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The map label for this gene is entA [H]

Identifier: 68536909

GI number: 68536909

Start: 2122843

End: 2123604

Strand: Direct

Name: entA [H]

Synonym: jk1819

Alternate gene names: 68536909

Gene position: 2122843-2123604 (Clockwise)

Preceding gene: 68536908

Following gene: 68536910

Centisome position: 86.21

GC content: 61.02

Gene sequence:

>762_bases
GTGATCGTGACAGGTGCTGCTGGAGGCATCGGCCGCGAGTGTGTGCGCCTGCTACGACAGAACGATCACACCGTGATCGG
CTGGGATCTACCGGAAGTAGACATCACCTCTTCAAACCCGACTGACCCACGCAGCGTGGAAAGCCACCTGTCGAAAGCAC
TGGCAGCTCACGGGCACATTGATGCACTCATCCACTGCGCGGGAACCTTAATCCCAGATAGCGCACTGACGGGCCCCACG
GCAGTTGACACAGTTGACACAGTCTCGGGTATCGGTACGGACCCCGACGAGACCGGAGCCTGGGAAAACAACTTCGCTGT
CAACGTCACCGGCTTAGCCCGCACATGCTCCGCAATCGCCCAGCACATGGTGGATCGCGGCACTGGAGCAATTGTGGCAG
TGACTTCCAATGCAGCAGCACAGCCCCGGGCACGCATGGCCTCCTATGGAGCTTCCAAAGCGGCAGCGACTGCCTGGTTG
AAAACTCTGGCGCTAGAGTGCGCCCCACACGGGGTGCGCTGCAACAGCGTATCCCCTGGTTCCACAGACACCGCGATGCT
ACGCACCAGCTGGCACGGCGAGGATCGAGCCGCGCAGACCCTTGCCGGTGTACCGGAGGACTACCGGTTAGGCATCCCCT
TACAACGCATCGCGCAGCCAGAAGATATCGCGGCAGCATGCCTCTTTCTTATCTCCCCTGCAGCCTGCCACATCACCATG
CACGACCTCCGTGTTGATGGTGGCGCCACCCTAGATGCCTAG

Upstream 100 bases:

>100_bases
GTCGATTACAGTGTCCGCTATGGATTTCAACATTCCTCCGCACCTAGCCACACGGCAGCCAACCGAGTCGCCGCCGGAGC
AAGCGCAACTACAACAAACG

Downstream 100 bases:

>100_bases
CCTCTGTACCCCACCAGCCCAACGAAAGGTTATCTCTATGGCGATTCCACCCATTTCGCCCTATCCCATCCCCACTCCAT
CCACCACACTGCCCGCCGAT

Product: 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MIVTGAAGGIGRECVRLLRQNDHTVIGWDLPEVDITSSNPTDPRSVESHLSKALAAHGHIDALIHCAGTLIPDSALTGPT
AVDTVDTVSGIGTDPDETGAWENNFAVNVTGLARTCSAIAQHMVDRGTGAIVAVTSNAAAQPRARMASYGASKAAATAWL
KTLALECAPHGVRCNSVSPGSTDTAMLRTSWHGEDRAAQTLAGVPEDYRLGIPLQRIAQPEDIAAACLFLISPAACHITM
HDLRVDGGATLDA

Sequences:

>Translated_253_residues
MIVTGAAGGIGRECVRLLRQNDHTVIGWDLPEVDITSSNPTDPRSVESHLSKALAAHGHIDALIHCAGTLIPDSALTGPT
AVDTVDTVSGIGTDPDETGAWENNFAVNVTGLARTCSAIAQHMVDRGTGAIVAVTSNAAAQPRARMASYGASKAAATAWL
KTLALECAPHGVRCNSVSPGSTDTAMLRTSWHGEDRAAQTLAGVPEDYRLGIPLQRIAQPEDIAAACLFLISPAACHITM
HDLRVDGGATLDA
>Mature_253_residues
MIVTGAAGGIGRECVRLLRQNDHTVIGWDLPEVDITSSNPTDPRSVESHLSKALAAHGHIDALIHCAGTLIPDSALTGPT
AVDTVDTVSGIGTDPDETGAWENNFAVNVTGLARTCSAIAQHMVDRGTGAIVAVTSNAAAQPRARMASYGASKAAATAWL
KTLALECAPHGVRCNSVSPGSTDTAMLRTSWHGEDRAAQTLAGVPEDYRLGIPLQRIAQPEDIAAACLFLISPAACHITM
HDLRVDGGATLDA

