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The map label for this gene is hemH [H]

Identifier: 68537091

GI number: 68537091

Start: 2326329

End: 2327603

Strand: Direct

Name: hemH [H]

Synonym: jk1996

Alternate gene names: 68537091

Gene position: 2326329-2327603 (Clockwise)

Preceding gene: 68537090

Following gene: 68537094

Centisome position: 94.47

GC content: 67.45

Gene sequence:

>1275_bases
ATGAGCACGAGCGCTGAAACCCCCGCTATCGCCCCCGACTCCGGCCTCCTACTGCTGTCTTTCGGTGGCCCGGAAAAGGC
CGAGGACGTGGTGCCTTTCCTGGAGAACGTCACGCGCGGCCGCGGCATCCCCCGCGCGCGTTTGGAGAAGGTCGGCGAGC
ACTACTTCGCGCTCGGCGGCCGCTCCCCCATCAACGACCAGAACAAGCAGCTGATCCGCAACATCGAGGCTGAGCTGGCC
CGGCGCGACATCGACCTGCCCGTGTACTTCGGCAACCGCAATTGGGAACCCTATGTGGAGGACGCACTGCAGCAGATGGC
CCGCGATGGCATCCGCCACGTGTACGTCTTCGCCACCAGCGCCTGGGGCGGTTACTCGGGTTGCTCGCAGTATCAGGAGG
ATCTGCGCCGCGCTATCGCCGCCTGCGAGGAGGCCGGCCTGGAGGCCCCGAAGGTGGAGCGCCTGCCGCAGTTCCACCGC
CACCCGACGTTCATCGCGGAGTTCGCTCGAGCAGTGGATGCGGCCCGCGAGCAGCTGCGCGCCGAGCACGGCGAGGAGGT
GGCCGCGCAGGCAGACCTGGTTTTCACCGCACACTCGGTGCCGACGGTGGCGGATAAGGCGGCGGGTCCGCACAAGTTCG
GCGGGAATCTGTACTCCCAGCAGGTGCTGGATGCCTCGCGTTTGATCCAGCAGGCCAGCAGCTTCGCTAACACCCCTGGT
AGTGGCGCGGATTACGGCTGGACTGGCCAGTTGGCTCGCCACGAGAACGTCGGCGGCCGCGGGGATGGCCCCGCGCACAC
GGGTGAAACTGTGGGGGTAGACGTGGGTGCCGGCACCGACCTGGACGTCGAGCTGGTGTGGCAGTCGCGCTCTGGTTCGC
CGCATGTGCCGTGGCTAGAGCCGGACGTGTGCGACCACATCGAGGCGCGCGCGGAGGCCGGCAACACCCGCGCGATTGTG
CTGTGCCCGGTTGGCTTCATCACCGACCACATGGAGGTCAAGTGGGATCTGGATACTGAGGCCCGCGATGCCGCCGCAAA
GGCGGGCATCCCCTTCGTGCGTGTTGCCACCCCGGGTTTGACCGCCGGTTTCGCAGGGATGGTGGTTGATCTTGTTGTTG
GTAGTGACGCCCCCAGTGCCAACCTCTCGGAAGATCAGCAGGCCGCGCGGGATCTGGCGGCGAAGGTGGTCGGCGAGCTG
GCGACGGTTCCGGACTTCGGCCGCACATTCAACGGCTCGCCGTGTGCGCCGGGGTGCTGCGGTAGCGAGGCCTAG

Upstream 100 bases:

>100_bases
AAGAACAACAAGCGCCGCTTCGGCGTAGCCTAACCCGGGTGCAGCCAGGCGCGACGGCGCGTTTAAGGAACAACGGGGGC
GAAGGGCTAGGCTGGTTCAC

Downstream 100 bases:

>100_bases
CGGCTGGGCGAGCTGCCTGGCGGCCCGGCCGCTCGCGCAGGGCGAGGCACCGCTCCCGCCGTTGGGCTCGGGCGCTGCCG
TAGCGGCGCCCGTTAGACCA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MSTSAETPAIAPDSGLLLLSFGGPEKAEDVVPFLENVTRGRGIPRARLEKVGEHYFALGGRSPINDQNKQLIRNIEAELA
RRDIDLPVYFGNRNWEPYVEDALQQMARDGIRHVYVFATSAWGGYSGCSQYQEDLRRAIAACEEAGLEAPKVERLPQFHR
HPTFIAEFARAVDAAREQLRAEHGEEVAAQADLVFTAHSVPTVADKAAGPHKFGGNLYSQQVLDASRLIQQASSFANTPG
SGADYGWTGQLARHENVGGRGDGPAHTGETVGVDVGAGTDLDVELVWQSRSGSPHVPWLEPDVCDHIEARAEAGNTRAIV
LCPVGFITDHMEVKWDLDTEARDAAAKAGIPFVRVATPGLTAGFAGMVVDLVVGSDAPSANLSEDQQAARDLAAKVVGEL
ATVPDFGRTFNGSPCAPGCCGSEA

Sequences:

>Translated_424_residues
MSTSAETPAIAPDSGLLLLSFGGPEKAEDVVPFLENVTRGRGIPRARLEKVGEHYFALGGRSPINDQNKQLIRNIEAELA
RRDIDLPVYFGNRNWEPYVEDALQQMARDGIRHVYVFATSAWGGYSGCSQYQEDLRRAIAACEEAGLEAPKVERLPQFHR
HPTFIAEFARAVDAAREQLRAEHGEEVAAQADLVFTAHSVPTVADKAAGPHKFGGNLYSQQVLDASRLIQQASSFANTPG
SGADYGWTGQLARHENVGGRGDGPAHTGETVGVDVGAGTDLDVELVWQSRSGSPHVPWLEPDVCDHIEARAEAGNTRAIV
LCPVGFITDHMEVKWDLDTEARDAAAKAGIPFVRVATPGLTAGFAGMVVDLVVGSDAPSANLSEDQQAARDLAAKVVGEL
ATVPDFGRTFNGSPCAPGCCGSEA
>Mature_423_residues
STSAETPAIAPDSGLLLLSFGGPEKAEDVVPFLENVTRGRGIPRARLEKVGEHYFALGGRSPINDQNKQLIRNIEAELAR
RDIDLPVYFGNRNWEPYVEDALQQMARDGIRHVYVFATSAWGGYSGCSQYQEDLRRAIAACEEAGLEAPKVERLPQFHRH
PTFIAEFARAVDAAREQLRAEHGEEVAAQADLVFTAHSVPTVADKAAGPHKFGGNLYSQQVLDASRLIQQASSFANTPGS
GADYGWTGQLARHENVGGRGDGPAHTGETVGVDVGAGTDLDVELVWQSRSGSPHVPWLEPDVCDHIEARAEAGNTRAIVL
CPVGFITDHMEVKWDLDTEARDAAAKAGIPFVRVATPGLTAGFAGMVVDLVVGSDAPSANLSEDQQAARDLAAKVVGELA
TVPDFGRTFNGSPCAPGCCGSEA

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 45277; Mature: 45145

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTSAETPAIAPDSGLLLLSFGGPEKAEDVVPFLENVTRGRGIPRARLEKVGEHYFALGG
CCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHEECCC
RSPINDQNKQLIRNIEAELARRDIDLPVYFGNRNWEPYVEDALQQMARDGIRHVYVFATS
CCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEEEC
AWGGYSGCSQYQEDLRRAIAACEEAGLEAPKVERLPQFHRHPTFIAEFARAVDAAREQLR
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHCHHHHCCHHHHHHHHHHHHHHHHHHH
AEHGEEVAAQADLVFTAHSVPTVADKAAGPHKFGGNLYSQQVLDASRLIQQASSFANTPG
HHHCHHHHHHHCEEEEECCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
SGADYGWTGQLARHENVGGRGDGPAHTGETVGVDVGAGTDLDVELVWQSRSGSPHVPWLE
CCCCCCCCCCCHHCCCCCCCCCCCCCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCCCC
PDVCDHIEARAEAGNTRAIVLCPVGFITDHMEVKWDLDTEARDAAAKAGIPFVRVATPGL
CHHHHHHHHHHHCCCCCEEEEECCHHHCCCEEEEECCCCHHHHHHHHCCCCEEEEECCCC
TAGFAGMVVDLVVGSDAPSANLSEDQQAARDLAAKVVGELATVPDFGRTFNGSPCAPGCC
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
GSEA
CCCC
>Mature Secondary Structure 
STSAETPAIAPDSGLLLLSFGGPEKAEDVVPFLENVTRGRGIPRARLEKVGEHYFALGG
CCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHEECCC
RSPINDQNKQLIRNIEAELARRDIDLPVYFGNRNWEPYVEDALQQMARDGIRHVYVFATS
CCCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHCCCCEEEEEEEC
AWGGYSGCSQYQEDLRRAIAACEEAGLEAPKVERLPQFHRHPTFIAEFARAVDAAREQLR
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHCHHHHCCHHHHHHHHHHHHHHHHHHH
AEHGEEVAAQADLVFTAHSVPTVADKAAGPHKFGGNLYSQQVLDASRLIQQASSFANTPG
HHHCHHHHHHHCEEEEECCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCC
SGADYGWTGQLARHENVGGRGDGPAHTGETVGVDVGAGTDLDVELVWQSRSGSPHVPWLE
CCCCCCCCCCCHHCCCCCCCCCCCCCCCCEEEEECCCCCCCEEEEEEECCCCCCCCCCCC
PDVCDHIEARAEAGNTRAIVLCPVGFITDHMEVKWDLDTEARDAAAKAGIPFVRVATPGL
CHHHHHHHHHHHCCCCCEEEEECCHHHCCCEEEEECCCCHHHHHHHHCCCCEEEEECCCC
TAGFAGMVVDLVVGSDAPSANLSEDQQAARDLAAKVVGELATVPDFGRTFNGSPCAPGCC
HHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
GSEA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12840036 [H]