Click here to switch to the map view.

The map label for this gene is gabP [H]

Identifier: 68537036

GI number: 68537036

Start: 2266667

End: 2268130

Strand: Direct

Name: gabP [H]

Synonym: jk1942

Alternate gene names: 68537036

Gene position: 2266667-2268130 (Clockwise)

Preceding gene: 68537035

Following gene: 68537039

Centisome position: 92.05

GC content: 60.79

Gene sequence:

>1464_bases
ATGAGCTCTACCTCCTCCACCTCTCCAGATAGCGCCAGTTCACACGCGAACTCGCGCACCGGCGATGCCAAGCTAGGCAA
CGGACTGAAGGTGCGCCACCTCACGATGATGGGCTTGGGCTCCACAATCGGTGCTGGGCTATTCCTAGGCACCGGCGTGG
GCATCGAGGCCGCCGGCCCTGCCGTGCTGCTGGCTTACATCGTCGCGGGCTTCATCGCCATCCTCGTGATGCAGATGCTG
GGCGAGATGGGCACCGTCATCCCCGCTTCCGGTTCCTTCTCCGAATACGCGGAACACGGCATCGGGCGCTGGGCTGGCTT
CACACAAGGTTGGATTTACTGGCTCGCGACGGTGGCAGTGCTCGGCGCCGAAATTACTGGTGCGGCGAGCTTTATGGGGG
CATGGTTCGGTATTGACGCCTGGATCCCCGCCGCCGCATGCGTGCTTTTCTTCGGAGTGGTGAACCTCCTGCAGATCCGC
GCCTTCGGCGAGTTCGAGTTCTGGTTCGCCTTCATCAAGGTAGCCGTGCTGGTGGCTTTCCTAGTCATCGGCTTCCTGCT
GGTCTTCGGTCTCTTGCCAGGACATACCTTCATCGGCACGGAGGTCTTCACCGCCGATGGCTTTATGCCCAATGGCATGG
GCGGCGTGGCCACGGCGATTCTGGCGGTGGCATTCGCCTTCGGAGGCATTGAGGTCGTAGCCATCGCTTCTGCAGAATCC
GAGAATCCCCAGCGCTCGCTGATCAACGCGGTGCGCTCCACCATCACCCGCATCTCGCTGTTCTACCTGGGTTCGGTGCT
AGTGATTACTTTCCTGCTCCCCCACTCTTCCCTGGGGCAGGCGGAAAGCGCAGCCGATAGTCCCTTCACTCGGGTGCTAA
ATCTGGCTGGCATTCCGGGCGTCGTCGGTTTCATGGAAGCCATTATTGTTTTGGCGCTACTGTCCGCCTTCAACGCGCAG
ATCTATGCCTCCAGCCGCATGATGTTTTCCCTTGCCAAGCGCCACGAGGCGCCCCAGGTTTTCACCCGCGTCGACGGTCG
AGGAGTGCCTGTCGCCGCGATTCTTCTCTCGGTGTGTTTGTCCATCGTGATGGTAGTGCTGAACTACCTGGATACGGGCT
GGTTGCTGACATTCATGCTGAATTCCGCGGGAGCTTCACTGTTGATCGTCTGGACGTTCATCGTCGTCTCCCAGCTGCGC
CTGCGCCGCCGCCTGGAGCAACACGCGGGCGAAGCGTTGCCGATCCGCATGTGGGGTTTCCCCTGGCTGACCATCGCCAC
GTTGGTTGTGTTGGCAGGGCTGGCTTTGCTAATGCTGACGGATCCAGATTCCCGTGTGCAGCTGTTTTCTGCAGCGACGA
TGTTCGCGATCCTGGTGGTGGCCAGCTTCGCCAATTCCGCCATCCGTGGGCTGAGCCCCTTCGAGAAACTGCCTCTGCCG
GAGATTTCCCCACAGTCCCGCTAA

Upstream 100 bases:

>100_bases
GGGCAGGCGGAGTAACCGCGCACGCGAACACCTGCGTTTTATGGCACCGTTTAATGGCACCGGGGCCAAGCCGCACCTTG
GCGCGTCGTATTCTTAGGTA

Downstream 100 bases:

>100_bases
CCGGTTTCTCCTGCTAGCGTCCGCCAGCCACATGCCCTATTGGGCTCGACGCAGGCGCGCTAGCAGCAACCGCTAAACGA
GCAACTCTCGCCTTAGCGAG

Product: gamma-aminobutyrate permease

Products: Proton [Cytoplasm]; 4-aminobutyrate [Cytoplasm] [C]

Alternate protein names: General aromatic amino acid permease [H]

Number of amino acids: Translated: 487; Mature: 486

Protein sequence:

>487_residues
MSSTSSTSPDSASSHANSRTGDAKLGNGLKVRHLTMMGLGSTIGAGLFLGTGVGIEAAGPAVLLAYIVAGFIAILVMQML
GEMGTVIPASGSFSEYAEHGIGRWAGFTQGWIYWLATVAVLGAEITGAASFMGAWFGIDAWIPAAACVLFFGVVNLLQIR
AFGEFEFWFAFIKVAVLVAFLVIGFLLVFGLLPGHTFIGTEVFTADGFMPNGMGGVATAILAVAFAFGGIEVVAIASAES
ENPQRSLINAVRSTITRISLFYLGSVLVITFLLPHSSLGQAESAADSPFTRVLNLAGIPGVVGFMEAIIVLALLSAFNAQ
IYASSRMMFSLAKRHEAPQVFTRVDGRGVPVAAILLSVCLSIVMVVLNYLDTGWLLTFMLNSAGASLLIVWTFIVVSQLR
LRRRLEQHAGEALPIRMWGFPWLTIATLVVLAGLALLMLTDPDSRVQLFSAATMFAILVVASFANSAIRGLSPFEKLPLP
EISPQSR

Sequences:

>Translated_487_residues
MSSTSSTSPDSASSHANSRTGDAKLGNGLKVRHLTMMGLGSTIGAGLFLGTGVGIEAAGPAVLLAYIVAGFIAILVMQML
GEMGTVIPASGSFSEYAEHGIGRWAGFTQGWIYWLATVAVLGAEITGAASFMGAWFGIDAWIPAAACVLFFGVVNLLQIR
AFGEFEFWFAFIKVAVLVAFLVIGFLLVFGLLPGHTFIGTEVFTADGFMPNGMGGVATAILAVAFAFGGIEVVAIASAES
ENPQRSLINAVRSTITRISLFYLGSVLVITFLLPHSSLGQAESAADSPFTRVLNLAGIPGVVGFMEAIIVLALLSAFNAQ
IYASSRMMFSLAKRHEAPQVFTRVDGRGVPVAAILLSVCLSIVMVVLNYLDTGWLLTFMLNSAGASLLIVWTFIVVSQLR
LRRRLEQHAGEALPIRMWGFPWLTIATLVVLAGLALLMLTDPDSRVQLFSAATMFAILVVASFANSAIRGLSPFEKLPLP
EISPQSR
>Mature_486_residues
SSTSSTSPDSASSHANSRTGDAKLGNGLKVRHLTMMGLGSTIGAGLFLGTGVGIEAAGPAVLLAYIVAGFIAILVMQMLG
EMGTVIPASGSFSEYAEHGIGRWAGFTQGWIYWLATVAVLGAEITGAASFMGAWFGIDAWIPAAACVLFFGVVNLLQIRA
FGEFEFWFAFIKVAVLVAFLVIGFLLVFGLLPGHTFIGTEVFTADGFMPNGMGGVATAILAVAFAFGGIEVVAIASAESE
NPQRSLINAVRSTITRISLFYLGSVLVITFLLPHSSLGQAESAADSPFTRVLNLAGIPGVVGFMEAIIVLALLSAFNAQI
YASSRMMFSLAKRHEAPQVFTRVDGRGVPVAAILLSVCLSIVMVVLNYLDTGWLLTFMLNSAGASLLIVWTFIVVSQLRL
RRRLEQHAGEALPIRMWGFPWLTIATLVVLAGLALLMLTDPDSRVQLFSAATMFAILVVASFANSAIRGLSPFEKLPLPE
ISPQSR

