDLTRRKGLSEF
STLPGKLADCQEKNPVYSELYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLTSQEVMTLITALGCGIGP
NEYNPDKLRYHNIIVMTDADVDGAHIRTLLLTFFYRQMPEIIERGHIFIAQPPLYKVQKGRQERYLKDEEAMSKYQISIA
VGSSRFYINPDTPPLKGKILEQLVFEYYLIQKIIVRMEHQFPKILLNRLIYHSVLSEEQCYCYESVKIWMRSLVDSLSSF
EEYGSSYDFVILKHHENEYFEPILRIRTYGINIDYVLSIDFIKSHEYKKLVSFGMQMNELFLSDAYIEYGIYRKQVHSFD
QAMEWLMQESRKGLVIQRYKGLGEMNPDQLWETTMNPKNRCMLRVTIKDAIEADHLFTTLMGDLVEPRRAFIEKNALKAT
NVDY
>Mature_804_residues
MLSAYDSSSIKILKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEAISGYCKKIVVIIHQDHSVSVQDDGRGIPT
GIHEEEGVSAAEVIMTILHAGGKFDNSNYKVSGGLHGVGVSVVNALSERLELVIKRDFKTYKQVYCEGRPLSPLEIIGDS
KHSGTIVRFWPSLKTFTGKTEFQYDILARRFRELSFLNSGIVIILRDCRNNKEENFHCAGGVKAFVKYLSVNKTPIHPNI
FYYLGNKGEISIEVALQWNDNFQEKIYSFTNNIPQRDGGTHLAGLRAAITRTMHFYMDKEGYNRKVKVVTIGDDAREGLV
AILSIKIPDPKFSSQTKDKLVSSEVKTAVESLVYEKLIEFFLENPIDSKNIINKVIGAARAREAARKIRDLTRRKGLSEF
STLPGKLADCQEKNPVYSELYLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLTSQEVMTLITALGCGIGP
NEYNPDKLRYHNIIVMTDADVDGAHIRTLLLTFFYRQMPEIIERGHIFIAQPPLYKVQKGRQERYLKDEEAMSKYQISIA
VGSSRFYINPDTPPLKGKILEQLVFEYYLIQKIIVRMEHQFPKILLNRLIYHSVLSEEQCYCYESVKIWMRSLVDSLSSF
EEYGSSYDFVILKHHENEYFEPILRIRTYGINIDYVLSIDFIKSHEYKKLVSFGMQMNELFLSDAYIEYGIYRKQVHSFD
QAMEWLMQESRKGLVIQRYKGLGEMNPDQLWETTMNPKNRCMLRVTIKDAIEADHLFTTLMGDLVEPRRAFIEKNALKAT
NVDY

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the type II topoisomerase family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=566, Percent_Identity=25.2650176678445, Blast_Score=117, Evalue=4e-26,
Organism=Homo sapiens, GI19913408, Length=552, Percent_Identity=24.6376811594203, Blast_Score=111, Evalue=3e-24,
Organism=Escherichia coli, GI48994957, Length=803, Percent_Identity=68.3686176836862, Blast_Score=1154, Evalue=0.0,
Organism=Escherichia coli, GI1789408, Length=556, Percent_Identity=39.2086330935252, Blast_Score=383, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17535065, Length=539, Percent_Identity=25.417439703154, Blast_Score=128, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI212645845, Length=515, Percent_Identity=24.8543689320388, Blast_Score=122, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI212645657, Length=171, Percent_Identity=29.8245614035088, Blast_Score=69, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6324241, Length=573, Percent_Identity=26.5270506108202, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI17136538, Length=538, Percent_Identity=26.5799256505576, Blast_Score=121, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011557
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 91821; Mature: 91821

