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The map label for this gene is ethA [H]

Identifier: 68537158

GI number: 68537158

Start: 2414155

End: 2415798

Strand: Direct

Name: ethA [H]

Synonym: jk2063

Alternate gene names: 68537158

Gene position: 2414155-2415798 (Clockwise)

Preceding gene: 68537156

Following gene: 68537166

Centisome position: 98.04

GC content: 63.44

Gene sequence:

>1644_bases
ATGAACGCAACGCCCGACCACTCCACAGCCGACCAAACCTCCACCGCGACCACTCCCCTGCCCGCCCTCGCAAACGCTAG
CGCCGAACACCCCCTCGACCTCCTTATCGTCGGCGCAGGCCTCTCTGGCATCGACATCGCCTACCACGTCTCCAAAAACT
TCCCTTCCTGGAACTGGGCAGCCGTCGATTCCAACTACGACGTCGGCGGTACCTGGGCCACCTTCCAATACCCCGGAATC
CGTTCAGATTCCGACATGGCCACGTTCTCCCTCCCCTTCAAGAAATGGCCACACAAGGGCACGCTCGGCTCAGGCAAGCA
AATCCGCGACTACTGCCACGAAGCCGCCGCCGAAATCGGCATGCTCGACCGCCTACAACTGTCCACCTGGGTCGAAACCG
TAAACTTCCACACCGACCGCGGACTGTGGGAGGTCACCATGCGCCTCGGTCGCACAGGCCGCGCAAACTCCGAAGGCACC
GACGACTCCGGCCTCGCGCAGCCCACCCTCACCACGTGGACGCGCCGCCTCCACTTCGCCACCGGATACTACCGCCATTC
GGAGGGCTTTACCGCGCAAATTGAGGGCGTCGATACCTTCCAAGGCACCGCCCTACACCCACAACAATGGCCCCGCGACC
TCGACGTGCGCGGCAAGAAGGTTACCGTGATTGGCTCCGGAGCCACGGCAATTACGCTGGTTCCAGCGCTGCATTCGATG
GGCGCGGACGTCACGATGCTGCAGCGAACTCCCACGTACATTGCCCCGCTGCCAGAGACGGACACGATCAGCTCCCTCGT
CGGCCTGGGTCTCAGCACACAGCCGGGCACATTCGGCCATCGTTTGGCCCGCAGCCTGCATATTGGGCGCGACATGGCGC
AGTACCACCTATGCCAGACATTCCCCAGCATCGCGAAGTTGGTGTTCCGGGGCTGGAATCGTCTGTACCTGCCCGCTGAC
GAGGTGCGCCGGAACTTCACTCCCCCGTATGGGCCGTGGGATCAGCGCGTCTGCAAGTCCCCCGGCGGCGACTTCTTTAA
GGCCGTGCGGGGTGGGGCGCGAGTCGTTACCGACCACATCGACCGCGTTGACGCAGGTGGGGTGCGATTGCGCTCCGGCG
GGTACATCGAAGCCGATGTTTTGGTGATCGCCACGGGGCTGCAGCTTTTGGCCTTTGGTGACGCCAACTTCTCCGTGGAC
GGCACTCCCGTACCGACCGAATCTCTGGTGGCTTATCGTGCCATGATGGCCAATCGCCTGCCGAATTTCTCGTACACCAT
TGGGTATTTGAACCAGTCGTGGACGCTGCGCGCGGATATGACTTCGCGCTATTTGGTGCAGCTGTGGAAGGACATGGAAG
CGCGAGGCGAGCAGTGGGCTTGCCCGCTGTTGCCCGCCGGAGAGGCCGCTGACCTGCCGCTTTTGGAGATGTCCAGCGGC
TATATTCAGCGGAGCGTGGCGACTCTGCCGCGTCAGGGTGCTGGGGATCCGTGGCGGATGGAGCAGGATTACATCAAGGA
GCGGCGCACCTACACGGGCGCGGACAACAAGCATGACATGGCATTTGGCGTGGAGGCTTTGGAGGCTGCGGCGCCGCTGG
CGGCTGGAGAGGGCGGCGGCGGTGCCGCTGAGCTGCGACAATAG

Upstream 100 bases:

>100_bases
TATCCCCTCCTCAGACATTGCCTAATTTTCAGTTTGCTAAGTGGAAGCAAAATATTGGTTCTCCCACGAGACGTCGCCAT
CGTGAACTAGCCTGTTCCCC

Downstream 100 bases:

>100_bases
CTCTGGCAGTGGTAGCCCTGGTTGCGGACACCGGCTCCGGCAGTGGTAGCCCTGGTATGCGGACCCTGGCTCCGGCTGTG
GTAGCCCTGGTATGCGGCCA

Product: putative flavin-binding monooxygenase

Products: NA

Alternate protein names: Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 547; Mature: 547

Protein sequence:

>547_residues
MNATPDHSTADQTSTATTPLPALANASAEHPLDLLIVGAGLSGIDIAYHVSKNFPSWNWAAVDSNYDVGGTWATFQYPGI
RSDSDMATFSLPFKKWPHKGTLGSGKQIRDYCHEAAAEIGMLDRLQLSTWVETVNFHTDRGLWEVTMRLGRTGRANSEGT
DDSGLAQPTLTTWTRRLHFATGYYRHSEGFTAQIEGVDTFQGTALHPQQWPRDLDVRGKKVTVIGSGATAITLVPALHSM
GADVTMLQRTPTYIAPLPETDTISSLVGLGLSTQPGTFGHRLARSLHIGRDMAQYHLCQTFPSIAKLVFRGWNRLYLPAD
EVRRNFTPPYGPWDQRVCKSPGGDFFKAVRGGARVVTDHIDRVDAGGVRLRSGGYIEADVLVIATGLQLLAFGDANFSVD
GTPVPTESLVAYRAMMANRLPNFSYTIGYLNQSWTLRADMTSRYLVQLWKDMEARGEQWACPLLPAGEAADLPLLEMSSG
YIQRSVATLPRQGAGDPWRMEQDYIKERRTYTGADNKHDMAFGVEALEAAAPLAAGEGGGGAAELRQ

Sequences:

>Translated_547_residues
MNATPDHSTADQTSTATTPLPALANASAEHPLDLLIVGAGLSGIDIAYHVSKNFPSWNWAAVDSNYDVGGTWATFQYPGI
RSDSDMATFSLPFKKWPHKGTLGSGKQIRDYCHEAAAEIGMLDRLQLSTWVETVNFHTDRGLWEVTMRLGRTGRANSEGT
DDSGLAQPTLTTWTRRLHFATGYYRHSEGFTAQIEGVDTFQGTALHPQQWPRDLDVRGKKVTVIGSGATAITLVPALHSM
GADVTMLQRTPTYIAPLPETDTISSLVGLGLSTQPGTFGHRLARSLHIGRDMAQYHLCQTFPSIAKLVFRGWNRLYLPAD
EVRRNFTPPYGPWDQRVCKSPGGDFFKAVRGGARVVTDHIDRVDAGGVRLRSGGYIEADVLVIATGLQLLAFGDANFSVD
GTPVPTESLVAYRAMMANRLPNFSYTIGYLNQSWTLRADMTSRYLVQLWKDMEARGEQWACPLLPAGEAADLPLLEMSSG
YIQRSVATLPRQGAGDPWRMEQDYIKERRTYTGADNKHDMAFGVEALEAAAPLAAGEGGGGAAELRQ
>Mature_547_residues
MNATPDHSTADQTSTATTPLPALANASAEHPLDLLIVGAGLSGIDIAYHVSKNFPSWNWAAVDSNYDVGGTWATFQYPGI
RSDSDMATFSLPFKKWPHKGTLGSGKQIRDYCHEAAAEIGMLDRLQLSTWVETVNFHTDRGLWEVTMRLGRTGRANSEGT
DDSGLAQPTLTTWTRRLHFATGYYRHSEGFTAQIEGVDTFQGTALHPQQWPRDLDVRGKKVTVIGSGATAITLVPALHSM
GADVTMLQRTPTYIAPLPETDTISSLVGLGLSTQPGTFGHRLARSLHIGRDMAQYHLCQTFPSIAKLVFRGWNRLYLPAD
EVRRNFTPPYGPWDQRVCKSPGGDFFKAVRGGARVVTDHIDRVDAGGVRLRSGGYIEADVLVIATGLQLLAFGDANFSVD
GTPVPTESLVAYRAMMANRLPNFSYTIGYLNQSWTLRADMTSRYLVQLWKDMEARGEQWACPLLPAGEAADLPLLEMSSG
YIQRSVATLPRQGAGDPWRMEQDYIKERRTYTGADNKHDMAFGVEALEAAAPLAAGEGGGGAAELRQ

