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The map label for this gene is merR1 [H]

Identifier: 68536664

GI number: 68536664

Start: 1850103

End: 1850507

Strand: Direct

Name: merR1 [H]

Synonym: jk1578

Alternate gene names: 68536664

Gene position: 1850103-1850507 (Clockwise)

Preceding gene: 68536662

Following gene: 68536667

Centisome position: 75.13

GC content: 54.32

Gene sequence:

>405_bases
ATGCAAAACAGTAATTTCAAGATCGGCGAGGTCGTTGACCAGACGGGGTTGTCGATTCCCACCTTGCGTTATTATGACAA
CGTCGGCCTGATTACCCCATCGGGGCGTAGCCCTGGTGGGTTCAGGCTTTATAGTGAGGCTGATGTACGTCGTGTTTTGC
TGGTGCGACGGATGAAACCGCTGGGGTTTACTCTGGATCAGATGCGGGAATTCCTGGAAGCTGCGGAGATTCTTCATAGT
TCAGATGGCGGGCAGGACAGTGATACCGCACAGCAGGCACGGAGTAATGCCAAGGCCACCCTTGCCGACATTCGTGAGGA
GACGCGCACCCGCTACGAAAAGCTACGCAAGCAAATTGCCTACGCTGAGGAATTCCTCGATCTGGTCAACACCCTGGCAC
CCTAA

Upstream 100 bases:

>100_bases
TTAGGTTTGGTGATGGTGGTCATGGTAGCGGGAGTTTTACTCAACCGCCAACCCAGGCACAGGAACCCGTGAGCAACATC
ACCGTGAAGGAGAACAGGCA

Downstream 100 bases:

>100_bases
ACTGCCCCCATCCTTCGCAGGGAGAAAAAGACCATCGTATTGAATGCGCTCTGTCGAATCGCGTTCCAGATGAAGTGGAC
GAACGCCCGCGGCCTCTCCG

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 134; Mature: 134

Protein sequence:

>134_residues
MQNSNFKIGEVVDQTGLSIPTLRYYDNVGLITPSGRSPGGFRLYSEADVRRVLLVRRMKPLGFTLDQMREFLEAAEILHS
SDGGQDSDTAQQARSNAKATLADIREETRTRYEKLRKQIAYAEEFLDLVNTLAP

Sequences:

>Translated_134_residues
MQNSNFKIGEVVDQTGLSIPTLRYYDNVGLITPSGRSPGGFRLYSEADVRRVLLVRRMKPLGFTLDQMREFLEAAEILHS
SDGGQDSDTAQQARSNAKATLADIREETRTRYEKLRKQIAYAEEFLDLVNTLAP
>Mature_134_residues
MQNSNFKIGEVVDQTGLSIPTLRYYDNVGLITPSGRSPGGFRLYSEADVRRVLLVRRMKPLGFTLDQMREFLEAAEILHS
SDGGQDSDTAQQARSNAKATLADIREETRTRYEKLRKQIAYAEEFLDLVNTLAP

Specific function: Mediates the mercuric-dependent induction of mercury resistance operon. In the absence of mercury merR represses transcription by binding tightly to the mer operator region; when mercury is present the dimeric complex binds a single ion and becomes a pote

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789687, Length=67, Percent_Identity=37.3134328358209, Blast_Score=62, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR011794
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 15111; Mature: 15111

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNSNFKIGEVVDQTGLSIPTLRYYDNVGLITPSGRSPGGFRLYSEADVRRVLLVRRMKP
CCCCCCCHHHHHHHCCCCCCCHHEECCCCEECCCCCCCCCEEECCHHHHHHHHHHHHHCC
LGFTLDQMREFLEAAEILHSSDGGQDSDTAQQARSNAKATLADIREETRTRYEKLRKQIA
CCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
YAEEFLDLVNTLAP
HHHHHHHHHHHHCC
>Mature Secondary Structure
MQNSNFKIGEVVDQTGLSIPTLRYYDNVGLITPSGRSPGGFRLYSEADVRRVLLVRRMKP
CCCCCCCHHHHHHHCCCCCCCHHEECCCCEECCCCCCCCCEEECCHHHHHHHHHHHHHCC
LGFTLDQMREFLEAAEILHSSDGGQDSDTAQQARSNAKATLADIREETRTRYEKLRKQIA
CCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHH
YAEEFLDLVNTLAP
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2536669; 10559175; 2492496; 2305262 [H]