Specific function: Involved in an early step of the biosynthesis of the catechol siderophore vibriobactin. Vibriobactin is a chelating compound involved in transporting iron from the bacterial environment into the cell cytoplasm [H]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=202, Percent_Identity=29.7029702970297, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI126723750, Length=149, Percent_Identity=30.8724832214765, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI5031737, Length=257, Percent_Identity=29.9610894941634, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI7705925, Length=257, Percent_Identity=27.6264591439689, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI15277342, Length=267, Percent_Identity=28.0898876404494, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI59889578, Length=232, Percent_Identity=28.0172413793103, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI10190704, Length=271, Percent_Identity=28.7822878228782, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1786812, Length=257, Percent_Identity=38.1322957198444, Blast_Score=147, Evalue=6e-37,
Organism=Escherichia coli, GI1787335, Length=263, Percent_Identity=30.0380228136882, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI87082100, Length=272, Percent_Identity=28.3088235294118, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788459, Length=273, Percent_Identity=30.4029304029304, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1789208, Length=265, Percent_Identity=25.6603773584906, Blast_Score=74, Evalue=8e-15,
Organism=Escherichia coli, GI1790717, Length=148, Percent_Identity=28.3783783783784, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1787905, Length=250, Percent_Identity=26.8, Blast_Score=66, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115534694, Length=262, Percent_Identity=30.1526717557252, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71994604, Length=266, Percent_Identity=30.8270676691729, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17560332, Length=273, Percent_Identity=27.8388278388278, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17562910, Length=275, Percent_Identity=28, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI72000259, Length=276, Percent_Identity=28.2608695652174, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17563726, Length=276, Percent_Identity=24.6376811594203, Blast_Score=78, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17562904, Length=273, Percent_Identity=26.3736263736264, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71994600, Length=267, Percent_Identity=30.7116104868914, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17531453, Length=272, Percent_Identity=24.6323529411765, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17560220, Length=280, Percent_Identity=25.3571428571429, Blast_Score=71, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17561402, Length=148, Percent_Identity=28.3783783783784, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17562990, Length=273, Percent_Identity=24.1758241758242, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI25147288, Length=267, Percent_Identity=26.9662921348315, Blast_Score=67, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17560150, Length=272, Percent_Identity=24.2647058823529, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17562906, Length=271, Percent_Identity=24.3542435424354, Blast_Score=64, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17559104, Length=276, Percent_Identity=25, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=215, Percent_Identity=27.906976744186, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI23397609, Length=268, Percent_Identity=30.5970149253731, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24639444, Length=272, Percent_Identity=25, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI21357041, Length=265, Percent_Identity=28.3018867924528, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24644337, Length=120, Percent_Identity=35.8333333333333, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24643142, Length=262, Percent_Identity=25.9541984732824, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI28571526, Length=265, Percent_Identity=28.3018867924528, Blast_Score=64, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR003560
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.28 [H]

Molecular weight: Translated: 26231; Mature: 26231

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVTGAAGGIGRECVRLLRQNDHTVIGWDLPEVDITSSNPTDPRSVESHLSKALAAHGHI
CEEECCCCCHHHHHHHHHHCCCCEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHHCCCH
DALIHCAGTLIPDSALTGPTAVDTVDTVSGIGTDPDETGAWENNFAVNVTGLARTCSAIA
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHH
QHMVDRGTGAIVAVTSNAAAQPRARMASYGASKAAATAWLKTLALECAPHGVRCNSVSPG
HHHHHCCCCEEEEEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCC
STDTAMLRTSWHGEDRAAQTLAGVPEDYRLGIPLQRIAQPEDIAAACLFLISPAACHITM
CCCCEEEEECCCCCHHHHHHHHCCCCCCCCCCCHHHHCCCHHHHHHHHHHHCCCCEEEEE
HDLRVDGGATLDA
EEEEECCCCCCCC
>Mature Secondary Structure
MIVTGAAGGIGRECVRLLRQNDHTVIGWDLPEVDITSSNPTDPRSVESHLSKALAAHGHI
CEEECCCCCHHHHHHHHHHCCCCEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHHCCCH
DALIHCAGTLIPDSALTGPTAVDTVDTVSGIGTDPDETGAWENNFAVNVTGLARTCSAIA
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHH
QHMVDRGTGAIVAVTSNAAAQPRARMASYGASKAAATAWLKTLALECAPHGVRCNSVSPG
HHHHHCCCCEEEEEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEECCCCCC
STDTAMLRTSWHGEDRAAQTLAGVPEDYRLGIPLQRIAQPEDIAAACLFLISPAACHITM
CCCCEEEEECCCCCHHHHHHHHCCCCCCCCCCCHHHHCCCHHHHHHHHHHHCCCCEEEEE
HDLRVDGGATLDA
EEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371453; 10952301 [H]