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI258645169, Length=389, Percent_Identity=23.1362467866324, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI110347453, Length=366, Percent_Identity=27.8688524590164, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI114326544, Length=450, Percent_Identity=23.7777777777778, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI114326550, Length=450, Percent_Identity=23.7777777777778, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI115648063, Length=425, Percent_Identity=24.4705882352941, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI115648022, Length=425, Percent_Identity=24.4705882352941, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI258614003, Length=390, Percent_Identity=21.7948717948718, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI258614005, Length=390, Percent_Identity=21.7948717948718, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI33286428, Length=426, Percent_Identity=24.1784037558685, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI181337167, Length=276, Percent_Identity=25, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI1789017, Length=429, Percent_Identity=39.6270396270396, Blast_Score=313, Evalue=2e-86,
Organism=Escherichia coli, GI1786302, Length=428, Percent_Identity=35.2803738317757, Blast_Score=265, Evalue=6e-72,
Organism=Escherichia coli, GI1786789, Length=447, Percent_Identity=35.7941834451902, Blast_Score=264, Evalue=1e-71,
Organism=Escherichia coli, GI87081708, Length=455, Percent_Identity=34.2857142857143, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI48994972, Length=433, Percent_Identity=34.4110854503464, Blast_Score=235, Evalue=6e-63,
Organism=Escherichia coli, GI87081915, Length=466, Percent_Identity=33.2618025751073, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI1786602, Length=441, Percent_Identity=34.0136054421769, Blast_Score=231, Evalue=8e-62,
Organism=Escherichia coli, GI1788480, Length=419, Percent_Identity=33.1742243436754, Blast_Score=228, Evalue=6e-61,
Organism=Escherichia coli, GI1790653, Length=443, Percent_Identity=30.2483069977427, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI87082250, Length=363, Percent_Identity=23.4159779614325, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17532491, Length=393, Percent_Identity=23.6641221374046, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17540018, Length=399, Percent_Identity=24.3107769423559, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=433, Percent_Identity=30.4849884526559, Blast_Score=187, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6322892, Length=464, Percent_Identity=31.4655172413793, Blast_Score=178, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6324061, Length=441, Percent_Identity=29.0249433106576, Blast_Score=176, Evalue=6e-45,
Organism=Saccharomyces cerevisiae, GI6319824, Length=433, Percent_Identity=29.0993071593533, Blast_Score=173, Evalue=7e-44,
Organism=Saccharomyces cerevisiae, GI6324553, Length=400, Percent_Identity=30.75, Blast_Score=172, Evalue=9e-44,
Organism=Saccharomyces cerevisiae, GI6324924, Length=446, Percent_Identity=29.1479820627803, Blast_Score=171, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6321053, Length=438, Percent_Identity=28.0821917808219, Blast_Score=169, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6324990, Length=369, Percent_Identity=30.6233062330623, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6319542, Length=404, Percent_Identity=28.4653465346535, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6320717, Length=410, Percent_Identity=29.0243902439024, Blast_Score=167, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6319543, Length=407, Percent_Identity=28.2555282555283, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6320251, Length=402, Percent_Identity=26.6169154228856, Blast_Score=162, Evalue=8e-41,
Organism=Saccharomyces cerevisiae, GI6321629, Length=430, Percent_Identity=28.3720930232558, Blast_Score=161, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6324059, Length=460, Percent_Identity=27.8260869565217, Blast_Score=152, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6319608, Length=433, Percent_Identity=24.4803695150115, Blast_Score=141, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6324981, Length=389, Percent_Identity=31.1053984575836, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6322967, Length=387, Percent_Identity=30.4909560723514, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6320364, Length=509, Percent_Identity=22.5933202357564, Blast_Score=103, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24667468, Length=421, Percent_Identity=26.8408551068884, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24666159, Length=308, Percent_Identity=25.3246753246753, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221512776, Length=308, Percent_Identity=25.3246753246753, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24668806, Length=416, Percent_Identity=23.7980769230769, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21356285, Length=416, Percent_Identity=23.7980769230769, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24668802, Length=416, Percent_Identity=23.7980769230769, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51595; Mature: 51464