Specific function: Catalyzes the activation of thiocarbamide-containing drugs such as ethionamide (ETH), isoxyl (ISO) and thiacetazone (TAC) into reactive species [H]

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006076
- InterPro:   IPR020946 [H]

Pfam domain/function: PF01266 DAO; PF00743 FMO-like [H]

EC number: NA

Molecular weight: Translated: 59795; Mature: 59795

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNATPDHSTADQTSTATTPLPALANASAEHPLDLLIVGAGLSGIDIAYHVSKNFPSWNWA
CCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCEEEEEEECCCCCCEEEEEECCCCCCCCEE
AVDSNYDVGGTWATFQYPGIRSDSDMATFSLPFKKWPHKGTLGSGKQIRDYCHEAAAEIG
EECCCCCCCCEEEEEECCCCCCCCCCEEEECCHHHCCCCCCCCCCHHHHHHHHHHHHHHC
MLDRLQLSTWVETVNFHTDRGLWEVTMRLGRTGRANSEGTDDSGLAQPTLTTWTRRLHFA
CHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
TGYYRHSEGFTAQIEGVDTFQGTALHPQQWPRDLDVRGKKVTVIGSGATAITLVPALHSM
CCEEECCCCCEEEECCCCCCCCCCCCHHHCCCCCCCCCCEEEEEECCCCEEHHHHHHHHC
GADVTMLQRTPTYIAPLPETDTISSLVGLGLSTQPGTFGHRLARSLHIGRDMAQYHLCQT
CCCEEEEECCCCEEECCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FPSIAKLVFRGWNRLYLPADEVRRNFTPPYGPWDQRVCKSPGGDFFKAVRGGARVVTDHI
HHHHHHHHHHCCCEEEECHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHCCCCEEEHHHH
DRVDAGGVRLRSGGYIEADVLVIATGLQLLAFGDANFSVDGTPVPTESLVAYRAMMANRL
HCCCCCCEEECCCCCEEEEHEEEECCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCC
PNFSYTIGYLNQSWTLRADMTSRYLVQLWKDMEARGEQWACPLLPAGEAADLPLLEMSSG
CCCEEEEEEECCCEEEEECHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEECCCC
YIQRSVATLPRQGAGDPWRMEQDYIKERRTYTGADNKHDMAFGVEALEAAAPLAAGEGGG
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCC
GAAELRQ
CHHCCCC
>Mature Secondary Structure
MNATPDHSTADQTSTATTPLPALANASAEHPLDLLIVGAGLSGIDIAYHVSKNFPSWNWA
CCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCEEEEEEECCCCCCEEEEEECCCCCCCCEE
AVDSNYDVGGTWATFQYPGIRSDSDMATFSLPFKKWPHKGTLGSGKQIRDYCHEAAAEIG
EECCCCCCCCEEEEEECCCCCCCCCCEEEECCHHHCCCCCCCCCCHHHHHHHHHHHHHHC
MLDRLQLSTWVETVNFHTDRGLWEVTMRLGRTGRANSEGTDDSGLAQPTLTTWTRRLHFA
CHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
TGYYRHSEGFTAQIEGVDTFQGTALHPQQWPRDLDVRGKKVTVIGSGATAITLVPALHSM
CCEEECCCCCEEEECCCCCCCCCCCCHHHCCCCCCCCCCEEEEEECCCCEEHHHHHHHHC
GADVTMLQRTPTYIAPLPETDTISSLVGLGLSTQPGTFGHRLARSLHIGRDMAQYHLCQT
CCCEEEEECCCCEEECCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FPSIAKLVFRGWNRLYLPADEVRRNFTPPYGPWDQRVCKSPGGDFFKAVRGGARVVTDHI
HHHHHHHHHHCCCEEEECHHHHHHCCCCCCCCHHHHHHHCCCHHHHHHHCCCCEEEHHHH
DRVDAGGVRLRSGGYIEADVLVIATGLQLLAFGDANFSVDGTPVPTESLVAYRAMMANRL
HCCCCCCEEECCCCCEEEEHEEEECCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCC
PNFSYTIGYLNQSWTLRADMTSRYLVQLWKDMEARGEQWACPLLPAGEAADLPLLEMSSG
CCCEEEEEEECCCEEEEECHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEECCCC
YIQRSVATLPRQGAGDPWRMEQDYIKERRTYTGADNKHDMAFGVEALEAAAPLAAGEGGG
HHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCC
GAAELRQ
CHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]