Theoretical pI: Translated: 8.27; Mature: 8.27

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSAYDSSSIKILKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEAISGYCKKIV
CCCCCCCCCHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEE
VIIHQDHSVSVQDDGRGIPTGIHEEEGVSAAEVIMTILHAGGKFDNSNYKVSGGLHGVGV
EEEECCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCHHHH
SVVNALSERLELVIKRDFKTYKQVYCEGRPLSPLEIIGDSKHSGTIVRFWPSLKTFTGKT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCEEEEECCCCHHCCCCC
EFQYDILARRFRELSFLNSGIVIILRDCRNNKEENFHCAGGVKAFVKYLSVNKTPIHPNI
CCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEECCCHHHHHHHHHCCCCCCCCCE
FYYLGNKGEISIEVALQWNDNFQEKIYSFTNNIPQRDGGTHLAGLRAAITRTMHFYMDKE
EEEECCCCEEEEEEEEEECCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHEECCC
GYNRKVKVVTIGDDAREGLVAILSIKIPDPKFSSQTKDKLVSSEVKTAVESLVYEKLIEF
CCCCEEEEEEECCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FLENPIDSKNIINKVIGAARAREAARKIRDLTRRKGLSEFSTLPGKLADCQEKNPVYSEL
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHCCCCCCCCEEEE
YLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLTSQEVMTLITALGCGIGP
EEEECCCCCCCCCCCCCCCCCEEEECCCCEECHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NEYNPDKLRYHNIIVMTDADVDGAHIRTLLLTFFYRQMPEIIERGHIFIAQPPLYKVQKG
CCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHCC
RQERYLKDEEAMSKYQISIAVGSSRFYINPDTPPLKGKILEQLVFEYYLIQKIIVRMEHQ
HHHHCCCCHHHHCEEEEEEEECCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FPKILLNRLIYHSVLSEEQCYCYESVKIWMRSLVDSLSSFEEYGSSYDFVILKHHENEYF
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHH
EPILRIRTYGINIDYVLSIDFIKSHEYKKLVSFGMQMNELFLSDAYIEYGIYRKQVHSFD
HHHHHHHHCCCCEEEEEEEEHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
QAMEWLMQESRKGLVIQRYKGLGEMNPDQLWETTMNPKNRCMLRVTIKDAIEADHLFTTL
HHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHCCCCCCCEEEEEEEHHHHHHHHHHHHH
MGDLVEPRRAFIEKNALKATNVDY
HHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MLSAYDSSSIKILKGLDAVRKRPGMYIGDTDDGTGLHHMVFEVVDNAIDEAISGYCKKIV
CCCCCCCCCHHHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEEE
VIIHQDHSVSVQDDGRGIPTGIHEEEGVSAAEVIMTILHAGGKFDNSNYKVSGGLHGVGV
EEEECCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEECCCCCHHHH
SVVNALSERLELVIKRDFKTYKQVYCEGRPLSPLEIIGDSKHSGTIVRFWPSLKTFTGKT
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCEEEEECCCCHHCCCCC
EFQYDILARRFRELSFLNSGIVIILRDCRNNKEENFHCAGGVKAFVKYLSVNKTPIHPNI
CCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEECCCHHHHHHHHHCCCCCCCCCE
FYYLGNKGEISIEVALQWNDNFQEKIYSFTNNIPQRDGGTHLAGLRAAITRTMHFYMDKE
EEEECCCCEEEEEEEEEECCCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHEECCC
GYNRKVKVVTIGDDAREGLVAILSIKIPDPKFSSQTKDKLVSSEVKTAVESLVYEKLIEF
CCCCEEEEEEECCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FLENPIDSKNIINKVIGAARAREAARKIRDLTRRKGLSEFSTLPGKLADCQEKNPVYSEL
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHCCCCCCCCEEEE
YLVEGDSAGGSAKQGRNRKNQAILPLKGKILNVEKARFDKMLTSQEVMTLITALGCGIGP
EEEECCCCCCCCCCCCCCCCCEEEECCCCEECHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NEYNPDKLRYHNIIVMTDADVDGAHIRTLLLTFFYRQMPEIIERGHIFIAQPPLYKVQKG
CCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHCC
RQERYLKDEEAMSKYQISIAVGSSRFYINPDTPPLKGKILEQLVFEYYLIQKIIVRMEHQ
HHHHCCCCHHHHCEEEEEEEECCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FPKILLNRLIYHSVLSEEQCYCYESVKIWMRSLVDSLSSFEEYGSSYDFVILKHHENEYF
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHH
EPILRIRTYGINIDYVLSIDFIKSHEYKKLVSFGMQMNELFLSDAYIEYGIYRKQVHSFD
HHHHHHHHCCCCEEEEEEEEHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
QAMEWLMQESRKGLVIQRYKGLGEMNPDQLWETTMNPKNRCMLRVTIKDAIEADHLFTTL
HHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHCCCCCCCEEEEEEEHHHHHHHHHHHHH
MGDLVEPRRAFIEKNALKATNVDY
HHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]