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The map label for this gene is lexA

Identifier: 68536183

GI number: 68536183

Start: 1304675

End: 1305478

Strand: Direct

Name: lexA

Synonym: jk1106

Alternate gene names: 68536183

Gene position: 1304675-1305478 (Clockwise)

Preceding gene: 68536181

Following gene: 68536184

Centisome position: 52.98

GC content: 60.07

Gene sequence:

>804_bases
GTGAGCATCGACGAATCGAGTGACAACCCCACCCCGCGCCCGAAGCTCGGCCGCCCGCCGAAGTCGGAGGCCGATAAGCG
CGCAGAGAAAGAGGCGCAGAAAGACGGCAAGAAGCCGGCATTGAGCACCCGTCAGCGCCGAATCCTCGAAGTCATTAGGG
ATTCGACCATCATCCGCGGCTACCCGCCGAGCATTCGCGAGATTGCAGACGCAGTTGGGCTGCACTCCACCTCTTCCGTT
TCTTATCACCTGACCCAGCTTGAGAAGCGGGGTTATCTCCGCCGCGATGGCAAACGTCCGCGAGCCGTAGACGTCCGAGC
ATTCGACGGTGGCCAGCTCACGAACGAAAGCACCAAAAAGAACGCAGGCTCGCCCCAGCCAACTTCCGCGGCTATCCCGG
AACCGACCACCGAAGGCGAGACCATGCCAGAGGCGACCTACGTTCCGGTTGTAGGCCAGATTGCGGCAGGCGCCCCAATT
CTCGCTGAGCAGAATGTTGAGGCTCACTTTCCCCTCCCGCAAGAACTCGTGGGCAATGGCGAGCTTTTTCTGCTTCAGGT
TGTCGGCGAATCCATGCACGACGCCGGCATTTTCAACGGTGACTGGGTAGTCGTGCGTTCGCAGTCCGTCGCCGAATTTG
GAGACTTCGTTGCGGCCATGATCGATGGCGAGGCGACAGTCAAGGAATTCCAAAAGGATGCCGACGGCCTATGGCTTATT
CCCCACAATCCGCTGTTCGAGCCCATCCCCGCTGAGGAGGCAACAATTCTGGGCAAGGTTGCCGCGGTCCTGCGCAAGAT
CTAA

Upstream 100 bases:

>100_bases
CGAAATTCGAACATTTTCGAACACATATACTAGTAATCGTTTAGTTTTCGGGTAGAGTCAATGGCGATAGCTGAACCGAA
TACCGAACGAGGTACACCCC

Downstream 100 bases:

>100_bases
GTCCCCCCCATTGGCTCTGACGCCGCCTTTTCGGCCCGCTAGCAACTAAAATGACCTTCATGGAATCAGCAGAGCGGCGC
CGCCAGATACTTTCCCTCAC

Product: LexA repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MSIDESSDNPTPRPKLGRPPKSEADKRAEKEAQKDGKKPALSTRQRRILEVIRDSTIIRGYPPSIREIADAVGLHSTSSV
SYHLTQLEKRGYLRRDGKRPRAVDVRAFDGGQLTNESTKKNAGSPQPTSAAIPEPTTEGETMPEATYVPVVGQIAAGAPI
LAEQNVEAHFPLPQELVGNGELFLLQVVGESMHDAGIFNGDWVVVRSQSVAEFGDFVAAMIDGEATVKEFQKDADGLWLI
PHNPLFEPIPAEEATILGKVAAVLRKI

Sequences:

>Translated_267_residues
MSIDESSDNPTPRPKLGRPPKSEADKRAEKEAQKDGKKPALSTRQRRILEVIRDSTIIRGYPPSIREIADAVGLHSTSSV
SYHLTQLEKRGYLRRDGKRPRAVDVRAFDGGQLTNESTKKNAGSPQPTSAAIPEPTTEGETMPEATYVPVVGQIAAGAPI
LAEQNVEAHFPLPQELVGNGELFLLQVVGESMHDAGIFNGDWVVVRSQSVAEFGDFVAAMIDGEATVKEFQKDADGLWLI
PHNPLFEPIPAEEATILGKVAAVLRKI
>Mature_266_residues
SIDESSDNPTPRPKLGRPPKSEADKRAEKEAQKDGKKPALSTRQRRILEVIRDSTIIRGYPPSIREIADAVGLHSTSSVS
YHLTQLEKRGYLRRDGKRPRAVDVRAFDGGQLTNESTKKNAGSPQPTSAAIPEPTTEGETMPEATYVPVVGQIAAGAPIL
AEQNVEAHFPLPQELVGNGELFLLQVVGESMHDAGIFNGDWVVVRSQSVAEFGDFVAAMIDGEATVKEFQKDADGLWLIP
HNPLFEPIPAEEATILGKVAAVLRKI

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family

Homologues:

Organism=Escherichia coli, GI1790476, Length=230, Percent_Identity=30.4347826086957, Blast_Score=99, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LEXA_CORJK (Q4JV87)

Other databases:

- EMBL:   CR931997
- RefSeq:   YP_250888.1
- HSSP:   P0A7C2
- ProteinModelPortal:   Q4JV87
- SMR:   Q4JV87
- STRING:   Q4JV87
- MEROPS:   S24.001
- GeneID:   3433566
- GenomeReviews:   CR931997_GR
- KEGG:   cjk:jk1106
- NMPDR:   fig|306537.3.peg.1029
- eggNOG:   COG1974
- HOGENOM:   HBG679610
- OMA:   IAENPDF
- ProtClustDB:   PRK00215
- BioCyc:   CJEI306537:JK1106-MONOMER
- GO:   GO:0006508
- GO:   GO:0006350
- HAMAP:   MF_00015
- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991
- Gene3D:   G3DSA:2.10.109.10
- Gene3D:   G3DSA:1.10.10.10
- PRINTS:   PR00726
- TIGRFAMs:   TIGR00498

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24; SSF51306 Pept_S24_S26_C

EC number: =3.4.21.88

Molecular weight: Translated: 29006; Mature: 28875

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: NA

Important sites: ACT_SITE 191-191 ACT_SITE 228-228

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIDESSDNPTPRPKLGRPPKSEADKRAEKEAQKDGKKPALSTRQRRILEVIRDSTIIRG
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEECC
YPPSIREIADAVGLHSTSSVSYHLTQLEKRGYLRRDGKRPRAVDVRAFDGGQLTNESTKK
CCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHCCCCCCCEEEEEECCCCCCCCCCHHC
NAGSPQPTSAAIPEPTTEGETMPEATYVPVVGQIAAGAPILAEQNVEAHFPLPQELVGNG
CCCCCCCCCCCCCCCCCCCCCCCCCEECCHHHHHHCCCCEEECCCCCCCCCCCHHHHCCC
ELFLLQVVGESMHDAGIFNGDWVVVRSQSVAEFGDFVAAMIDGEATVKEFQKDADGLWLI
CEEEEEECCCHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEE
PHNPLFEPIPAEEATILGKVAAVLRKI
CCCCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SIDESSDNPTPRPKLGRPPKSEADKRAEKEAQKDGKKPALSTRQRRILEVIRDSTIIRG
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCEECC
YPPSIREIADAVGLHSTSSVSYHLTQLEKRGYLRRDGKRPRAVDVRAFDGGQLTNESTKK
CCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHCCCCCCCEEEEEECCCCCCCCCCHHC
NAGSPQPTSAAIPEPTTEGETMPEATYVPVVGQIAAGAPILAEQNVEAHFPLPQELVGNG
CCCCCCCCCCCCCCCCCCCCCCCCCEECCHHHHHHCCCCEEECCCCCCCCCCCHHHHCCC
ELFLLQVVGESMHDAGIFNGDWVVVRSQSVAEFGDFVAAMIDGEATVKEFQKDADGLWLI
CEEEEEECCCHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEE
PHNPLFEPIPAEEATILGKVAAVLRKI
CCCCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA