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The map label for this gene is accD2 [H]

Identifier: 68536752

GI number: 68536752

Start: 1939781

End: 1941145

Strand: Direct

Name: accD2 [H]

Synonym: jk1662

Alternate gene names: 68536752

Gene position: 1939781-1941145 (Clockwise)

Preceding gene: 68536737

Following gene: 68536753

Centisome position: 78.77

GC content: 67.55

Gene sequence:

>1365_bases
ATGGCGACCATGAGCTCTACCACCGACACATCGACAACTGCCGGGAAGATCGCCGACCTCCGCGATCGCTTGGCGGAGAC
CCACAAGCCGCAGGGGGACGAGATCCCGCGCGCTCGTCGCCGCGTGGACGCACTGCTGGATGCTGGTAGCTTCGTGGAGA
CCGACGCGCTGGCCCGCCACCGCTCCACCGCCTTCAAGGCAGACAAGTTCCGCCCAGTCACCGACGGCATTGTCGCCGGC
TACGGCACCATCGACGACCGCCCGGTATGCGTGTTCTCGCAGGACGCCACCCTCTTCGACGGCCAAATCGGCGAGACCGC
GGGCGAGAAGATCCTGAAGGTCATGGAACTGGCCGTGAAGTCCGGCACCCCGCTGATCGGCATTTACGAGGGCGCCGGCG
CTCGCCCAAACGAGGGCATCGCGGCCCTGGAGTTCTTCTCCCGCATCCAGAGCCTGCAGACGAAGCTCTCCGGCGTAGTT
CCGCAGATCGCCCTGGTCGCCGGCCCCACCAGCGGCGCGTTGGTGCACTCGGTGGTACTGTCCGACGTTGTCGTTGCGGT
CAAGGGTGCCGGCGAACTGGTAGATGACGCCACAGACGGCACCGCCCACGTCGTCGCCGAGGACGACGCTTCCGCGCTGG
GACTCGTCGCGGACATCCTCGGCTACCTGCCCAGCAACAACCGGGCGCTCCCCCTGCGCGGGGACGAGACGGAGGCAGAG
CCGGAGACAGACGAGCTGGACGGCCTGATCCCCGACTCGGACGTGCAGGCCTACGACATGCACGAGGTACTGAACCGTGT
AGTCGACGCGGATTCCGTGCTGGAGCTCCAGAAGTTCCATGCGCCGAACCTGATCACGGCACTGGCGCGCGTGGGCGGCC
GGAGTGTGGGCGTCATCGCGAACCAGCCCGAACAACAAGCAGGGGCGATCGACAACGCGGCGGCCGAGAAGGCAGCGCGC
TTCATCCGCTTCTGCGACGCTTTCAACGTGCCGCTGGTGACCTTCGTGGACTCGGCGGGCTACGCACCGGACGTACTGTT
CCGCCGCACCGCGAAGCTGATCGGCGTGACGGCCGCGGCGAGCGTCGGCAAGATCGCCGTGGTCACCCGCAAGGCCTTCG
GCGACGCCTACCTTTCCCTGGGCGCAAAGCGCCTGGGCACCGACCTGGTGTATGCATGGCCGACCGCGCAGATCGCGCAA
GACGATAGCTACCAGACGGAGCCTTACTCCGCCGCGGAGCGGGGCCTAGTGGACGCAGTAATCCCGCCGCGCGAGACCCG
CTCCCGCATCGTCGACGGCCTGCGCCTGGTGGAGCGCAAGGCCGAGGACGGCTACCCGCGCAAGCACGACAACCTGCCTT
TCTAG

Upstream 100 bases:

>100_bases
TAGCGGCGTGCGCATGGGAGTACTGTCCTTTCTTTTCACATGCCTTCCCTCAGACACTCTAGCCCCACCAATCACGGCGC
TGAAGTTTTTACACCGTATT

Downstream 100 bases:

>100_bases
GAGGAAGCGCGTGACTGATTTTCAGGTAATCAAGGGCAACCCGGACGAGGTTGAGACCCAAGCTCTGCAGCTCATCGTCG
ACGACCTGGCCAAGGAGGCC

Product: acyl-CoA carboxylase, beta subunit

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MATMSSTTDTSTTAGKIADLRDRLAETHKPQGDEIPRARRRVDALLDAGSFVETDALARHRSTAFKADKFRPVTDGIVAG
YGTIDDRPVCVFSQDATLFDGQIGETAGEKILKVMELAVKSGTPLIGIYEGAGARPNEGIAALEFFSRIQSLQTKLSGVV
PQIALVAGPTSGALVHSVVLSDVVVAVKGAGELVDDATDGTAHVVAEDDASALGLVADILGYLPSNNRALPLRGDETEAE
PETDELDGLIPDSDVQAYDMHEVLNRVVDADSVLELQKFHAPNLITALARVGGRSVGVIANQPEQQAGAIDNAAAEKAAR
FIRFCDAFNVPLVTFVDSAGYAPDVLFRRTAKLIGVTAAASVGKIAVVTRKAFGDAYLSLGAKRLGTDLVYAWPTAQIAQ
DDSYQTEPYSAAERGLVDAVIPPRETRSRIVDGLRLVERKAEDGYPRKHDNLPF

Sequences:

>Translated_454_residues
MATMSSTTDTSTTAGKIADLRDRLAETHKPQGDEIPRARRRVDALLDAGSFVETDALARHRSTAFKADKFRPVTDGIVAG
YGTIDDRPVCVFSQDATLFDGQIGETAGEKILKVMELAVKSGTPLIGIYEGAGARPNEGIAALEFFSRIQSLQTKLSGVV
PQIALVAGPTSGALVHSVVLSDVVVAVKGAGELVDDATDGTAHVVAEDDASALGLVADILGYLPSNNRALPLRGDETEAE
PETDELDGLIPDSDVQAYDMHEVLNRVVDADSVLELQKFHAPNLITALARVGGRSVGVIANQPEQQAGAIDNAAAEKAAR
FIRFCDAFNVPLVTFVDSAGYAPDVLFRRTAKLIGVTAAASVGKIAVVTRKAFGDAYLSLGAKRLGTDLVYAWPTAQIAQ
DDSYQTEPYSAAERGLVDAVIPPRETRSRIVDGLRLVERKAEDGYPRKHDNLPF
>Mature_453_residues
ATMSSTTDTSTTAGKIADLRDRLAETHKPQGDEIPRARRRVDALLDAGSFVETDALARHRSTAFKADKFRPVTDGIVAGY
GTIDDRPVCVFSQDATLFDGQIGETAGEKILKVMELAVKSGTPLIGIYEGAGARPNEGIAALEFFSRIQSLQTKLSGVVP
QIALVAGPTSGALVHSVVLSDVVVAVKGAGELVDDATDGTAHVVAEDDASALGLVADILGYLPSNNRALPLRGDETEAEP
ETDELDGLIPDSDVQAYDMHEVLNRVVDADSVLELQKFHAPNLITALARVGGRSVGVIANQPEQQAGAIDNAAAEKAARF
IRFCDAFNVPLVTFVDSAGYAPDVLFRRTAKLIGVTAAASVGKIAVVTRKAFGDAYLSLGAKRLGTDLVYAWPTAQIAQD
DSYQTEPYSAAERGLVDAVIPPRETRSRIVDGLRLVERKAEDGYPRKHDNLPF

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=474, Percent_Identity=36.9198312236287, Blast_Score=289, Evalue=5e-78,
Organism=Homo sapiens, GI295821216, Length=494, Percent_Identity=35.4251012145749, Blast_Score=277, Evalue=2e-74,
Organism=Homo sapiens, GI11545863, Length=410, Percent_Identity=25.8536585365854, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI25147362, Length=473, Percent_Identity=35.3065539112051, Blast_Score=286, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI25147359, Length=473, Percent_Identity=35.3065539112051, Blast_Score=286, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI17552936, Length=414, Percent_Identity=25.1207729468599, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24586065, Length=448, Percent_Identity=25, Blast_Score=110, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 48278; Mature: 48147

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATMSSTTDTSTTAGKIADLRDRLAETHKPQGDEIPRARRRVDALLDAGSFVETDALARH
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHH
RSTAFKADKFRPVTDGIVAGYGTIDDRPVCVFSQDATLFDGQIGETAGEKILKVMELAVK
HHHHHCCCCCCCCCCCCEECCCCCCCCEEEEEECCCCEECCCCCHHHHHHHHHHHHHHHH
SGTPLIGIYEGAGARPNEGIAALEFFSRIQSLQTKLSGVVPQIALVAGPTSGALVHSVVL
CCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHH
SDVVVAVKGAGELVDDATDGTAHVVAEDDASALGLVADILGYLPSNNRALPLRGDETEAE
HHHHHHHCCCCHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCEECCCCCCCCCC
PETDELDGLIPDSDVQAYDMHEVLNRVVDADSVLELQKFHAPNLITALARVGGRSVGVIA
CCHHHHCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEE
NQPEQQAGAIDNAAAEKAARFIRFCDAFNVPLVTFVDSAGYAPDVLFRRTAKLIGVTAAA
CCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHH
SVGKIAVVTRKAFGDAYLSLGAKRLGTDLVYAWPTAQIAQDDSYQTEPYSAAERGLVDAV
CCCEEEEEEHHHHHHHHHHHCHHHHCCCEEEECCCHHHCCCCCCCCCCCCHHHCCCEECC
IPPRETRSRIVDGLRLVERKAEDGYPRKHDNLPF
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
ATMSSTTDTSTTAGKIADLRDRLAETHKPQGDEIPRARRRVDALLDAGSFVETDALARH
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHH
RSTAFKADKFRPVTDGIVAGYGTIDDRPVCVFSQDATLFDGQIGETAGEKILKVMELAVK
HHHHHCCCCCCCCCCCCEECCCCCCCCEEEEEECCCCEECCCCCHHHHHHHHHHHHHHHH
SGTPLIGIYEGAGARPNEGIAALEFFSRIQSLQTKLSGVVPQIALVAGPTSGALVHSVVL
CCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHH
SDVVVAVKGAGELVDDATDGTAHVVAEDDASALGLVADILGYLPSNNRALPLRGDETEAE
HHHHHHHCCCCHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCEECCCCCCCCCC
PETDELDGLIPDSDVQAYDMHEVLNRVVDADSVLELQKFHAPNLITALARVGGRSVGVIA
CCHHHHCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHCCCHHHHHHHHHCCCEEEEEE
NQPEQQAGAIDNAAAEKAARFIRFCDAFNVPLVTFVDSAGYAPDVLFRRTAKLIGVTAAA
CCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHH
SVGKIAVVTRKAFGDAYLSLGAKRLGTDLVYAWPTAQIAQDDSYQTEPYSAAERGLVDAV
CCCEEEEEEHHHHHHHHHHHCHHHHCCCEEEECCCHHHCCCCCCCCCCCCHHHCCCEECC
IPPRETRSRIVDGLRLVERKAEDGYPRKHDNLPF
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7489918; 11234002 [H]