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The map label for this gene is gorA [H]

Identifier: 68536230

GI number: 68536230

Start: 1353606

End: 1354976

Strand: Direct

Name: gorA [H]

Synonym: jk1153

Alternate gene names: 68536230

Gene position: 1353606-1354976 (Clockwise)

Preceding gene: 68536229

Following gene: 68536231

Centisome position: 54.97

GC content: 63.68

Gene sequence:

>1371_bases
GTGCCTGATTTCGACCTCATCATTGTCGGCACCGGCTCCGGCAACTCCCTGCCCAGCCCCGCCAACGAGCACCAAAGAAT
CGCCATCGTGGAAAAGGGCACCTTCGGCGGAACCTGCATCAACGTGGGCTGCATCCCGACCAAGATGTTCGTCCACACCG
CCGACGTCGCCCGCAGCTTCTCCGAGGCCTCCCGCCTGAGCCTCACCGGCGAGCTCCAGCACGTCGACTGGAAGGACATC
CAGCGCCGCGTCTTCGCCGACCGCATCGATCCCATCAGCGAGAGCGGCGCCGACTACCGCGCGGGAGACGAAACCCCGAA
CATCACCCTCTTCGAAGGCACCGCCCGCTTCGTTGGCCCCCGCACGCTGCAGATCGGCGACGGCCCCACCATCACCGGCG
CCAACATCGTGCTCGCCACCGGCGGCCGCCCACGCATCCACCCCGCCCTCGCCGACGTGCGCTACCGCACCAACGAGGAC
ATCATGCGCCTCGATGAGCTGCCGAAGTCCCTCATCGTCGTCGGCGGCGGCATCGTCGCCGTGGAGTTCGCCGCCATGTT
CTCTGGCCTCGGCACGCAGGTTACGCTCATCAATCGCTCGGAGAAGCTGTTGCGGAAGTTGGACGCCGACATCTCCGATA
CCTTCACCACCCAAGCCAAGCAGCAGTGGACGAACCACTTGGGGTGCAACATCACCGCCGCCGAGGAAACCGACGATGGC
CAGATCACCCTCACCCTTGACGACGGAACTACCGTCACGGCCGAAGAGGTCCTCGTTGCGATGGGGCGCGTCAACAATTC
GGACACGTTGGACTGCGAAACGGGTGGCGTCAAAACCCGAAAAGACGGCCTAATCGAGGTCGACGAATACGGCCGCACCA
GCGCCGACGGCGTGTGGGCGCTGGGCGATGCGTGCAATGACTTCGAGCTCAAGCACGTCGCCAACGCCGAGGCACGGGTG
GTGGCGCACAACCTAGCCCACCCCAATGACCTGCGAAAGTTCAACCACGATGTGGTCCCCAGCGGCGTGTTCACGCATCC
GCAGATCGGCGTAGTGGGCCTGACCGAGCAGGAGGCGCGCGAGACCGGCCGCCCCCTCACCGTCAAAATCCAGAAATACA
GCGACGTGGCCTATGGCTGGGCGATGGAAGATACAACCGGGTTCTGCAAGGTCATCGCCGACCGCAGCACCGGCGAGATC
CTCGGCGCGCACATCATCGGGCCGGAGGCAAGCTCGCTGATCCAGTGCTTCGTCACCGCCATGACCTTCGGAATTAGTGC
CCGCGATTTCGCCGAAAAGCAGTATTGGCCCCACCCTGCTCTGACAGAATTAGTCGAGAACGCCCTACTTGGGTTAGATA
TCGAAAACTAA

Upstream 100 bases:

>100_bases
CTGCACGACGTGTTCCTCTCCCGCCCCAAGATCCGCTCCAAGGCGTTCGCCGCCACCGACGAGTGGCTTAGCGACGTCTT
CAACGAAAGGAATGTTCACC

Downstream 100 bases:

>100_bases
CAAAGGAGCCATCTCGCCATGTTTGCAGTAGTCACCGGAGCAGCCTCAGGTATTGGCCGGGAGGTGGCTCTGCAACTAGC
TGAACGCGGTTATGCGGTGG

Product: mycothione reductase

Products: NA

Alternate protein names: Mycothiol-disulfide reductase; NADPH-dependent mycothione reductase [H]

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MPDFDLIIVGTGSGNSLPSPANEHQRIAIVEKGTFGGTCINVGCIPTKMFVHTADVARSFSEASRLSLTGELQHVDWKDI
QRRVFADRIDPISESGADYRAGDETPNITLFEGTARFVGPRTLQIGDGPTITGANIVLATGGRPRIHPALADVRYRTNED
IMRLDELPKSLIVVGGGIVAVEFAAMFSGLGTQVTLINRSEKLLRKLDADISDTFTTQAKQQWTNHLGCNITAAEETDDG
QITLTLDDGTTVTAEEVLVAMGRVNNSDTLDCETGGVKTRKDGLIEVDEYGRTSADGVWALGDACNDFELKHVANAEARV
VAHNLAHPNDLRKFNHDVVPSGVFTHPQIGVVGLTEQEARETGRPLTVKIQKYSDVAYGWAMEDTTGFCKVIADRSTGEI
LGAHIIGPEASSLIQCFVTAMTFGISARDFAEKQYWPHPALTELVENALLGLDIEN

Sequences:

>Translated_456_residues
MPDFDLIIVGTGSGNSLPSPANEHQRIAIVEKGTFGGTCINVGCIPTKMFVHTADVARSFSEASRLSLTGELQHVDWKDI
QRRVFADRIDPISESGADYRAGDETPNITLFEGTARFVGPRTLQIGDGPTITGANIVLATGGRPRIHPALADVRYRTNED
IMRLDELPKSLIVVGGGIVAVEFAAMFSGLGTQVTLINRSEKLLRKLDADISDTFTTQAKQQWTNHLGCNITAAEETDDG
QITLTLDDGTTVTAEEVLVAMGRVNNSDTLDCETGGVKTRKDGLIEVDEYGRTSADGVWALGDACNDFELKHVANAEARV
VAHNLAHPNDLRKFNHDVVPSGVFTHPQIGVVGLTEQEARETGRPLTVKIQKYSDVAYGWAMEDTTGFCKVIADRSTGEI
LGAHIIGPEASSLIQCFVTAMTFGISARDFAEKQYWPHPALTELVENALLGLDIEN
>Mature_455_residues
PDFDLIIVGTGSGNSLPSPANEHQRIAIVEKGTFGGTCINVGCIPTKMFVHTADVARSFSEASRLSLTGELQHVDWKDIQ
RRVFADRIDPISESGADYRAGDETPNITLFEGTARFVGPRTLQIGDGPTITGANIVLATGGRPRIHPALADVRYRTNEDI
MRLDELPKSLIVVGGGIVAVEFAAMFSGLGTQVTLINRSEKLLRKLDADISDTFTTQAKQQWTNHLGCNITAAEETDDGQ
ITLTLDDGTTVTAEEVLVAMGRVNNSDTLDCETGGVKTRKDGLIEVDEYGRTSADGVWALGDACNDFELKHVANAEARVV
AHNLAHPNDLRKFNHDVVPSGVFTHPQIGVVGLTEQEARETGRPLTVKIQKYSDVAYGWAMEDTTGFCKVIADRSTGEIL
GAHIIGPEASSLIQCFVTAMTFGISARDFAEKQYWPHPALTELVENALLGLDIEN

Specific function: Catalyzes the NAD(P)H-dependent reduction of mycothione (the oxidized disulfide form of mycothiol) to mycothiol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=441, Percent_Identity=28.5714285714286, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI91199540, Length=469, Percent_Identity=26.226012793177, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI22035672, Length=413, Percent_Identity=30.2663438256659, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI291045266, Length=416, Percent_Identity=27.4038461538462, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI33519430, Length=436, Percent_Identity=25.6880733944954, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI33519428, Length=436, Percent_Identity=25.6880733944954, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI33519426, Length=436, Percent_Identity=25.6880733944954, Blast_Score=126, Evalue=5e-29,
Organism=Homo sapiens, GI148277071, Length=436, Percent_Identity=25.6880733944954, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI148277065, Length=436, Percent_Identity=25.6880733944954, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI291045268, Length=413, Percent_Identity=25.4237288135593, Blast_Score=102, Evalue=7e-22,
Organism=Escherichia coli, GI1789915, Length=416, Percent_Identity=33.6538461538462, Blast_Score=209, Evalue=4e-55,
Organism=Escherichia coli, GI1786307, Length=429, Percent_Identity=30.5361305361305, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI87082354, Length=438, Percent_Identity=28.7671232876712, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI87081717, Length=454, Percent_Identity=27.0925110132159, Blast_Score=155, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI71983429, Length=424, Percent_Identity=29.9528301886792, Blast_Score=176, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI71983419, Length=424, Percent_Identity=29.9528301886792, Blast_Score=176, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI32565766, Length=469, Percent_Identity=28.3582089552239, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17557007, Length=472, Percent_Identity=28.3898305084746, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71982272, Length=440, Percent_Identity=25, Blast_Score=101, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6325166, Length=426, Percent_Identity=29.81220657277, Blast_Score=176, Evalue=5e-45,
Organism=Saccharomyces cerevisiae, GI6321091, Length=471, Percent_Identity=26.5392781316348, Blast_Score=136, Evalue=7e-33,
Organism=Saccharomyces cerevisiae, GI6325240, Length=469, Percent_Identity=24.0938166311301, Blast_Score=113, Evalue=5e-26,
Organism=Drosophila melanogaster, GI21358499, Length=473, Percent_Identity=27.061310782241, Blast_Score=162, Evalue=5e-40,
Organism=Drosophila melanogaster, GI24640549, Length=452, Percent_Identity=27.6548672566372, Blast_Score=128, Evalue=7e-30,
Organism=Drosophila melanogaster, GI24640553, Length=452, Percent_Identity=27.6548672566372, Blast_Score=128, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24640551, Length=452, Percent_Identity=27.6548672566372, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI17737741, Length=457, Percent_Identity=27.5711159737418, Blast_Score=117, Evalue=2e-26,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR017817
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.15 [H]