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTSSTSPDSASSHANSRTGDAKLGNGLKVRHLTMMGLGSTIGAGLFLGTGVGIEAAGP
CCCCCCCCCCCCHHCCCCCCCCCCCCCCCEEEEEHHHHCCHHHHHHHHHHCCCCCCCCCH
AVLLAYIVAGFIAILVMQMLGEMGTVIPASGSFSEYAEHGIGRWAGFTQGWIYWLATVAV
HHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHCCCHHHCCHHHHHHHHHHHHHH
LGAEITGAASFMGAWFGIDAWIPAAACVLFFGVVNLLQIRAFGEFEFWFAFIKVAVLVAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LVIGFLLVFGLLPGHTFIGTEVFTADGFMPNGMGGVATAILAVAFAFGGIEVVAIASAES
HHHHHHHHHHHCCCCCEECCEEEECCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEECCCC
ENPQRSLINAVRSTITRISLFYLGSVLVITFLLPHSSLGQAESAADSPFTRVLNLAGIPG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCHHHHHHHHCCCCH
VVGFMEAIIVLALLSAFNAQIYASSRMMFSLAKRHEAPQVFTRVDGRGVPVAAILLSVCL
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCHHHHHHHHHH
SIVMVVLNYLDTGWLLTFMLNSAGASLLIVWTFIVVSQLRLRRRLEQHAGEALPIRMWGF
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCC
PWLTIATLVVLAGLALLMLTDPDSRVQLFSAATMFAILVVASFANSAIRGLSPFEKLPLP
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCC
EISPQSR
CCCCCCC
>Mature Secondary Structure 
SSTSSTSPDSASSHANSRTGDAKLGNGLKVRHLTMMGLGSTIGAGLFLGTGVGIEAAGP
CCCCCCCCCCCHHCCCCCCCCCCCCCCCEEEEEHHHHCCHHHHHHHHHHCCCCCCCCCH
AVLLAYIVAGFIAILVMQMLGEMGTVIPASGSFSEYAEHGIGRWAGFTQGWIYWLATVAV
HHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCHHHHHHCCCHHHCCHHHHHHHHHHHHHH
LGAEITGAASFMGAWFGIDAWIPAAACVLFFGVVNLLQIRAFGEFEFWFAFIKVAVLVAF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LVIGFLLVFGLLPGHTFIGTEVFTADGFMPNGMGGVATAILAVAFAFGGIEVVAIASAES
HHHHHHHHHHHCCCCCEECCEEEECCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEECCCC
ENPQRSLINAVRSTITRISLFYLGSVLVITFLLPHSSLGQAESAADSPFTRVLNLAGIPG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCHHHHHHHHCCCCH
VVGFMEAIIVLALLSAFNAQIYASSRMMFSLAKRHEAPQVFTRVDGRGVPVAAILLSVCL
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCHHHHHHHHHH
SIVMVVLNYLDTGWLLTFMLNSAGASLLIVWTFIVVSQLRLRRRLEQHAGEALPIRMWGF
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCC
PWLTIATLVVLAGLALLMLTDPDSRVQLFSAATMFAILVVASFANSAIRGLSPFEKLPLP
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCC
EISPQSR
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; 4-aminobutyrate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + 4-aminobutyrate [Periplasm] = Proton [Cytoplasm] + 4-aminobutyrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7592354; 12948626 [H]