Molecular weight: Translated: 49319; Mature: 49188

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDFDLIIVGTGSGNSLPSPANEHQRIAIVEKGTFGGTCINVGCIPTKMFVHTADVARSF
CCCCEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCEEEEECCCCHHHHEEHHHHHHHH
SEASRLSLTGELQHVDWKDIQRRVFADRIDPISESGADYRAGDETPNITLFEGTARFVGP
HHHHHEEEEECEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCHHHCCC
RTLQIGDGPTITGANIVLATGGRPRIHPALADVRYRTNEDIMRLDELPKSLIVVGGGIVA
EEEEECCCCEEECCEEEEECCCCCCCCHHHHHEEECCCHHHHHHHHCCCEEEEECCCHHH
VEFAAMFSGLGTQVTLINRSEKLLRKLDADISDTFTTQAKQQWTNHLGCNITAAEETDDG
HHHHHHHCCCCCEEEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCC
QITLTLDDGTTVTAEEVLVAMGRVNNSDTLDCETGGVKTRKDGLIEVDEYGRTSADGVWA
EEEEEECCCCEEEHHHHHHHHHCCCCCCEEEECCCCCEECCCCCEEECCCCCCCCCCEEE
LGDACNDFELKHVANAEARVVAHNLAHPNDLRKFNHDVVPSGVFTHPQIGVVGLTEQEAR
ECCCCCCCCCHHHCCCCCEEEECCCCCCHHHHHCCCCCCCCCCCCCCCCEEEECCHHHHH
ETGRPLTVKIQKYSDVAYGWAMEDTTGFCKVIADRSTGEILGAHIIGPEASSLIQCFVTA
HCCCCEEEEEEECCCEEEEEEECCCCCEEEEEECCCCCCEEEEEEECCCHHHHHHHHHHH
MTFGISARDFAEKQYWPHPALTELVENALLGLDIEN
HHHCCCHHHHHHHHCCCCHHHHHHHHHHHHCEEECC
>Mature Secondary Structure 
PDFDLIIVGTGSGNSLPSPANEHQRIAIVEKGTFGGTCINVGCIPTKMFVHTADVARSF
CCCEEEEEECCCCCCCCCCCCCCCEEEEEECCCCCCEEEEECCCCHHHHEEHHHHHHHH
SEASRLSLTGELQHVDWKDIQRRVFADRIDPISESGADYRAGDETPNITLFEGTARFVGP
HHHHHEEEEECEECCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCHHHCCC
RTLQIGDGPTITGANIVLATGGRPRIHPALADVRYRTNEDIMRLDELPKSLIVVGGGIVA
EEEEECCCCEEECCEEEEECCCCCCCCHHHHHEEECCCHHHHHHHHCCCEEEEECCCHHH
VEFAAMFSGLGTQVTLINRSEKLLRKLDADISDTFTTQAKQQWTNHLGCNITAAEETDDG
HHHHHHHCCCCCEEEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCC
QITLTLDDGTTVTAEEVLVAMGRVNNSDTLDCETGGVKTRKDGLIEVDEYGRTSADGVWA
EEEEEECCCCEEEHHHHHHHHHCCCCCCEEEECCCCCEECCCCCEEECCCCCCCCCCEEE
LGDACNDFELKHVANAEARVVAHNLAHPNDLRKFNHDVVPSGVFTHPQIGVVGLTEQEAR
ECCCCCCCCCHHHCCCCCEEEECCCCCCHHHHHCCCCCCCCCCCCCCCCEEEECCHHHHH
ETGRPLTVKIQKYSDVAYGWAMEDTTGFCKVIADRSTGEILGAHIIGPEASSLIQCFVTA
HCCCCEEEEEEECCCEEEEEEECCCCCEEEEEECCCCCCEEEEEEECCCHHHHHHHHHHH
MTFGISARDFAEKQYWPHPALTELVENALLGLDIEN
HHHCCCHHHHHHHHCCCCHHHHHHHHHHHHCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]